Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Erika Hurtado-Salgado, Luz Cardenas-Cardenas, Jorge Salmeron, Rufino Luna-Gordillo, Eduardo Ortiz-Panozo, Betania Allen-Leigh, Nenetzen Saavedra-Lara, Eduardo L. Franco, Eduardo Lazcano-Ponce
Summary: This study analyzed screening data from Mexico's public cervical cancer prevention program from 2010 to 2015, and found that hrHPV testing with cytological triage can detect twice as many CIN2+ cases compared to screening using cytology alone in women aged 35 to 64.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Takeo Shibata, Sumit Shah, Teresa Evans, Hannah Coleman, Benjamin J. Lieblong, Horace J. Spencer, Charles M. Quick, Toshiyuki Sasagawa, Owen W. Stephens, Erich Peterson, Donald Johann, Yong-Chen Lu, Mayumi Nakagawa
Summary: The use of high-throughput sequencing has shown that HPV vaccine can induce specific T cell expansion in both peripheral blood and cervical tissue. This approach not only confirms the presence of vaccine-specific T cells in the body, but also provides a novel method to assess vaccine-specific responses in various anatomical areas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Philip E. Castle, Brian Befano, Mark Schiffman, Nicolas Wentzensen, Thomas Lorey, Nancy Poitras, Marianne Hyer, Li C. Cheung
Summary: This study compared the risks of cervical intraepithelial neoplasia grade 2 (CIN2) or more severe diagnoses (CIN2+) between women living with HIV (WLWH) and women not known to have HIV (HIV[-]) following cervical cancer screening. WLWH were more likely to test HPV positive and have abnormal cytology compared to HIV[-] women. The results suggest that both populations could be managed similarly once the screening results are known.
PREVENTIVE MEDICINE
(2022)
Article
Gastroenterology & Hepatology
R. L. Goetgebuer, J. E. Kreijne, C. A. Aitken, G. Dijkstra, F. Hoentjen, N. K. de Boer, B. Oldenburg, A. E. van der Meulen, C. I. J. Ponsioen, M. J. Pierik, F. J. van Kemenade, I. M. C. M. de Kok, A. G. Siebers, J. Mannien, C. J. van der Woude, A. C. de Vries
Summary: Women with inflammatory bowel disease are at increased risk for cervical intraepithelial neoplasia. The main risk factors include smoking and disease location. HPV vaccination and adherence to cervical cancer screening are crucial for these women.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Oncology
Stephan Polterauer, Olaf Reich, Andreas Widschwendter, Laudia Hadjari, Gerhard Bogner, Alexander Reinthaller, Elmar Joura, Gerda Trutnovsky, Alexandra Ciresa-Koenig, Julia Ganhoer-Schimboeck, Ina Boehm, Regina Berger, Eva Langthaler, Stephan W. Aberle, Georg Heinze, Andreas Gleiss, Christoph Grimm
Summary: This study investigates the non-inferiority of topical IMQ therapy compared to LLETZ in patients diagnosed with HSIL. The results show that IMQ treatment leads to lower HPV clearance rates compared to LLETZ, suggesting that LLETZ remains the standard treatment for HSIL patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Fangbin Song, Peisha Yan, Xia Huang, Chun Wang, Hui Du, Xinfeng Qu, Ruifang Wu
Summary: This study aimed to investigate the risk of HPV genotyping for cervical precancer and cancer and assess its effects on genotype-specific screening and HPV vaccine.
