MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway

Calprotectin protects against experimental colonic inflammation in mice

(2018) Carlos J Aranda et al.   BRITISH JOURNAL OF PHARMACOLOGY

OUP accepted manuscript

(2018)   Journal of Crohns & Colitis

COMP-angiopoietin-1 ameliorates inflammation-induced lymphangiogenesis in dextran sulfate sodium (DSS)-induced colitis model

(2018) Ae Sin Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

N-Methylcytisine Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Mice by Inhibiting the Inflammatory Response

(2018) Yan-Fang Jiao et al.   MOLECULES

The ventromedial hypothalamic nucleus plays an important role in anxiolytic-like effect of neuropeptide S

(2018) Jin Hong Jiang et al.   NEUROPEPTIDES

The role of Cortistatin-14 in the gastrointestinal motility in mice

(2018) JinHong Jiang et al.   Pharmacological Reports

MK2–TNF–Signaling Comes Full Circle

(2018) Manoj B. Menon et al.   TRENDS IN BIOCHEMICAL SCIENCES

Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABAA Receptor Signaling Pathway

(2018) JinHong Jiang et al.   Frontiers in Pharmacology

MK2 Inhibition Attenuates Fibroblast Invasion and Severe Lung Fibrosis

(2018) Jiurong Liang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fecal calprotectin is significantly linked to azathioprine metabolite concentrations in Crohn’s disease

(2018) Julian Essmann et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Differential regulation of cytokine and chemokine expression by MK2 and MK3 in airway smooth muscle cells

(2018) Mariam Ba et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans

(2017) Alice Rigoni et al.   INFLAMMATORY BOWEL DISEASES

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

(2017) Ling Zhao et al.   MOLECULES

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

Maternal high-fat diet consumption enhances offspring susceptibility to DSS-induced colitis in mice

(2017) Shima Bibi et al.   Obesity

MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C

(2017) Qinghang Meng et al.   Journal of the American Heart Association

Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics

(2017) Ping Li et al.   Frontiers in Pharmacology

Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations

(2016) Alexander R. Moschen et al.   Cell Host & Microbe

Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture

(2016) Doan Duy Hai Tran et al.   CELLULAR SIGNALLING

Treatment with MAPKAP2 (MK2) inhibitor and DNA methylation inhibitor, 5-aza dC, synergistically triggers apoptosis in hepatocellular carcinoma (HCC) via tristetraprolin (TTP)

(2016) Doan Duy Hai Tran et al.   CELLULAR SIGNALLING

Nebulized Delivery of the MAPKAP Kinase 2 Peptide Inhibitor MMI-0100 Protects Against Ischemia-Induced Systolic Dysfunction

(2016) David I. Brown et al.   International Journal of Peptide Research and Therapeutics

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation

(2016) Christopher Tiedje et al.   NUCLEIC ACIDS RESEARCH

Protective effect of isoquercitrin against acute dextran sulfate sodium-induced rat colitis depends on the severity of tissue damage

(2016) Norbert Cibiček et al.   Pharmacological Reports

Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice

(2016) Ming-hua Duan et al.   Saudi Journal of Gastroenterology

The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions

(2016) Stephen M. Vindigni et al.   Therapeutic Advances in Gastroenterology

The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell–Mediated Th1 Differentiation and Autoimmune Encephalomyelitis

(2015) Klara Soukup et al.   JOURNAL OF IMMUNOLOGY

A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

(2014) Puneet Kaur Randhawa et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial

(2014) L Kristin Newby et al.   LANCET

Utility of serum TNF-α, infliximab trough level, and antibody titers in inflammatory bowel disease

(2014) Éva Pallagi-Kunstár   WORLD JOURNAL OF GASTROENTEROLOGY

The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis

(2011) D Camuesco et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cell-penetrating peptides can confer biological function: Regulation of inflammatory cytokines in human monocytes by MK2 inhibitor peptides

(2011) Jamie L. Brugnano et al.   JOURNAL OF CONTROLLED RELEASE

The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease

(2011) Ya Jing FENG et al.   Journal of Digestive Diseases

Peptide Inhibitors of MK2 Show Promise for Inhibition of Abdominal Adhesions

(2011) Brian C. Ward et al.   JOURNAL OF SURGICAL RESEARCH

Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo

(2011) Akihito Muto et al.   VASCULAR PHARMACOLOGY

Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease

(2010) G. Docena et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor   Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation

(2010) R. J. Mourey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Facilitation of central imidazoline I1-site/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase signalling mediates the hypotensive effect of ethanol in rats with acute renal failure

(2009) Mahmoud M El-Mas et al.   BRITISH JOURNAL OF PHARMACOLOGY