Article
Immunology
Jia Wang, Jingjing Yang, Wenhui Xia, Mengna Zhang, Haonan Tang, Keyi Wang, Chenyu Zhou, Ling Qian, Yuan Fan
Summary: In this study, the functional role of Escherichia coli (E. coli) and its supernatant in regulating the Th17/Treg balance and cytokines and chemokines profile in Oral lichen planus (OLP) immune microenvironment was examined. It was found that E. coli and its supernatant activated the TLR4/NF-kappa B signaling pathway, leading to increased expression of cytokines and chemokines and Th17/Treg imbalance in OLP. Furthermore, E. coli and supernatant promoted T cell proliferation and migration, and induced apoptosis in oral keratinocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yilin Yao, Lei Pan, Ye Wei, Minghua Feng, Xiye Li, Lei Sun, Guoyao Tang, Yufeng Wang
Summary: This study investigated the function and mechanism of TRIM21 in T cells of oral lichen planus (OLP). TRIM21 was found to be highly expressed in OLP tissues, mainly in CD3(+) T lymphocytes. It was shown that TRIM21 promotes inflammation in OLP by ubiquitinating NF-κB and activating the NF-κB signaling pathway.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Bingyu Shen, Haoqing Zhang, Zhengjin Zhu, Zixi Ling, Fangyuan Zeng, Yazhou Wang, Jianguo Wang
Summary: Baicalin, extracted from Scutellaria, has anti-inflammatory effects and can reduce pulmonary edema caused by ALI. It inhibits the expression of TLR4 and MyD88, leading to a decrease in inflammatory molecules. Baicalin also promotes an increase in white blood cells and improves lung pathology, indicating its potential as a treatment for ALI.
Article
Dentistry, Oral Surgery & Medicine
Honglin Liao, Yuxue Luo, Li Long, Jiakuan Peng, Xuemei Qiu, Peiyang Yuan, Hao Xu, Lu Jiang
Summary: The study found that anxiety levels were higher in OLP patients compared to healthy individuals, with female patients showing higher levels of anxiety. Gender had an impact on anxiety levels among OLP patients. The research suggests that OLP patients can be classified into weakly anxiety-related or highly anxiety-related types.
Article
Multidisciplinary Sciences
Zhihui Zhang, Yan Zhang, Zhongfang Zhao, Pei Li, Danyang Chen, Wei Wang, Ying Han, Shiqi Zou, Xin Jin, Jianling Zhao, Hongwei Liu, Xiao Wang, Weili Zhu
Summary: The study found that paeoniflorin can promote the proliferation, migration, and multilineage differentiation of OLP-MSCs, and change the inflammatory microenvironment through T lymphocytes, suggesting a potential therapeutic effect in the treatment of OLP.
SCIENTIFIC REPORTS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Asma El-Howati, Martin H. Thornhill, Helen E. Colley, Craig Murdoch
Summary: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa. The mechanisms of pathogenesis are still not fully understood, but evidence suggests a chronic, dysregulated immune response leading to increased expression of cytokines, chemokines, and adhesion molecules. CD8+ cytotoxic and CD4+ Th1 polarised T cells are the main lymphocytes involved, but recent evidence indicates the involvement of other T cell subsets.
Article
Dentistry, Oral Surgery & Medicine
Sai-wei Zheng, Pan Xu, Li-ting Cai, Zheng-wu Tan, Yi-ting Guo, Rui-xin Zhu, Yuan He
Summary: The study revealed that Prevotella melaninogenica was more abundant in OLP patients compared to healthy controls, and could invade the epithelium and even lamina propria of OLP. This bacterium is capable of adhering to and invading macrophages, activating the transcription of IL-1 beta, IL- 6, and TNF-alpha in the NF-kappa B signaling pathway.
