Article
Cardiac & Cardiovascular Systems
Jennifer J. Stuart, Lauren J. Tanz, Eric B. Rimm, Donna Spiegelman, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: This study aimed to evaluate the association between hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) and identify the proportion mediated by established CVD risk factors. The results showed that women with HDP during their first pregnancy had a higher risk of CVD, which was mainly mediated by established CVD risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Jennifer Sacramento-Pacheco, Maria Begona Sanchez-Gomez, Juan Gomez-Salgado, Maria Mercedes Novo-Munoz, Gonzalo Duarte-Climents
Summary: Cardiovascular diseases are the leading cause of death in Spain, mainly due to the lack of control of cardiovascular risk factors. The prevalence of these risk factors varies across different autonomous regions in Spain, with high blood pressure, smoking, diabetes, overweight, and obesity being the most common.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Raji Balasubramanian, Katherine H. Shutta, Marta Guasch-Ferre, Tianyi Huang, Shaili C. Jha, Yiwen Zhu, Aladdin H. Shadyab, JoAnn E. Manson, Dolores Corella, Montserrat Fito, Frank B. Hu, Kathryn M. Rexrode, Clary B. Clish, Susan E. Hankinson, Laura D. Kubzansky
Summary: Chronic psychological distress is associated with increased risk of cardiovascular disease, and inflammatory factors may play a crucial role in this association. This study found that a metabolite profile linked with distress was associated with increased risk of CVD and inflammation-related risk factors.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Cardiac & Cardiovascular Systems
Filippos Triposkiadis, Andrew Xanthopoulos, John Parissis, Javed Butler, Dimitrios Farmakis
Summary: Chronic heart failure (HF) is rare in the young and common in the elderly. The causes of HF in the young are usually specific, such as adult congenital heart disease, cardiomyopathies, myocarditis, or cardiotoxicity. On the other hand, the mechanisms underlying HF development in the elderly have not been fully understood. It is proposed that in most elderly patients, HF is the consequence of cardiovascular aging accelerated by specific risk factors, such as hypertension, obesity, type 2 diabetes mellitus (T2DM), coronary artery disease (CAD), and valvular heart disease (VHD), which affect both the heart and the vasculature.
HEART FAILURE REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Antonella Meloni, Christian Cadeddu, Lucia Cugusi, Maria Pia Donataccio, Martino Deidda, Susanna Sciomer, Sabina Gallina, Cristina Vassalle, Federica Moscucci, Giuseppe Mercuro, Silvia Maffei
Summary: Metabolic syndrome is a clinical condition characterized by the aggregation of major risk factors for cardiovascular disease and type 2 diabetes, including dyslipidemia, high blood pressure, abnormal blood sugar, and abdominal obesity. These risk factors have an independent effect but become synergistic when combined, leading to a doubled risk of cardiovascular diseases and a 1.5-fold increase in all-cause mortality. This article explores gender differences in the epidemiology, etiology, pathophysiology, and clinical expression of metabolic syndrome components, as well as gender differences in new biochemical markers of metabolic syndrome and cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jiangluyi Cai, Lian Cui, Yu Wang, Ying Li, Xilin Zhang, Yuling Shi
Summary: Psoriasis is associated with cardiometabolic comorbidities such as cardiovascular diseases, obesity, diabetes mellitus, and metabolic syndrome, with risk increasing with psoriasis severity. Biologic therapy improves life quality of patients and reduces incidences of cardiometabolic comorbidities, but caution is needed considering the pathogenic mechanisms and prevention strategies of these comorbidities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Patricio Lopez-Jaramillo, Philip Joseph, Jose P. Lopez-Lopez, Fernando Lanas, Alvaro Avezum, Rafael Diaz, Paul A. Camacho, Pamela Seron, Gustavo Oliveira, Andres Orlandini, Sumathy Rangarajan, Shofiqul Islam, Salim Yusuf
Summary: In a multinational South American cohort, variations in CVD incidence and mortality rates were examined between sub-populations stratified by country, sex, and urban or rural location. The study found that men had higher rates of CVD and death compared to women, and death rates were higher in rural areas. Hypertension, obesity, diabetes, and tobacco use were identified as leading risk factors for both CVD and death.
EUROPEAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Elisabeth Buur Stougaard, Signe Abitz Winther, Hanan Amadid, Marie Frimodt-Moller, Frederik Persson, Tine Willum Hansen, Peter Rossing
Summary: The study aimed to assess the associations between PBR, PBR-hf, and MVHS with cardio-renal risk factors in individuals with type 1 diabetes, as well as compare these dimensions with controls. Results showed that the endothelial glycocalyx dimension was impaired in individuals with T1D compared to controls, but there was no association with albuminuria levels or cardio-renal risk factors. The use of the GlycoCheck device may not contribute significantly to cardio-renal risk stratification in T1D.
