Article
Cardiac & Cardiovascular Systems
Walid Nachar, Nolwenn Merlet, Foued Maafi, Teodora Mihalache-Avram, Melanie Mecteau, Danielle Gelinas, Yanfen Shi, Mathieu Brodeur, Sonia Alem, Lucie Blondeau, Marieve Cossette, Marie-Claude Guertin, David Rhainds, David Busseuil, Eric Rheaume, Jean-Claude Tardif
Summary: Through different experimental models, the study showed that the therapeutic effect of ApoA-I mimetic on LVDD without AVS is not significant, indicating that the previously observed improvements in LVDD may be caused by the improvement in AVS.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zhongyue Pu, Yuuki Shimizu, Takumi Hayashi, Yiyang Che, Junya Suzuki, Kazuhito Tsuzuki, Shingo Narita, Rei Shibata, John W. Calvert, Toyoaki Murohara
Summary: The study reveals the crucial role of cardiac lymphatic vessels in maintaining cardiac homeostasis and function, and suggests that the cardiac lymphatic system could be a novel therapeutic target for heart disease.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Jianmin Chen, Lucy V. Norling, Jose Garrido Mesa, Marina De Paula Silva, Sophie E. Burton, Chris Reutelingsperger, Mauro Perretti, Dianne Cooper
Summary: Rheumatoid arthritis is associated with an increased risk of heart failure, leading to death. Treatment with hrAnxA1 can improve cardiac function in arthritic mice, slowing disease progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Gehad M. Elnagar, Mohamed M. Elseweidy, Nesreen M. I. M. Elkomy, Mohammed M. Keshawy, Ola M. Fathy, Mohammed S. Sobh, Yasmin K. Mahmoud
Summary: This study found that policosanol can alleviate renal inflammation and pyroptosis caused by a high cholesterol diet, improve renal dysfunction and dyslipidemia. Policosanol modulates multiple signaling pathways, reduces oxidative stress and inhibits inflammatory response, thereby reducing renal injury.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Medicine, General & Internal
Nathalie Noirclerc, Olivier Huttin, Christian de Chillou, Christine Selton-Suty, Laura Fillipetti, Jean Marc Sellal, Erwan Bozec, Erwan Donal, Zohra Lamiral, Masatake Kobayashi, Joao Pedro Ferreira, Patrick Rossignol, Nicolas Girerd
Summary: The study found that patients with paroxysmal atrial fibrillation exhibit early cardiac remodeling, characterized by increased left ventricular mass and left atrial enlargement. Although less than 10% of patients show diastolic dysfunction, there is a significant association with atrial fibrillation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Education, Scientific Disciplines
Hongli Wang, Zhinan Zheng, Nanrong Zhang, Yan Zhou, Sanqing Jin
Summary: Regular transient limb ischemia (RTLI) has been shown to prevent atherosclerosis in hypercholesterolemic rabbits by improving endothelial function.
Article
Cardiac & Cardiovascular Systems
Lifen Xu, Melania Balzarolo, Emma L. Robinson, Vera Lorenz, Giacomo Della Verde, Lydia Joray, Michika Mochizuki, Beat A. Kaufmann, Gideon Valstar, Saskia C. A. de Jager, Hester M. den Ruijter, Stephane Heymans, Otmar Pfister, Gabriela M. Kuster
Summary: NOX1 is involved in the pathogenesis of metabolic heart disease by mediating endothelial activation and contributing to myocardial inflammation and remodeling. Its high expression in monocytes of human patients suggests that NOX1 may be a potential target for mitigating heart disease associated with diastolic dysfunction.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Valeriu-Gabi Dinca, Adriana Diaconu, Bogdan-Ioan Coculescu, Alexandra-Ligia Dinca, Diana Mihaela Ciuc, Rodica Daniela Birla, Cristian Daniel Marica, Sorin Ioan Tudorache, Gheorghe Manole, Elena Claudia Coculescu
Summary: This study focuses on the relationship between adiponectin concentration and heart disease. Adiponectin is believed to be a cytokine/chemokine/hormone secreted by abdominal fat cells, and it plays a role in generating diabetes and ischaemic heart disease. The study measures the serum levels of adiponectin, cholesterol, triglycerides, etc., and examines if adiponectin can be a diagnostic and risk stratification marker for a group of patients with diastolic cardiac dysfunction.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Einar Sjaastad Norden, Bard Andre Bendiksen, Henriette Andresen, Kaja Knudsen Bergo, Emil Knut Espe, Almira Hasic, Ida Marie Hauge-Iversen, Ioanni Veras, Rizwan I. Hussain, Ivar Sjaastad, Geir Christensen, Alessandro Cataliotti
Summary: This study found that in a HFpEF model, sacubitril/valsartan (sac/val) reduced hypertrophy and improved diastolic dysfunction compared to valsartan alone, independent of blood pressure. The observed anti-hypertrophic effects in preserved ejection fraction suggest the potential benefit of sac/val in hypertrophic remodeling and impaired diastolic function.
