Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

CAR T therapies drive into new terrain

(2017) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Vaccine adjuvants as potential cancer immunotherapeutics

(2016) Burcu Temizoz et al.   INTERNATIONAL IMMUNOLOGY

Peptide-based synthetic vaccines

(2016) Mariusz Skwarczynski et al.   Chemical Science

An Improved Method for the Synthesis of Lipopeptide TLR2-Agonists Using Click Chemistry

(2013) Margaret Brimble et al.   SYNLETT

Structure–Activity Relationships in Toll-Like Receptor 2-Agonists Leading to Simplified Monoacyl Lipopeptides

(2011) Geetanjali Agnihotri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural requirement for the agonist activity of the TLR2 ligand Pam2Cys

(2010) Weiguang Zeng et al.   AMINO ACIDS

Structure−Activity Relationships in Toll-like Receptor-2 Agonistic Diacylthioglycerol Lipopeptides

(2010) Wenyan Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Peptide Sequence of Diacyl Lipopeptides Determines Dendritic Cell TLR2-Mediated NK Activation

(2010) Masahiro Azuma et al.   PLoS One

Unmet needs in modern vaccinology

(2010) Geert Leroux-Roels   VACCINE

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

Self-Adjuvanting Lipopeptide Vaccines

(2008) Peter Moyle et al.   CURRENT MEDICINAL CHEMISTRY