Article
Oncology
Mayumi Saito, Aarthi Rajesh, Carrie Innes, Rachael van der Griend, Peter Fitzgerald, Bryony Simcock, Peter Sykes, Merilyn Hibma
Summary: The progression of cervical intraepithelial neoplasia (CIN) to higher grade disease is associated with Blimp-1 positive cell staining in the lesion and low numbers of infiltrating CD4 cells in the dermal region beneath the lesion.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Infectious Diseases
Hong-Fang Zhi, Liu-Feng Yang, Jing Ge, Xuan-Tao Yang
Summary: This study analyzed the status of human papillomavirus (HPV) infections in women in Yunnan, China and their correlation with the grade of cervical intraepithelial neoplasia (CIN). The study found that HPV infection in Yunnan was dominated by single infection and high-risk HPV types. Patients aged 30 to 45 years had a higher incidence of high-grade squamous intraepithelial lesions (HSIL), and the most common high-risk HPV subtypes were HPV16, HPV58, and HPV52.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Sonia Andersson, David Megyessi, Karen Belkic, Susanna Alder, Ellinor Ostensson, Miriam Mints
Summary: This study identified four independent risk factors for disease recurrence in women first-time treated for high-grade CIN, including age 45 years or above, unclear margins, positive HPV at first follow-up, and abnormal cytology at first follow-up. The findings also suggested the need for repeated HPV evaluation and recommended home vaginal self-sampling, especially for women aged 45 and older, during the ongoing pandemic.
Article
Obstetrics & Gynecology
Neal M. Lonky, Lanfang Xu, Diane M. Da Silva, Juan C. Felix, Chun Chao
Summary: This study aimed to evaluate the risk of high-grade cervical lesion diagnosed through colposcopy in women with human papillomavirus vaccination compared to women without vaccination. The results showed that vaccination history did not significantly lower the odds of a cervical intraepithelial neoplasm grade 2+ diagnosis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Virology
Yunfeng Fu, Ying Li, Xiao Li, Xinyu Wang, Weiguo Lu
Summary: To assess the effectiveness of DH3-human papillomavirus (HPV) partial genotyping for risk stratification in cervical cancer screening, a retrospective cohort study was conducted with 7263 Chinese women aged 21-71 years. DH3-HPV and Hybrid Capture 2 (HC2) tests were performed on baseline cytological samples after a 3-year follow-up. The results showed that DH3-HPV and HC2 provided similar risk estimates across different cytological results. Partial genotyping of DH3-HPV performed well in stratifying the risk of cervical intraepithelial neoplasia, with higher risks observed for HPV16/18 compared to other high-risk HPV types. Women with an HPV-negative result had significantly lower cumulative risks of developing CIN3+ or CIN2+ compared to those with normal cytology. These findings suggest that DH3-HPV partial genotyping can effectively balance the benefits and harms of cervical cancer screening.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Maria-Eulalia Fernandez-Montoli, Fatima Heydari, Fabrizia Lavecchia, Miquel-Angel Pavon, Esther Guerra, Xavier Matias-Guiu, Maria-Dolores Marti, Sara Tous
Summary: This retrospective study aimed to assess the long-term response to imiquimod in patients with vulvar HSIL and to analyze the role of HPV in the persistence or recurrence of vulvar HSIL after imiquimod treatment. The results showed that imiquimod effectively treated vulvar HSIL, with a higher number of complete and partial responses. Patients who had a partial or no response to imiquimod had a higher risk of recurrence, especially in immunosuppressed patients. The study also found that patients who tested positive for HPV after imiquimod treatment were more likely to experience recurrence.
Article
Biotechnology & Applied Microbiology
Ziwen Zheng, Xiaorong Yang, Xinyu Yao, Ling Li
Summary: The study explored the prognostic value of HPV 16/18 genotyping and geminin mRNA quantification in predicting the progression of low-grade cervical squamous intraepithelial lesion (LSIL). Results showed that HPV 16/18 positivity rate and geminin mRNA levels can differentiate between high-grade and low-grade squamous intraepithelial lesions, suggesting a potential role of geminin in the progression of LSIL. Combining HPV genotyping and geminin mRNA qRT-PCR could improve clinical intervention efficacy for progressive LSIL.
Article
Nutrition & Dietetics
Wei Wang, Aimin Yang, Huina Zhang, Yuanxing Li, Jing Yang, Weihong Zhao, Zhilian Wang, Haixia Lou, Wenhao Wang, Tingting Liang, Lili Zhang, Xiaoqiang Su, Chen Wang, Jintao Wang, Jinghui Song, Li Li, Weiguo Lv, Chengquan Zhao, Min Hao
Summary: This study indicates that RBC folate concentration is associated with the prevalence of CIN grades and the progression of CIN1 in female Chinese adults.
