Article
Chemistry, Applied
Iris Garrido-Cano, Vicente Candela-Noguera, Guadalupe Herrera, Juan Miguel Cejalvo, Ana Lluch, M. Dolores Marcos, Felix Sancenon, Pilar Eroles, Ramon Martinez-Manez
Summary: Mesoporous silica nanoparticles (MSNs) are efficiently internalized by human cells, with uptake mechanisms differing among cell types and particles. These biocompatible materials do not induce ROS/RNS production, nor affect mitochondrial membrane potential or cell cycle within cells.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Review
Chemistry, Inorganic & Nuclear
Neha Benedicta Fernandes, Yogendra Nayak, Sanjay Garg, Usha Y. Nayak
Summary: The field of advanced nanotechnology offers a wide range of nanotheranostics for treating malignant tumors. Among them, Mesoporous Silica Nanoparticles (MSNs) combined with upconversion nanoparticles have gained prominence in biomedicine research due to their remarkable properties in drug targeting, bio-imaging, and photodynamic/photothermal therapy. MSNs have versatile pore sizes, high drug loading efficiency, and can be functionalized to enhance their applicability. This article focuses on MSN-based hybrid nanotheranostics and their designing strategies, characterization, applications, efficacy, limitations, biotoxicity, as well as current challenges and future perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Materials Science, Ceramics
Amira M. EL-Rafei
Summary: In this study, different forms of silica fume waste were used to prepare silica-based products. The results showed that the preparation of mesoporous nano-silica from silica fume without using a template and the needed post-heated treatment to get rid of it is an energy-saving technology.
CERAMICS INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Araceli Lerida-Viso, Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Vicente Marti-Centelles, Ramon Martinez-Manez
Summary: This review highlights the importance of mesoporous silica nanoparticles (MSNs) in biomedical applications and discusses their potential uses in nanomedicine. The biosafety properties of MSNs are analyzed, and the potential challenges related to the clinical application of silica materials are discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Jongkook Hwang, Jin Hyung Lee, Jinyoung Chun
Summary: The study introduced a facile synthetic method to prepare spherical mesoporous silica nanoparticles with tunable mesopores, utilizing acetic acid and PEG as key components to control the particle size and morphology.
Article
Chemistry, Multidisciplinary
Ji Yeon Park, Wonsik Mun, Jinyoung Chun, Byoung-In Sang, Robert J. Mitchell, Jin Hyung Lee
Summary: The preparation method of natural biogenic silica nanoparticles from rice husks affects their biocompatibility, with alkali extraction method resulting in the lowest toxicity. Incorporating polyethylene glycol before alkali extraction increases their toxicity, while the presence of residual carbon and variations in calcination temperature and time also impact their toxicity.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Biophysics
Maria de los Angeles Ramirez, Elisa Bindini, Paolo Moretti, Galo J. A. A. Soler Illia, Heinz Amenitsch, Patrizia Andreozzi, Maria Grazia Ortore, Sergio E. Moya
Summary: The evolution of mesoporous silica nanoparticles (MSNs) in simulated body fluid was studied, and it was found that unmodified MSNs showed structural changes at high concentrations, while PEGylated MSNs remained more stable.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Muhammad Umair Amin, Sajid Ali, Muhammad Yasir Ali, Imran Tariq, Usman Nasrullah, Shashank Reddy Pinnapreddy, Christian Woelk, Udo Bakowsky, Jana Bruessler
Summary: Lipid coating of mesoporous silica nanoparticles enhances drug delivery to multidrug resistant cancer cells while improving stability and biocompatibility of the nanocarriers. The lipid coating reduces systemic drug release and increases drug delivery to tumor sites, leading to higher cellular uptake. Lipid coated silica nanoparticles exhibit sustained drug release and increased cytotoxicity over time, offering a promising approach for cancer treatment with reduced side effects.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Fangman Chen, Fan Zhang, Yanbin Wang, Jiahui Peng, Lei Cao, Qian Mei, Mingfeng Ge, Li Li, Meiwan Chen, Wen-fei Dong, Zhimin Chang
Summary: In this study, mesoporous organosilica nanoparticles (MON) coated with biomimetic cancer cell membrane were developed for controlled release of cisplatin and reduction inactivation, aiming to enhance platinum-based chemotherapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yingshan Jin, Yuting Lu, Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Xin Zhang, Myeong-Hyeon Wang
Summary: Multidrug-resistant (MDR) pathogens are a major concern globally, and nanomaterials and phyto-compounds are being explored as novel antibacterial agents to target them. This study aimed to develop and characterize Paeoniflorin loaded silica oxide nanoparticles (Pae-SiO2 NPs) for increased effectiveness against MDR bacteria. The Pae-SiO2 NPs showed strong antibacterial effects on Staphylococcus aureus and Bacillus cereus, with low toxicity to human embryonic kidney cells and red blood cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Maria Vallet-Regi
Summary: This article reports our contributions to mesoporous silica materials in biomedicine, demonstrating their potential in drug delivery with high loading capacity and stimuli-responsive features. The research findings suggest that mesoporous silica nanoparticles have promising applications in drug delivery.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Nisar Ul Khaliq, Juyeon Lee, Joohyeon Kim, Yejin Kim, Sohyeon Yu, Jisu Kim, Sangwoo Kim, Daekyung Sung, Hyungjun Kim
Summary: Cancer remains a major global health challenge, and traditional chemotherapy often leads to side effects and drug resistance, necessitating the development of alternative treatments like gene therapy. Mesoporous silica nanoparticles (MSNs) offer numerous advantages as gene delivery carriers, including high loading capacity, controlled drug release, and easy surface functionalization. They are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies have reviewed the use of MSNs for delivering therapeutic nucleic acids to cancer cells and discussed their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are also discussed.
