Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2 H -pyrrol-2-one actives verified by ALARM NMR

Published 2015 View Full Article

Authors

Keywords

Chemical aggregation, Drug discovery, High-throughput screening, Pan-assay interference compounds, PAINS, Structure–activity relationships

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Volume 25, Issue 21, Pages 4740-4752

Publisher

Elsevier BV

Online

2015-08-11

DOI

10.1016/j.bmcl.2015.08.020

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