JOURNAL OF NUTRITION
(2022)
Letter
Acoustics
I. Pino, A. M. Vidal Urbinati, A. D. Iacobone, M. E. Guerrieri, E. P. Preti, D. Franchi
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Oncology
Ida Pino, Anna Daniela Iacobone, Ailyn Mariela Vidal Urbinati, Maria Di Giminiani, Davide Radice, Maria Elena Guerrieri, Eleonora Petra Preti, Silvia Martella, Dorella Franchi
Summary: This article discusses the experience of fertility-sparing treatment for endometrial cancer and compares the oncological and reproductive outcomes of different hormonal therapies. The study suggests that the combination of LNG-IUD and metformin showed a significantly lower risk of recurrence compared to other treatment regimens.
Article
Medicine, General & Internal
Fabio Bottari, Anna Daniela Iacobone, Davide Radice, Eleonora Petra Preti, Mario Preti, Dorella Franchi, Sara Boveri, Maria Teresa Sandri, Rita Passerini
Summary: This study evaluated the performance of six HPV DNA tests and one mRNA test in detecting cervical intraepithelial lesions (CIN) and as a test-of-cure in follow-up after surgical conservative treatment. The results showed that these tests had good concordance with HC2 and a very good and comparable sensitivity in CIN2+ detection.
Article
Biochemistry & Molecular Biology
Marianna Martinelli, Chiara Giubbi, Laura Saderi, Rosario Musumeci, Federica Perdoni, Biagio Eugenio Leone, Robert Fruscio, Fabio Landoni, Andrea Piana, Giovanni Sotgiu, Clementina Elvezia Cocuzza
Summary: HPV genotyping and viral load may serve as potential diagnostic biomarkers for high-grade cervical lesions. This study evaluated a new HPV test and found that the distribution of HR-HPV genotypes and viral copy numbers differed between women with high- and low-grade cervical lesions. These findings suggest that HPV genotyping and normalized viral load may help identify women at increased risk of cervical lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Sharonjit K. Dhillon, Clementina E. Cocuzza, Pui Yan Jenny Chung, Marianna Martinelli, Chiara Giubbi, Ruth C. Njoku, Ramya Bhatia, Kate Cuschieri, Marc Arbyn
Summary: HPV assays used in cervical cancer screening should meet international criteria. OncoPredict HPV (R) Screening is a PCR assay that targets 13 high-risk HPVs. It shows accurate detection of CIN2+ and excellent reproducibility. OncoPredict HPV (R) SCR meets international validation criteria for hrHPV DNA tests in cervical cancer screening.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Anna Daniela Iacobone, Davide Radice, Maria Elena Guerrieri, Noemi Spolti, Barbara Grossi, Fabio Bottari, Sara Boveri, Silvia Martella, Ailyn Mariela Vidal Urbinati, Ida Pino, Dorella Franchi, Eleonora Petra Preti
Summary: The aim of this study was to investigate the correlation between clinical and colposcopic features and the development of high-grade Vaginal Intraepithelial Neoplasia (VAIN). A retrospective analysis of 255 women diagnosed with VAIN revealed that smoking and a history of hysterectomy for CIN2+ were associated with VAIN development. Colposcopic grade G2, papillary lesion, and vascularity were significantly associated with a greater risk of VAIN3. Accurate diagnosis based on risk factors, colposcopic patterns, and histologic grade is crucial for personalized management of VAIN.