Article
Engineering, Environmental
Yu-Di Deng, Xu-Dong Zhang, Xu-Shan Yang, Zhen-Lie Huang, Xi Wei, Xing-Fen Yang, Wen-Zhen Liao
Summary: This study investigated the subacute toxicity of mesoporous silica nanoparticles (MSNs) in mice and found that they induced intestinal oxidative stress, apoptosis in colonic epithelial cells, mitochondrial damage, and alterations in intestinal flora composition. Additionally, MSNs affected the expression of metabolites involved in various metabolic pathways. These results suggest that the subacute toxicity of MSNs is mainly due to intestinal damage.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Jason William Grunberger, Hamidreza Ghandehari
Summary: Silica nanoparticles (SNPs) have versatile synthetic methods and tunable physicochemical properties, making them promising for biomedical applications. In this study, hollow mesoporous SNPs (HMSNPs) with different layer compositions were fabricated, and their degradation profiles were characterized in simulated body fluid. The results showed that the composition and number of layers influenced degradation rates, with particles containing more disulfide bridges being more responsive to enzymatic degradation. These findings suggest the potential utility of layer-by-layer HMSNPs for controlled drug delivery.
Article
Environmental Sciences
Xin Zhang, Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan, Yuting Lu, Myeong-Hyeon Wang
Summary: In this study, spherical silica nanoparticles (SiO2 NPs) were prepared using a modified Stober's method and tested for the removal of methyl orange (MO). The SiO2 NPs had a zeta size of 152.5 nm, a PDI of 0.377, and a zeta potential of -5.59 mV. The adsorption of MO by SiO2 NPs was influenced by parameters such as initial dye concentration, reaction time, temperature, and pH. The highest adsorption rate was observed to be 69.40 mg/g of SiO2 NPs. The toxicity of the SiO2 NPs treated MO dye solution was tested and found to have no significant toxic effects on corn seeds and Artemia salina.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Applied
Lulu Wan, Gan Ye, Yuying Chang, Zhaohan Yang, Guangming Shi, Qiuli Zhang, Jin Wang
Summary: This study developed an efficient approach to upgrade the oxidative desulfurization (ODS) performance of Zr-MOFs with proton stimulation. Experimental results showed that the introduction of protons can significantly improve the ODS efficiency. This work provides a facile and efficient strategy for enhancing the ODS performance of pristine MOFs.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Qiqi Lu, Xiu-Zhi Wei, Qi Zhang, Xinghua Zhang, Lungang Chen, Jianguo Liu, Yubao Chen, Longlong Ma
Summary: The application of Pd-M bimetallic clusters in the selective hydrogenation reaction was investigated, and the Pd0.6Ni@S-1 catalyst was found to exhibit high selectivity in the conversion of phenylacetylene to styrene. The confinement effect of zeolite inhibited over-hydrogenation and improved the stability of the catalysts. Furthermore, the solvent properties also influenced the product distribution.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Review
Chemistry, Applied
Bo Li, Lumin Hong, Changdi Jing, Xianyang Yue, Huabo Huang, Qianqian Jiang, Jianguo Tang
Summary: MOF materials with adjustable pore structure and polymetallic sites have been explored as electrocatalysts for OER. Bimetallic materials show higher electrocatalytic activity than monometallic materials, while carbon-coated and doped MOF catalysts exhibit stable and good OER activity. The synergistic interaction between polymetallic active sites effectively improves the intrinsic activity of MOF on OER.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Shichun Gu, Ruyi Wang, Junxiong Zhang, Hairong Dong, Liping Deng, Xue Wang, Yapeng He
Summary: In this study, monodispersed hollow mesoporous organosilica nanospheres with controlled core cavity and mesoporous shell were successfully synthesized. These hollow nanospheres showed a high adsorption capacity for Pb2+ in water solution and exhibited acceptable recycling and stability.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Lucie Havelkova, Bogdana Bashta, Michaela Vankova, Jiri Zednik, Jiri Brus, Jan Svoboda, Alice Vagenknechtova, Jan Sedlacek
Summary: An atom-economic one-step chain-growth coordination homopolymerization providing high yields of functionalized hyper-cross-linked polyacetylenes with a permanent micro/mesoporous texture and a BET area of up to 1062 m2/g is reported. The homopolymerization is highly compatible with the heteroatom groups of the monomers and allows the preparation of well-defined porous networks with a wide spectrum of univalent groups.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Shirui Pang, Yuxin Liu, Zhe Zhang, Yuxin Li, Chunguang Li, Zhan Shi, Shouhua Feng
Summary: This study focuses on using a functional separator to suppress the shuttle effect of soluble lithium polysulfides in Li-S batteries. It is found that the functionalized sulfonic acid group not only accelerates the conduction of lithium ions, but also repels polysulfide anions through electrostatic interactions. The performance of the batteries is significantly improved with the use of this functionalized separator.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Pingping Li, Lei Han, Donghun Kim, Kemal Celebi
