Review
Microbiology
Sineewanlaya Wichit, Nuttamonpat Gumpangseth, Rodolphe Hamel, Sakda Yainoy, Siwaret Arikit, Chuchard Punsawad, Dorothee Misse
Summary: Chikungunya and Zika viruses have globally re-emerged over the past 60 years and there is currently no specific antiviral treatment. Understanding viral-host interactions is crucial for developing targeted therapeutics, but limited information is available in this area at present.
Article
Microbiology
Cassandra Koh, Annabelle Henrion-Lacritick, Lionel Frangeul, Maria-Carla Saleh
Summary: Palm Creek virus can interfere with mosquito-borne flavivirus replication in Culex mosquitoes, but does not have an effect on the transmission of Zika and chikungunya viruses in Aedes mosquitoes. Additionally, the interference mechanism is unlikely to be through RNA interference.
Article
Microbiology
Bachirou Tinto, Didier Patinde Alexandre Kabore, Dramane Kania, Therese Samdapawinde Kagone, Alice Kiba-Koumare, Laura Pinceloup, Guillaume Thaurignac, Philippe Van de Perre, Roch Kounbobr Dabire, Thierry Baldet, Serafin Guitierrez, Patricia Gil, Ahidjo Ayouba, Sara Salinas, Yannick Simonin
Summary: Based on a study of blood donor samples in Burkina Faso, the seroprevalence of Zika virus and dengue virus is high in the region, especially for dengue virus. Although molecular evidence of Zika virus circulation could not be demonstrated, this research suggests the need to strengthen arbovirus surveillance in Burkina Faso and further investigate the epidemiology of these viruses.
Article
Engineering, Multidisciplinary
M. Venkatesan, Abd Elnaby Kabeel, Sriharikota Chandra Sekhar, Ravishankar Sathyamurthy, Muthu Manokar Athikesavan
Summary: Seaweeds, primitive plants and macroalgae, typically grow in shallow water areas such as backwaters, estuaries, and seas. They attach to coral reefs, rocks, and other substrata. Researchers collected seaweeds from the Kanyakumari region and processed them to extract methanol using the Saccharification method. The highest yield of methanol (51.2%) was obtained with a substrate concentration of 15% and a time duration of approximately 48 hours. The study focused on producing methanol from a high concentration and choice of seaweed (Sargassum wightii).
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Virology
Roman B. Bayandin, Marat T. Makenov, Sanaba Boumbaly, Olga A. Stukolova, Anastasia V. Gladysheva, Andrey V. Shipovalov, Maksim O. Skarnovich, Ousmane Camara, Aboubacar Hady Toure, Victor A. Svyatchenko, Alexander N. Shvalov, Vladimir A. Ternovoi, Mamadou Y. Boiro, Alexander P. Agafonov, Lyudmila S. Karan
Summary: This article presents a case report of Zika fever in a pregnant woman from Guinea in 2018. The Zika virus isolated from the patient belonged to the African lineage, specifically the Nigerian sublineage. In addition, serological screening revealed a varying seroprevalence of Zika virus infection among febrile patients in Faranah, ranging from 5.6% to 17.1%.
Article
Clinical Neurology
Sonja E. Leonhard, Susan Halstead, Suzannah B. Lant, Maria de Fatima Pessoa Militao de Albuquerque, Carlos Alexandre Antunes de Brito, Livia Brito Bezerra de Albuquerque, Mark A. Ellul, Rafael Freitas de Oliveira Franca, Dawn Gourlay, Michael J. Griffiths, Adelia Maria de Miranda Henriques-Souza, Maria I. de Morais Machado, Raquel Medialdea-Carrera, Ravi Mehta, Roberta da Paz Melo, Solange D. Mesquita, Alvaro J. P. Moreira, Lindomar J. Pena, Marcela Lopes Santos, Lance Turtle, Tom Solomon, Hugh J. Willison, Bart C. Jacobs, Maria L. Brito Ferreira
Summary: This study investigated the clinical phenotype and antibody signature of GBS patients following Zika virus and chikungunya virus outbreaks in Northeast Brazil. The majority of patients had evidence of recent arbovirus infection, with longer hospital stays observed in those infected with both Zika and chikungunya viruses.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Immunology
Ruklanthi de Alwis, Raphael M. Zellweger, Edmond Chua, Lin-Fa Wang, Tanu Chawla, October M. Sessions, Damien Marlier, John E. Connolly, Veronika von Messling, Danielle E. Anderson
Summary: The differences in Asian sub-lineages of Zika virus may partially explain the range of disease severity observed. Neurotropic sub-lineages are associated with higher levels of systemic inflammation and cell recruitment in adults. Anti-inflammatory therapeutics may be explored as early treatment to prevent adult Zika-associated disease.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Microbiology
Rebecca A. Zimler, Barry W. Alto
Summary: The study revealed that both Aedes aegypti and Ae. albopictus in Florida have a high competence for Zika virus infection, which may contribute to high rates of Zika virus transmission in the Florida populations. The extrinsic incubation period (EIP) for Zika virus was found to be shorter in Ae. albopictus compared to Ae. aegypti.
