Article
Pathology
Yalan Liu, Lingli Chen, Dongxian Jiang, Lijuan Luan, Jie Huang, Yingyong Hou, Chen Xu
Summary: The study aims to explore the relationship between OPN and HER2 in gastric cancer, particularly in the context of EMT. Nanostring analysis revealed differential gene expression between HER2 3+ and non-3+ areas, with OPN showing a positive correlation with HER2. Knocking down OPN and HER2 resulted in decreased invasion/migration abilities in GC cell lines, indicating a potential role of HER2 in promoting EMT through the regulation of OPN.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao, Wei Wang
Summary: The research revealed that FZD5 prevents EMT in gastric cancer and is associated with longer survival. ELF3 acts as a downstream effector of FZD5, repressing ZEB1 expression and guarding against EMT.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
YaJie Li, Yan Zhao, Yi Li, XiaoYi Zhang, Chao Li, NiYa Long, XueShu Chen, LiYa Bao, JianJiang Zhou, Yuan Xie
Summary: The research reveals the association between gastrin and gastric cancer metastasis, indicating that gastrin induces EMT, migration, and invasion of GC cells through the Wnt/beta-catenin signaling pathway. This discovery may provide a new direction for developing therapeutic targets for preventing gastric cancer metastasis.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Oncology
Evan M. McCabe, Theodore P. Rasmussen
Summary: The epithelial to mesenchymal transition (EMT) is a cellular process crucial in embryogenesis, where cancer stem cells (CSCs) play a role by differentiating and undergoing EMT. Long noncoding RNAs (lncRNAs) also have a role in CSCs and EMT, with the potential to serve as biomarkers and therapeutic targets in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
JunJian He, WeiChao Hu, Qin Ouyang, ShengWei Zhang, LiJiao He, WeiYan Chen, XinZhe Li
Summary: This paper reviews the pathogenic mechanisms by which H. pylori induces gastric stem cell-like properties and CSCs, and supplements the existing Correa model. H. pylori infection leads to dysfunction of developmental signaling pathways and alteration of gastric mucosal microenvironment, potentially promoting gastric stem cell-like properties through epithelial-mesenchymal transition.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Ik Cha, Jeeyun Lee, Woo Kyoung Jeong, Seung Tae Kim, Jae-Hun Kim, Jung Yong Hong, Won Ki Kang, Kyoung-Mee Kim, Seon Woo Kim, DongilW Choi
Summary: The study developed a predictive model for the epithelial-to-mesenchymal transition (EMT) subtype of gastric cancer using computed tomography (CT) images and known clinicopathologic variables. A nomogram was constructed for individualized estimation of EMT subtype, providing a useful screening tool for personalized medicine.
EUROPEAN RADIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rodrigo A. Acuna, Manuel Varas-Godoy, Diego Herrera-Sepulveda, Mauricio A. Retamal
Summary: Connexins are a family of proteins that play a crucial role in cellular communication, but certain types may have pro-tumorigenic effects. Research has shown that Cx46 can modulate the characteristics of cancer stem cells and epithelial-to-mesenchymal transition in breast cancer cells, potentially influencing future cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Shuo Wang, Yuze Zhao, Yuguang Song, Guoliang Qiao, Yan Di, Jing Zhao, Pingping Sun, Huixia Zheng, He Huang, Hongyan Huang
Summary: In gastric cancer, the expression of the ERBB2d16 isoform is associated with EMT, immunosuppression, and resistance to trastuzumab therapy. The ERBB2d16/ERBB2 ratio may serve as a prognostic marker for gastric cancer patients receiving trastuzumab therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell & Tissue Engineering
Yan Qiu, Libo Yang, Honghong Liu, Xiaobo Luo
Summary: The use of the anti-HER2 drug trastuzumab has significantly improved the prognosis of HER2-positive breast cancer patients, but 50% of patients relapse due to trastuzumab resistance, which is closely related to the presence of breast cancer stem cells (BCSCs). BCSCs are resistant to conventional therapy and may drive distant metastasis and cancer relapse.
