Article
Immunology
Erika J. Wolf, Mark W. Miller, Sage E. Hawn, Xiang Zhao, Sara E. Wallander, Beth McCormick, Christine Govan, Ann Rasmusson, Annjanette Stone, Steven A. Schichman, Mark W. Logue
Summary: Traumatic stress is associated with accelerated epigenetic age and increased risk for dementia. The advanced epigenetic age might be linked to dementia-associated biomarkers. Externalizing comorbidity is associated with accelerated epigenetic age, which in turn is associated with subsequent increases in neuropathology and inflammatory markers. Advanced epigenetic age and neuropathology biomarkers are associated with worse cognitive function.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Clinical Neurology
Dovile Poceviciute, Cristina Nunez-Diaz, Bodil Roth, Shorena Janelidze, Andreas Giannisis, Oskar Hansson, Malin Wennstrom
Summary: Alzheimer's disease is characterized by Aβ plaques, NFT, and neuroinflammation, but recent studies suggest that peripheral inflammation might also play a role. This study found that plasma IgA levels were higher in AD patients, especially in APOE ε4 non-carriers, and these levels were associated with cognitive decline and neuropathology. This suggests that the relationship between AD pathology and plasma IgA levels may be influenced by APOE allele status.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Andrew L. Zhou, Nidhi Sharda, Vidur V. Sarma, Kristen M. Ahlschwede, Geoffry L. Curran, Xiaojia Tang, Joseph F. Poduslo, Krishna R. Kalari, Val J. Lowe, Karunya K. Kandimalla
Summary: Age-related changes in the plasma pharmacokinetics and brain influx of A beta isoforms and insulin may potentially increase the risk of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Editorial Material
Cell Biology
Brianna Cyr, Juan Pablo de Rivero Vaccari
Summary: The study investigates the effect of age on brain inflammation response, finding that older individuals exhibit more exacerbated inflammatory immune responses when faced with systemic infections.
Article
Gastroenterology & Hepatology
Jinghua Jin, Zhi Xu, Lina Zhang, Can Zhang, Xiaoduo Zhao, Yuxuan Mao, Haojian Zhang, Xingguang Liang, Juanli Wu, Ying Yang, Jing Zhang
Summary: Peripheral beta-amyloid (A beta), including gut-derived A beta, is believed to contribute to the formation of A beta plaques in the brain, and the gut microbiota has an impact on Alzheimer's disease (AD) through the gut-brain axis. This study investigated the potential interactions among gut-derived A beta, gut microbiota, and AD pathogenesis. The results showed that the gut is a critical source of A beta in the brain, and gut microbiota can upregulate A beta production in the gut, potentially contributing to AD pathogenesis.
Review
Neurosciences
Elizabeth J. Andrews, Alessandra C. Martini, Elizabeth Head
Summary: This study investigates the sex-specific effects on the development of Alzheimer's disease (AD) in the Down syndrome (DS) population and explores potential underlying mechanisms. It reveals that women are more susceptible to AD and suggests that the earlier onset of menopause in women with DS may contribute to this vulnerability.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Joshua Adekunle Babalola, Magdalena Lang, Meekha George, Anika Stracke, Carmen Tam-Amersdorfer, Izaskun Itxaso, Domjan Lucija, Jelena Tadic, Irene Schilcher, Tina Loeffler, Stefanie Flunkert, Manuela Prokesch, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Ute Panzenboeck, Gerald Hoefler
Summary: In this study, astaxanthin was found to enhance the clearance of misfolded proteins in the brains of Alzheimer's disease patients, reduce inflammation, and alter the expression levels of transport proteins.
Review
Nutrition & Dietetics
Tobias Ziegler, Melina Tsiountsioura, Lisa Meixner-Goetz, Gerhard Cvirn, Manfred Lamprecht
Summary: With the increasing elderly population, neurodegenerative diseases are on the rise, making it important to detect brain aging early and slow down its progression. Neurotrophins such as BDNF and NGF, as well as amyloid-beta and tau proteins, play significant roles in cognitive function and aging. Polyphenols, a class of plant-metabolites, have gained attention for their health benefits and anti-oxidative properties in relation to these biomarkers.
Article
Clinical Neurology
Vijayasree V. Giridharan, Jaqueline S. Generoso, Allan Collodel, Diogo Dominguini, Cristiano Julio Faller, Flavio Tardin, Gursimrat S. Bhatti, Fabricia Petronilho, Felipe Dal-Pizzol, Tatiana Barichello
Summary: Pneumococcal meningitis can disrupt the blood-brain barrier and increase the expression of RAGE in the brain, leading to neurological inflammation and cognitive impairment. Targeted inhibition of RAGE can alleviate symptoms in surviving rats with meningitis.
Article
Neurosciences
Muyu Situ, Ali Francisco Citalan-Madrid, Svetlana M. Stamatovic, Richard F. Keep, Anuska V. Andjelkovic
Summary: The study reveals that Cerebral amyloid angiopathy (CAA) causes dysfunction of the blood-brain barrier (BBB), triggering intense proinflammatory responses and cognitive decline. Age exacerbates BBB injury in CAA vasculopathy, playing a significant role in the effects of amyloid beta (Aβ).