Article
Virology
Rebecca A. Zimler, Barry W. Alto
Summary: The Asian lineage of Zika virus caused an epidemic in Brazil in 2015 and subsequently spread throughout the Americas. This study evaluated the susceptibility to infection and transmission of Zika virus among geographic populations of Aedes aegypti and Ae. albopictus in Florida. The results showed that Ae. aegypti had higher susceptibility to infection and dissemination compared to Ae. albopictus.
Article
Energy & Fuels
S. Kavitha, T. Gajendran, K. Saranya, V. Manivasagan
Summary: Contemporary studies show that macroalgae biomass, specifically Sargassum wightii, rich in cellulose, can be a promising source for ethanol production. This investigation focuses on the optimization of cellulose extraction and medium components for Lachnoclostridium phytofermentans KSM 1203 for bioethanol production through consolidated bioprocessing. The alkali pretreatment and sodium hypochlorite treatment were found to effectively remove lignin and hemicelluloses, resulting in the optimal conditions for ethanol yield of 13.75 g/L.
Article
Virology
Chelsea M. Crooks, Andrea M. Weiler, Sierra L. Rybarczyk, Mason Bliss, Anna S. Jaeger, Megan E. Murphy, Heather A. Simmons, Andres Mejia, Michael K. Fritsch, Jennifer M. Hayes, Jens C. Eickhoff, Ann M. Mitzey, Elaina Razo, Katarina M. Braun, Elizabeth A. Brown, Keisuke Yamamoto, Phoenix M. Shepherd, Amber Possell, Kara Weaver, Kathleen M. Antony, Terry K. Morgan, Xiankun Zeng, Dawn M. Dudley, Eric Peterson, Nancy Schultz-Darken, David H. O'Connor, Emma L. Mohr, Thaddeus G. Golos, Matthew T. Aliota, Thomas C. Friedrich
Summary: The study suggests that ZIKV of any genetic lineage poses a threat to pregnant individuals and their infants, but the African-lineage ZIKV did not demonstrate more severe pathogenic features compared to the Asian-lineage.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Sofia G. Seabra, Pieter J. K. Libin, Kristof Theys, Anna Zhukova, Barney Potter, Hanna Nebenzahl-Guimaraes, Alexander E. Gorbalenya, Igor A. Sidorov, Victor Pimentel, Marta Pingarilho, Ana T. R. de Vasconcelos, Simon Dellicour, Ricardo Khouri, Olivier Gascuel, Anne-Mieke Vandamme, Guy Baele, Lize Cuypers, Ana B. Abecasis
Summary: This study characterized the genetic diversity and phylodynamics of the Zika virus and proposed a dynamic classification system that reflects its divergence levels. Through comprehensive analyses of the full-length coding region of the virus, the study identified genetic groups and differentiation patterns.
Article
Microbiology
Maria Vittoria Mancini, Rapeepat Tandavanitj, Thomas H. H. Ant, Shivan M. M. Murdochy, Daniel D. D. Gingell, Chayanee Setthapramote, Piyatida Natsrita, Alain Kohl, Steven P. P. Sinkins, Arvind H. H. Patel, Giuditta De Lorenzo
Summary: In this study, a promising Zika virus vaccine candidate was validated in a mosquito-mouse transmission model, showing its ability to protect animals from the disease and reduce virus transmission. The study also revealed the enhancement of viral infection and spread through mosquito bites.
Article
Virology
Isa Cristina Ribeiro Piauilino, Raillon Keven dos Santos Souza, Mauricio Teixeira Lima, Yanka Karolinna Batista Rodrigues, Luis Felipe Alho da Silva, Ayrton Sena Gouveia, Alexandre Vilhena da Silva Neto, Barbara Aparecida Chaves, Maria das Gracas Costa Alecrim, Camila Helena Aguiar Botto de Menezes, Marcia da Costa Castilho, Djane Clarys Baia-da-Silva, Flor Ernestina Martinez Espinosa, Marcos Vinicius Da Silva Pone, Sheila Moura Pone
Summary: Pregnant women infected with the Zika virus have immunity against the yellow fever virus. However, the presence of yellow fever virus antibodies does not provide protection against severe adverse outcomes from Zika virus exposure in the uterus.
