Design, Synthesis and Molecular Docking Analysis of Flavonoid Derivatives as Potential Telomerase Inhibitors

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Synthesis, antitumor activity evaluation and mechanistic study of novel hederacolchiside A 1 derivatives bearing an aryl triazole moiety

(2018) Hui-ning Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In silico insight into voltage-gated sodium channel 1.7 inhibition for anti-pain drug discovery

(2018) Mingxing Wang et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Cryo-EM structure of substrate-bound human telomerase holoenzyme

(2018) Thi Hoang Duong Nguyen et al.   NATURE

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway

(2018) Gaofei Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In silico exploration of aryl sulfonamide analogs as voltage-gated sodium channel 1.7 inhibitors by using 3D-QSAR, molecular docking study, and molecular dynamics simulations

(2018) Mingxing Wang et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site

(2017) Zhuang Hou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Telomerase Inhibitors from Natural Products and Their Anticancer Potential

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors

(2017) Dong-Shu Zheng et al.   Experimental and Therapeutic Medicine

Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo

(2016) Yang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural product-based design, synthesis and biological evaluation of Albiziabioside A derivatives that selectively induce HCT116 cell death

(2016) Gaofei Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

(2016) Yuxin Tian et al.   MOLECULES

Novel myricetin derivatives: Design, synthesis and anticancer activity

(2015) Wei Xue et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of celastrol derivatives as anticancer agents

(2015) Wen-Jian Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A library of 1,2,3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluation

(2015) Gaofei Wei et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532

(2015) Christopher Bryan et al.   STRUCTURE

Click Chemistry for Drug Development and Diverse Chemical–Biology Applications

(2013) Prakasam Thirumurugan et al.   CHEMICAL REVIEWS

Cinnamic Acid Derivatives in Tuberculosis, Malaria and Cardiovascular Diseases - A Review

(2012) Prithwiraj De et al.   CURRENT ORGANIC CHEMISTRY

Stabilization and Structural Alteration of the G-Quadruplex DNA Made from the Human Telomeric Repeat Mediated by Tröger’s Base Based Novel Benzimidazole Derivatives

(2012) Ananya Paul et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antioxidant and Antimicrobial Activities of Cinnamic Acid Derivatives

(2012) M. Sova   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives

(2011) Chia-Chung Lee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of small molecule inhibitors of telomerase activity through transcriptional regulation of hTERT and calcium induction pathway in human lung adenocarcinoma A549 cells

(2010) Yerra Koteswara Rao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE