Article
Environmental Sciences
Juan Wang, Christer Janson, Andrei Malinovschi, Mathias Holm, Karl A. Franklin, Lars Modig, Ane Johannessen, Vivi Schluenssen, Thorarinn Gislason, Nils Oskar Jogi, Dan Norback
Summary: This study examined the relationship between home environment exposures and asthma, allergic rhinitis, and atopic dermatitis among offspring of participants in the Respiratory Health in Northern Europe (RHINE) study. The results showed that dampness/mold at home and living in new buildings were associated with asthma occurrence.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Allergy
Birgit Pfaller, Sarah Bendien, Agnes Ditisheim, Thomas Eiwegger
Summary: Managing allergic diseases during pregnancy presents challenges and potential risks for mother and child, especially with limited safety data on anti-allergic drugs during pregnancy.
Review
Biochemistry & Molecular Biology
Tobias Weihrauch, Maren M. Limberg, Natalie Gray, Martin Schmelz, Ulrike Raap
Summary: Allergic diseases can cause various symptoms such as itching, coughing, sneezing, and watery eyes, leading to severe physiological and psychological impairments. The mechanisms of these conditions are still not fully understood, but recent studies have shown the high relevance of neurotrophins in allergic inflammation. Neurotrophins induce cytokine release, facilitate interactions between immune cells and neurons, and show different expression levels in health and disease. In this review, the role of neurotrophins in atopic disorders like atopic dermatitis, allergic asthma, and allergic rhinitis is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Po-Yu Huang, Ying-Hsien Huang, Mindy Ming-Huey Guo, Ling-Sai Chang, Ho-Chang Kuo
Summary: This review identified a higher prevalence of allergic diseases, such as allergic rhinitis and urticaria, in children with Kawasaki disease. Intravenous immunoglobulin therapy can reduce allergic symptoms in these patients. Long-term care for Kawasaki disease patients should focus on the management of allergic diseases.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Hyo Geun Choi, Il Gyu Kong
Summary: The study found that the incidence of asthma and allergic rhinitis among Korean adolescents decreased from 2019 to 2020, while there was no change in the incidence of atopic dermatitis. Subgroup analyses showed consistent results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Francesca Levi-Schaffer
Summary: The understanding of the pathologic mechanisms of asthma and atopic dermatitis has improved in recent years. However, the high heterogeneity of both diseases complicates diagnosis and treatment, with current strategies mainly focusing on symptom control rather than full healing. There is a need for more personalized approaches to improve diagnosis and treatment efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Mohammad-Hossein Shams, Reza Jafari, Nahid Eskandari, Mohsen Masjedi, Farnaz Kheirandish, Mazdak Ganjalikhani Hakemi, Ramin Ghasemi, Ali-Mohammad Varzi, Seyyed-Mohsen Sohrabi, Peyman Amanolahi Baharvand, Mozhgan Safari
Summary: Allergic diseases have significantly increased globally in recent decades, influenced by genetic factors, industrialization, improved hygiene, and climate change. Changes in lifestyle and diet habits also play a key role in the prevalence of allergic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Allergy
Tai Ren, Jiawen Chen, Yongfu Yu, Hua He, Jun Zhang, Fei Li, Katrine Svendsen, Carsten Obel, Hui Wang, Jiong Li
Summary: This study found that women with a history of asthma, atopic dermatitis, and allergic rhinitis before conception had a 37% increased risk of peripartum mental disorders. Women who had more frequent or recent hospital contacts for atopic diseases had higher risks. Specific associations were observed between asthma and neurotic, stress-related and somatoform disorders, and between atopic dermatitis and substance abuse.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Health Care Sciences & Services
