EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

PHD2 inactivation in Type I cells drives HIF-2α dependent multi-lineage hyperplasia and the formation of paraganglioma-like carotid bodies

(2018) James W. Fielding et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA

(2017) Stuart M. Fell et al.   GENES & DEVELOPMENT

The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis

(2016) Shuijie Li et al.   DEVELOPMENTAL CELL

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

(2016) Alex R.D. Delbridge et al.   JOURNAL OF EXPERIMENTAL MEDICINE

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner

(2016) J. Guo et al.   SCIENCE

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

(2016) Javier Rodriguez et al.   Cell Reports

Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

(2014) D. Macias et al.   EMBO Molecular Medicine

Rare Germline Mutations Identified by Targeted Next-Generation Sequencing of Susceptibility Genes in Pheochromocytoma and Paraganglioma

(2014) Jenny Welander et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

(2014) Anne-Theres Henze et al.   Nature Communications

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

(2012) Liang Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Bim Protein Degradation Contributes to Cisplatin Resistance

(2011) Juan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl Hydroxylase PHD3 Enhances the Hypoxic Survival and G1 to S Transition of Carcinoma Cells

(2011) Heidi Högel et al.   PLoS One

Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase

(2009) Qing Zhang et al.   CANCER CELL

The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIMEL

(2009) Y Guo et al.   ONCOGENE

The kinesin KIF1B  acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

(2008) S. Schlisio et al.   GENES & DEVELOPMENT

A germline mutation of the KIF1Bβ gene on 1p36 in a family with neural and nonneural tumors

(2008) I-Tien Yeh et al.   HUMAN GENETICS

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice

(2008) T. Bishop et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

(2008) Arthur P. Young et al.   NATURE CELL BIOLOGY