Review
Biochemistry & Molecular Biology
Jerremy Weerts, Sanne G. J. Mourmans, Arantxa Barandiaran Aizpurua, Blanche L. M. Schroen, Christian Knackstedt, Etto Eringa, Alfons J. H. M. Houben, Vanessa P. M. van Empel
Summary: Heart failure with preserved ejection fraction (HFpEF) is a disease with increasing incidence and no effective treatment. Coronary microvascular dysfunction plays a key role in the pathophysiology of HFpEF, possibly due to a low-grade pro-inflammatory state caused by systemic comorbidities. The presence or absence of peripheral microvascular dysfunction in HFpEF may reflect whether it is predominantly a cardiac or a systemic disease.
Article
Physiology
Sascha H. Kranen, Ricardo S. Oliveira, Bert Bond, Craig A. Williams, Alan R. Barker
Summary: The measurement of slope 2 StO(2) is reliable in adolescents, but it is not correlated with vascular function and does not change with the changes in FMD after exercise.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Critical Care Medicine
Binu Tharakan, Felicia A. Hunter, Saravanakumar Muthusamy, Sonya Randolph, Crystal Byrd, Veena N. Rao, E. Shyam P. Reddy, Ed W. Childs
Summary: This study determined the specific role of ERG in regulating microvascular permeability in human lung microvascular endothelial cells and evaluated the protective effect of exogenous ERG on barrier dysfunction. The results demonstrate that ERG is a potent regulator of barrier integrity and permeability, and enhancing ERG provides protection against barrier dysfunction and hyperpermeability.
Review
Biology
Stamatina Lamprou, Nikolaos Koletsos, Gesthimani Mintziori, Panagiota Anyfanti, Christina Trakatelli, Vasileios Kotsis, Eugenia Gkaliagkousi, Areti Triantafyllou
Summary: Prediabetes is a significant metabolic state with high potential for progression to diabetes. People with prediabetes have an increased risk of cardiovascular disease and mortality. Microvascular and endothelial dysfunction in peripheral organs and tissues can be detected and monitored, and are currently being studied as markers of subclinical and future cardiovascular disease in prediabetes.
Review
Cardiac & Cardiovascular Systems
Rajan Rehan, Andy Yong, Martin Ng, James Weaver, Rajesh Puranik
Summary: The coronary microcirculation is crucial in regulating coronary blood flow to meet the changing metabolic demands of the myocardium. Coronary microvascular dysfunction (CMD) refers to the remodeling of the coronary microcirculation, and it plays a role in the pathogenesis of various cardiovascular diseases. CMD is often overlooked in clinical practice despite recent diagnostic advancements, but it holds potential for the development of new therapeutic targets. This review explores the diagnosis and pathogenic role of CMD, its prognostic significance, and the current therapeutic landscape.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Critical Care Medicine
Sara Tehrani, Patrik Gille-Johnson
Summary: This study found that patients with critical COVID-19 have impaired skin microvascular function, particularly a marked decrease in endothelial function. Additionally, it was observed that three months after disease onset, patients may not fully recover microvascular function.
Article
Peripheral Vascular Disease
Alexandros Rovas, Konrad Buscher, Irina Osiaevi, Carolin Christina Drost, Jan Sackarnd, Phil-Robin Tepasse, Manfred Fobker, Joachim Kuhn, Stephan Braune, Ulrich Gobel, Gerold Thoelking, Andreas Groeschel, Jan Rossaint, Hans Vink, Alexander Lukasz, Hermann Pavenstaedt, Philipp Kuempers
Summary: This study compares microvascular injury patterns and proteomic signatures in COVID-19 and bacterial sepsis patients, and finds substantial overlap between the two diseases. Disease severity is the main factor influencing data variation. The study also identifies two main coregulated plasma protein signatures in both diseases that are associated with microvascular dysfunction and markers of clinical severity.