Summary: This study presents a fast synthetic strategy for the preparation of high-quality platelike MFI crystals using a thin-wall tubular reactor. The strategy is efficient, time-saving, and can be optimized, making it applicable to the preparation and optimization of other important materials.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Haitao Yin, Wei Wang, Yuxin Li, Hu Wen, Shuang Chen, Nanzhe Jiang
Summary: This study presents a template-free and solid-state-like crystallisation method for the synthesis of ZSM-5 zeolite, which can be scaled-up in production. Mechanical mixing of starting material components improves the dispersion of materials, leading to ZSM-5 zeolite with high crystallinity and size uniformity.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Congli Li, Jiang Wang, Zhenfei Wang, Jinxiang Dong, Qi Shi
Summary: This study investigates the evolution and autoreduction behavior of Cu species in CuCl/NaY adsorbent during vacuum thermal activation. It is found that Cu species migrate from supercages to the nearby plane of the six-membered ring connecting the supercage and sod cage during vacuum activation. At 150 degrees C, vacuum autoreduction occurs, resulting in the formation of Cu+Cl- species. The results provide reference for the preparation of pi-complex adsorbents.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Irena Khatrin, Iman Abdullah, Alan J. Mccue, Yuni K. Krisnandi
Summary: Hierarchical porous system with two types of mesopores provides a solution to the diffusion limitation in conventional zeolites. Cobalt oxide impregnated hierarchical ZSM-5 zeolite samples with intra- and inter-crystalline mesopores were synthesized using two different strategies. The physicochemical properties of the modified catalysts were analyzed, revealing distinct features given by the two mesoporous configurations. Catalytic activity analysis showed that Co-oxide/ZSM-5 with inter-crystalline mesopores exhibited higher activity in methane partial oxidation reaction compared to Co-oxide/ZSM-5 with intra-crystalline mesopores.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Nataliia Reinders, Martin Durovic, Pavla Honcova, Zaneta Dohnalova, Jana Luxova, Stanislav Slang, Jhonatan Rodriguez-Pereira, Petra S. Sulcova
Summary: This study presents a new method for preparing a microporous Ni2P/C catalyst with high catalytic activity. The redox reaction and carbon matrix formation during high-temperature treatment contribute to the stability and activity of the catalyst. Experimental and analytical results suggest that the microporous structure of the composite plays a crucial role in its catalytic performance. These findings are important for practical applications of efficient hydrogen production by water electrolysis.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Ana Raquel Bertao, Viktoriya Ivasiv, Cristina Almeida-Aguiar, Patricia R. Correia, Antonio M. Fonseca, Manuel Banobre-Lopez, Fatima Baltazar, Isabel C. Neves
Summary: This study developed a zeolite-based delivery system (ZDS) using silver and 5-Fluorouracil as antimicrobial and antineoplastic agents. The ZDS was characterized and its antimicrobial properties were investigated, showing better antibacterial effectiveness for the ZDS containing both silver and 5-FU.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Naonobu Katada, Nobuki Ozawa, Etsushi Tsuji, Keigo Kanehara, Akiho Otsuka, Taiga Sakamoto, Kirari Umezawa, Hitoshi Matsubara, Satoshi Suganuma, Momoji Kubo
Summary: First principles calculations were used to investigate the pathway for methylation of benzene with methane catalyzed by MFI type zeolite-supported Co species. The strong adsorption of benzene on Co is found to lower the activation energy for methane dissociation and promote the formation of toluene precursor. The activation energy of methane dissociation is also affected by the Al-Al distance.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Yuan Liu, An T. Ta, Kyoung Chul Park, Shenyang Hu, Natalia B. Shustova, Simon R. Phillpot
Summary: We use density functional theory to investigate the interactions of cerium, americium, and curium cations with crown ethers. Our results demonstrate that crown ethers can capture cerium, americium, and curium ions, and modifying the crown ether structure by substituting nitrogen atoms for oxygen atoms significantly increases their binding energies with radionuclides.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Zhengwu Peng, Shixing Wang, Yihui Wu, Xiang Liu, Hongliang Liu, Dekun Zhang, Likang Fu
Summary: An efficient adsorbent for recovery of germanium was prepared and characterized in this study. The adsorption behavior of Ge(IV) on the adsorbent was analyzed, and the results showed that it follows pseudo-secondary kinetic model and Langmuir isotherm model. The adsorbent exhibited good anionic anti-interference ability and can still maintain high adsorption efficiency after repeated adsorption.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)