Shung-Jie Chang, Ho-Chang Kuo, Wen-Jiun Chou, Ching-Shu Tsai, Sheng-Yu Lee, Liang-Jen Wang
Summary: This study examines the relationship between cytokine levels, neuropsychological function, and behavioral manifestations in patients with attention deficit hyperactivity disorder (ADHD) and atopic diseases. The study finds that behavioral symptoms and attention scores are significantly different between individuals with and without ADHD, regardless of atopic diseases. However, plasma levels of certain cytokines are negatively correlated with inattention symptoms.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Maya Berlin, Hadar Flor-Hirsch, Elkana Kohn, Anna Brik, Rimona Keidar, Ayelet Livne, Ronella Marom, Amit Ovental, Dror Mandel, Ronit Lubetzky, Pam Factor-Litvak, Josef Tovbin, Moshe Betser, Miki Moskovich, Ariela Hazan, Malka Britzi, Itai Gueta, Matitiahu Berkovitch, Ilan Matok, Uri Hamiel
Summary: The study aimed to investigate the association between maternal PCBs levels and atopic reactions in their offspring. The findings showed no significant association between exposure to PCBs and asthma, allergic rhinitis, or atopic dermatitis in children. More multi-participant studies with longer follow-up into later pediatric age are needed to further explore these relationships.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Allergy
Lucy E. Bradshaw, Laura A. Wyatt, Sara J. Brown, Rachel H. Haines, Alan A. Montgomery, Michael R. Perkin, Sandra Lawton, Tracey H. Sach, Joanne R. Chalmers, Matthew J. Ridd, Carsten Flohr, Joanne Brooks, Richard Swinden, Eleanor J. Mitchell, Stella Tarr, Nicola Jay, Kim S. Thomas, Hilary Allen, Michael J. Cork, Maeve M. Kelleher, Eric L. Simpson, Stella T. Lartey, Susan Davies-Jones, Robert J. Boyle, Hywel C. Williams
Summary: The study found that daily emollient application during the first year of life does not prevent atopic dermatitis, food allergy, asthma, or hay fever. The difference in incidence rates of atopic dermatitis, food allergy, asthma, and hay fever between the emollient group and the control group was relatively small.
Article
Nutrition & Dietetics
Qinyuan Li, Qi Zhou, Guangli Zhang, Xiaoyin Tian, Yuanyuan Li, Zhili Wang, Yan Zhao, Yaolong Chen, Zhengxiu Luo
Summary: This systematic review and meta-analysis investigated the effects of vitamin D supplementation on children with allergic diseases. The results showed that overall, vitamin D supplementation did not significantly reduce the risk of asthma exacerbations in children. However, it may reduce the risk in children with low baseline serum vitamin D levels. Additionally, vitamin D supplementation was found to reduce the severity of atopic dermatitis and symptoms of allergic rhinitis in children.
Review
Allergy
Conor Broderick, Stefanie Ziehfreund, Karin van Bart, Bernd Arents, Kilian Eyerich, Stephan Weidinger, Joseph Rastrick, Alexander Zink, Carsten Flohr, BIOMAP Consortium
Summary: Biomarkers associated with the development of comorbidities in atopic dermatitis (AD) patients have been inconsistently reported, and there is a lack of high-quality studies. Commonly reported biomarkers include filaggrin mutations and allergen specific-IgE, while promising biomarkers include specific-IgE and/or skin prick tests for predicting asthma development, and genetic polymorphisms for predicting eczema herpeticum occurrence.
Article
Allergy
Peter Schmid-Grendelmeier, Melinda J. Gooderham, Karin Hartmann, George N. Konstantinou, Marc Fellmann, Christopher Koulias, Claire Clibborn, Pinaki Biswas, Patrick M. Brunner
Summary: This article evaluated the efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis and allergic comorbidities. The results showed that abrocitinib was effective and safe in managing atopic dermatitis in patients with or without allergic comorbidities.
Review
Allergy
Chengmei Li, Hua Zhou, Wei Zhang, Datian Che
Summary: Bacterial lysate treatment significantly improves allergy symptom control without increasing adverse risk according to this meta-analysis.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)