Article
Plant Sciences
Wenhao Liao, Yueqiang Wen, Jing Wang, Maoyuan Zhao, Shangbin Lv, Nianzhi Chen, Yuchen Li, Lina Wan, Qiao Zheng, Yu Mou, Ziyi Zhao, Jianyuan Tang, Jinhao Zeng
Summary: This study aims to investigate the role and potential mechanism of GA on gastric precancerous lesions (GPL), the key turning point of gastritis to gastric cancer, with the aim of delaying, blocking or reversing the dynamic overall process of inflammation-cancer transformation and thus blocking GPL to prevent the development of gastric cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Junquan Song, Rongyuan Wei, Shiying Huo, Jianpeng Gao, Xiaowen Liu
Summary: Through the analysis of differentially expressed genes between metastatic gastric cancer and primary gastric cancer, a metastasis-related epithelial-mesenchymal transition signature (MEMTS) was constructed. High MEMTS indicates a poor prognosis in patients with gastric cancer, and patients with low MEMTS may benefit more from adjuvant chemoradiotherapy. MEMTS reliably predicts the response to immunotherapy in gastric cancer and is significantly associated with cancer-associated fibroblasts and stromal score in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yuna Kim, Yoo Jin Bae, Jie-Hyun Kim, Hyunki Kim, Su-Jin Shin, Da Hyun Jung, Hyojin Park
Summary: Trastuzumab-resistant gastric cancer cells exhibit an epithelial-mesenchymal transition (EMT)-like phenotype, and trastuzumab resistance is promoted by the Wnt/beta-catenin signaling pathway. The Wnt/beta-catenin pathway is a key signaling pathway for trastuzumab resistance in gastric cancer cells.
Review
Biochemistry & Molecular Biology
Joanna Kozak, Alicja Forma, Marcin Czeczelewski, Pawel Kozyra, Elzbieta Sitarz, Elzbieta Radzikowska-Buchner, Monika Sitarz, Jacek Baj
Summary: Epithelial-mesenchymal transition (EMT) is a key process in the development of gastric cancer, affecting patient outcomes. There is an urgent need for research on pharmacological agents targeting EMT to prevent progression and potential metastasis of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Le Phuong Hoang Anh, Ken Nishimura, Akihiro Kuno, Nguyen Thuy Linh, Tetsuo Kato, Manami Ohtaka, Mahito Nakanishi, Eiji Sugihara, Taka-Aki Sato, Yohei Hayashi, Aya Fukuda, Koji Hisatake
Summary: Somatic cell reprogramming proceeds through a series of events to generate induced pluripotent stem cells (iPSCs). In this study, the researchers found that the downregulation of Osr2 is crucial for efficient reprogramming by using a cell-based model. Osr2 acts as a novel EMT regulator and its downregulation diminishes TGF-beta signaling and activates Wnt signaling, promoting MET and acquiring pluripotency.
Article
Oncology
Jung Hwan Ji, Soong June Bae, Seul-Gi Kim, Min Hwan Kim, Gun-Min Kim, Joohyuk Sohn, Joon Jeong, Jee Hung Kim, Sung Gwe Ahn
Summary: This study investigated the impact of different doses of carboplatin on pathologic complete response rate, grade 3/4 anaemia occurrence, and transfusion rate in patients treated with neoadjuvant TCHP. The results showed that carboplatin at AUC5 has comparable cytotoxic effects to carboplatin at AUC6 and is associated with fewer complications related to anaemia in HER2+ breast cancer patients.
Article
Environmental Sciences
Yu-Jin Jeong, Chang-Ung Kim, Kyung-Soo Lee, Ji Hyung Kim, Seo Young Park, Ahn Young Jeong, Jun Bong Lee, Doo-Jin Kim, Young-Jun Park, Moo-Seung Lee
Summary: In this study, it was found that PM-isolated Pseudomonas stutzeri (PMPS) induces higher levels of inflammatory responses in lung epithelial cells, alveolar cells, and macrophages compared to Pseudomonas stutzeri (PS). The pathogenicity of PMPS is mediated by Toll-like receptors (TLRs) signaling pathways, which also regulate the expression of the antibiotic peptide beta-defensin 3 (BD3) that suppresses PMPS proliferation. Furthermore, pretreatment with PM enhances inflammatory responses and tissue damage caused by PMPS, while reducing BD3 expression.