Article
Virology
Yannick Treguier, Jade Cochard, Julien Burlaud-Gaillard, Roxane Lemoine, Philippe Chouteau, Philippe Roingeard, Jean-Christophe Meunier, Marianne Maquart
Summary: The study found an interaction between Zika virus and apolipoprotein E, which was observed in virus-induced host-cell membrane rearrangements and newly formed intracellular particles. This interaction was conserved during ZIKV intracellular trafficking and release, indicating a common mechanism for viruses from the Flaviviridae family.
Article
Chemistry, Analytical
Alexander A. Kravtsov, Andrey V. Blinov, Andrey A. Nagdalian, Alexey A. Gvozdenko, Alexey B. Golik, Maxim A. Pirogov, Maxim A. Kolodkin, Naiyf S. Alharbi, Shine Kadaikunnan, Muthu Thiruvengadam, Mohammad Ali Shariati
Summary: CeO2 nanoparticles and CeO2-Ag nanocomposites were synthesized using a sol-gel process. The silver concentration in the composites ranged from 0.031-0.25 wt%. Calcination of cerium hydroxide dried gel at temperatures of 125-800 degrees C resulted in the formation of CeO2 nanoparticles with an average size of 10-20 nm at an annealing temperature of 650 degrees C. The acid-base properties of CeO2 and CeO2-Ag nanocomposites were studied and their photocatalytic activities were evaluated using a dye photodegradation experiment.
Article
Chemistry, Analytical
Andrey V. V. Blinov, David G. G. Maglakelidze, Zafar A. A. Rekhman, Maria A. A. Yasnaya, Alexey A. A. Gvozdenko, Alexey B. B. Golik, Anastasiya A. A. Blinova, Maxim A. A. Kolodkin, Naiyf S. S. Alharbi, Shine Kadaikunnan, Muthu Thiruvengadam, Mohammad Ali Shariati, Andrey A. A. Nagdalian
Summary: This article presents the synthesis of selenium nanoparticles (Se NPs) stabilized by a quaternary ammonium compound-catamine AB. The Se NPs were obtained through chemical reduction in an aqueous medium. The optimization of the synthesis method and the characterization of the particle size and stability of the Se NPs were conducted. The results showed a bimodal distribution in negatively charged particles and the influence of active acidity and ionic strength on the stability of the Se NPs sols.
Article
Biology
Jamal M. Khaled, Naiyf S. Alharbi, Rayan M. Al-Huwaymil, Shine Kadaikunnan, Ahmed S. Alobaidi, Abdullah M. Alfalih
Summary: The stability of (1R, 2S)-(-)-Ephedrine hydrochloride in plasma and urine samples inoculated with C. albicans was examined using HPLC method. The results showed that C. albicans had an impact on the drug concentration in both plasma and urine samples, with the drug content remaining stable in plasma samples stored at -20 degrees C for three months but degrading in urine samples after one month.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Energy & Fuels
Venkatesan Karthick, Abdul Abduz Zahir, Muniappan Ayyanar, Singamoorthy Amalraj, Karunanithi Anbarasan, Abdul Abdul Rahuman, Shine Kadaikunnan, Chinnaperumal Kamaraj, Muthu Thiruvengadam, Peramaiyan Gangapriya, Purushothaman Tamizharasan
Summary: Nowadays, nanosized drugs continue to dominate the field of pharmacology due to their small molecular size, solubility, and penetrability. In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized from Lablab purpureus leaf extract and their antioxidant, antidiabetic, and antimicrobial properties were evaluated. The synthesized ZnO NPs were characterized using various techniques and were found to have a typical particle size of 28 +/- 3.00 nm. The ZnO NPs exhibited inhibition of a-amylase and a-glucosidase, as well as excellent free radical scavenging activity. They also showed antimicrobial efficacy against gram-positive and gram-negative bacteria. The study suggests that ZnO NPs may have potential applications in reducing oxidative stress and maintaining healthy glucose levels.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Multidisciplinary Sciences
Govindan Rajivgandhi, Shine Kadaikunnan, Govindan Ramachandran, Gnansekaran Chackaravarthi, Chenthis Kanisha Chelliah, Muthuchamy Maruthupandy, Manoharan Natesan, Franck Quero, Wen-Jun Li
