Article
Pharmacology & Pharmacy
Song-Hee Kim, Da-Eun Jung, Jin Yong Song, Jihye Jung, Jae-Kyung Jung, Heesoon Lee, Eunmiri Roh, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim
Summary: CABA and other small-molecule inhibitors can protect mice from APAP-induced liver injury by inhibiting IKK beta activity and interrupting sterile inflammation in liver cells.
Article
Chemistry, Multidisciplinary
Zhu-Qi Huang, Wu Luo, Wei-Xin Li, Pan Chen, Zhe Wang, Rui-Jie Chen, Yi Wang, Wei-Jian Huang, Guang Liang
Summary: Costunolide (CTD) has anti-atherosclerotic effects by reducing inflammatory responses and oxLDL uptake, and its mechanism involves the inhibition of NF-kappa B signaling pathway through covalent binding to IKKβ.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Medicine, Research & Experimental
Zhuqi Huang, Sirui Shen, Xue Han, Weixin Li, Wu Luo, Liming Lin, Mingjiang Xu, Yi Wang, Weijian Huang, Gaojun Wu, Guang Liang
Summary: In this study, upregulated DCLK1 in macrophages in atherosclerotic lesions of ApoE(-/-) mice fed an HFD was identified, and it was determined that macrophage-specific DCLK1 deletion attenuates atherosclerosis by reducing inflammation in mice. RNA sequencing analysis indicated that DCLK1 mediates oxLDL-induced inflammation via NF-kappa B signaling pathway, and DCLK1 directly interacts with IKK beta and phosphorylates IKK beta at S177/181, thereby activating NF-kappa B and promoting inflammatory gene expression in macrophages.
EMBO MOLECULAR MEDICINE
(2023)
Article
Immunology
Yun-Hai Luo, Zuo-Tian Huang, Ke-Zhen Zong, Zhen-Rui Cao, Da-Di Peng, Bao-Yong Zhou, Ai Shen, Ping Yan, Zhong-Jun Wu
Summary: The study identified miR-194- suppressed PHLDA1 as a critical intersection of dual inflammatory signals in hepatic IRI, showing that PHLDA1 upregulation could lead to liver pathological injury, apoptosis, and cytokine release. Overexpression of miR-194 decreased PHLDA1, alleviating the damage, and further enrichment of PHLDA1 reversed this effect.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Miao Zeng, Xiaolu Zhang, Nuan Lv, Luming Wang, Yanrong Suo, Jiali Gan, Lin Yang, Bin Yu, Xijuan Jiang, Wenyun Zeng
Summary: This study aimed to investigate the efficacy and mechanism of Sodium Danshensu (SDSS) in inhibiting inflammation in macrophages and stabilizing vulnerable plaques in atherosclerosis. The results demonstrated that SDSS significantly reduced the formation and area of aortic plaques while stabilizing vulnerable plaques. It was found that SDSS targets IKK beta to inhibit the NF-kappa B pathway. Furthermore, the combined use of an IKK beta-specific inhibitor enhanced the beneficial effects of SDSS.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Ting He, Yinglei Gao, Yanfen Fang, Yangming Zhang, Shuwei Zhang, Fajun Nan, Jian Ding, Yi Chen
Summary: This study found that GCJ-490A effectively inhibited the proliferation of NSCLC cells and induced apoptosis both in vitro and in vivo. Furthermore, GCJ-490A increased histone acetylation at the IKK?? promoter by inhibiting HDAC1 and HDAC6, resulting in the downregulation of c-Met. This downregulation was essential for the synergistic anti-tumor activity of GCJ-490A and gefitinib. These findings provide a potential strategy for NSCLC treatment by using HDAC inhibitors in combination with EGFR inhibitors.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ozge Kizilay Mancini, David N. Huynh, Liliane Menard, Dominique Shum-Tim, Huy Ong, Sylvie Marleau, Ines Colmegna, Marc J. Servant
Summary: Patients with atherosclerosis and T2DM show impaired immunopotency of MSCs due to an inflammatory shift in their secretome mediated by constitutively active IKK beta, which can be rescued by modulation of IKK beta, enhancing their myocardial repair ability post-MI.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cell Biology
Qianqian Huang, Sheng Chen, Xiaowei Xiong, Tingting Yin, Yanan Zhang, Guohua Zeng, Qiren Huang
Summary: Vascular endothelium dysfunction caused by endothelium inflammation is a trigger of numerous cardiovascular diseases. This study investigated the effect of Asprosin (ASP) on endothelium inflammation induced by hyperlipidemia. The results showed that ASP may play a pro-inflammation role in obesity-associated endothelium dysfunction, and could be a potential target for the prevention and treatment of obesity-related cardiovascular diseases.