ENVIRONMENTAL POLLUTION
(2023)
Article
Fisheries
Sib Sankar Giri, Sang Guen Kim, Kang Jeong Woo, Won Joon Jung, Sung Bin Lee, Young Min Lee, Su Jin Jo, Mae Hyun Hwang, JaeHong Park, Ji Hyung Kim, V Sukumaran, Se Chang Park
Summary: This study investigated the effects of Bougainvillea glabra leaf as a feed supplement on the growth, immune response, and disease resistance of carp. The results showed that a dietary supplementation with 40g/kg BG leaf significantly improved the growth performance, immune response, and disease resistance of carp.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yeonjin Je, Kyungdo Han, Jaeyoung Chun, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jong Pil Im, Joo Sung Kim
Summary: Abdominal obesity is associated with an increased risk of developing Crohn's disease, but not ulcerative colitis, according to a population-based cohort study in Korea.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Medicine, General & Internal
Yuna Kim, Sung Hwan Yoo, Jaeyoung Chun, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This study found that exposing patients to virtual reality (VR) prior to endoscopic procedures can reduce their anxiety levels, leading to less discomfort and incomplete procedures, as well as decreased use of sedative medication. The proportion of patients with high anxiety significantly decreased in the VR group compared to the control group, and patients in the VR group reported higher satisfaction with sedation.
YONSEI MEDICAL JOURNAL
(2023)
Article
Nutrition & Dietetics
Mi Jung Kwon, Jae Yong Park, Sung Gyun Kim, Jwa-Kyung Kim, Hyun Lim, Joo-Hee Kim, Ji Hee Kim, Seong-Jin Cho, Eun Sook Nam, Ha Young Park, Nan Young Kim, Ho Suk Kang
Summary: Using nationwide data from the Korean National Health Insurance Service-Health Screening Cohort database, this study aimed to explore the link between gout and incident osteoporosis/osteoporotic fractures. The results showed that gout patients had a slightly higher risk of developing osteoporosis compared to controls, but no significant association was found between gout and incident osteoporotic fractures. This study provides insights into the health implications of gout in the Korean population.
Article
Medicine, General & Internal
Dong-Chan Eun, Yong-Ho Lee, Jin-Oh Park, Kyung-Soo Suk, Hak-Sun Kim, Seong-Hwan Moon, Si-Young Park, Byung-Ho Lee, Sang-Jun Park, Ji-Won Kwon, Sub-Ri Park
Summary: In this retrospective study, the clinical and radiological outcomes of patients with multilevel lumbar stenosis who underwent BESS and microscopic ULBD were compared. The results showed that the BESS group had better clinical outcomes, with significant improvements in back and leg pain scores and medication use. Radiological outcomes were also superior in the BESS group. The short-term follow-up period demonstrated the efficacy of multilevel decompression with the BESS technique.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Physical
Juchan Lee, Myung Joon Kim, InverstigationByeong Geun Jeong, Chan Kwon, Yumin Cha, Soo Ho Choi, Ki Kang Kim, Mun Seok Jeong
Summary: The study investigates the effect of sulfur vacancies on the electrical properties of MoS2. After generating sulfur vacancies through treatment with hydrazine, the density of shallow traps increased by a factor of 4, whereas that of deep-level traps increased by a factor of 200. These results indicate that sulfur vacancies induce both deep- and shallow-level traps, with a higher trap density at the deep level.
APPLIED SURFACE SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Hyo-Joon Yang, Young-Il Kim, Ji Yong Ahn, Kee Don Choi, Sang Gyun Kim, Seong Woo Jeon, Jie-Hyun Kim, Sung Kwan Shin, Hyuk Lee, Wan Sik Lee, Gwang Ha Kim, Jae Myung Park, Woon Geon Shin, Il Ju Choi
Summary: This study validated the effectiveness of the eCura system in undifferentiated-type early gastric cancer, and found that close follow-up without additional treatment can be considered for low-risk patients, while additional surgery is recommended for intermediate- and high-risk patients.