Article
Medicine, General & Internal
Mingyu Hao, Xiaohong Huang, Xueting Liu, Xiaokang Fang, Haiyan Li, Lingbo Lv, Liming Zhou, Tiecheng Guo, Dewen Yan
Summary: This study developed a new nomogram model based on clinical parameters to predict diastolic cardiac dysfunction in patients with Type 2 diabetes mellitus (T2DM). The model included age, body mass index (BMI), triglyceride (TG), creatine phosphokinase isoenzyme (CK-MB), serum sodium (Na), and urinary albumin/creatinine ratio (UACR) as predictors. The model showed good predictive performance and can serve as a reliable tool for large-scale epidemiological studies and early screening of T2DM patients with cardiac complications.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Bonnie Kyle, Mateusz Zawadka, Hilary Shanahan, Jackie Cooper, Andrew Rogers, Ashraf Hamarneh, Vivek Sivaraman, Sibtain Anwar, Andrew Smith
Summary: The study found that patients with diastolic dysfunction after cardiac surgery had higher rates of overall morbidity, including higher postoperative morbidity scores, longer durations of intubation, and longer stays in the ICU.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas Gautier, Valerie Deckert, Virginie Aires, Naig Le Guern, Lil Proukhnitzky, Danish Patoli, Stephanie Lemaire, Guillaume Maquart, Amandine Bataille, Marion Xolin, Charlene Magnani, David Masson, Erwana Harscoet, Bruno Da Silva, Louis-Marie Houdebine, Genevieve Jolivet, Laurent Lagrost
Summary: The study found that constitutive expression of fully functional human apoC1 in transgenic rabbits attenuated atherosclerosis, which was associated with inhibition of plasma CETP activity and alterations in plasma HDL levels.
Article
Cardiac & Cardiovascular Systems
David Hong, Seung Hun Lee, Doosup Shin, Ki Hong Choi, Hyun Kuk Kim, Sang Jin Ha, Hyun Sung Joh, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo Myung Lee
Summary: This study evaluated the association between cardiac diastolic dysfunction and coronary microvascular dysfunction (CMD) in patients without significant left ventricular systolic dysfunction and epicardial coronary stenosis. The study found that CMD was independently associated with cardiac diastolic dysfunction and both were associated with an increased risk of cardiovascular death or admission for heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Dandan Peng, Zhenqiu Yu, Mingwei Wang, Junping Shi, Lei Sun, Yuanyuan Zhang, Wenbin Zhao, Chen Chen, Jiake Tang, Chunyi Wang, Jie Ni, Wen Wen, Jingjie Jiang
Summary: This study reveals that metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with left ventricular diastolic dysfunction (LVDD) and cardiac remodeling, especially in patients with diabetes, overweight/obesity, and moderate-to-severe hepatic steatosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Liangjie Xu, Jinchuan Yan, Fen Zhang, Cuicui Zhou, Tingpan Fan, Xinxin Chen, Xinggang Cui, Hong Zhou, Yi Liang
Summary: This study found a correlation between IL-17 and LVDD in patients with normal LVEF, and the combination of IL-17 and IL-6 showed diagnostic and prognostic value in predicting LVDD. Patients with lower levels of IL-17 and IL-6 had a better prognosis, indicating the potential significance of measuring these cytokines in assessing LVDD prognosis.
