Journal
SEMINARS IN CANCER BIOLOGY
Volume 67, Issue -, Pages 49-56Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2019.08.032
Keywords
SOX7; Tumor biology; Cardiovascular development
Categories
Funding
- National Natural Science Foundation of China [31771055, 81570231]
- Natural Science Foundation of Shaanxi Province [2017JQ3021]
- Major project of Military Logistics [ALJ17J001]
- Achievement Training Program of Air Force Military Medical University [2016CGPY0301]
- Natural Science Foundation of Xi'an City [2016049SF/YX05(2)]
- High-tech Project of Xijing Hospital [XJGX15Y32]
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The sex-determining region Y-box 7 (Sox7) is an important member of the SOX F family, which is characterized by a high-mobility-group DNA-binding domain. Previous studies have demonstrated the role of SOX7 in cardiovascular development. SOX7 expression could be detected in normal adult tissues. Furthermore, the expression levels of SOX7 were different in different tumors. Most studies showed the downregulation of SOX7 in tumors, while some studies reported its upregulation in tumors. In this review, we first summarized the upstream regulators (including transcription factors, microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and some exogenous regulators) and downstream molecules (including factors in the Wnt/beta-catenin signaling pathway and some other signaling pathways) of SOX7. Then, the roles of SOX7 in multiple tumors were presented. Finally, the significance of divergent SOX7 expression during cardiovascular development was briefly discussed. The information compiled in this study characterized SOX7 during tumorigenesis and cardiovascular development, which should facilitate the design of future research and promote SOX7 as a therapeutic target.
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