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Romain Versele, Emmanuel Sevin, Fabien Gosselet, Laurence Fenart, Pietra Candela
Summary: The blood-brain barrier is a crucial barrier for maintaining brain homeostasis, and cytokine-induced neuroinflammation may play a role in BBB dysfunction and contribute to the progression of Alzheimer's disease. Cytokines like TNF-alpha and IL-1 beta can modulate BBB permeability, leading to amyloid-beta peptide accumulation and potentially influencing the progression of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Run Jin, Aidan Kai Yeung Chan, Jingsong Wu, Tatia Mei Chun Lee
Summary: The review discusses the potential mechanisms and strategies for ameliorating age-related neurocognitive changes associated with inflammation, providing important insights for understanding the pathophysiological mechanisms of neurocognitive disorders and developing preventative measures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Meagan S. Kingren, Marlene E. Starr, Hiroshi Saito
Summary: The incidence and mortality rates of sepsis increase significantly with age, especially in older adults. However, there is currently a lack of effective therapeutic strategies targeting older patients with severe sepsis, despite ongoing research efforts. Further research using aged animal models with clinically relevant treatments is essential for future progress in this area.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cell Biology
Jong Youl Lee, Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, So Jeong Lee, Hyeong Seok An, Kyung Eun Kim, Won-Ho Kim, Yong Chul Bae, Heeyoung Kang, Gu Seob Roh
Summary: Age-related microglial activation is associated with cognitive impairment. TonEBP plays important roles in age-related microglial activation and memory deficits. TonEBP haploinsufficiency reduces microglial activation, synaptic pruning, dendritic spine loss, and memory deficits in middle-aged and amyloid beta oligomer-treated mice. Additionally, TonEBP knockdown attenuates migration and phagocytosis in amyloid beta oligomer-treated BV2 cells.
Article
Geriatrics & Gerontology
Wan-Hsuan Lu, Kelly Virecoulon Giudici, John E. Morley, Sophie Guyonnet, Angelo Parini, Geetika Aggarwal, Andrew D. Nguyen, Yan Li, Randall J. Bateman, Bruno Vellas, Philipe de Souto Barreto
Summary: The study found limited added values of multi-biomarkers beyond the basic A beta models for predicting clinically meaningful cognitive decline among non-demented older adults. However, a combined assessment of inflammatory and cellular stress status with A beta pathology through measuring plasma biomarkers may improve the evaluation of cognitive performance.
Article
Biotechnology & Applied Microbiology
Monique Michels, Emily Corneo, Luana Cucker, Carla Sasso Simon, Gabriel Fernandes Alves de Jesus, Carolina Michels, Kristian Madeira, Ana Paula Voytena, Marina Rossetto, Fernanda Ramlov, Danusa de Castro Damasio, Felipe Dal-Pizzol
Summary: This study evaluated the efficacy of Bifidobacterium lactis CCT 7858 in preventing antibiotic-related diarrhea and improving gastrointestinal symptoms. The results showed that this strain can reduce diarrhea and gastrointestinal symptoms.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Pharmacology & Pharmacy
Daniela Pacheco dos Santos Haupenthal, Marcus Barg Resmini, Leandro Almeida Da Silva, Mateus Cardoso Colares, Laura de Roch Casagrande, Ligia Milanez Venturini, Thiago Antonio Moretti de Andrade, Fernando Russo Costa do Bomfim, Anand Thirupathi, Paulo Emilio Feuser, Felipe Dal Pizzol, Paulo Cesar Lock Silveira
Summary: This study evaluated the effects of intra-articular treatment of triamcinolone hexacetonide (TH) associated with gold nanoparticles (GNPs) in osteoarthritis. The results showed that the combined treatment with TH and GNPs can reduce pro-inflammatory cytokines, increase anti-inflammatory cytokines, improve oxidative damage in joints, and increase antioxidant levels. Additionally, the combination therapy also increases cartilage thickness and chondrocyte count, preventing the progression of the disease.
CURRENT DRUG TARGETS
(2023)
Review
Critical Care Medicine
Pedro Povoa, Luis Coelho, Felipe Dal-Pizzol, Ricard Ferrer, Angela Huttner, Andrew Conway Morris, Vandack Nobre, Paula Ramirez, Anahita Rouze, Jorge Salluh, Mervyn Singer, Daniel A. Sweeney, Antoni Torres, Grant Waterer, Andre C. Kalil
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Biomarkers can be used as indicators for infection, dysregulated host response, treatment response, and can aid in prognosticating patient risk. Over 250 biomarkers have been identified and evaluated, but none can accurately differentiate between sepsis and sepsis-like syndrome.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Heloisa de Medeiros Borges, Caroline Serafim Dagostin, Emily Corneo, Eduardo Ronconi Dondossola, Henrique Teza Bernardo, Karolyne De Pieri Pickler, Barbara da Costa Pereira, Mariane Amanda de Oliveira, Rahisa Scussel, Monique Michels, Ricardo Andrez Machado-de-Avila, Felipe Dal-Pizzol, Eduardo Pacheco Rico
Summary: Animal models have contributed significantly to the understanding of cerebral ischemia and the development of potential therapies. The zebrafish model has shown promise in modeling human diseases. This study evaluated the neuroprotective effects of minocycline using zebrafish and compared the results with other models.
Article
Microbiology
Monique Michels, Emily Corneo, Luana Bezerra Goncalves Rocha, Rodrigo Dias, Ana Paula Lorenzen Voytena, Marina Rossetto, Fernanda Ramlov, Felipe Dal-Pizzol, Gabriel Fernandes Alves Jesus
Summary: This study aimed to evaluate the potential and specificity of Microbe-Associated Molecular Patterns (MAMPs) in inflammatory and antioxidant response in NIH-3T3 fibroblast cells and wound healing process. The findings showed that MAMPs significantly promoted wound healing and exhibited specific effects in anti-inflammatory and antioxidant activities.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Neurosciences
Melina More Bertotti, Evandro Tostes Martins, Fernando Zanela Areas, Helena Dresch Vascouto, Norma Beatriz Rangel, Hiago Murilo Melo, Katia Lin, Emil Kupek, Felipe Dal Pizzol, Alexandra J. Golby, Roger Walz
Summary: The accuracy of the GCS-P score as a prognostic index for predicting hospital mortality in patients with severe traumatic brain injury was evaluated and compared with a model combining GCS, pupil response, and other prognostic factors. The results show that the GCS-P score can accurately predict the mortality of patients with severe traumatic brain injury.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Medicine, Research & Experimental
Tatiana Barichello, Vijayasree V. Giridharan, Carlos Henrique R. Catalao, Cristiane Ritter, Felipe Dal-Pizzol
Summary: Sepsis is a life-threatening disorder caused by an unregulated immune response to infection. This response triggers a complex process that promotes the production of inflammatory mediators, resulting in the disruption of blood-brain barrier function and the activation of glial cells. These changes lead to sepsis-associated encephalopathy, which can contribute to cognitive deterioration and increased susceptibility to cognitive decline later in life.
Article
Neurosciences
Samira S. Valvassori, Taise Possamai-Della, Jorge M. Aguiar-Geraldo, Romulo Goronci Sant'Ana, Gustavo C. Dal-Pont, Bruna Pescador, Alexandra I. Zugno, Joao Quevedo, Felipe Dal-Pizzol
Summary: The study aimed to investigate the effects of sepsis on behavioural and biochemical responses induced by m-amphetamine. Rats underwent cecal ligation and puncture surgery and were then injected with saline or m-amphetamine. The results showed that sepsis enhanced the behavioural responses to m-amphetamine, induced inflammatory response, and altered neurotrophic factors in the brain.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Franciele Rabelo, Isabela da S. Lemos, Camila P. Dal Toe, Debora D. Casagrande, Maria Luisa S. Freitas, Micaela R. Quadra, Igor R. Lima, Jaqueline S. Generoso, Monique Michels, Paulo C. L. Silveira, Felipe Dal Pizzol, Emilio Luiz Streck
Summary: Maple Syrup Urine Disease (MSUD) is a genetic disorder that causes the accumulation of certain amino acids in the body. This can lead to oxidative stress and inflammation, which play a role in the disease's progression. In this study, the researchers investigated the acute effects of a specific amino acid on inflammatory markers in rats.
METABOLIC BRAIN DISEASE
(2023)
Article
Chemistry, Applied
Gabriel Fernandes Alves de Jesus, Marina Piola Rossetto, Ana Voytena, Bianca Feder, Heloisa Borges, Gabriel da Costa Borges, Zoe Paulina Feuser, Silvia Dal-Bo, Monique Michels
Summary: The microbiome has a significant impact on various skin disorders, and dysbiosis in the skin and/or gut microbiome is associated with altered immune response, leading to the development of skin diseases such as atopic dermatitis, psoriasis, acne vulgaris, and dandruff. Paraprobiotics have shown promise in the treatment of skin disorders by modulating the microbiota and immune system. This study aimed to develop an anti-dandruff formulation using a paraprobiotic (Neoimuno) as the active ingredient.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Ana Paula Pesarico, Gabriel Fernandes Alves Jesus, Emily Corneo, Heloisa de Medeiros Borges, Karen de Vasconcelos Calixto, Michelle Lima Garcez, Tatiani Bellettini-Santos, Ana Paula Lorenzen Voytena, Marina Rossetto, Fernanda Ramlov, Felipe Dal-Pizzol, Monique Michels
Summary: This study investigates the protective effects of several Bacillus strains against LPS-induced intestinal inflammation. The results show that B. coagulans and B. amyloliquefaciens have significant protective effects against pathological changes and increased inflammatory cytokines.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