Article
Rheumatology
Nikolaos Koletsos, Eugenia Gkaliagkousi, Antonios Lazaridis, Areti Triantafyllou, Panagiota Anyfanti, Panagiotis Dolgyras, Konstantina Dipla, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma
Summary: This study demonstrates that patients with SLE show reduced microvascular reactivity during reperfusion, even in the absence of overt cardiovascular disease or risk factors, compared to controls. These findings indicate that skin microvascular dysfunction is present in SLE independent of the cardiovascular burden these patients carry, suggesting it may serve as an early indicator of vascular damage.
Review
Hematology
Shigeo Godo, Akira Suda, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa
Summary: Accumulating evidence over the past few decades has shown that structural and functional abnormalities of coronary microvasculature are highly prevalent and associated with adverse clinical outcomes in patients with various cardiovascular diseases. CMD has been recognized as an important clinical entity, with potential mechanisms including enhanced coronary vasoconstrictive reactivity at the microvascular level.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Medicine, General & Internal
Francesco Pelliccia, Franco Cecchi, Iacopo Olivotto, Paolo G. Camici
Summary: Myocardial ischemia is a pathophysiological feature of hypertrophic cardiomyopathy that affects heart function and sudden cardiac death. Coronary microvascular dysfunction is the main factor contributing to myocardial ischemia, and thus a multimodality approach is necessary for the detailed assessment of microvascular dysfunction and ischemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Stina Bjoerkman, Caroline Lilliecreutz, Marie Bladh, Tomas Stromberg, Carl Johan Ostgren, Arina Mahmoud, Arian Kafashian, Sara Bergstrand, Sofia Sederholm Lawesson
Summary: Microvascular dysfunction was observed in women with previous pre-eclampsia at long-term follow-up, suggesting a possible link between endothelial dysfunction and increased cardiovascular disease risk in women with hypertensive disorders of pregnancy.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Yike Li, Zixiang Ye, Ziyu Guo, Enmin Xie, Min Wang, Xuecheng Zhao, Mei Liu, Peizhao Li, Changan Yu, Yanxiang Gao, Jingang Zheng
Summary: This study performed a pooled analysis to compare the effects of ticagrelor and clopidogrel on coronary microcirculation dysfunction in STEMI patients who underwent the primary percutaneous coronary intervention. The results showed that ticagrelor had more benefits for coronary microcirculation than clopidogrel in STEMI patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Peripheral Vascular Disease
Damiano Rizzoni, Carolina De Ciuceis, Piotr Szczepaniak, Pierre Paradis, Ernesto L. Schiffrin, Tomasz J. Guzik
Summary: Low-grade inflammation and oxidative stress are crucial in the development of hypertension and related organ damage. Innate immune cells and adaptive immunity play a role in vascular inflammation, while effector T lymphocytes may promote hypertension and microvascular remodeling. Immune mechanisms contribute to oxidative stress and target organ damage in hypertension.
Review
Environmental Sciences
Cody P. Anderson, Elizabeth J. Pekas, Song-Young Park
Summary: PAD is characterized by atherosclerotic plaques in lower-body arteries, often accompanied by microvascular disease leading to poor wound healing and ulcer development. Understanding mechanisms of ulcer development is crucial for treatment. Heat therapies have emerged as potential options for attenuating PAD progression and preventing ulcer development by stimulating the cardiovascular system and reducing fatigue during walking.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Ossama Mahmoud, Mahmoud El-Sakka, Barry G. H. Janssen
Summary: This study introduces a new two-step image processing algorithm that utilizes a trained Convolutional Neural Network to functionally analyze Intravital Video Microscopy (IVM) microscopic images without manual intervention. The algorithm efficiently analyzes IVM image data with an accuracy of 83%, marking the first application of machine learning for the functional analysis of microvascular blood flow in vivo.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Rogerio Nogueira Soares, Raylene A. Reimer, Patricia K. Doyle-Baker, Juan M. Murias
Summary: This study found that mild obesity affects the responses of arm micro- and macrovascular function, but does not impact the forearm skeletal muscle response to glucose ingestion. Obese individuals showed a significant reduction in brachial artery function after glucose ingestion, whereas no significant changes were observed in lean participants.