Article
Pharmacology & Pharmacy
Xiaotao Xu, Yang Su, Kaixuan Wu, Fan Pan, Aizhong Wang
Summary: DOCK2 is a crucial regulator in macrophage activation and acute lung injury, controlling IKKβ activation and inflammatory cytokine release. Inhibition of DOCK2 may be a promising approach for treating endotoxemia-related ALI.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bernhard Moser, Bernhard Hochreiter, Jose Basilio, Viola Gleitsmann, Anja Panhuber, Alan Pardo-Garcia, Bastian Hoesel, Manuel Salzmann, Ulrike Resch, Mamoona Noreen, Johannes A. Schmid
Summary: The IKK complex, consisting of IKK alpha and IKK beta, activates the inflammatory transcription factor NF-kappa B, constitutively active in many cancers. Research has shown that IKK alpha phosphorylates c-Myc on serines 67/71, leading to stabilized c-Myc, increased transcriptional activity, higher cell proliferation, and decreased apoptosis in cancer cells.
Article
Neurosciences
Jinwang Ye, Suyue Zhong, Yunsong Deng, Xuanbao Yao, Qiong Liu, Jian-Zhi Wang, Shifeng Xiao
Summary: Class IIa histone deacetylases (HDAC) play a role in inflammation by promoting IKK activation and subsequent NF-kappa B activation. In this study, HDAC7 was found to be elevated in astrocytes after LPS challenge, leading to NF-kappa B activation, pro-inflammatory gene upregulation, and anxiety-like behaviors. Inhibition of HDAC7 attenuated LPS-induced inflammation and anxiety-like behaviors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hang Yang, Zuotian Huang, Yunhai Luo, Dengliang Lei, Ping Yan, Ai Shen, Wenbin Liu, Dewei Li, Zhongjun Wu
Summary: This study reveals that TRIM37 plays a role in hepatic ischemia/reperfusion (I/R) injury by enhancing inflammation and promoting cell death. Targeting TRIM37 might be a potential treatment strategy against hepatic I/R injury.
MOLECULAR MEDICINE
(2023)
Article
Immunology
Xilong Kang, Yang Jiao, Yingying Zhou, Chuang Meng, Xiaohui Zhou, Li Song, Xinan Jiao, Zhiming Pan
Summary: Inflammation is a double-edged sword that can control infection or injuries. This study identified miR-5112 as a regulator of inflammation and a potential therapeutic target for bacterial infection and colitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Miriam Giacomarra, Martina La Torre, Giovanna Montana
Summary: The present study aimed to investigate the effects of inhibition of BMS-345541 mediated IKK kinase phosphorylation on the cellular defence system, anti-inflammatory response, and HSP90 activity. The study was conducted in A549 cell line with a homozygous Keap1 mutation (G333C). The results suggest that the inhibition of IKK is effective in reducing the inflammatory response through mechanisms involving both the heat shock cellular defense system and the antioxidative pathway.
Article
Biochemistry & Molecular Biology
Kuo-Feng Tseng, Ping-Hsuan Tsai, Jie-Sian Wang, Fang-Yu Chen, Ming-Yi Shen
Summary: Sesamol can alleviate macrophage-mediated renal inflammation and reduce renal fibrosis, offering a potential approach to the treatment of chronic kidney disease.
