Article
Immunology
Christo Tsilifis, Tuulia Torppa, Eleri J. Williams, Michael H. Albert, Fabian Hauck, Elena Soncini, Elizabeth Kang, Harry Malech, Catharina Schuetz, Horst von Bernuth, Mary A. Slatter, Andrew R. Gennery
Summary: X-linked chronic granulomatous disease (XL-CGD) is a disorder that affects the production of superoxide in phagocytes, leading to infections and autoimmune disease. A study found that HSCT can be effective in treating symptomatic XL-CGD carriers, improving their symptoms and reducing the need for immunosuppressive therapy. However, there are risks of transplant-related complications.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Hematology
Siobhan O. Burns, Emma C. Morris
Summary: Inborn errors of immunity (IEIs) are rare disorders caused by germline mutations in immune system regulating genes, primarily manifesting as severe infections and possibly associated with autoimmunity, inflammation, and malignancy. Allogeneic hematopoietic stem cell transplant (HSCT) has become a preferred treatment for early, severely affected IEI children and is now increasingly considered for adult patients as well.
Article
Immunology
Tomislav Ledenko, Iva Soric Hosman, Marijana Coric, Alenka Gagro
Summary: Inflammatory rheumatic diseases and autoimmune liver diseases have many similarities and can coexist in patients. This article reports a case of simultaneous development of juvenile dermatomyositis and autoimmune sclerosing cholangitis, both meeting the diagnostic criteria for each disease. The challenges in diagnosing these conditions and their shared genetic predisposition are discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Moniek A. de Witte, Anke Janssen, Klaartje Nijssen, Froso Karaiskaki, Luuk Swanenberg, Anna van Rhenen, Rick Admiraal, Lotte van der Wagen, Monique C. Minnema, Eefke Petersen, Reinier A. P. Raymakers, Kasper Westinga, Trudy Straetemans, Constantijn J. M. Halkes, Jaap-Jan Boelens, Jurgen Kuball
Summary: A multicenter study evaluated the outcome of alpha beta T-cell depleted allogeneic hematopoietic stem cell transplantation in adults, with only 26% developing aGVHD grades 2-4 within 100 days and a low incidence of cGVHD after 2 years. Prophylactic donor lymphocyte infusion improved the condition of some patients.
Article
Cell & Tissue Engineering
Rakefet Sidlik Muskatel, Bar Nathansohn-Levi, Shlomit Reich-Zeliger, Michal Mark, Liat Stoler-Barak, Chava Rosen, Irit Milman-Krentsis, Esther Bachar Lustig, Robert Pete Gale, Nir Friedman, Yair Reisner
Summary: Partial tolerance toward pancreatic autoantigens in the treatment of type 1 diabetes mellitus can be achieved by autologous or allogeneic hematopoietic stem cell transplantation, but both have limitations. In this study, a non-myeloablative conditioning approach using donor-derived anti-3rd party central memory CD8 veto T cells was found to effectively eliminate autoimmune T-cell clones and prevent diabetes in a mouse model. This approach shows promise as a treatment strategy for individuals at risk of developing type 1 diabetes or for preventing beta cell destruction after allogenic beta cell transplantation.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Hematology
Federica R. Achini-Gutzwiller, Marco W. Schilham, Erik G. J. von Asmuth, Anja M. Jansen-Hoogendijk, Cornelia M. van der Zijde, Maarten J. D. van Tol, Robbert G. M. Bredius, Tayfun Gungor, Arjan C. Lankester, Dirk Jan A. R. Moes
Summary: This multicenter study characterized the pharmacokinetics of alemtuzumab in children with nonmalignant diseases and found that high exposure on the day of hematopoietic stem cell transplantation correlated with delayed T-cell reconstitution and increased risk of graft failure, while not significantly affecting other outcomes.
