Review
Medicine, Research & Experimental
Sheersha Pramanik, Sourav Mohanto, Ravi Manne, Rahul R. Rajendran, A. Deepak, Sijo Joy Edapully, Triveni Patil, Oly Katari
Summary: Nanotechnology has shown promise in the treatment of chronic pulmonary diseases by enhancing targeted therapeutic delivery and improving drug pharmacokinetics. Using nanoparticles for inhalation delivery can effectively treat chronic pulmonary diseases, offering feasibility and potential advantages.
MOLECULAR PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Anas Ahmad, Mohammad Imran, Nisha Sharma
Summary: The assessment of human and environmental risks of nanoparticulate material is crucial and requires the development of scientific tools and techniques. Challenges exist in toxicology assessment and regulatory guidance for nanocarriers. Nanotoxicology plays a significant role in pharmaceutical drug development and commercialization potential.
Article
Pharmacology & Pharmacy
Iching G. Yu, David M. Ryckman
Summary: By reformulating caspofungin for aerosolization, high drug concentration in the lungs is achieved with minimal systemic distribution, leading to significant increase in lung deposition and potential improvement in efficacy, supporting the need for further animal toxicology studies and human clinical trials for treating IPA with inhaled caspofungin.
Article
Polymer Science
Faqir Ullah, Kifayat Ullah Shah, Shefaat Ullah Shah, Asif Nawaz, Touseef Nawaz, Kamran Ahmad Khan, Raed F. Alserihi, Hossam H. Tayeb, Shams Tabrez, Mulham Alfatama
Summary: This study successfully loaded montelukast into chitosan nanoparticles for asthma treatment and improved the properties of the nanoparticles to enhance drug delivery in dry powder inhalers.
Review
Instruments & Instrumentation
Yue Tan, Dawei Yu, Jiayao Feng, Huimin You, Yan Bai, Jincan He, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su
Summary: This review summarizes the existing literature on the toxicity assessment of silica nanoparticles (SiNPs), and identifies that the composition, physicochemical properties, administration route, frequency and duration of administration, and animal models' sex are related to their tissue and blood toxicity, immunotoxicity, and genotoxicity. However, the correlation between in vitro and in vivo toxicity has not been well established, mainly due to unrealistic dosages used in both cases. The article also discusses important factors to consider in SiNPs toxicology and current approaches to reducing their toxicity.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Popat Kumbhar, Jaskiran Kaur, Gabriele De Rubis, Keshav Raj Paudel, Parteek Prasher, Vyoma K. Patel, Leander Corrie, Dinesh Kumar Chellappan, Gaurav Gupta, Sachin Kumar Singh, Vandana Patravale, John Disouza, Kamal Dua
Summary: Pulmonary infections are a significant cause of mortality worldwide. The clinical applications of therapeutics for these infections are limited due to their side effects and inappropriate administration routes. Inhalation drug delivery is a promising approach for targeting pulmonary infections, but it faces barriers. Nanoparticulate delivery can overcome these barriers, and various inhalable nanoparticles have been explored for efficient treatment. Inhalation devices are important for drug delivery, and selecting the appropriate device is crucial. Currently, there are few inhalable formulations available in the market and in clinical trials, indicating the need for more efforts in this area.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sara A. A. Valente, Guido R. R. Lopes, Isabel Ferreira, Miguel F. F. Galrinho, Margarida Almeida, Paula Ferreira, Maria T. T. Cruz, Manuel A. A. Coimbra, Claudia P. Passos
Summary: Non-invasive routes for insulin delivery are being developed to replace painful subcutaneous injections. Polysaccharides from roasted coffee beans and spent coffee grounds, specifically galactomannans and arabinogalactans, were utilized to prepare insulin-loaded microparticles. The polysaccharides were obtained through purification and ethanol precipitation or microwave-assisted extraction and ultrafiltration.
Article
Pharmacology & Pharmacy
Arjunan Karuppaiah, Divakar Selvaraj, Mohan Sellappan, Arumugam Nagarajan, Dinesh Babu, Habibur Rahman, Thiagarajan Madheswaran, Bharadhan Bose, Tamilselvan Natrajan
Summary: Metallic nanoparticles (MNPs) have been widely used in clinical practice for diagnostic and therapeutic purposes, but their potential toxicity is a concern. Numerous research studies are being conducted to explore strategies to reduce the toxicity of MNPs, including modifying their size, dose, agglomeration, release, and excretion rates. In addition, managing the toxicity of MNPs can be achieved through purification, surface functionalization, synergistic effects, and targeted therapy approaches. These strategies can decrease the dose of MNPs without compromising their therapeutic benefits, thus reducing their toxicity.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Pharmacology & Pharmacy
Li Ding, Jieliang Wang, Shihao Cai, Hugh Smyth, Zhengrong Cui
Summary: Certain pulmonary diseases are often accompanied by respiratory tract infections, which may lead to chronic biofilm-based infections that are challenging to treat with antimicrobial agents. Therefore, effective agents and delivery carriers must be developed to target biofilms in the lung. This review focuses on inhalable agents to treat biofilms, discussing existing options as well as promising novel agents and delivery devices.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Farzin Firozian, Zahra Arabkhani, Mohammad Mehdi Mahboobian, Mojdeh Mohammadi, Gholamabbas Chehardoli
Summary: The study developed a cationic dextran stearate-glycidyl trimethylammonium chloride (Dex-St-GTMAC) copolymer as a drug carrier to deliver indomethacin to cornea tissues. The prepared polymeric micelles showed sustained drug release and improved penetration of indomethacin into cornea tissues.
