4.5 Article

Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention

Journal

NEUROSCIENCE
Volume 412, Issue -, Pages 175-189

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2019.05.068

Keywords

attentional selection; sustained attention; COMT; DBH; individual differences; catecholamines

Categories

Funding

  1. European Union FP7 Marie Curie ITN Grant [606901]
  2. National Institute for Health Research (NIHR) Oxford Health Biomedical Research Centre
  3. Wellcome Trust [203139/Z/16/Z]
  4. Marie Curie Early Stage Researcher Fellowship
  5. British Academy Postdoctoral Fellowship [pf130059]
  6. BRIDGE (Birmingham-Illinois Partnership for Discovery, Engagement and Education) Fellowship
  7. Wellcome Trust Senior Investigator Award [104571/Z/14/Z]

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Visual attention enables us to prioritise behaviourally relevant visual information while ignoring distraction. The neural networks supporting attention are modulated by two catecholamines, dopamine and noradrenaline. The current study investigated the effects of single nucleotide polymorphisms in two catecholaminergic genes - COMT (Val(158)Met) and DBH (444 G/A) - on individual differences in attention functions. Participants (n = 125) were recruited from the Oxford Biobank by genotype-based recall. They were tested on a continuous performance task (sustained attention), a Go/No-Go task (response inhibition), and a task assessing attentional selection in accordance with the Theory of Visual Attention (TVA). We found a significant effect of DBH genotype status on the capacity to maintain attention over time (sustained attention) as measured by the continuous performance task. Furthermore, we demonstrated a significant association between COMT genotype status and effective threshold of visual perception in attentional selection as estimated based on the TVA task performance. No other group differences in attention function were found with respect to the studied genotypes. Overall, our findings provide novel experimental evidence that: (i) dopaminergic and noradrenergic genotypes have dissociable effects on visual attention; (ii) either insufficient or excessive catecholaminergic activity may have equally detrimental effects on sustained attention. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

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