Review
Food Science & Technology
Thiago Silveira Alvares, Gustavo Vieira de Oliveira, Monica Volino-Souza, Carlos Adam Conte-Junior, Juan Manuel Murias
Summary: Dietary nitrate ingestion has a positive effect on muscular strength and muscular endurance, with a more significant impact observed during isometric and isotonic contractions. Dosage, frequency of ingestion, training level, muscle group, and type of contraction do not appear to significantly affect the outcomes. Further experimental research is needed to explore this topic.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Food Science & Technology
Cristina Rezende, Gustavo Vieira de Oliveira, Monica Volino-Souza, Patricia Castro, Juan Manuel Murias, Thiago Silveira Alvares
Summary: The study showed that turmeric supplementation could improve cerebral oxygenation and blood volume during dynamic handgrip exercise in older males and females. Changes in heart rate and blood pressure were not significant. The findings suggest the potential of curcumin as an intervention for improving cerebral oxygenation and blood volume in older individuals.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Physiology
Rafael de Almeida Azevedo, Daniel A. Keir, Jonas Forot, Danilo Iannetta, Guillaume Y. Millet, Juan M. Murias
Summary: This study investigates the relationship between the development of slow component of oxygen uptake and muscle fatigue, finding that they are correlated in a time- and intensity-dependent manner. The results suggest that the slow component of oxygen uptake may depend on muscle fatigue, even if the mechanisms of reduced contractile function differ among intensities.
Article
Physiology
Rafael de Almeida Azevedo, Jonas Forot, Guillaume Y. Millet, Juan M. Murias
Summary: This study investigated the relationship between pulmonary oxygen uptake and muscle oxygen uptake in females and males during cycling exercise at different intensities. The results showed a correlation between the two variables regardless of exercise intensity and sex of the participants.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Sport Sciences
Daniel A. Keir, Danilo Iannetta, Felipe Mattioni Maturana, John M. Kowalchuk, Juan M. Murias
Summary: This article highlights the importance of non-invasive identification of lactate threshold and respiratory compensation point during incremental exercise through pulmonary gas exchange and ventilatory variables. It also provides practical strategies for explaining the physiological mechanisms, identifying thresholds, and addressing related issues, as well as an online tool for practice and data analysis.
Article
Nutrition & Dietetics
Y. B. Somani, R. N. Soares, J. Gosalia, J. M. Delgado, M. Flanagan, S. Basu, D. B. Kim-Shapiro, J. M. Murias, D. N. Proctor
Summary: The onset of menopause and changes to ovarian hormones often lead to endothelial dysfunction in women. A study showed that acute dietary nitrate supplementation can improve endothelial function and reduce the magnitude of endothelial dysfunction caused by ischemia-reperfusion injury in healthy, early postmenopausal women.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Nutrition & Dietetics
Rafael A. Azevedo, Delbar Jazayeri, Samuel T. Yeung, Rojan Khoshreza, Guillaume Y. Millet, Juan Murias, Saied J. Aboodarda
Summary: Experiencing pain in one leg can decrease exercise tolerance and neuromuscular fatigue development in the contralateral leg. However, the effects of nonlocal experimental pain induced by blood flow occlusion on corticospinal modulation remain unknown. This study found that 25% maximal voluntary contraction (25%IMVC) duration was the shortest during blood flow occlusion, and the decline in maximal voluntary contraction was smaller compared to cycling exercise, indicating that pain reduces exercise performance. Additionally, transcranial magnetic stimulations revealed the modulation of the nervous system in response to pain stimulation.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Physiology
Danilo Iannetta, Jenny Zhang, Juan M. Murias, Saied Jalal Aboodarda