Review
Biochemistry & Molecular Biology
Paola Zanetta, Margherita Ormelli, Angela Amoruso, Marco Pane, Barbara Azzimonti, Diletta Francesca Squarzanti
Summary: Oral lichen planus is an immune-mediated chronic inflammatory disorder associated with human microbiota imbalance. Probiotics have immune-modulatory and microbiota-balancing activities, which make them a potential treatment for oral lichen planus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jingjing Li, Suiyuan Ren, Meng Li, Jingai Bi, Guang Yang, Erguang Li
Summary: Paeoniflorin has therapeutic activity against ulcerative colitis, exerting its effects through inhibition of inflammation and eosinophil infiltration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Randa A. A. Zaghloul, Ahmed M. M. Zaghloul, Dalia H. H. El-Kashef
Summary: This study found that baicalin has the potential to reduce liver fibrosis by inhibiting oxidative stress and inflammation, providing anti-oxidant and anti-inflammatory effects.
Article
Dentistry, Oral Surgery & Medicine
Yineng Han, Yiping Huang, Qiaolin Yang, Lingfei Jia, Yunfei Zheng, Weiran Li
Summary: This study revealed that SNHG5 mediates periodontal inflammation through the NF-kappa B signaling pathway, providing a potential therapeutic target for periodontitis treatment.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Anatomy & Morphology
Xiaosong Xiang, Yongxin Hu, Zhiqiang Song, Chunlin Wang
Summary: This study aimed to investigate the role and underlying mechanisms of TRPM2 in periodontal disease. The results showed that knockdown of TRPM2 promoted proliferation and osteogenic differentiation of hPDLSCs, and this effect was mediated through the NF-kappa B/NLRP3 pathway. These findings are important for understanding the pathogenesis of periodontal disease and exploring potential therapeutic strategies.
Review
Dentistry, Oral Surgery & Medicine
E. C. Mooney, S. E. Sahingur
Summary: Inflammation is triggered by innate sensors, and immune cell activation is a strictly regulated process supported by negative feedback mechanisms. Ubiquitination plays a critical role in regulating the immune system, with A20 serving as an important ubiquitin-editing enzyme in inflammation.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Heyu Zhang, Tiejun Li
Summary: This study investigated the association between oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in a retrospective cohort of 3568 patients. The findings suggest that not all cases of OSCC are transformed from OLP, indicating that the previous understanding of OLP transformation may have been overestimated. Strict diagnostic criteria for OLP and close surveillance are important in correctly identifying the origin of OSCC and avoiding overestimation of the risk of OLP transformation.
Article
Immunology
Xiaofang Lv, Chun Fan, Zhongxin Jiang, Wenxuan Wang, Xu Qiu, Qiuxia Ji
Summary: Porphyromonas gingivalis-LPS/ATP stimulation significantly increased the expression of NF-kappa B, the NLRP3 inflammasome, GSDMD, and IL-1β at gene and protein levels, as well as membrane damage, caspase-1 activity, and LDH release. However, pretreatment with ISL noticeably suppressed these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Feiyan Yu, Miao Li, Qianqian Wang, Jing Wang, Shuang Wu, Rui Zhou, Han Jiang, Xiaoyi Li, Yu Zhou, Xi Yang, Xiao He, Yan Cheng, Xiuyun Ren, Hong Zhang, Mei Tian
Summary: This study investigated the metabolic changes in the brain and the potential mechanism involved in aberrant affective behaviors during toothache. The results showed that glucose metabolism peaked on the 3rd day and gradually decreased after dental pulp injury. PET imaging revealed the involvement of the visual pathway in toothache regulation, and NR2B in the cACC played a role in emotional regulation during toothache.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Medicine, Research & Experimental
Linkun Xu, Sui Zhang, Yue Chen, Feiyan Yu, Chong Han, Dongchao Wu, Dongning He
Summary: This study investigated the changes of labial soft tissue contours with different jumping spaces after immediate implant placement and restoration in the maxillary esthetic area. The size of the jumping space was found to be moderately negatively correlated with the level and average thickness of gingival mucosa and the linear changes under gingival margin.
BIOMOLECULES AND BIOMEDICINE
(2023)