Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 290, Issue -, Pages 38-41Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2019.06.008
Keywords
Obsessive-compulsive disorder; Resting-state networks; FMRI
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Funding
- FCT fellowship grant from the PhD-iHES program [PDE/BDE/113601/2015]
- Fundacao Calouste Gulbenkian [P-139977]
- FCT fellowship grant from the PhDOC program [SFRH/BD/52291/2013]
- SwitchBox-FP7-HEALTH-2010-grant [259772-2]
- Portuguese North Regional Operational Program (ON.2 - O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER)
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Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients' daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.
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