4.6 Article

Hematological and biochemical parameters for Chinese rhesus macaque

Journal

PLOS ONE
Volume 14, Issue 9, Pages -

Publisher

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0222338

Keywords

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Funding

  1. PUMC young Fund [3332019008, 2017310038]
  2. Natural Science Foundation of Yunnan province [2018FB132]
  3. Fundamental Research Funds for the Central Universities [2016ZX310179-3, 2016ZX310179-4]
  4. CAMS Innovation Fund for Medical Sciences [2019-I2M-1-004, 2018-I2M-3-002, 2016-I2M-2-1-001]

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Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques. To characterize the reference for these parameters, this study collected 1805 Chinese rhesus macaques living in Southwestern China. A total of 24 blood physiological indexes and 27 biochemical parameters were determined. Sex and age were found to affect these parameters. In conclusion, a comprehensive and systematic reference of hematological and biochemical parameters for Chinese rhesus macaque was established in this work on the basis of a large cohort. Such reference will benefit biomedical research employing rhesus macaques as animal models.

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