Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

(2018) Robert L. Bowman et al.   Cell Stem Cell

Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial InjuryNovelty and Significance

(2018) Grégory Franck et al.   CIRCULATION RESEARCH

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular DiseaseNovelty and Significance

(2018) Soichi Sano et al.   CIRCULATION RESEARCH

Identification of clonal hematopoiesis mutations in solid tumor patients undergoing unpaired next-generation sequencing assays

(2018) Catherine C. Coombs et al.   CLINICAL CANCER RESEARCH

The Ins and Outs of Myeloid Cells in Atherosclerosis

(2018) Ariane Schumski et al.   Journal of Innate Immunity

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Predicting progression to AML

(2018) Rob S. Sellar et al.   NATURE MEDICINE

Somatic mutations precede acute myeloid leukemia years before diagnosis

(2018) Pinkal Desai et al.   NATURE MEDICINE

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

(2018) Ofir Wolach et al.   Science Translational Medicine

Prediction of acute myeloid leukaemia risk in healthy individuals

(2018) Sagi Abelson et al.   NATURE

Population dynamics of normal human blood inferred from somatic mutations

(2018) Henry Lee-Six et al.   NATURE

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis

(2018) Kathryn J. Moore et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies

(2017) Christopher B. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma

(2017) Christopher J. Gibson et al.   JOURNAL OF CLINICAL ONCOLOGY

Exome-wide association study of plasma lipids in >300,000 individuals

(2017) Dajiang J Liu et al.   NATURE GENETICS

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

(2017) David Furman et al.   NATURE MEDICINE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dnmt3arestrains mast cell inflammatory responses

(2017) Cristina Leoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

Clonal hematopoiesis

(2017) Max Jan et al.   SEMINARS IN HEMATOLOGY

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms

(2016) D. A. Hinds et al.   BLOOD

Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

(2016) Esther A. Obeng et al.   CANCER CELL

Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease

(2016) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Test in Context

(2016) Paul M Ridker   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

(2016) Andrew L. Young et al.   Nature Communications

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

(2015) Eunhee Kim et al.   CANCER CELL

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

(2015) Cara Lunn Shirai et al.   CANCER CELL

Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells

(2015) O A Guryanova et al.   LEUKEMIA

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

Somatic mutation in cancer and normal cells

(2015) I. Martincorena et al.   SCIENCE

Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

(2015) Thomas McKerrell et al.   Cell Reports

Phosphatase Wip1 Negatively Regulates Neutrophil Migration and Inflammation

(2014) B. Sun et al.   JOURNAL OF IMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

(2013) Omar Abdel-Wahab et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

Red Blood Cell Distribution Width and Mortality Risk in a Community-Based Prospective Cohort

(2009) Todd S. Perlstein et al.   ARCHIVES OF INTERNAL MEDICINE

Red Blood Cell Distribution Width and the Risk of Death in Middle-aged and Older Adults

(2009) Kushang V. Patel et al.   ARCHIVES OF INTERNAL MEDICINE

Predicting the 30-Year Risk of Cardiovascular Disease

(2009) Michael J. Pencina et al.   CIRCULATION

Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease

(2008) Marcello Tonelli et al.   CIRCULATION

Age as a modifiable risk factor for cardiovascular disease

(2008) Allan D Sniderman et al.   LANCET

A Role for JAK2 Mutations in Myeloproliferative Diseases

(2007) Kelly J. Morgan et al.   Annual Review of Medicine