Journal
ORGANIC LETTERS
Volume 21, Issue 21, Pages 8523-8527Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02840
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Funding
- NSFC-Joint Foundation of Yunnan Province [U1702287]
- National Science Fund for Distinguished Young Scholars [81525026]
- National Natural Science Foundation of China [81772820, 21472199]
- Natural Science Foundation of SZU [2017051]
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(+/-)-Lucidumone (1), an enantiomeric meroterpenoid possessing an unprecedented skeleton comprising a fused 6/5/6/6/5 polycyclic system, was isolated from Ganoderma lucidum and structurally identified. The absolute configuration of (-)-I was assigned by single-crystal X-ray crystallography. A plausible biosynthetic pathway for 1 is proposed. A chemical biology approach reveals that (-)-1 selectively inhibits COX-2 by directly binding with an amino acid residue of Tyr385, representing a new structure scaffold of COX-2 inhibitors.
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