Journal
BEHAVIOURAL PROCESSES
Volume 122, Issue -, Pages 21-25Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.beproc.2015.10.018
Keywords
Attention; Depression; Mouse; Nest building; Social defeat stress
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Funding
- Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM) (The MEXT, Japan)
- Research Project on the Development of Agricultural Products and Foods with Health-promoting benefits (NARO) (The MAFF, Japan)
- Council for Science, Technology and Innovation (CSTI) under the Cross-ministerial Strategic Innovation Promotion Program (SIP) Technologies for creating next-generation agriculture, forestry, and fisheries
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Behavioral and physiological evaluations of animal models of depression are essential to thoroughly understand the mechanisms of depression in humans. Various models have been developed and characterized, and the socially defeated mouse has been widely used for studying depression. Here, we developed and characterized a mouse model of social aversion using a subchronic and mild social defeat stress (sCSDS) paradigm. Compared to control mice, sCSDS mice showed significantly increased body weight gain, water intake, and social aversion to dominant mice on the social interaction test. We observed nest building behavior in sCSDS mice using the pressed cotton as a nest material. Although sCSDS mice eventually successfully built nests, the onset of nest building was severely delayed compared to control mice. The underlying mechanism of this significant delay in nest building by sCSDS mice is unclear. However, our results demonstrate that nest building evaluation is a simple and useful assay for understanding behavior in socially defeated mice and screening drugs such as antidepressants. (c) 2015 Elsevier B.V. All rights reserved.
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