Article
Immunology
Lauren Goldschen, Jack Ellrodt, Hermioni L. Amonoo, Candace H. Feldman, Siobhan M. Case, Karestan C. Koenen, Laura D. Kubzansky, Karen H. Costenbader
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by unpredictable disease flares. A connection between posttraumatic stress disorder (PTSD) and the development of SLE has been identified, suggesting that stress-related disorders alter susceptibility to SLE. Perturbations in the autonomic nervous system, neuroendocrine system, and at the genomic level may cause and sustain immune dysregulation, contributing to the development and propagation of SLE in those predisposed genetically.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Yi-Rou Wu, Chung-Hsi Hsing, Chiao-Juno Chiu, Hsin-Yi Huang, Yu-Hsiang Hsu
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unknown etiology that affects multiple organ systems. Dysregulation of cytokines, particularly IL-1 and IL-10 families, plays a vital role in immune activation and self-tolerance in the pathogenesis of SLE. These cytokines could be potential targets for therapeutic intervention in SLE.
Review
Biochemistry & Molecular Biology
Wojciech Lubon, Malgorzata Lubon, Przemyslaw Kotyla, Ewa Mrukwa-Kominek
Summary: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease, with up to one-third of patients experiencing various ocular manifestations. Ocular findings may be the initial signs of the disease and can lead to severe complications and vision loss. Early diagnosis and proper management are crucial, requiring collaboration among specialists. Adequate preparation of ophthalmologists can help differentiate SLE complications from other eye disorders. New therapies for SLE show promise, but their ocular side effects are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Antonis Fanouriakis, Myrto Kostopoulou, Jeanette Andersen, Martin Aringer, Laurent Arnaud, Sang-Cheol Bae, John Boletis, Ian N. Bruce, Ricard Cervera, Andrea Doria, Thomas Doerner, Richard A. Furie, Dafna D. Gladman, Frederic A. Houssiau, Luis Sousa Ines, David Jayne, Marios Kouloumas, Laszlo Kovacs, Chi Chiu Mok, Eric F. Morand, Gabriella Moroni, Marta Mosca, Johanna Mucke, Chetan B. Mukhtyar, Gyoergy Nagy, Sandra Navarra, Ioannis Parodis, Jose M. Pego-Reigosa, Michelle Petri, Bernardo A. Pons-Estel, Matthias Schneider, Josef S. Smolen, Elisabet Svenungsson, Yoshiya Tanaka, Maria G. Tektonidou, Y. K. Onno Teng, Angela Tincani, Edward M. Vital, Ronald F. van Vollenhoven, Chris Wincup, George Bertsias, Dimitrios T. Boumpas
Summary: The EULAR recommendations for the management of systemic lupus erythematosus (SLE) have been updated based on emerging new evidence. The updated recommendations provide consensus guidance on the use of various medications and treatment strategies to control the disease, as well as recommendations for assessing treatment response and tapering therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell & Tissue Engineering
Hongda Wang, Yiming Zhao, Bingbing Ren, Yafei Qin, Guangming Li, Dejun Kong, Hong Qin, Jingpeng Hao, Daqing Sun, Hao Wang
Summary: The study found that ERCs transfected with the Gal-9 gene could effectively inhibit the proliferation of CD4(+) T cells and reduce the expression levels of related proteins. In a mouse model of experimental hepatitis, Gal-9 high-expressing ERCs restored liver function, ameliorated liver pathological damage, and suppressed T cell proliferation and Th1, Th17 cell responses.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Rheumatology
Jingru Tian, Dingyao Zhang, Xu Yao, Yaqing Huang, Qianjin Lu
Summary: This study estimated the epidemiology of SLE globally, finding variations in incidence and prevalence rates across different countries and regions. It also highlighted the impact of gender, age, and prevalence estimation method on the findings. SLE was found to occur more frequently in high-income countries.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Mingxuan Chi, Kuai Ma, Yunlong Li, Min Quan, Zhongyu Han, Zhaolun Ding, Xin Liang, Qinxiu Zhang, Linjiang Song, Chi Liu
Summary: Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by multiple immunoregulatory abnormalities that lead to damage to various tissues and organs. Researchers have identified aberrant expression of miRNAs in SLE patients, which may be associated with abnormal immune responses and disease progression in SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Ali Duarte-Garcia, Mehmet Hocaoglu, Maria Valenzuela-Almada, Shirley-Ann Osei-Onomah, Jesse Y. Dabit, Alain Sanchez-Rodriguez, Stephanie Q. Duong, Rachel E. Giblon, Hannah E. Langenfeld, Graciela S. Alarcon, Charles G. Helmick, Cynthia S. Crowson
Summary: The incidence and prevalence of systemic lupus erythematosus (SLE) are increasing in the US population, potentially due to the rising ethnic diversity. However, the severity of SLE and the survival gap between SLE and the general population have remained unchanged over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Christina Adamichou, Irini Genitsaridi, Dionysis Nikolopoulos, Myrto Nikoloudaki, Argyro Repa, Alessandra Bortoluzzi, Antonis Fanouriakis, Prodromos Sidiropoulos, Dimitrios T. Boumpas, George K. Bertsias
Summary: A machine learning algorithm was developed to assist in the diagnosis of SLE by analyzing patient data sets, leading to improved diagnostic and treatment outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Eric F. Morand, Gabriel Abreu, Richard A. Furie, Vera Golder, Raj Tummala
Summary: A post hoc analysis reveals that treatment with anifrolumab in patients with SLE leads to earlier, more frequent, and more sustained attainment of LLDAS. LLDAS is highly associated with responses measured by BICLA and SRI(4).