Article
Surgery
So Young Han, Hong Jin Yoon, Jie-Hyun Kim, Hye Sun Lee, Jaeyoung Chun, Young Hoon Youn, Hyojin Park
Summary: By analyzing the characteristics of patients with early gastric cancer who underwent ESD, we developed a nomogram to predict the risk of non-CR. This nomogram includes endoscopic features, radiologic findings, and pathology results, and it showed good predictive performance in the external validation.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Chemistry, Medicinal
Si-Eun Oh, Jie-Hyun Kim, Hee-Jong Shin, Seong-Ah Kim, Chan-Kee Park, Hae-Young Lopilly Park
Summary: We investigate the changes in extracellular matrix (ECM) and biomechanical properties of the sclera after systemic hypotension induced by oral hydrochlorothiazide. Angiotensin II (AngII) receptor levels and ECM components were evaluated, along with the effect of losartan inhibition and its impact on retinal ganglion cells (RGCs). The results show that AngII plays a role in scleral fibrosis after systemic hypotension, and inhibiting AngII could modulate the tissue properties of the sclera, providing protection for RGCs.
Article
Gastroenterology & Hepatology
Sang Jo Han, Su Jung Baik, Young Hoon Yoon, Jie Hyun Kim, Hye Sun Lee, Soyoung Jeon, Hyojin Park
Summary: This study aimed to compare the risk of metabolic syndrome and fatty liver diseases between gastric cancer survivors and non-cancer subjects. The results showed that gastric cancer survivors who underwent surgical treatment had lower risks of metabolic syndrome, fatty liver by ultrasonography, and metabolic dysfunction-associated fatty liver disease (MAFLD) than non-cancer subjects. However, there were no significant differences in the risks between non-surgical gastric cancer survivors and non-cancer subjects.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Yuna Kim, Yoo Jin Bae, Jie-Hyun Kim, Hyunki Kim, Su-Jin Shin, Da Hyun Jung, Hyojin Park
Summary: Trastuzumab-resistant gastric cancer cells exhibit an epithelial-mesenchymal transition (EMT)-like phenotype, and trastuzumab resistance is promoted by the Wnt/beta-catenin signaling pathway. The Wnt/beta-catenin pathway is a key signaling pathway for trastuzumab resistance in gastric cancer cells.
Article
Gastroenterology & Hepatology
Da Hyun Jung, Young Hoon Youn, Hye-Kyung Jung, Seung Young Kim, Cheal Wung Huh, Cheol Min Shin, Jung-Hwan Oh, Kyu Chan Huh, Moo In Park, Suck Chei Choi, Ki Bae Kim, Seon-Young Park, Joong Goo Kwon, Yu Kyung Cho, Jung Ho Park, Jeong Eun Shin, Eun Jeong Gong, Jae Hak Kim, Su Jin Hong, Hyun Jin Kim, Sam Ryong Jee, Ju Yup Lee, Kee Wook Jung, Hee Man Kim, Kwang Jae Lee
Summary: The study suggests that continuous treatment is more appropriate than on-demand treatment for non-erosive GERD or mild erosive esophagitis. Transitioning to on-demand treatment should be considered after a sufficient period of continuous treatment.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Oncology
Chang Gon Kim, Min Hwan Kim, Jee Hung Kim, Seul-Gi Kim, Gun Min Kim, Tae Yeong Kim, Won-Ji Ryu, Jee Ye Kim, Hyung Seok Park, Seho Park, Young Up Cho, Byeong Woo Park, Seung Il Kim, Joon Jeong, Joohyuk Sohn
Summary: This study analyzed data from postmenopausal women with HR-positive, HER2-negative ABC who were treated with CDK4/6 inhibitors and found that on-treatment dNLR predicted progression-free survival (PFS). Flow cytometry analysis revealed potential systemic immune responses induced by CDK4/6 inhibitors, including prevention of T cell exhaustion and reduction of myeloid-derived suppressor cell frequency.
BREAST CANCER RESEARCH
(2023)