HEART LUNG AND CIRCULATION
(2021)
Letter
Cardiac & Cardiovascular Systems
Alexandre Gautier, Gregory Ducrocq, Yedid Elbez, Kim M. Fox, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Laurent J. Feldman, Philippe Gabriel Steg
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Amanda K. Morrow, T. Andrew Zabel, Jennifer Dodson, Sarah A. Korth
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yohann Rautureau, Marianne Berlatie, Daniel Rivas, Kurunradeth Uy, Alexandre Blanchette, Geraldine Miquel, Marie-Eve Higgins, Melanie Mecteau, Audrey Nault, Louis Villeneuve, Veronique Lavoie, Gabriel Theberge-Julien, Genevieve Brand, Line Lapointe, Maxime Denis, Camille Rosa, Annik Fortier, Lucie Blondeau, Marie-Claude Guertin, Marie-Pierre Dube, Eric Thorin, Jonathan Ledoux, David Rhainds, Eric Rheaume, Jean-Claude Tardif
Summary: ADCY9 gene plays a role in determining atherosclerotic outcomes in patients and in mice it has been shown to potentiate endothelial function and inhibit atherogenesis. The inactivation of Adcy9 leads to increased cAMP accumulation in response to certain activators and enhances endothelial-dependent vasodilation. Additionally, ADCY9 can regulate endothelial permeability and actin cytoskeleton in response to thrombin, affecting the development of atherosclerosis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Marc-Andre Legault, Louis-Philippe Lemieux Perreault, Jean-Claude Tardif, Marie-Pierre Dube
Summary: ExPheWas is a gene-based phenome-wide association study browser and platform, providing interactive visualizations and data tools for conducting gene-based Mendelian randomization studies to understand the relationship between genes and phenotypes.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Senthil Selvaraj, Deepak L. Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A. Brinton, Terry A. Jacobson, Rebecca A. Juliano, Lixia Jiao, Jean-Claude Tardif, Christie M. Ballantyne
Summary: This study aimed to investigate the treatment effects of icosapent ethyl in patients with heart failure (HF). The results showed that icosapent ethyl reduced triglyceride and hs-CRP levels in patients with HF, and had similar cardiovascular risk reduction effects.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Jean Claude Tardif, Marc A. Pfeffer, Simon Kouz, Wolfgang Koenig, Aldo P. Maggioni, John J. McMurray, Vincent Mooser, David D. Waters, Jean C. Gregoire, Philippe L. L'Allier, J. Wouter Jukema, Harvey D. White, Therese Heinonen, Donald M. Black, Fouzia Laghrissi-Thode, Sylvie Levesque, Marie Claude Guertin, Marie Pierre Dube, Dal-GenE Investigators
Summary: The dal-GenE study aimed to test the pharmacogenetic hypothesis that the effect of dalcetrapib on cardiovascular events is influenced by an ADCY9 gene polymorphism. However, the study found that dalcetrapib did not significantly reduce the risk of occurrence of ischemic cardiovascular events. Further trials are needed to investigate the effect of dalcetrapib on patients with the AA genotype.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Miller, Deepak L. Bhatt, Ph Gabriel Steg, Eliot A. Brinton, Terry A. Jacobson, Lixia Jiao, Jean-Claude Tardif, Christie M. Ballantyne, Matthew Budoff, R. Preston Mason
Summary: The study found that the use of IPE can reduce the risk of cardiovascular disease in smokers to the level observed in non-smokers.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mathieu R. Brodeur, David Rhainds, Daniel Charpentier, Marie Boule, Teodora Mihalache-Avram, Melanie Mecteau, Genevieve Brand, Valerie Pedneault-Gagnon, Annik Fortier, Eric J. Niesor, Eric Rheaume, Cyrille Maugeais, Jean-Claude Tardif
Summary: The effects of CETP inhibitors on HDL particle composition were studied in rabbits and humans. The study found that these inhibitors increased the concentration of large apo E-containing HDL particles, which can interact with hepatic LDL receptors.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Reza Fadaei, Samaneh Mohassel Azadi, Eric Rheaume, Habibolah Khazaie
