Article
Oncology
Jamil S. Samaan, Yazan Abboud, Janice Oh, Yi Jiang, Rabindra Watson, Kenneth Park, Quin Liu, Katelyn Atkins, Andrew Hendifar, Jun Gong, Arsen Osipov, Debiao Li, Nicholas N. Nissen, Stephen J. Pandol, Simon K. Lo, Srinivas Gaddam
Summary: The incidence of pancreatic cancer is increasing at a greater rate in young women compared to young men. A study using the SEER 21 database found that young Hispanic women had the highest increase in incidence, followed by young Black women. This highlights the disproportionate burden of disease on young women of color.
Article
Oncology
Pascal Belleau, Astrid Deschenes, Nyasha Chambwe, David A. Tuveson, Alexander Krasnitz
Summary: The study explores the feasibility and accuracy of inferring genetic ancestry from cancer-derived data. A data synthesis framework is developed to optimize and evaluate the performance of ancestry inference based on various molecular profiles. The results demonstrate the accuracy and robustness of the inference procedure, making it possible to determine the continental-level ancestry of cancer patients.
Article
Oncology
Farhad Islami, Jordan Baeker Bispo, Hyunjung Lee, Daniel Wiese, K. Robin Yabroff, Priti Bandi, Kirsten Sloan, Alpa V. Patel, Elvan C. Daniels, Arif H. Kamal, Carmen E. Guerra, William L. Dahut, Ahmedin Jemal
Summary: The American Cancer Society has published a report on cancer disparities in the United States, highlighting the significant variations in cancer occurrence and outcomes based on race, ethnicity, socioeconomic factors, and geographic location. Black and American Indian/Alaska Native individuals face higher cancer mortality rates, and education level and residential area also contribute to these disparities. The report emphasizes the importance of addressing social determinants of health and implementing equitable policies and interventions to reduce cancer disparities.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Farhad Islami, Carmen E. Guerra, Adair Minihan, K. Robin Yabroff, Stacey A. Fedewa, Kirsten Sloan, Tracy L. Wiedt, Blake Thomson, Rebecca L. Siegel, Nigar Nargis, Robert A. Winn, Lisa Lacasse, Laura Makaroff, Elvan C. Daniels, Alpa Patel, William G. Cance, Ahmedin Jemal
Summary: This report provides comprehensive data on disparities in cancer occurrence, risk factors, and access to preventive measures and screening in the US. Policy recommendations are made to reduce these inequalities, emphasizing the need for broad implementation of evidence-based interventions to address social inequities and systemic racism.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Oncology
S. Powell-Brett, N. de Liguori Carino, K. Roberts
Summary: Pancreatic exocrine insufficiency (PEI) is prevalent in pancreatic cancer patients, and treatment with pancreatic enzyme replacement therapy (PERT) can improve quality of life and survival. However, many patients do not currently receive PERT. The nutritional consequences of PEI are extensive, especially in the elderly due to age-related gastrointestinal and pancreatic changes.
Review
Oncology
G. Roeyen, F. Berrevoet, I Borbath, K. Geboes, M. Peeters, B. Topal, E. Van Cutsem, J-L Van Laethem
Summary: Pancreatic exocrine insufficiency (PEI) is a common condition in patients with pancreatic cancer (PC). PERT treatment is widely used, but there is limited clinical evidence supporting its effectiveness. More research is needed to evaluate the efficacy of PERT in PC patients.
Article
Oncology
Dany Habr, Roxanne Ferdinand
Summary: Racial/ethnic minority groups are disproportionately impacted by cancer but are underrepresented in clinical trials. Strategies are needed to ensure diversity in trials and properly interpret risk/benefit of emerging therapies.
Editorial Material
Cell & Tissue Engineering
Jason R. Pitarresi, Anil K. Rustgi
Summary: In this issue, two studies developed human stem-cell-derived organoid culture systems to mimic pancreatic acinar and ductal lineages, offering opportunities to study cellular plasticity and transformation in pancreatic cancer initiation and progression.