Summary: According to recent research, chitosan, a natural polysaccharide rich biopolymer, is an important carrier molecule for drug loading. Plant essential oils are also frequently used to treat infectious diseases. The study focused on encapsulating plant essential oils into chitosan nanoparticles to inhibit A549 human lung cancer cells. The results showed that chitosan had a unique and uniform size morphology, and the chitosan loaded essential oils at 1000 lg/mL concentration were more effective in damaging the cancer cells compared to chitosan or essential oils alone.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Jamal M. Khaled, Naiyf S. Alharbi, Shine Kadaikunnan, Ahmed S. Alobaidi, Khaled Nauman, Abdul-Kareem M. Ghilan, Abeer O. Almazyed, Mohammed S. Aldosary, Saeed Al Rashedi, Abdullah M. Alfalih, Mohamed A. Farrag, Mohammed S. Alharbi
Summary: This study aimed to evaluate and monitor the prevalence of human pathogenic Candida strains and their resistance to antifungal drugs in Riyadh, Saudi Arabia. It also evaluated the synergy of antimicrobial agents against Candida species' resistance to antifungal drugs.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Environmental Sciences
Muthukumar Abinaya, Sathappan Shanthi, Jesudasan Palmy, Khalid A. Al-Ghanim, Marimuthu Govindarajan, Baskaralingam Vaseeharan
Summary: This study evaluated the efficacy of exopolysaccharides (EPSs) from probiotic Bacillus licheniformis and EPS-mediated zinc oxide nanoparticles (EPS-ZnO NPs) as feed additives for Mozambique tilapia. The results showed that a diet supplemented with EPS and EPS-ZnO NPs improved the growth performance, immune response, antioxidant activity, and disease resistance of the fish.
Article
Environmental Sciences
Chinnaperumal Kamaraj, Rajappan Chandra Satish Kumar, Khalid A. Al-Ghanim, Marcello Nicoletti, V. Sathiyamoorthy, Sabarathinam Sarvesh, Chinnasamy Ragavendran, Marimuthu Govindarajan
Summary: This study found that medicinal herb-based essential oil formulations have strong larvicidal effects on mosquitoes that transmit dengue, filariasis, and malaria. They also have the ability to reduce their oviposition and repel mosquitoes. This research is of great importance for local herbal product manufacturers and the cosmetics industry to develop 100% herbal insect repellent products to combat mosquito-borne diseases.
Article
Environmental Sciences
Jeyaraj Jeyavani, Ashokkumar Sibiya, Thambusamy Stalin, Ganesan Vigneshkumar, Khalid A. Al-Ghanim, Mian Nadeem Riaz, Marimuthu Govindarajan, Baskaralingam Vaseeharan
Summary: In recent years, the persistence of polypropylene microplastics in freshwater ecosystems and biota has become an ever-growing threat. This research aimed to prepare and evaluate the toxicity of polypropylene microplastics to the filter feeder Oreochromis mossambicus. The results showed that sustained exposure to microplastics had more severe toxic effects compared to acute exposure, leading to disruptions in homeostasis, increased levels of reactive oxygen species, alteration in antioxidant parameters, oxidation of lipid molecules, and denaturation of the neurotransmitter enzyme acetylcholinesterase. In addition, higher levels of apoptosis, DNA damage, and histological changes were found in the liver tissues of fish exposed to microplastics for 14 days. This research highlights the detrimental effects of constant ingestion of polypropylene microplastics on freshwater environments and the resulting ecological threats.
Article
Environmental Sciences
Thirupati Lakshmi Harika, Khalid A. Al-Ghanim, Mian Nadeem Riaz, Kaliyamoorthy Krishnappa, Jeganathan Pandiyan, Marimuthu Govindarajan
Summary: This study collected scats of fishing cats from the mangrove habitats in Coringa Wildlife Sanctuary, Andhra Pradesh, India, and analyzed the levels of three metals. The concentration of copper was found to be the highest. The study suggests that heavy metal pollution in the mangrove forest poses a significant threat to the fishing cat population in the Coringa Wildlife Sanctuary.
Article
Agronomy
Khalid A. Al-Ghanim, Kaliyamoorthy Krishnappa, Jeganathan Pandiyan, Marcello Nicoletti, Baskar Gurunathan, Marimuthu Govindarajan
Summary: Agricultural and medical insect pests cause damage to crops and spread diseases, affecting both edible crops and non-target fauna and flora. The use of ecofriendly phytopesticides can mitigate the negative effects of synthetic chemicals.
