Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein)

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Title
Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein)
Authors
Keywords
ABCB1, ABCG2, Osimertinib, Brain accumulation, Oral availability, Tyrosine kinase inhibitor
Journal
PHARMACOLOGICAL RESEARCH
Volume 146, Issue -, Pages 104297
Publisher
Elsevier BV
Online
2019-06-05
DOI
10.1016/j.phrs.2019.104297

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