Review
Clinical Neurology
Fardin Nabizadeh, Parya Valizadeh, Parisa Sharifi, Rasa Zafari, Omid Mirmosayyeb
Summary: This systematic review and meta-analysis suggest that Parkinson's disease is associated with a reduced risk of myocardial infarction, although the exact mechanism is unclear.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Cell Biology
Giulia Germena, Laura Cecilia Zelarayan, Rabea Hinkel
Summary: Exosomes are small membranous vesicles that contain biological material and can mediate cell-to-cell communication, maintaining homeostasis or modulating disease processes. They play a crucial role in cardiovascular diseases and have potential diagnostic value, although their specific physiological and pathophysiological functions in the cardiovascular system are still not fully understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Simon Frerich, Rainer Malik, Marios K. Georgakis, Moritz F. Sinner, Steven J. Kittner, Braxton D. Mitchell, Martin Dichgans
Summary: This study used genetic data to assess the associations between cardiac traits and stroke risk, finding that cardiac traits have limited effects on stroke risk beyond known clinical risk factors.
Article
Cardiac & Cardiovascular Systems
Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
Summary: This study shows that in elderly and very elderly Asian populations, improvements in cardiovascular health status are associated with a reduced risk of cardiovascular disease, but body mass index and total cholesterol are not sufficiently predictive of all-cause mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Katherine A. Fu, Kimberly C. Paul, Ake T. Lu, Steve Horvath, Adrienne M. Keener, Yvette Bordelon, Jeff M. Bronstein, Beate Ritz
Summary: The study found that certain blood DNA methylation markers are associated with Parkinson's disease risk, which may provide insights into factors that are affected differently in early Parkinson's disease patients compared to controls.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lukasz M. Milanowski, Xu Hou, Jenny M. Bredenberg, Fabienne C. Fiesel, Liam T. Cocker, Alexandra Soto-Beasley, Ronald L. Walton, Audrey J. Strongosky, Ayman H. Faroqi, Maria Barcikowska, Magdalena Boczarska-Jedynak, Jaroslaw Dulski, Lyuda Fedoryshyn, Piotr Janik, Anna Potulska-Chromik, Katherine Karpinsky, Anna Krygowska-Wajs, Tim Lynch, Diana A. Olszewska, Grzegorz Opala, Aleksander Pulyk, Irena Rektorova, Yanosh Sanotsky, Joanna Siuda, Mariusz Widlak, Jaroslaw Slawek, Monika Rudzinska-Bar, Ryan Uitti, Monika Figura, Stanislaw Szlufik, Sylwia Rzonca-Niewczas, Elzbieta Podgorska, Pamela J. McLean, Dariusz Koziorowski, Owen A. Ross, Dorota Hoffman-Zacharska, Wolfdieter Springer, Zbigniew K. Wszolek
Summary: This study identified a potential genetic cause of Parkinson's disease in two affected siblings. However, functional analysis of patient-derived fibroblasts did not reveal significant changes, suggesting that the CTSB gene may harbor variants with different penetrance that can determine disease risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Haydeh Payami, Gwendolyn Cohen, Charles F. Murchison, Timothy R. Sampson, David G. Standaert, Zachary D. Wallen
Summary: Parkinson's disease is a rapidly growing neurological disorder with no known prevention methods. While intrinsic risk factors like age, sex, and genetics cannot be avoided, environmental factors can. This study suggests that repeated blows to the head in sports/combat may be a potential new risk factor. Approximately 23% of Parkinson's disease cases in females and 30% in males could be attributed to pesticide/herbicide exposure, military-related chemical exposures, and repeated blows to the head, highlighting the potential for prevention.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Timothy Grover, Viswas Dayal, Adrian Fourcin, Catherine Milabo, Patricia Limousin, Thomas Foltynie
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Cardiac & Cardiovascular Systems
Renjie Chen, Yixuan Jiang, Jialu Hu, Honglei Chen, Huichu Li, Xia Meng, John S. Ji, Ya Gao, Weidong Wang, Cong Liu, Weiyi Fang, Hongbing Yan, Jiyan Chen, Weimin Wang, Dingcheng Xiang, Xi Su, Bo Yu, Yan Wang, Yawei Xu, Lefeng Wang, Chunjie Li, Yundai Chen, Michelle L. Bell, Aaron J. Cohen, Junbo Ge, Yong Huo, Haidong Kan
Summary: This study found that short-term exposure to air pollutants such as PM2.5, NO2, SO2, and CO may trigger the onset of ACS and its subtypes. The associations were strongest in the first hour of exposure and attenuated thereafter.
Review
Clinical Neurology
Philipp Mahlknecht, Thomas Foltynie, Patricia Limousin, Werner Poewe
Summary: A robust body of evidence has established the efficacy of deep brain stimulation (DBS) in reducing off time and dyskinesias in levodopa-treated patients with Parkinson's disease (PD). However, the long-term impact of DBS on the overall progression of disability in PD is less clear.
MOVEMENT DISORDERS
(2022)
Article
Multidisciplinary Sciences
Keran Wang, Zhehui Luo, Chenxi Li, Jayant M. Pinto, Eric J. Shiroma, Eleanor M. Simonsick, Honglei Chen
Summary: In older adults, poor olfaction is associated with lower kidney function but not future risk of chronic kidney disease (CKD).
