Article
Immunology
Daichi Murakami, Masamitsu Kono, Denisa Nanushaj, Fumie Kaneko, Tonia Zangari, Yasuteru Muragaki, Jeffrey N. Weiser, Muneki Hotomi
Summary: This study revealed that cigarette smoke exposure significantly promotes pneumococcal transmission in an infant mouse model by enhancing bacterial shedding from the colonized host and increasing susceptibility to colonization in new hosts. Local inflammation and mucosal changes were identified as important underlying mechanisms for transmission promotion by smoke exposure, attributable to the constituents of cigarette smoke rather than smoke itself. These findings provide the first experimental evidence of the impact of environmental factors on pneumococcal transmission and pathogenesis mechanisms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Environmental Sciences
Hongchao Zhang, Huabin Zhou, Xianhe Guo, Guopei Zhang, Mingyang Xiao, Shengwen Wu, Cuihong Jin, Jinghua Yang, Xiaobo Lu
Summary: An increasing amount of evidence suggests that cigarette smoking has negative effects on cognitive performance, possibly through the disruption of calcium signaling. This study investigates the implications of abnormalities in calcium signaling induced by cigarette smoke (CS) exposure. The activation of the AFOSB-CACNA2D1 axis, which plays a role in calcium homeostasis, was observed in the hippocampal tissues of a mouse model of CS-induced cognitive impairment. Furthermore, the study found that AFOSB directly regulates the transcription of the Cacna2d1 gene. Overall, this research provides insight into the neurotoxic mechanisms of CS and identifies potential targets for intervention.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Elizabeth Erickson-DiRenzo, Meena Easwaran, Joshua D. Martinez, Karuna Dewan, Chih Kwang Sung
Summary: High-dose cigarette smoke exposure increased vocal fold epithelial cell proliferation without altering cell junction expression. It also induced hypertrophy of mucus-producing submucosal glands. However, only low-dose cigarette smoke exposure increased MUC5AC gene expression.
Article
Chemistry, Analytical
Tim Axelrod, Evgeni Eltzov, Merav Lerman, Dorin Harpaz, Robert S. Marks
Summary: This study demonstrates that cigarette filters can reduce the harmful effects of cigarette smoke, but they cannot completely eliminate the impact on the human body. Smoking also affects quorum sensing and increases the risk of pulmonary infections.
Article
Cardiac & Cardiovascular Systems
Yasmeen M. Farra, Jacqueline Matz, Bhama Ramkhelawon, Jessica M. Oakes, Chiara Bellini
Summary: The study revealed that chronic cigarette smoking reduces the mechanical functionality of the aorta, causes morphometric alterations in distinct segments of the aorta, and accelerates the progression of atherosclerosis. Exposed mice showed decreased ability of the aorta to store elastic energy and reduced aortic distensibility. Additionally, a more vulnerable atherosclerotic phenotype was observed in exposed vessels.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Ting Zeng, Yanxia Liu, Yingfang Jiang, Lan Zhang, Yagang Zhang, Lin Zhao, Xiaoli Jiang, Qiang Zhang
Summary: This article focuses on materials that help reduce the levels of major carcinogens in cigarette smoke. The research progress on adsorption effects and mechanisms of advanced materials such as cellulose, zeolite, activated carbon, graphene, and molecularly imprinted polymers are highlighted. The review aims to serve as an insightful reference for the design of hybrid and functionally oriented advanced materials.
Article
Toxicology
Rui Xiong, Leihong Wu, Yue Wu, Levan Muskhelishvili, Qiangen Wu, Ying Chen, Tao Chen, Matthew Bryant, Hans Rosenfeldt, Sheila M. Healy, Xuefei Cao
Summary: Exposure to cigarette smoke has been shown to impair mucociliary clearance and is associated with chronic obstructive pulmonary diseases. In this study, miRNAs associated with impaired mucociliary clearance in an in vitro airway tissue model exposed to cigarette smoke were identified. The downregulation of miR-449a by cigarette smoke may interfere with ciliogenesis and derepress cell-cycle proteins, potentially serving as an early biomarker for cigarette smoke exposure and harm.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Chemistry, Analytical
Yong-Hyun Kim, Min-Seok Kim
Summary: This study developed a standardized method for preparing whole cigarette smoke condensate (WCSC) to obtain consistent quality WCSC. The effectiveness of the method was verified by evaluating the concentrations of total particulate matter (TPM) and organic compounds (OCs) in the samples at each step of WCSC preparation from cigarette smoke.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Shubhangini Kataruka, Veronika Kinterova, Filip Horvat, Marcos Iuri Roos Kulmann, Jiri Kanka, Petr Svoboda
Summary: miRNAs are important negative regulators of gene expression in mammalian cells, but their repressive activity is weak during oocyte and maternal-to-zygotic transition. Certain miRNAs, such as porcine ssc-miR-205 and bovine bta-miR-10b, are exceptions and can efficiently suppress gene expression despite the diluting effect of oocyte growth. The study highlights the importance of establishing a favorable miRNA:mRNA stoichiometry for effective gene suppression.