Article
Medicine, General & Internal
Anna Daniela Iacobone, Maria Elena Guerrieri, Eleonora Petra Preti, Noemi Spolti, Gianluigi Radici, Giulia Peveri, Vincenzo Bagnardi, Giulio Tosti, Angelo Maggioni, Fabio Bottari, Chiara Scacchi, Mariacristina Ghioni
Summary: In this retrospective analysis, the incidence, clinical and pathological features of cervico-vaginal involvement in extra-mammary Paget's disease (EMPD) of the vulva were investigated. It was found that 2.5% of patients developed cervico-vaginal involvement at 5 years, 6.5% at 10 years, and 14.0% at 15 years. Abnormal glandular cytology was the primary method of detection, and most patients had invasive EMPD and required hysterectomy with colpectomy. Liquid-based cytology with immunocytochemistry was recommended for early diagnosis and lifelong follow-up.
Editorial Material
Oncology
Marc Arbyn, Stefanie Costa, Ardashel Latsuzbaia, Eliane Kellen, Paolo Girogi Rossi, Clementina E. Cocuzza, Partha Basu, Philip E. Castle
Summary: In 2017, cervical cancer screening in the Netherlands was switched to HPV testing using cobas 4800. Women were provided with a self-sampling kit for free and could collect samples at home. Initially, only 7% of tests were done through self-sampling, but with improved promotion and accessibility, the proportion increased to 16% in 2020. Self-sampling showed lower HPV positivity and detection rate of precancer compared to clinician sampling, suggesting a need for optimization in handling and testing protocols.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Virology
Sharonjit K. Dhillon, Cindy Simoens, Lize Cuypers, Jannes Bode, Jesper Bonde, Philippe Corbisier, Clementina E. Cocuzza, Marc Van Ranst, Marc Arbyn
Summary: The study protocol VALCOR was conducted to evaluate the performance of Aptima SARS-CoV-2 assay using clinical samples. The results showed that Aptima had excellent performance in sensitivity, specificity, and overall agreement, with the ability to detect clinical samples at a low limit of detection. This highlights the importance of evaluating diagnostic assays for reliable test outcomes.
Article
Health Care Sciences & Services
Ida Pino, Maria Di Giminiani, Davide Radice, Ailyn Mariela Vidal Urbinati, Anna Daniela Iacobone, Maria Elena Guerrieri, Eleonora Petra Preti, Silvia Martella, Dorella Franchi
Summary: This retrospective study evaluated the safety, oncological, and pregnancy outcomes of repeated fertility-sparing treatment (FST) in women with recurrent endometrial cancer (EC). The results showed that repeated FST is a safe and effective option for women who desire to preserve fertility after the recurrence of early-stage EC.
Article
Oncology
Clementina Elvezia Cocuzza, Sharonjit Kaur Dhillon, Marianna Martinelli, Chiara Giubbi, Ruth Chinyere Njoku, Ramya Bhatia, Kate Cuschieri, Marc Arbyn
Summary: OncoPredict HPV QT is a fully genotyping viral load test that has been clinically validated according to international criteria for cervical cancer screening.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Virology
Marianna Martinelli, Chiara Giubbi, Maria Letizia Di Meo, Federica Perdoni, Rosario Musumeci, Biagio Eugenio Leone, Robert Fruscio, Fabio Landoni, Clementina Elvezia Cocuzza
Summary: This study evaluated the accuracy of HPV testing using self-collected urine and vaginal samples, comparing them to physician-collected cervical swabs. The results showed significant concordance in high-risk HPV detection between self-collected samples and clinical counterparts. The study highlights the efficacy of self-sampling in detecting high-grade cervical lesions and emphasizes its role in increasing participation.
Article
Microbiology
Illari Sechi, Narcisa Muresu, Mariangela V. Puci, Laura Saderi, Arcadia Del Rio, Andrea Cossu, Maria R. Muroni, Santina Castriciano, Marianna Martinelli, Clementina E. Cocuzza, Giovanni Sotgiu, Andrea Piana
Summary: This study evaluated the reliability and accuracy of HPV-DNA tests using dry vaginal self-collection FLOQSwabs (R) devices eluted in 2 mL of molecular medium. The results showed high agreement in HPV-DNA results among the samples tested at different time points. The questionnaire revealed a high acceptability of self-collection among women, although there was a preference for standard collection devices.