Article
Biochemistry & Molecular Biology
Karthik Reddy Kami Reddy, Danthasinghe Waduge Badrajee Piyarathna, Abu Hena Mostafa Kamal, Vasanta Putluri, Shiva Shankar Ravi, Roni J. Bollag, Martha K. Terris, Yair Lotan, Nagireddy Putluri
Summary: Bladder Cancer is the ninth most common cancer globally and the sixth most common cancer in the US. African Americans have a lower incidence of bladder cancer compared to European Americans, but a higher risk of cancer-related death. This study identifies ethnic-specific lipid alterations in bladder cancer, which may contribute to understanding the disparity in mortality.
Article
Infectious Diseases
Kanwal Raghav, Seerat Anand, Anirudh Gothwal, Pooja Singh, Arvind Dasari, Michael J. Overman, Jonathan M. Loree
Summary: Although racial/ethnic disparities in healthcare have long been recognized, recent discourse around structural racism will hopefully lead to improved transparency surrounding these issues. Despite the disproportionate impact of COVID-19 on racial/ethnic minorities, the extent and reliability of race reporting in COVID research is unclear. Research during the first wave of the pandemic lacked appropriate racial/ethnicity reporting, but mirrored COVID-19 incidence in the USA, highlighting the increased burden of infection among Black individuals.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Taylor Aurelius, Ankita Maheshwari, Gie Ken-Dror, Sapna D. Sharma, Sageet Amlani, Gunaratnam Gunathilagan, David L. Cohen, Chakravarthi Rajkumar, Stuart Maguire, Sissi Ispoglou, Ibrahim Balogun, Anthea Parry, Lakshmanan Sekaran, Hafiz Syed, Enas Lawrence, Ravneeta Singh, Ahamad Hassan, Chris Wharton, Khalid Javaid, Neetish Goorah, Peter Carr, Eman Abdus Sami, Shri Ram Sharma, Padmavathy N. Sylaja, Kameshwar Prasad, Pankaj Sharma
Summary: This study compared the age of onset of stroke between South Asian patients living in the United Kingdom and India and White British stroke patients. The results showed that South Asian patients in both countries experienced stroke at a much younger age compared to their White British counterparts. Ethnicity was found to be an independent predictor of early age of stroke onset. These findings have significant implications for public health policymakers in countries with large South Asian populations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Zaneta Malczyk, Wojciech Roczniak, Bogdan Mazur, Jaroslaw Kwiecien, Katarzyna Ziora, Karolina Gorska-Flak, Joanna Oswiecimska
Summary: The study found that pancreatic efficiency of lipase secretion in girls with anorexia nervosa was normal, but the kinetics of this enzyme secretion were disturbed, potentially due to disorders in the functioning of the adipose-insular and islet-acinar axes.
Review
Oncology
Dominic J. Vitello, David J. Bentrem
Summary: Despite poor prognosis in patients with pancreatic ductal adenocarcinoma, neoadjuvant therapy may offer similar benefits. Primary measures of response include radiographic, biochemical, margin status, and pathological assessment.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Basil Nduma, Solomon Ambe, Chukwuyem Ekhator, Ekokobe Fonkem
Summary: This study investigates the incidence and prevalence of pancreatic cancer in Mississippi, focusing on racial and gender disparities. The results show that black males face the highest risk of pancreatic cancer in Mississippi, and females have lower rates compared to males regardless of race. Furthermore, there are significant geographical variations, with the Delta cancer coalition region showing the highest incidence rates. To inform healthcare interventions at the state level, future research should explore additional factors such as lifestyle and behavioral factors, comorbidities, disease stage, and geographical remoteness.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Oncology
Basil Nduma, Solomon Ambe, Chukwuyem Ekhator, Ekokobe Fonkem