Article
Immunology
Hamed Janbazacyabar, Jeroen van Bergenhenegouwen, Johan Garssen, Thea Leusink-Muis, Ingrid van Ark, Marthe T. van Daal, Gert Folkerts, Saskia Braber
Summary: Increased exposure to environmental cigarette smoke (CS) during prenatal and postnatal periods increases offspring susceptibility to allergic airway responses, leading to changes in lung function parameters, immune cell frequencies, cytokine levels, and immunoglobulin levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Norio Yamamoto, Keiko Kan-o, Miyoko Tatsuta, Yumiko Ishii, Tomohiro Ogawa, Seiji Shinozaki, Satoru Fukuyama, Yoichi Nakanishi, Koichiro Matsumoto
Summary: Recent clinical studies have shown that inhalation of incense smoke may cause impaired lung function and asthma. Experimental evidence suggests that incense smoke exposure can lead to airway hyperresponsiveness, disruption of epithelial tight junction proteins in the lungs, and damage to bronchial epithelial barrier function. Antioxidants may be effective in treating incense smoke-induced airway dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ryan H. Nguyen, Laura B. Vater, Lava R. Timsina, Gregory A. Durm, Katelin Rupp, Keylee Wright, Miranda H. Spitznagle, Brandy Paul, Shadia Jalal, Lisa Carter-Harris, Karen S. Hudmon, Nasser H. Hanna, Patrick J. Loehrer, DuyKhanh P. Ceppa
Summary: The study found that counties with stronger smoke-free air ordinances had lower smoking rates and fewer new lung cancer cases per year. Therefore, strengthening smoke-free air ordinances is crucial for reducing lung cancer incidence.
Article
Endocrinology & Metabolism
Seung Hoon Kim, Minah Park, Gyu Ri Kim, Hye Jin Joo, Sung-In Jang
Summary: Mixed use of electronic and conventional cigarettes and exposure to secondhand smoke increase the risk of prediabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Toxicology
Xiaojiang Qin, Anqi Gao, Xiaomin Hou, Xinrong Xu, Liangjin Chen, Lin Sun, Yuxuan Hao, Yiwei Shi
Summary: Pulmonary hypertension is a chronic progressive disease associated with cigarette smoke exposure and abnormal alterations in connexin expression. Smokers have a higher risk of developing PH and increased mortality. Current treatments are unable to reverse vascular remodeling associated with PH. Therefore, early intervention is crucial in preventing the development of PH.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Shengzhe Ji, Zhen Liu, Peng Liu
Summary: This study evaluated the impact of cigarette grade/price and size on tobacco smoke pollution. The results showed that cigarette grade and price did not significantly affect PM2.5 levels, but cigarette size had a significant effect. However, the evaluation of cigarette safety cannot solely rely on tar and nicotine, and further research on other harmful substances and smoking habits is needed.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Adalisa Ponzano, Enrica Concetta Colangelo, Lucia Di Biase, Federica Romani, Gian Mario Tiboni
GYNECOLOGICAL ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
Adalisa Ponzano, Gian Mario Tiboni
GYNECOLOGICAL ENDOCRINOLOGY
(2017)
Article
Genetics & Heredity
M. Di Nisio, A. Ponzano, G. M. Tiboni, M. D. Guglielmi, A. W. S. Rutjes, E. Porreca
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2018)
Article
Reproductive Biology
Maria Cristina Budani, Stefania Fensore, Marco Di Marzio, Gian Mario Tiboni
REPRODUCTIVE TOXICOLOGY
(2018)
Article
Hematology
Marcello Di Nisio, Adalisa Ponzano, Gian Mario Tiboni, Maria Domenica Guglielmi, Anne Wilhelmina Saskia Rutjes, Ettore Porreca
THROMBOSIS RESEARCH
(2018)
Article
Developmental Biology
Valentina Di Nisio, Gianna Rossi, Maria Grazia Palmerini, Guido Macchiarelli, Gian Mario Tiboni, Sandra Cecconi
Article
Biotechnology & Applied Microbiology
Valentina Di Nisio, Gianna Rossi, Roberto Iorio, Cristina Pellegrini, Guido Macchiarelli, Gian Mario Tiboni, Sabrina Petricca, Sandra Cecconi
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Genetics & Heredity
Marco D'Aurora, Federica Romani, Sara Franchi, Francesca Diomede, Ilaria Merciaro, Gianna Gabriella Impicciatore, Oriana Trubiani, Liborio Stuppia, Gian Mario Tiboni, Valentina Gatta
Review
Biochemistry & Molecular Biology
Maria Cristina Budani, Gian Mario Tiboni
Review
Environmental Sciences
Maria Cristina Budani, Gian Mario Tiboni
Summary: Nitric oxide plays important roles in the ovary, with multiple isoenzymes of NOS expressed and localized in this tissue. It has been shown to contribute significantly to steroidogenesis, folliculogenesis, and oocyte meiotic maturation, although more research is needed, especially in the context of human ovarian physiology.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Reproductive Biology
Maria Cristina Budani, Stefania Fensore, Marco Di Marzio, Gian Mario Tiboni
Summary: Exposure to fluconazole during the first trimester of pregnancy is associated with an increased prevalence of heart defects in offspring, indicating that caution should be exercised when prescribing fluconazole to pregnant women and women of childbearing potential.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Reproductive Biology
Maria Cristina Budani, Gian Mario Tiboni
Summary: The investigation of the effects of nutrition on female fertility and IVF outcomes has gained increasing attention. Studies have focused on carbohydrates, proteins, and fatty acids, with some showing potential benefits of whole grains, vegetables, and omega-3 PUFAs, while controversial results exist for omega-6 PUFAs and dairy. Overall, nutrition is a modifiable factor that plays a significant role in female reproduction and IVF outcomes, but further research is needed due to limited studies and discrepancies in the available data.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Reproductive Biology
Gian Mario Tiboni, Adalisa Ponzano, Alessio Ferrone, Sara Franceschelli, Lorenza Speranza, Antonia Patruno
Summary: This study evaluated for the first time the effect of valproic acid on NO synthesis in mouse embryos, revealing a time-dependent shift in NOS isoform expression induced by valproic acid.
REPRODUCTIVE TOXICOLOGY
(2021)
Review
Obstetrics & Gynecology
Adalisa Ponzano, Gian Mario Tiboni
MINERVA GINECOLOGICA
(2018)