Article
Hematology
Makoto Iwasaki, Junya Kanda, Yasuyuki Arai, Tadakazu Kondo, Takayuki Ishikawa, Yasunori Ueda, Kazunori Imada, Takashi Akasaka, Akihito Yonezawa, Kazuhiro Yago, Masaharu Nohgawa, Naoyuki Anzai, Toshinori Moriguchi, Toshiyuki Kitano, Mitsuru Itoh, Nobuyoshi Arima, Tomoharu Takeoka, Mitsumasa Watanabe, Hirokazu Hirata, Kosuke Asagoe, Isao Miyatsuka, Le My An, Masanori Miyanishi, Akifumi Takaori-Kondo
Summary: This study developed a novel predictive model using a stacked ensemble of multiple machine-learning algorithms to achieve better risk stratification for GRFS. The results indicated lower probability of GRFS in the high-risk group compared to the low-risk group.
Article
Critical Care Medicine
Shawn P. E. Nishi, Lisa M. Lowenstein, Tito R. Mendoza, Maria A. Lopez, Laura C. Crocker, Karen Sepucha, Jiangong Niu, Robert J. Volk
Summary: Among patients recently assessed for LCS, the quality of decision-making is highly variable, with patients valuing early cancer detection over concerns about harms. Patients were more likely to receive information on the benefits of LCS than on the risks, and one-third experienced some degree of decisional conflict. However, most patients felt they were adequately involved in the screening decision-making process.
Article
Geriatrics & Gerontology
Qiao Zong, Zhanchun Feng, Jia Wang, Zehao Zheng, Chaoyi Chen, Da Feng
Summary: Shared decision-making (SDM) is crucial in managing polypharmacy among older people with chronic diseases, and this study quantitatively compares the impact of SDM and other factors on polypharmacy in inpatients and community patients. The study also examines the impact of different decision types on polypharmacy in community patients.
Article
Public, Environmental & Occupational Health
Ellen A. Lipstein, Maggie Breslin, Cassandra M. Dodds, Michael D. Kappelman, Nicholas J. Ollberding, Peter Margolis, Yingying Xu, William B. Brinkman
Summary: Through a nested, cluster-randomized trial, we found no difference in knowledge improvement with a shared decision making intervention as part of consent. There were no significant differences in knowledge or decisional support between study arms, but there was variation in clinician use of the intervention.
PATIENT EDUCATION AND COUNSELING
(2021)
Article
Public, Environmental & Occupational Health
Sascha M. Keij, Nanny Van Duijn-Bakker, Anne M. Stiggelbout, Arwen H. Pieterse
Summary: This study identified five key elements of patient readiness for shared decision making and ten characteristics that may influence these elements. Readiness for SDM may vary between and within patients, and clinicians should be aware that some patients may need support to enhance their readiness.
PATIENT EDUCATION AND COUNSELING
(2021)
Article
Health Care Sciences & Services
Chia-Hsien Chen, Hsin-Yi Chuang, Yen Lee, Glyn Elwyn, Wen-Hsuan Hou, Ken N. Kuo
Summary: This study examined the relationships among decision antecedents, process, and outcomes in patients with lumbar degenerative disease, finding that decision making self-efficacy and readiness significantly predicted patients' engagement in shared decision making, leading to fewer decisional conflicts and greater decision satisfaction.
MEDICAL DECISION MAKING
(2022)
Article
Public, Environmental & Occupational Health
Ellen A. Lipstein, William B. Brinkman, Yin Zhang, Kevin A. Hommel, Richard F. Ittenbach, Chunyan Liu, Lee A. Denson
Summary: This study aimed to assess the feasibility and acceptability of a multi-component intervention for pediatric inflammatory bowel disease. The results showed that two out of three intervention components were feasible and the intervention led to a significant increase in visit length. Parents, patients, and most physicians rated the intervention as acceptable. The intervention was associated with a higher level of observed shared decision making. Overall, the intervention shows promise in supporting shared decision making and engaging parents and patients in pediatric IBD decisions.