Article
Multidisciplinary Sciences
Govindan Rajivgandhi, Shine Kadaikunnan, Govindan Ramachandran, Gnanasekaran Chackaravarthi, Chenthis Kanisha Chelliah, Muthuchamy Maruthupandy, Manoharan Natesan, Franck Quero, Wen-Jun Li
Summary: In this study, chitosan loaded plant essential oils (CsEOs) were tested against Pseudomonas aeruginosa, Escherichia coli, K. pneumoniae, and Staphylococci aureus, and their anti-cancer properties were evaluated against A549 lung cancer cells. The results showed significant inhibition of the bacteria by CsEOs and a considerable inhibition of A549 lung cancer cells. The study concluded that CsEOs have excellent anti-bacterial and anti-cancer properties, making them suitable for delivering drugs and bioactive compounds to target sites.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Thirupathi Balaji, Chethakkad Manikkan Manushankar, Khalid A. Al-Ghanim, Chinnaperumal Kamaraj, Durairaj Thirumurugan, Sundaram Thanigaivel, Marcello Nicoletti, Nadezhda Sachivkina, Marimuthu Govindarajan
Summary: The utilization of algae-derived nanoparticles has attracted attention for their environmentally sustainable characteristics and ability to interact with biologically active metabolites. In this study, copper oxide nanoparticles (CuONPs) were synthesized using P. boergesenii and their antibacterial and anticancer activities were evaluated. Various analytical techniques were used to characterize the CuONPs' stability and size distribution. The CuONPs showed significant antibacterial activity against Bacillus subtilis and Escherichia coli and exhibited cytotoxic effects on malignant melanoma cells.
Article
Chemistry, Physical
K. Parveen Begaum, T. Prabhu, M. Thirunavukkarasu, P. Sangeetha, Saleem Javed, Jamal M. Khaled, Ghulam Abbas, S. Muthu
Summary: This study aims to investigate the global minimum energy structure of anti-blood cancer drug 4-(Bis (2-chloroethyl)amino)-L-phenylalanine (4B2CA-LPA) using functionalized density functional theory (DFT) calculations and examine the geometries and topological features of covalent and non-covalent interactions. The study also explores new non-covalent attraction forces in this molecule and analyzes electrostatic potential variation and global reactive descriptor energy variations in the solvation phases. Furthermore, the study evaluates the electronic excitations and optical properties of 4B2CA-LPA in liquids.
CHEMICAL PHYSICS IMPACT
(2023)
Article
Engineering, Environmental
Arumugam Priyadharsan, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Shine Kadaikunnan, Ramalingam Karthik Raja, Muthu Thiruvengadam
Summary: The present research investigated the formation of environmentally compatible and cost-effective green medicated palladium nanoparticles (EA-PdNPs) using aqueous extracts of Evolvulus alsinoides (EA) and their antibacterial and photocatalytic behavior. The EA extracts acted as a reduction and capping agent for the formation of EA-PdNPs. The synthesized EA-PdNPs showed promising antibacterial activity against Staphylococcus aureus and Escherichia coli, as well as efficient photocatalytic degradation of Rhodamine B dye. The non-toxicity of EA-PdNPs was confirmed using Daphnia magna and zebrafish embryo as model organisms.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Plant Sciences
Anaswara Rani, Sneha Asha, Minsa Mini, Pooja P. Rajan, Merin Tomy, Ashita Jose, Xavier Ts, Praveen Kumar
Summary: This study focuses on the eco-friendly synthesis of copper oxide nanoparticles using Centra-therum punctatum leaf extract. The synthesized nanoparticles showed potent antimicrobial activity and effectively inhibited biofilm formation by Pseudomonas aeruginosa. These findings demonstrate the potential of copper oxide nanoparticles for environmentally friendly synthesis and applications.
SOUTH AFRICAN JOURNAL OF BOTANY
(2024)
Article
Plant Sciences
Bruno Fagundes dos Santos, Talita Oliveira de Arauja, Camilla Oliveira Rios, Advanio Inacio Siqueira-Silva, Eduardo Gusmao Pereira
Summary: This study investigated the interaction between iron excess and phosphorus deficiency in Paspalum densum. The results showed that iron excess decreased phosphorus concentration in roots, while phosphorus deficiency increased iron concentration in leaves. Stomatal limitation was the main cause of decreased photosynthesis due to iron excess. Phosphorus deficiency contributed to higher phosphorus use efficiency and biomass.
SOUTH AFRICAN JOURNAL OF BOTANY
(2024)