Summary: This study focused on racial and gender disparities in pancreatic cancer incidence and mortality in Mississippi from 2003 to 2019. Data was obtained from the Mississippi Cancer Registry and the findings revealed higher rates among black individuals compared to white individuals, and lower rates among females compared to males. Geographic variations were also observed, with the Delta cancer coalition region having the highest incidence rates.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Oncology
Jessica K. Sheth Bhutada, Amie E. Hwang, Lihua Liu, Kai-Ya Tsai, Dennis Deapen, David R. Freyer
Summary: Although survival rates have improved for most adolescents and young adults with cancer, those with metastatic disease still have poor outcomes. This study compared the survival rates of AYAs and older adults with poor-prognosis metastatic cancers and found that AYAs generally had better survival rates, except for kidney cancer. Disparities in survival rates were also found among different races/ethnicities and socioeconomic statuses. Overcoming the impact of metastasis in these cancers is crucial for improving outcomes in AYA oncology.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Surgery
Eunjung Lee, Eric S. Kawaguchi, Juanjuan Zhang, Sue E. Kim, Dennis Deapen, Lihua Liu, Nasim Sheidaee, Amie E. Hwang, Irene Kang, Kulmeet Sandhu, Giske Ursin, Anna H. Wu, Agustin A. Garcia
Summary: The study investigated the prevalence of weight loss surgery in women with breast or endometrial cancer, finding that postdiagnosis weight loss surgery was associated with a decreased hazard for death. Approximately 2000 patients in California underwent weight loss surgery after being diagnosed with breast or endometrial cancer.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Dermatology
Veronica Di Carlo, Charles A. Stiller, Nora Eisemann, Andrea Bordoni, Melissa Matz, Maria P. Curado, Laetitia Daubisse-Marliac, Mikhail Valkov, Jean-Luc Bulliard, David Morrison, Chris Johnson, Fabio Girardi, Rafael Marcos-Gragera, Mario Sekerija, Siri Laronningen, Eunice Sirri, Michel P. Coleman, Claudia Allemani
Summary: This study aims to assess whether differences in morphology can explain global variation in survival for cutaneous melanoma. Results showed that the proportion of nodular melanoma ranged from 7% to 13% worldwide, with acral lentiginous melanoma being more common in Asia and Central and South America. The study highlights the need for specific health policies to improve awareness, early diagnosis, and access to treatment for nodular and acral lentiginous melanomas.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Brian Z. Huang, Lihua Liu, Juanjuan Zhang, Stephen J. Pandol, Steven R. Grossman, Veronica Wendy Setiawan
Article
Oncology
Citadel J. Cabasag, Paula J. Fagan, Jacques Ferlay, Jerome Vignat, Mathieu Laversanne, Lihua Liu, Maaike A. Aa, Freddie Bray, Isabelle Soerjomataram
Summary: This study provides an overview of the global burden of ovarian cancer and predicts the future burden, particularly in low Human Development Index (HDI) countries. It shows geographic variations in incidence and mortality rates, with higher burden in low HDI countries. The study highlights the need for global action to reduce the burden and inequality of ovarian cancer in access to quality cancer care and treatment.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Mihir M. Desai, Giovanni E. Cacciamani, Karanvir Gill, Juanjuan Zhang, Lihua Liu, Andre Abreu, Inderbir S. Gill
Summary: Analysis of the recent SEER data reveals a significant increase in the incidence rates of mPCa, which coincides with the USPSTF recommendations against PCa screening. These trends are observed across different races and age groups and are associated with changes in screening practices.
Article
Oncology
Jessica K. Sheth Bhutada, Amie E. Hwang, Lihua Liu, Kai-Ya Tsai, Dennis Deapen, David R. Freyer
Summary: Despite overall survival improvements for adolescents and young adults with cancer, certain subgroups such as non-Hispanic Blacks, males, and those with low socioeconomic status face increased risk of metastatic disease. Metastatic melanoma stands out for demonstrating multiple sociodemographic disparities. Future cancer-specific studies should investigate the connection between sociodemographic risk factors and biological drivers of metastases to inform targeted public health efforts.