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pediatrics
Wei Quan, Jingnan An, Gang Li, Guanghui Qian, Meifang Jin, Chenxi Feng, Si Li, Xiaozhong Li, Yunyun Xu, Xiaohan Hu
Summary: This study identified significantly elevated levels of IL-2, IL-10, and IL-21 in cSLE patients compared to healthy controls, with a positive correlation to disease activity. This suggests potential new approaches for regulating T lymphocyte subsets in cSLE diagnosis.
Review
Dentistry, Oral Surgery & Medicine
Merve Benli, Fareeha Batool, Celine Stutz, Catherine Petit, Sophie Jung, Olivier Huck
Summary: Studies have shown that SLE patients are at higher risk of compromised oral and dental health, with an increased risk of periodontal diseases and temporomandibular joint disorders. The use of systemic drugs, especially immunosuppressive and anticoagulants in SLE patients, may impact their oral management. Results emphasize the importance of early appropriate oral management of these patients to improve oral health-related quality of life and prevent the need for more invasive therapeutics. A multidisciplinary approach is necessary for the dental and medical management of such patients.
Review
Rheumatology
Courtney Stull, Grant Sprow, Victoria P. Werth
Summary: The majority of patients with systemic lupus erythematosus (SLE) exhibit skin manifestations, which can be classified as SLE-specific or SLE-nonspecific based on histopathologic findings. SLE-specific skin diseases include chronic cutaneous lupus erythematosus (CLE), subacute CLE, and acute CLE, each with different subsets of skin lesions and varying likelihood of associated SLE. SLE-nonspecific lesions are more common and tend to coincide with active systemic disease, and can also be seen in other connective tissue diseases. Familiarity with the spectrum of cutaneous diseases in SLE is important for rheumatologists to prognosticate systemic disease likelihood and ensure timely dermatologic care for controlling disease activity and preventing damage.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Chemistry, Medicinal
Przemyslaw Kotyla, Olga Gumkowska-Sroka, Bartosz Wnuk, Kacper Kotyla
Summary: Systemic sclerosis and systemic lupus erythematosus are two distinct autoimmune diseases belonging to connective tissue disorders, with no groundbreaking therapeutic approaches developed yet. The discovery of JAK kinases may offer a new therapeutic potential for previously untreatable diseases.
Article
Rheumatology
Makiko Yashiro-Furuya, Shuzo Sato, Momo Akanuma, Kairi Sato, Eiji Suzuki, Takashi Kanno, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Hiroko Kobayashi, Hiroshi Watanabe, Kiyoshi Migita
Summary: This study aimed to evaluate the efficacy of Rituximab in Japanese AAV patients, especially the elderly. The results showed that Rituximab was effective in Japanese AAV patients and may be helpful in reducing the use of steroids in elderly-onset patients.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Shuhei Yoshida, Eiji Suzuki, Haruki Matsumoto, Kohei Yokose, Yuya Fujita, Temmoku Jumpei, Naoki Matsuoka, Makiko Furuya, Junpei Temmoku, Tomoyuki Asano, Shuzo Sato, Hiroshi Watanabe, Kiyoshi Migita
Summary: This study demonstrates that combining tocilizumab with glucocorticoids as induction therapy for Takayasu arteritis patients can effectively maintain remission without relapse and gradually reduce the dosage of glucocorticoids.
