Article
Immunology
Shunjie Bai, Liang Fang, Jing Xie, Huili Bai, Wei Wang, Jian-jun Chen
Summary: This study identified four potential biomarkers, including AAT, TRSF, HDLC, and APOA1, for diagnosing MDD patients with suicidal ideation. Levels of AAT and APOA1 significantly improved after treatment, with the biomarker panel showing excellent diagnostic performance.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Food Science & Technology
Weihe Cang, Junrui Wu, Ruixue Ding, Weiming Wang, Na Li, Haisu Shi, Lin Shi, Yuankun Lee, Rina Wu
Summary: This study comprehensively evaluates the potential role of probiotics in major depressive disorder (MDD) and summarizes the current pathological hypothesis, available treatments, and novel bio-materials. Clinical evidence and factors that may counteract probiotic applications are discussed. The endocannabinoid system shows promise as a target for probiotic therapy.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Caitlin C. Clements, Robert Karlsson, Yi Lu, Anders Jureus, Christian Ruck, Evelyn Andersson, Julia Boberg, Nancy L. Pedersen, Cynthia M. Bulik, Axel Nordenskjold, Erik Palsson, Patrick F. Sullivan, Mikael Landen
Summary: Analysis of severe cases of major depressive disorder (MDD) using genome-wide SNP genotyping revealed a higher burden of genetic risk loci, stronger genetic correlations with other psychiatric disorders, and weaker correlations with personality and stress-related traits, suggesting a different genetic architecture at the severe end of the MDD spectrum.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Wen Liu, Xiaowei Jiang, Yide Xin, Zijing Deng, Yu Xie, Yifang Zhou, Yifan Wu, Qikun Sun, Lingtao Kong, Feng Wu, Yanqing Tang
Summary: This study identified differences in dynamic amplitude low-frequency fluctuations (dALFF) between patients with major depressive disorder (MDD) and those who converted to bipolar disorder (BD), and described the role of sex effects in differentiating the two disorders. A positive correlation was found between dALFF values and WCST scores in MDD patients, and this correlation was observed only in female MDD patients in the occipital gyrus.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Frederikke Hordam Gronemann, Janne Petersen, Sarah Alulis, Kristoffer Jarlov Jensen, Jesper Riise, Mikkel Zollner Ankarfeldt, Espen Jimenez Solem, Nikolaj Bodker, Merete Osler
Summary: This study found that the majority of MDD patients in Denmark initially received treatment with antidepressants or ECT, and often changed medications during the course of treatment. TRD patients were more likely to use SNRIs, and a significant proportion initiated new treatments in the following year.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Po-Han Chou, Wen-Chun Liu, Wei-Hao Lin, Chih-Wei Hsu, Shao-Cheng Wang, Kuan-Pin Su
Summary: Near-infrared spectroscopy (NIRS) can be used to differentiate major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SZ) at the individual level by analyzing the spatiotemporal characteristics of hemodynamic responses. This can provide diagnostic support in clinical settings.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Health Care Sciences & Services
Ambra Craba, Giuseppe Marano, Georgios D. Kotzalidis, Carla Avallone, Francesco Maria Lisci, Maria Luigia Crosta, Antonino Callea, Laura Monti, Domenico De Berardis, Carlo Lai, Marta Balocchi, Ilenia Sessa, Desiree Harnic, Gabriele Sani, Marianna Mazza
Summary: This study aimed to investigate the correlation between attachment and resilience in patients with major depressive disorder (MDD) and bipolar disorder (BD). The results showed that patients had lower resilience than healthy controls, and a lower proportion of secure attachment was found among patients. These findings suggest that early life experiences and attachment play a crucial role in the development of resilience in individuals with mood disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Jia Huang, Yiyun Cai, Yousong Su, Min Zhang, Yifan Shi, Na Zhu, Feng Jin, Daihui Peng, Yiru Fang
Summary: The study found that over 70% of depressive episode patients have gastrointestinal symptoms, and a higher frequency of these symptoms is associated with suicide ideation, anxiety, insomnia, and body pain. There are moderate but significant associations between gastrointestinal symptoms and psychological characteristics.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Jan Sarlon, Annette B. Bruehl, Undine E. Lang, Andreas Kordon