Article
Public, Environmental & Occupational Health
Robert Hsu, Kai-Ya Tsai, Krithika Chennapan, Katherine Y. Wojcik, Alice W. W. Lee, Jorge J. Nieva, Lihua Liu
Summary: Filipino thyroid cancer patients have a higher incidence of high-risk pathological features and greater mortality risk. Further investigation is needed to understand the connection between these factors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Liu Lihua, Talar S. Habeshian, Zhang Juanjuan, Noah C. Peeri, Du Mengmeng, Immaculata De Vivo, Veronica Wendy Setiawan
Summary: The incidence of endometrial cancer, especially early-onset cases, is increasing, with striking differences in demographic and tumor characteristics as well as racial and ethnic patterns. This study utilized data from the Cancer in North America (CiNA) Analytic File to examine trends in invasive endometrial cancer incidence by age and ethnicity. The faster increase in early-onset cases, particularly among non-White women, suggests a possible association with the rising obesity epidemic in younger generations.
JNCI CANCER SPECTRUM
(2023)
Article
Public, Environmental & Occupational Health
Alice W. Lee, Angela Sou, Maitri Patel, Sofia Guzman, Lihua Liu
Summary: The incidence of nasopharyngeal cancer is significantly higher among Asian/Pacific Islanders (APIs) compared to other racial groups. APIs have the highest incidence of nasopharyngeal cancer across all histologic subtypes and almost all age groups.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Oncology
Kali Zhou, Ziwei Song, Nairi Rostomian, Jennifer L. Dodge, Mariana C. Stern, V. Wendy Setiawan, Norah A. Terrault, Myles G. Cockburn, Lihua Liu
Summary: Immigrants make up a significant proportion of HCC patients in the US, and those who are foreign-born have better survival rates compared to US-born patients. Further research is needed to understand the mechanisms behind this survival disparity.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Multidisciplinary Sciences
Guogui Huang, Fei Guo, Klaus F. Zimmermann, Lihua Liu, Lucy Taksa, Zhiming Cheng, Massimiliano Tani, Marika Franklin
Summary: This study assesses the loss of life expectancy caused by COVID-19 in 27 countries by considering both the actual and expected changes in life expectancy between 2019 and 2020. The results show that 21 out of 27 countries would have experienced an increase in life expectancy if COVID-19 had not occurred. Taking into account the expected mortality changes, the study finds that the average loss of life expectancy in 2020 across the 27 countries was 1.33 years at age 15 and 0.91 years at age 65. These findings highlight the profound impact of COVID-19 on mortality when considering year-on-year intrinsic variations, especially in countries with higher life expectancy increase in recent years.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Nicholas G. Zaorsky, James A. Proudfoot, Angela Y. Jia, Raed Zuhour, Randy Vince Jr, Yang Liu, Xin Zhao, Jim Hu, Nicola C. Schussler, Jennifer L. Stevens, Suzanne Bentler, Rosemary D. Cress, Jennifer A. Doherty, Eric B. Durbin, Susan Gershman, Iona Cheng, Lou Gonsalves, Brenda Y. Hernandez, Lihua Liu, Bozena M. Morawski, Maria Schymura, Stephen M. Schwartz, Kevin C. Ward, Charles Wiggins, Xiao-Cheng Wu, Jonathan E. Shoag, Lee Ponsky, Alan Dal Pra, Edward M. Schaeffer, Ashley E. Ross, Yilun Sun, Elai Davicioni, Valentina Petkov, Daniel E. Spratt
Summary: In this study, the Decipher Prostate Genomic Classifier (GC) was used to analyze a US national database of men with prostate cancer. The use of the GC test was found to be associated with conservative management, higher rates of adverse pathology at the time of surgery, and greater use of postoperative radiotherapy.
JNCI CANCER SPECTRUM
(2023)
Meeting Abstract
Oncology
Talar S. Habeshian, Lihua Liu, Juan-Juan Zhang, Margaret Du, Immaculata De Vivo, Veronica W. Setiawan
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Lihua Liu, Juanjuan Zhang, Kathy Wojcik, Irene Kang, Mary Falcone, Caryn Lerman
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