Review
Biochemistry & Molecular Biology
Zakia Akter, Fabiha Zaheen Khan, Md. Asaduzzaman Khan
Summary: This article reviews the mechanism of action of gold nanoparticles (AuNPs) and their application in enhancing therapeutics against triple-negative breast cancer (TNBC). Various studies indicate that AuNPs can improve drug bioavailability, site-specific drug delivery, and the efficacy of chemotherapy, radiotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT), as well as modulate gene expression. The mechanistic actions of AuNPs in inhibiting cell proliferation, progression, and metastasis have been demonstrated in vitro and in vivo studies, making them a promising approach for TNBC therapeutics.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xiaoqing Fan, Chutian Mai, Ling Zuo, Jumin Huang, Chun Xie, Zebo Jiang, Runze Li, Xiaojun Yao, Xingxing Fan, Qibiao Wu, Peiyu Yan, Liang Liu, Jianxin Chen, Ying Xie, Elaine Lai -Han Leung
Summary: BWBDS treatment can reverse sepsis-induced liver injury by modulating gut microbiota, promoting macrophage anti-inflammatory activity, enhancing intestinal integrity, and selectively promoting the growth of Lactobacillus johnsonii. This study also suggests that L. johnsonii can reduce liver injury by enhancing macrophage anti-inflammatory activity and interleukin-10+ M2 macrophage production.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Cell Biology
Yi-Fu He, Xi-Min Hu, Md. Asaduzzaman Khan, Bo-Yao Yu, Yi-Cun Sheng, Xian-Zhong Xiao, Xin-Xing Wan, Si-Pin Tan, Kun Xiong
Summary: Sepsis-induced brain injury increases the risk of mortality in septic patients. This study found that HSF1 alleviates sepsis-induced brain injury by inhibiting pyroptosis through the NLRP3-dependent pathway, suggesting HSF1 as a potential molecular target for treating brain injury in sepsis.
MEDIATORS OF INFLAMMATION
(2023)
Article
Plant Sciences
Mengnan Liu, Ziyi Li, Yue Ouyang, Mingtai Chen, Xin Guo, Maryam Mazhar, Junli Kang, Hua Zhou, Qibiao Wu, Sijin Yang
Summary: This study identified the active components and potential pharmacological mechanisms of Danshen Decoction (DSD) for the treatment of cardiovascular diseases (CVDs) using mass spectrometry and network pharmacology. It was found that DSD contains 35 compounds that may contribute to its therapeutic effects on CVDs through various signaling pathways. Clinical and experimental studies supported the positive significance of DSD as adjuvant therapy for CVDs. Further large-scale clinical and in-depth experimental research is needed to uncover the mechanisms of DSD in CVD treatment.
Article
Genetics & Heredity
Jingcheng Zhang, Ying Zhang, Ziyuan Wang, Jiachao Zhao, Zhenyu Li, Keju Wang, Lin Tian, Baojin Yao, Qibiao Wu, Tan Wang, Jing Wang
Summary: This study comprehensively analyzed the expression of m6A RNA methylation regulators in IPF patients and healthy volunteers and constructed a diagnosis and prognosis model. The results showed that METTL14, G3BP2, and ZC3H13 were independent protective factors for predicting IPF incidence and prognosis. The m6A regulation patterns play a role in fibrogenesis and cell adhesion processes. Additionally, the high-risk m6A group showed upregulation of neutrophils, and sensitive drugs for different risk groups were identified.
FRONTIERS IN GENETICS
(2023)
Article
Public, Environmental & Occupational Health
Cong Xu, Jue Wang, Lili Yu, Xinbing Sui, Qibiao Wu
Summary: Due to the high transmissibility and immune escape of Omicron subvariant BA.5, it has become the dominant strain of the SARS-CoV-2 virus and caused a surge of COVID-19 cases. This study aims to analyze the characteristics of this outbreak and summarize effective anti-epidemic measures and experiences.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Pharmacology & Pharmacy
Md Asaduzzaman Khan, Mousumi Tania
Summary: Cordycepin, a nucleoside from Cordyceps mushrooms, has potential anticancer properties by targeting various kinases involved in cancer development and progression. Abnormal kinase expression through different molecular mechanisms can be disrupted by cordycepin, inhibiting their activity and potentially contributing to its anticancer effects. Targeting kinases might be one of the molecular mechanisms involved in the anticancer potential of cordycepin, considering the crucial roles of kinase inhibitors in cancer treatment.