Summary: This study assessed the electrophysiological correlates of mindfulness in patients with major depressive disorder (MDD) under stress and relaxation conditions. It found that perceived mindfulness was strongly inversely correlated with symptom severity, but no correlations were found with the electrophysiological parameters.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Yung-Chieh Yen, Chin-Yu Huang, Hsue-Wei Chan, You-Yu Wang, Te-Chang Changchien, Deng-Wu Wang, Po-Chun Lin, Ting-Ting Chang, Yu-Wen Chiu
Summary: The study investigated the impact of clinical screening and intervention for depression in cancer patients and how it affects cancer prognosis. Results showed that patients adhering to psychiatric treatment after cancer diagnosis had lower hazards compared to those without MDD, while those diagnosed with MDD after cancer diagnosis and adhered poorly to psychiatric treatment had the greatest hazard. The effect of intervention for MDD varied across different primary cancer types.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychiatry
Jin Liu, Bangshan Liu, Mi Wang, Yumeng Ju, Qiangli Dong, Xiaowen Lu, Jinrong Sun, Liang Zhang, Hua Guo, Futao Zhao, Weihui Li, Li Zhang, Zexuan Li, Yan Zhang, Mei Liao, Lingjiang Li
Summary: Cognitive deficits in major depressive disorder (MDD) may progressively worsen with increased number of episodes and total illness duration, with shifting ability serving as a critical component of progressive impairment.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Victor M. Tang, Dengdeng Yu, Cory R. Weissman, Brett D. M. Jones, Guan Wang, Matthew E. Sloan, Daniel M. Blumberger, Zafiris J. Daskalakis, Bernard Le Foll, Daphne Voineskos
Summary: This study examined the treatment outcomes of patients with major depressive disorder (MDD) and comorbid alcohol use disorder (AUD). The results showed that patients with comorbid AUD had poorer response to antidepressant treatment. Addressing this comorbidity requires unique assessment and treatment approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Thiemo Knaust, Matthias B. D. Siebler, Dagmar Tarnogorski, Philipp Skiberowski, Helge Hoellmer, Christian Moritz, Holger Schulz
Summary: This study compared hippocampal subfield volumes among soldiers with PTSD, MDD, and AdjD using routine clinical data. The results showed no significant volume differences between these stress-related mental disorders.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychiatry
Xiao-Li Sun, Li-Na Ma, Zhen-Zhu Chen, Yan-Bing Xiong, Jiao Jia, Yu Wang, Yan Ren
Summary: This study found significant differences in the metabolic phenotypes between bipolar disorder (BD), major depressive disorder (MDD), and healthy controls. Glycerolipid metabolism was significantly involved in both BD and MDD, while pyruvate metabolism was significantly involved in MDD. Pyruvate, choline, and acetate may be potential biomarkers for distinguishing MDD from BD, and pantothenic acid may be a potential biomarker for distinguishing BD from MDD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Behavioral Sciences
David M. M. Kern, Carla M. M. Canuso, Ella Daly, Jonathan C. C. Johnson, Dong Jing Fu, Teodora Doherty, Cori Blauer-Peterson, M. Soledad Cepeda
Summary: This study investigated the impact of treatment-resistant depression (TRD) or prior suicidal ideation/suicide attempt (SI/SA) on mortality by suicide among patients with major depressive disorder (MDD). The findings showed that patients with TRD and MDD+SI/SA have a higher risk of mortality by suicide compared to patients with MDD alone. Suicide rates were higher in patients with recent history of SI/SA, younger age, and male sex.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Emil F. Coccaro, Royce J. Lee
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
(2019)
Article
Psychology, Clinical
Jennifer R. Fanning, David K. Marcus, Jonathan R. Preszler, Emil F. Coccaro
Summary: Identification of individuals with clinically significant aggressive behavior is critical for prevention and management. The study found that DSM-5 IED represents a distinct behavioral disorder rather than the severe end of an aggressive behavior continuum.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Pediatrics
Karam Radwan, Emil F. Coccaro
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2020)
Article
Psychology, Clinical
Matthew W. Southward, Jennifer S. Cheavens, Emil F. Coccaro
Summary: Despite the lack of consensus on the specific meaning of the general factor of psychopathology (p-factor), research findings suggest that the p-factor is strongly associated with dispositional negative emotionality, impairment, and impulsive responsivity to emotions, contributing to the advancement of theories in psychopathology.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