Summary: This study evaluated the extent of peripheral and central fatigue, and corresponding perceptual attributes, at task failure following cycling within different exercise intensity domains. The findings demonstrate that the extent of peripheral fatigue is highly domain-specific, whereas the extent of central fatigue is not. Sensations such as fatigue, pain, and dyspnea demonstrated intensity domain specificity and might have contributed to reaching maximal levels of perceived effort and, thus, task failure.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Austin T. Beever, Andrea Y. Zhuang, Saied Jalal Aboodarda, Juan M. Murias, Martin J. MacInnis
Summary: Hypoxia has a negative impact on aerobic exercise, but exercise testing in hypoxic conditions has not been extensively studied. This research investigated the effects of simulated altitude on gas exchange threshold, respiratory compensation point, and maximal oxygen uptake. The findings suggest that mild simulated altitude affects maximal oxygen uptake and peak power output significantly, while gas exchange threshold and respiratory compensation point remain unchanged. Moderate altitude decreases all four variables.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Physiology
Hilkka Kontro, Craig Bertagnolli, Juan M. Murias, Martin J. MacInnis
Summary: The study found that an elevated COHb concentration intensified physiological responses to exercise at the MLSS and reduced the MLSS in trained individuals. Lower effective [Hb] due to CO inhalation decreased V?O2peak and MLSS performance, with higher aerobic fitness associated with greater impairments.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Education, Scientific Disciplines
Serena Trang, Felipe Mattioni Maturana, Juan M. Murias, Michael R. Herbert, Daniel A. Keir
Summary: In exercise physiology, laboratory components are crucial for applying theoretical concepts to personal exercise experiences and introducing data collection and analysis. The gas exchange threshold (GET) and the respiratory compensation point (RCP) are key exercise thresholds that require proper identification. However, the processing and preparation of data have been time-consuming and challenging for students. This article presents a blended laboratory model featuring the Exercise Thresholds App, which provides immediate feedback and eliminates the need for data postprocessing, allowing students to practice threshold identification skills.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Physiology
Rafael de Almeida Azevedo, Pablo R. Fleitas-Paniagua, Mackenzie Trpcic, Danilo Iannetta, Guillaume Y. Millet, Juan M. Murias
Summary: The aim of this study is to investigate the effects of different ramp-incremental (RI) slopes on fatigability and recovery in females and males. The results showed that gender had no significant effect on performance fatigability and recovery, and different RI slopes did not alter the level of performance fatigability at task failure.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Physiology
Pablo R. Fleitas-Paniagua, Rafael de Almeida Azevedo, Mackenzie Trpcic, Juan M. Murias, Bruce Rogers
Summary: Detrended fluctuation analysis (DFA a1), an index of heart rate variability (HRV), has been of interest as a surrogate marker for exercise intensity boundaries. This report examined the behavior of heart rate variability thresholds (HRVT) across different ramp incremental slopes. The study found that the cycling ramp slope did not have a significant effect on HRVT1 and HRVT2 in terms of heart rate (HR) or VO2.
PHYSIOLOGICAL REPORTS
(2023)
Article
Physiology
Alessandro Moura Zagatto, Vithor Hugo Fialho Lopes, Yago Medeiros Dutra, Rodrigo Araujo Bonetti de Poli, Eimear Dolan, Letizia Rasica, Juan M. Murias, Paulo Henrique Silva Marques de Azevedo
Summary: This study aimed to investigate the effects of sodium bicarbonate (NaHCO3) ingestion on constant load cycling performance and neuromuscular fatigue. The results showed that NaHCO3 ingestion did not affect performance or indicators of neuromuscular fatigue. However, participants performed better when they were informed that they were ingesting an ergogenic supplement, suggesting a placebo effect may contribute to the apparent ergogenic effect of NaHCO3.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)