Article
Pharmacology & Pharmacy
Cruz-Zazueta Isabel, Arias-Duran Luis, Estrada-Soto Samuel, Pinon-Segundo Elizabeth, Herrera-Ruiz Dea, Alcala-Alcala Sergio
Summary: In this study, FEL-PLGA-PVM/MA composites were prepared and characterized for their physical and rheological properties. The composites showed sustained drug release and mucoadhesive properties. Nebulization of the composites in hypertensive rats led to a significant decrease in blood pressure, indicating the promising potential of these novel composites for treating systemic diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Hadeel Kheraldine, Ousama Rachid, Abdella M. Habib, Ala-Eddin Al Moustafa, Ibrahim F. Benter, Saghir Akhtar
Summary: Traditional drug delivery systems typically use carriers to improve drug efficacy, but recent research has shown that polymeric drug delivery systems may have intrinsic biological actions.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Toxicology
Sandra Nirina Andriamasinoro, Denis Dieme, Caroline Marie-Desvergne, Alessandra Maria Serventi, Maximilien Debia, Sami Haddad, Michele Bouchard
Summary: The study revealed that only a small percentage of the inhaled silver nanoparticles reached the lungs, with most likely remaining in the upper respiratory tract. The nanoparticles that entered the liver and gastrointestinal tract from the lungs suggested a certain ingestion of silver nanoparticles. Additionally, the presence of silver nanoparticles in the blood and extrapulmonary organs indicated a small fraction entering the systemic circulation via direct translocation from the respiratory tract.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Chanhee Oh, Ok Hwa Jeon, Junhee Han, Kyungsu Kim, Hyun Koo Kim, Ji-Ho Park
Summary: Inhalable nanotherapeutics using exogenous pulmonary surfactant (PS) were developed to treat lung adenocarcinoma, showing selective interaction with adenocarcinoma cells in vitro and prolonged retention in the alveolar space after inhalation. Inhalation treatments with paclitaxel-loaded PSNVs significantly inhibited tumor growth in a lung cancer mouse model compared to free paclitaxel and synthetic NVs, suggesting great potential for treating lung adenocarcinoma.
ACS APPLIED NANO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Yingying Xu, Yijing Zheng, Xuqiu Ding, Chengyan Wang, Bin Hua, Shilian Hong, Xiaoman Huang, Jiali Lin, Peng Zhang, Wei Chen
Summary: In this study, a PEGylated peptide-based mRNA delivery vector was developed to enhance pulmonary mRNA delivery efficacy and safety. The results showed that an appropriate PEG chain length selection significantly improved mRNA transfection efficiency and biocompatibility of the carrier.
Article
Biochemistry & Molecular Biology
Richard O. Jacques, Shirley C. Mills, Paula Cazzonatto Zerwes, Feyisope O. Fagade, John E. Green, Scott Downham, Darren W. Sexton, Anja Mueller
CELL BIOCHEMISTRY AND FUNCTION
(2015)
Article
Immunology
Stefan Bidula, Darren W. Sexton, Alireza Abdolrasouli, Anand Shah, Anna Reed, Darius Armstrong-James, Silke Schelenz
JOURNAL OF INFECTIOUS DISEASES
(2015)
Article
Immunology
Stefan Bidula, Darren W. Sexton, Silke Schelenz
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2016)
Article
Chemistry, Medicinal
Norazah Basar, Olayinka Ayotunde Oridupa, Kenneth J. Ritchie, Lutfun Nahar, Nashwa Mostafa M. Osman, Angela Stafford, Habibjon Kushiev, Asuman Kan, Satyajit D. Sarker
PHYTOTHERAPY RESEARCH
(2015)
Article
Medicine, General & Internal
Jalpa Kotecha, Ludmila Shulgina, Darren W. Sexton, Christopher P. Atkins, Andrew M. Wilson
JOURNAL OF CLINICAL MEDICINE
(2016)
Article
Oncology
Kimberley Hanson, Stephen R. Robinson, Karamallah Al-Yousuf, Adam E. Hendry, Darren W. Sexton, Victoria Sherwood, Grant N. Wheeler
Review
Medicine, General & Internal
Karolina M. Stepien, Robert Heaton, Scott Rankin, Alex Murphy, James Bentley, Darren Sexton, Iain P. Hargreaves
JOURNAL OF CLINICAL MEDICINE
(2017)
Article
Biology
Audrey Dubourg, Dong Xia, John P. Winpenny, Suha Al Naimi, Maha Bouzid, Darren W. Sexton, Jonathan M. Wastling, Paul R. Hunter, Kevin M. Tyler
Article
Multidisciplinary Sciences
Wei Wang, Yan He, Guodong Yu, Baolong Li, Darren W. Sexton, Thomas Wileman, Alexandra A. Roberts, Chris J. Hamilton, Ruoxi Liu, Yimin Chao, Yujuan Shan, Yongping Bao
Review
Immunology
Stefan Bidula, Darren W. Sexton, Silke Schelenz
JOURNAL OF IMMUNOLOGY RESEARCH
(2019)
Article
Cell Biology
Adam Richardson, Andrew K. Powell, Darren W. Sexton, Jason L. Parsons, Nick J. Reynolds, Kehinde Ross
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Medicine, General & Internal
Robert A. Heaton, Simon Heales, Khalid Rahman, Darren W. Sexton, Iain Hargreaves
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Education, Scientific Disciplines
Dietmar Steverding, Kevin M. Tyler, Darren W. Sexton
PERSPECTIVES ON MEDICAL EDUCATION
(2016)