DRUG DISCOVERY TODAY
(2023)
Article
Pharmacology & Pharmacy
Cong Xu, Ze-Bo Jiang, Le Shao, Zi-Ming Zhao, Xing-Xing Fan, Xinbing Sui, Li-Li Yu, Xuan-Run Wang, Ruo-Nan Zhang, Wen-Jun Wang, Ya-Jia Xie, Yi-Zhong Zhang, Xiao-Wen Nie, Chun Xie, Ju-Min Huang, Jing Wang, Jue Wang, Elaine Lai-Han Leung, Qi-Biao Wu
Summary: This study found that the combination of ll-elemene and erlotinib induced ferroptosis and enhanced the sensitivity to EGFR-TKIs in EGFR-TKI-resistant lung cancer patients.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Multidisciplinary Sciences
Ziyi Li, Mengnan Liu, Mingtai Chen, Gang Luo, Jiao Wu, Maryam Mazhar, Fang Yang, Yu Zheng, Hao Wu, Qibiao Wu, Sijin Yang
Summary: This meta-analysis assessed the clinical efficacy of Danshen Decoction for the treatment of heart failure (HF). The results showed that Danshen Decoction combined with conventional treatment significantly improved clinical efficacy, increased left ventricular ejection fraction, reduced left ventricular end-diastolic dimension and end-systolic diameter, and decreased levels of brain natriuretic peptide, N-terminal pro-B type natriuretic peptide and hypersensitive C-reactive protein. However, more rigorous, large-scale, multicenter randomized clinical trials are needed to further evaluate the efficacy and safety of Danshen Decoction in HF patients due to methodological and quality limitations.
Correction
Immunology
Yu-tian Cao, Kai-yu Zhang, Jing Sun, Yan Lou, Tian-su Lv, Xinyi Yang, Wen-hui Zhang, Jiang-yi Yu, Qi-biao Wu, Xi-qiao Zhou
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Han Dong, Dongfang Ge, Biao Qu, Ping Zhu, Qibiao Wu, Tianyun Wang, Jue Wang, Zheng Li
Summary: In this study, a systematic review and meta-analysis found that the combination therapy of transarterial chemoembolization (TACE) plus multikinase inhibitor (MKI) significantly prolonged time to progression (TTP) and increased objective response rate (ORR) in patients with unresectable hepatocellular carcinoma (HCC). However, it did not improve overall survival (OS) and progression-free survival (PFS). The serious adverse events (AEs) associated with MKI treatment, but not TACE, showed a significant difference.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaoying Sun, Xinxing Wan, Md Asaduzzaman Khan, Keke Zhang, Xuan Yi, Zhouqi Wang, Ke Chen
Summary: This study analyzed the differential expression of circRNAs in human BAT and WAT, and identified new biomarkers for BAT.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Pharmacology & Pharmacy
Jian Wang, Run-Ze Li, Wen-Jun Wang, Hu-Dan Pan, Chun Xie, Lee-Fong Yau, Xing-Xia Wang, Wei-Li Long, Rui-Hong Chen, Tu-Liang Liang, Lin-Rui Ma, Jia-Xin Li, Ju-Min Huang, Qi-Biao Wu, Liang Liu, Jian-Xing He, Elaine Lai-Han Leung
Summary: Non-small cell lung cancer (NSCLC) is a highly lethal malignant tumor. Immunotherapy has become the standard treatment for advanced NSCLC, but drug resistance and low response rates remain challenges. This study found that the sphingolipid metabolism enzyme CERS4 is positively correlated with the efficacy of anti-PD-1 therapy for NSCLC. Upregulating CERS4 expression can improve the effectiveness of anti-PD-1 therapy. The study also revealed the role of sphingolipid metabolites in regulating the immunotherapeutic function of NSCLC and provided potential targets for predicting and improving the efficacy of ICIs for NSCLC.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Plant Sciences
Xiangyang Zhai, Qida He, Min Chen, Lili Yu, Chiin Tong, Ying Chen, Jue Wang, Xingxing Fan, Han Xie, Zimao Liang, Xinbing Sui, Li Zeng, Qibiao Wu
Summary: Based on a systematic review and meta-analysis, we found that P. ternata-containing traditional Chinese medicine combined with 5-HT3 receptor antagonists effectively improved chemotherapy-induced nausea and vomiting and reduced the incidence of side effects. However, additional high-quality clinical trials are needed to further validate these findings.
Article
Public, Environmental & Occupational Health
Satyajit Kundu, Md Hasan Al Banna, Abu Sayeed, Musammet Rasheda Begum, Keith Brazendale, M. Tasdik Hasan, Sanjida Jahan Habiba, Mohammad Tazrian Abid, Md Asaduzzaman Khan, Sukanta Chowdhury, Tapos Kormoker, Ram Proshad, Md Shafiqul Islam Khan
Summary: This study assessed the knowledge, attitude, and preventive practices towards COVID-19 among Bangladeshi residents during the lockdown period. The findings highlight the potential effectiveness of online health education programs in improving attitudes and practices towards controlling the pandemic.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)