PATIENT EDUCATION AND COUNSELING
(2022)
Review
Health Care Sciences & Services
Brittany Humphries, Montserrat Leon-Garcia, Ena Nino de Guzman Quispe, Carlos Canelo-Aybar, Claudia Valli, Kevin Pacheco-Barrios, Arnav Agarwal, Susan Mirabi, Mark H. Eckman, Gordon Guyatt, Shannon M. Bates, Pablo Alonso-Coello, Feng Xie
Summary: This study examined the use of decision analysis in shared decision making, finding that most studies concluded decision analysis was generally beneficial, but there was limited information on the implementation process. Rigorous randomized controlled trials are needed to confirm the effectiveness of these interventions, while qualitative studies should seek to understand their potential implementation.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Xuejing Li, Dan Yang, Meiqi Meng, Junqiang Zhao, Yiyi Yin, Hefang Wang, Xiaoyan Zhang, Qian Liu, Mengdi Li, Jianping Liu, Yufang Hao
Summary: Shared decision-making (SDM) is in its early stages in mainland China. There is a lack of comprehensive understanding of decisional needs concepts, and limited research on decision support and decisional outcomes. Uniform standards for developing patient decision aids are lacking. Chinese SDM studies primarily focus on physiological needs.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Hematology
Keith M. Sullivan, Mitchell Horwitz, Ifeyinwa Osunkwo, Nirmish Shah, John J. Strouse
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Health Care Sciences & Services
Tamara J. Somers, Sarah A. Kelleher, Caroline S. Dorfman, Rebecca A. Shelby, Hannah M. Fisher, Krista Rowe Nichols, Keith M. Sullivan, Nelson J. Chao, Gregory P. Samsa, Amy P. Abernethy, Francis J. Keefe
JMIR MHEALTH AND UHEALTH
(2018)
Article
Biophysics
Ko K. Maung, Benny J. Chen, Ian Barak, Zhiguo Li, David A. Rizzieri, Cristina Gasparetto, Keith M. Sullivan, Gwynn D. Long, Ashley M. Engemann, Barbara Waters-Pick, Krista Rowe Nichols, Richard Lopez, Yubin Kang, Stefanie Sarantopoulos, Anthony D. Sung, Nelson J. Chao, Mitchell E. Horwitz
Summary: Prophylactic donor lymphocyte infusions depleted of CD45RA+ naive T cells are safe and feasible in reducing the risk of acute or chronic GvHD, as shown in this dose escalation study.
BONE MARROW TRANSPLANTATION
(2021)
Editorial Material
Dermatology
Adela R. Cardones, Russell P. Hall, Keith M. Sullivan, Joanna Hooten, Seung Yun Lee, Beiyu Liu, Cynthia L. Green, Nelson J. Chao, Krista Rowe Nichols, Lionel L. Banez, Ankoor Shah, Nicole Leung, Mark L. Palmeri
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Editorial Material
Rheumatology
Keith M. Sullivan, Lynette Keyes-Elstein
NATURE REVIEWS RHEUMATOLOGY
(2020)
Letter
Rheumatology
Lynette Keyes-Elstein, Erica Brittain, Ashley Pinckney, Ellen A. Goldmuntz, Keith M. Sullivan
NATURE REVIEWS RHEUMATOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Edward A. Stadtmauer, Keith M. Sullivan, Mohamed El Idrissi, Bruno Salaun, Aranzazu Alonso Alonso, Charalambos Andreadis, Veli-Jukka Anttila, Adrian J. C. Bloor, Raewyn Broady, Claudia Cellini, Antonio Cuneo, Alemnew F. Dagnew, Emmanuel Di Paolo, HyeonSeok Eom, Ana Pilar Gonzalez-Rodriguez, Andrew Grigg, Andreas Gunther, Thomas C. Heineman, Isidro Jarque, Jae-Yong Kwak, Alessandro Lucchesi, Lidia Oostvogels, Marta Polo Zarzuela, Anne E. Schuind, Thomas C. Shea, Ulla Marjatta Sinisalo, Filiz Vural, Lucrecia Yanez San Segundo, Pierre Zachee, Adriana Bastidas
Summary: The adjuvanted recombinant zoster vaccine, Shingrix, has shown high efficacy in preventing herpes zoster in adults over 50 years of age, even in immunocompromised individuals, including those who recently underwent autologous haematopoietic stem cell transplant. The vaccine induced robust and persistent immune responses regardless of age or underlying disease, showing a promising impact in reducing the risk of herpes zoster post-transplantation.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