Article
Otorhinolaryngology
Zichun Cao, Aiwen Yang, Aimee A. D'Aloisio, Lourdes Suarez, Sandra Deming-Halverson, Chenxi Li, Zhehui Luo, Jayant M. Pinto, Emily J. Werder, Dale P. Sandler, Honglei Chen
Summary: Poor olfaction is common in older adults, but often goes unrecognized. This study examined the self-awareness and reporting accuracy of poor olfaction in middle-aged and older women. It found that self-reports of poor olfaction were lower compared to objective tests, and there were significant associations between poor olfaction and factors such as age, marital status, smoking, coffee drinking, obesity, health status, Parkinson disease, cognitive impairment, depression, anxiety, and seasonal allergy.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Christine G. Parks, Srishti Shrestha, Stuart Long, Thomas Flottemesch, Sarah Woodruff, Honglei Chen, Gabriella Andreotti, Jonathan N. Hofmann, Laura E. Beane Freeman, Dale P. Sandler
Summary: This article describes the experience of linking the Agricultural Health Study cohort to Medicare claims data and explores the possibility of missing data. The study found that incomplete claims data can lead to a reduced sample size in analyses and that the missingness may not be random.
PREVENTIVE MEDICINE REPORTS
(2022)
Article
Clinical Neurology
Gunther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Annette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
Summary: This article presents an update on the treatment guidelines for early and advanced Parkinson's disease (PD). The recommended interventions include deep brain stimulation (DBS), brain lesioning, and continuous medication delivery. The evaluation of treatment effects is primarily based on high-level evidence, with clinical consensus used for certain specific situations.
MOVEMENT DISORDERS
(2022)
Article
Multidisciplinary Sciences
Shengfang Song, Zhehui Luo, Chenxi Li, Xuemei Huang, Eric J. Shiroma, Eleanor M. Simonsick, Honglei Chen
Summary: This study longitudinally assessed depressive symptoms in older adults with Parkinson's disease (PD) and found that depressive symptoms start to increase a few years prior to PD diagnosis and become significantly different from expected levels one year before diagnosis.
Article
Otorhinolaryngology
Andrea L. C. Schneider, Rebecca F. Gottesman, Thomas H. Mosley, Srishti Shrestha, Nicholas R. Rowan, A. Richey Sharrett, Honglei Chen, Vidyulata Kamath
Summary: The study found an association between head injury and olfactory dysfunction, particularly in individuals with multiple prior head injuries and more severe head injury. The findings also suggested that individuals with prior head injury were more likely to underestimate or overestimate their olfactory deficits compared to objective olfactory testing.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Neurosciences
Gareth Morinan, Yuriy Dushin, Grzegorz Sarapata, Samuel Rupprechter, Yuwei Peng, Christine Girges, Maricel Salazar, Catherine Milabo, Krista Sibley, Thomas Foltynie, Ioana Cociasu, Lucia Ricciardi, Fahd Baig, Francesca Morgante, Louise-Ann Leyland, Rimona S. Weil, Ro'ee Gilron, Jonathan O'Keeffe
Summary: Parkinson's disease is a common neurological disorder characterized by bradykinesia. Using computer vision to objectively quantify bradykinesia could standardize decision-making for treatment and clinical trials, as well as facilitate remote assessment.
NPJ PARKINSONS DISEASE
(2023)
Editorial Material
Clinical Neurology
Tom Foltynie
Article
Clinical Neurology
Tom Foltynie, Sonia Gandhi, Cristina Gonzalez-Robles, Marie-Louise Zeissler, Georgia Mills, Roger Barker, James Carpenter, Anette Schrag, Anthony Schapira, Oliver Bandmann, Stephen Mullin, Joy Duffen, Kevin McFarthing, Jeremy Chataway, Mahesh Parmar, Camille Carroll
Summary: Multi-arm, multi-stage platform designs have improved the efficiency of clinical trials in the field of oncology. Foltynie et al. discuss the challenges and considerations of using this approach to assess potential disease-modifying treatments in progressive neurological conditions such as Parkinson's disease.
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Andre Zacharia, Diego Kaski, Walid Bouthour, Viswas Dayal, Matthieu Bereau, Philipp Mahlknecht, Dejan Georgiev, Julie Peron, Tom Foltynie, Ludvic Zrinzo, Marjan Jahanshahi, John Rothwell, Patricia Limousin
Summary: This study investigated the effects of 80 Hz vs. 130 Hz frequency STN-DBS on eye movements and executive control in Parkinson's disease patients. The results showed that 80 Hz STN-DBS reduced the ability to maintain stable fixation, resulting in a higher antisaccade error rate, without affecting inhibition or motor state.
NPJ PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Nirosen Vijiaratnam, Thomas Foltynie
Summary: The recent validation of the alpha-synuclein seed amplification assay as a biomarker for the diagnosis of Parkinson's disease has provided a basis for a proposed staging system in clinical studies. However, further challenges exist in finding biomarkers for disease modifying agents, including optimizing distinction between different alpha-synucleinopathies and predicting clinical benefit. The use of additional biomarkers, such as CSF proteins and imaging techniques, may enhance trial planning and assessment of interventions.