Summary: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease (CVD), and HDL cholesterol efflux capacity (CEC) may be impaired in OSA patients, potentially contributing to the risk of CVD.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Emmanuelle Vidal-Petiot, Yedid Elbez, Jules Mesnier, Gregory Ducrocq, Ian Ford, Michal Tendera, Roberto Ferrari, Jean-Claude Tardif, Kim M. Fox, Philippe Gabriel Steg
Summary: This study compared the benefits of strict vs. standard control of blood pressure with the potential benefits of controlling other modifiable risk factors in patients with chronic coronary syndromes. The results showed that the benefit associated with strict blood pressure control was marginal and driven only by the diastolic component, while uncontrolled other risk factors were associated with a gradually increasing risk. Therefore, optimizing other risk factors should be prioritized over further reduction of systolic blood pressure. The optimal blood pressure target in chronic coronary syndromes may be <=139/79 mmHg.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Oncology
Maxine Sun, Marie-Christyne Cyr, Johanna Sandoval, Louis-Philippe Lemieux Perreault, Lambert Busque, Jean-Claude Tardif, Marie-Pierre Dube
Summary: This study analyzed a cohort of 48,919 cancer patients from the UK Biobank and found that individuals with mosaic chromosomal alterations (mCA) are at an increased risk of death from cardiovascular disease (CVD), particularly in patients with kidney cancer and breast cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremie Abtan, Gregory Ducrocq, Yedid Elbez, Roberto Ferrari, Ian Ford, Kim M. Fox, Jean-Claude Tardif, Michal Tendera, Nicolas Danchin, Alexander Parkhomenko, Christopher M. Reid, Gabriel Steg
Summary: There is no association between consumption of coffee or tea and ischemic outcomes or all-cause mortality in outpatients with stable coronary artery disease.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Ange Maguy, Yuvaraj Mahendran, Jean-Claude Tardif, David Busseuil, Jin Li
Summary: This study explores the association between autoantibodies targeting cardiac ion channels and unexplained AF. They found a common autoantibody response against K(ir)3.4 protein in patients with AF, even before the development of clinically apparent AF. Functional studies and a mouse model of K(ir)3.4 autoimmunity support the causal relationship between K(ir)3.4 autoantibodies and AF.
Article
Cardiac & Cardiovascular Systems
Alexandre Gautier, Fabien Picard, Gregory Ducrocq, Yedid Elbez, Kim M. Fox, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Philippe Gabriel Steg
Summary: This study found that new-onset atrial fibrillation (NOAF) is common among patients with chronic coronary syndromes (CCS) and is associated with increased risk of cardiovascular adverse events. Age, body mass index, glomerular filtration rate, ethnicity, alcohol intake, and left ventricular ejection fraction were identified as predictors of NOAF. The study suggests that more intensive preventive measures and systematic screening for atrial fibrillation should be considered in this patient population.
EUROPEAN HEART JOURNAL
(2023)
Article
Health Care Sciences & Services
Robert Avram, Jeffrey E. Olgin, Zeeshan Ahmed, Louis Verreault-Julien, Alvin Wan, Joshua Barrios, Sean Abreau, Derek Wan, Joseph E. Gonzalez, Jean-Claude Tardif, Derek Y. So, Krishan Soni, Geoffrey H. Tison
Summary: This study presents a fully automated approach to interpret angiographic coronary artery stenosis using neural networks. The algorithms were trained on a large dataset and validated on real-world angiograms from multiple institutions. The results demonstrate the potential of neural networks in automated analysis of coronary artery stenosis.
NPJ DIGITAL MEDICINE
(2023)