Article
Obstetrics & Gynecology
Melody Devos, Paula Diaz Vidal, Jason Bouziotis, Ellen Anckaert, Marie-Madeleine Dolmans, Isabelle Demeestere
Summary: Chemotherapy exposure prior to ovarian tissue cryopreservation increases follicle apoptosis rates but not follicular activation. The PI3K/AKT/mTOR and Hippo signaling pathways are modified in the cortex. However, the consequences of treatment on follicle activation and survival require further investigation.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Hanna Ornes Olesen, Susanne Elisabeth Pors, Lea Bejstrup Jensen, Annika Patricia Gronning, Camilla Engel Lemser, Maria Thai Hien Nguyen Heimbuerger, Linn Salto Mamsen, Natalie Getreu, Soren Tvorup Christensen, Claus Yding Andersen, Stine Gry Kristensen
Summary: Daily administration of N-acetylcysteine (NAC) for 7-12 days post-transplantation can reduce ischemia-reperfusion injury and increase follicle survival in human ovarian xenografts. This treatment works by upregulating the antioxidant defense system and exerting anti-inflammatory and antiapoptotic effects.
HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylene Brunelle, Nicolas Gevry, Bruce D. Murphy
Summary: This study identifies SF-1 as a key regulator of the formation of the ovarian reserve, with its depletion leading to smaller ovaries and reduced primordial follicles. The study also identifies the dysregulated pathways and genes involved in follicle formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Obstetrics & Gynecology
L. Cacciottola, A. Camboni, A. Cernogoraz, J. Donnez, M. M. Dolmans
Summary: The size of the ovarian follicle pool is regulated by both apoptosis and autophagy. Apoptosis is responsible for the physiological decline of the follicle pool over time and increases in the event of prior chemotherapy. Autophagy plays a major role in the diminution of the follicle pool before puberty.
HUMAN REPRODUCTION
(2023)
Article
Genetics & Heredity
Soner Celik, Sinan Ozkavukcu, Ciler Celik-Ozenci
Summary: The rapid loss of the primordial follicle (PF) pool is a major drawback of ovarian tissue cryopreservation and re-transplantation (OTCT) technique. This study investigated the protective effects of anti-Mullerian hormone on follicle reserve after OTCT in mice. Results showed that anti-Mullerian hormone treatment attenuated PF loss after bilateral oophorectomy and transplantation.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Obstetrics & Gynecology
Ana B. Maldonado-Carceles, Makiko Mitsunami, Andrea Florio, Paige L. Williams, Jennifer B. Ford, Irene Souter, Jorge E. Chavarro, Lidia Minguez-Alarcon
Summary: This study evaluated the associations between the intake of caffeinated, alcoholic, and sweetened beverages and ovarian reserve. The results showed that low-to-moderate intakes of these beverages were not associated with ovarian reserve in women seeking fertility care.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Makiko Mitsunami, Lidia Minguez-Alarcon, Andrea A. Florio, Siwen Wang, Jill A. Attaman, Irene Souter, Russ Hauser, Jorge E. Chavarro
Summary: This study aimed to investigate the association between intake of soy food and isoflavone with ovarian reserve. Previous studies on the relationship between soy intake and human fertility are inconsistent. However, no studies have evaluated the relationship between soy or isoflavone intake with markers of ovarian reserve other than follicle-stimulating hormone (FSH).
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Jingyi Wen, Kecheng Huang, Xiaofang Du, Hanwang Zhang, Ting Ding, Cuilian Zhang, Wenmin Ma, Ying Zhong, Wenyu Qu, Yi Liu, Zhiying Li, Song Deng, Aiyue Luo, Yan Jin, Jinjin Zhang, Shixuan Wang
Summary: The study found that inhibin B levels rapidly decrease with age in healthy reproductive age women. Inhibin B is positively correlated with AMH, AFC, and other ovarian reserve markers, and has a slightly higher predictive value for AFC compared to FSH.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Genetics & Heredity
Zexu Jiao, Orhan Bukulmez
Summary: Diminished ovarian reserve (DOR) negatively affects patient outcomes in assisted reproductive technology treatment, prompting the need for alternative approaches to restore fertility. Various techniques such as mitochondrial transfer and activation of primordial follicles have been explored to improve oocyte quality and quantity in DOR patients.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Stefania Gonfloni, Carla Jodice, Bianca Gustavino, Elvia Valentini
Summary: Chemotherapy and radiotherapy are common strategies to fight cancer, but they may cause side effects such as premature ovarian insufficiency and infertility in women. Understanding the mechanisms underlying the loss of follicle reserve due to cancer treatments is crucial in developing clinical strategies to protect ovarian reserve. Recent studies have identified the involvement of p53 and CHK2 in the oocyte response to DNA stressors commonly used in cancer treatment. This review explores the molecular mechanisms of the DNA damage stress response and its crosstalk with signaling pathways related to primordial follicle activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Hanna ornes Olesen, Susanne Elisabeth Pors, Cristina Subiran Adrados, Mette Christa Zeuthen, Linn Salto Mamsen, Anette Tonnes Pedersen, Stine Gry Kristensen
Summary: This study investigated whether needle puncturing prior to transplantation can enhance revascularization and improve follicle survival in xenotransplanted human ovarian cortex. The results showed that needle puncturing had no effect on vascular regeneration after 3, 6 and 10 days of transplantation, but it did affect angiogenic genes and improved follicle morphology.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Lidia Minguez-Alarc, Paige L. Williams, Irene Souter, Jennifer B. Ford, Russ Hauser, Jorge E. Chavarro
Summary: This study examined the association between self-reported psychological stress and markers of ovarian reserve. The results showed that higher levels of stress were associated with lower follicle count and serum AMH levels. These associations varied by several socioeconomic factors.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Biochemistry & Molecular Biology
Yue Lv, Rui-Can Cao, Hong-Bin Liu, Xian-Wei Su, Gang Lu, Jin-Long Ma, Wai-Yee Chan
Summary: This study identified curcumin as a potential drug for treating POI patients and fertility preservation by maintaining ovarian reserve and protecting primordial follicles from overactivation through affecting FOXO3 translocation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Akira Iwase, Yuko Hasegawa, Yumiko Tsukui, Mio Kobayashi, Hikaru Hiraishi, Tomoko Nakazato, Yoshikazu Kitahara
Summary: Anti-Mullerian hormone (AMH) is an indirect indicator of ovarian reserve and fertility. It is used to test the number of remaining follicles. A decline in AMH suggests a decrease in follicles, while polycystic ovary syndrome patients often have elevated AMH levels. AMH varies with folliculogenesis and changes in the follicle cohort, which play a crucial role in ovarian activity throughout a woman's lifetime.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tansel Sapmaz, Ebru Kale, Mahmud Esad Pence, Kubra Sevgin, Muhammetnur Tekayev, Sude Topkaraoglu, Gulfem Basol, Muserref Banu Yilmaz, Ekrem Sapmaz, Oktay Irkorucu
Summary: The objective of this study was to assess the impact of Vitamin E and Vitamin C on markers of the oxidant-antioxidant system, ovarian follicle reserves, and the surface epithelium in autologous intraperitoneal ovarian transplantation conducted in rats. The study showed that Vit E and Vit C preserved the ovarian follicle reserve and had a protective effect on the antioxidant system in autologous intraperitoneal ovarian transplantation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)