MODERN RHEUMATOLOGY
(2023)
Article
Oncology
Takeshi Hatanaka, Satoru Kakizaki, Atsushi Hiraoka, Kazuya Kariyama, Kunihiko Tsuji, Toru Ishikawa, Hidenori Toyoda, Satoshi Yasuda, Atsushi Naganuma, Toshifumi Tada, Koichi Takaguchi, Akemi Tsutsui, Ei Itobayashi, Noritomo Shimada, Hiroshi Shibata, Takaaki Tanaka, Takuya Nagano, Michitaka Imai, Shinichiro Nakamura, Kazuhiro Nouso, Hisashi Kosaka, Masaki Kaibori, Takashi Kumada
Summary: This retrospective study compared the survival of elderly and non-elderly patients with hepatocellular carcinoma (HCC) and found that despite improvement in liver function, survival in elderly patients did not improve. The study suggests that curative treatments should be evaluated and conducted when appropriate for each elderly patient.
Article
Oncology
Takeshi Hatanaka, Atsushi Naganuma, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Noritomo Shimada, Kazuhito Kawata, Hisashi Kosaka, Satoru Kakizaki, Takaaki Tanaka, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Takashi Kumada
Summary: This study demonstrates that the HCC-GRIm score serves as a novel prognostic score for HCC patients treated with Atez/Bev, with a high score being associated with unfavorable prognosis in terms of disease progression and overall survival.
Article
Oncology
Takeshi Hatanaka, Atsushi Naganuma, Ai Furusawa, Yuki Tamura, Naoto Saito, Yuhei Suzuki, Takashi Hoshino, Yutaka Yata, Toshio Uraoka, Satoru Kakizaki
Summary: This retrospective study aimed to compare the chronological change in spleen volume between patients treated with Atez/Bev and LEN. The results showed that spleen volume gradually increased during Atez/Bev treatment, while it remained mostly consistent during LEN treatment. Caution is required when managing patients treated with Atez/Bev, especially those with a high NLR.
Article
Rheumatology
Ryo Yanai, Nobuyuki Yajima, Nao Oguro, Yasuhiro Shimojima, Shigeru Ohno, Hiroshi Kajiyama, Kunihiro Ichinose, Shuzo Sato, Michio Fujiwara, Yoshia Miyawaki, Ryusuke Yoshimi, Takashi Kida, Yusuke Matsuo, Keisuke Nishimura, Ken-ei Sada
Summary: Patients with SLE who change attending physicians may experience increased organ damage, according to a study. The number of attending physicians they have is significantly associated with the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SDI) and corticosteroid-related damage.
RHEUMATOLOGY AND THERAPY
(2023)
Review
Medicine, General & Internal
Shuhei Yoshida, Jumpei Temmoku, Tomoyuki Asano, Tsuyoshi Iwasaki, Haruki Matsumoto, Yuya Fujita, Makiko Yashiro-Furuya, Naoki Matsuoka, Naohiko Gunji, Shuzo Sato, Hiroshi Watanabe, Hiromasa Ohira, Kiyoshi Migita
Summary: We report a case of severe enteritis after cyclophosphamide therapy, emphasizing the importance of prompt discontinuation of the drug and intensive management when gastrointestinal symptoms occur.
Article
Health Care Sciences & Services
Shuhei Yoshida, Eiji Suzuki, Yuya Sumichika, Kenji Saito, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Hiroshi Watanabe, Kiyoshi Migita
Summary: This study compared the clinical features and outcomes of Japanese patients with giant cell arteritis (GCA) and Takayasu arteritis (TA) and found no significant difference in survival rates between the two groups. However, the relapse-free survival rates were significantly higher in the GCA group compared to the TA group. Large vessel involvement did not affect the relapse and survival rates in Japanese patients with GCA.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Rheumatology
Shuzo Sato, Xian K. Zhang, Naoki Matsuoka, Yuya Sumichika, Kenji Saito, Shuhei Yoshida, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Tomoyuki Asano, Kiyoshi Migita
Summary: This study found that Fli-1 protein regulates the expression of CXCL13, which affects the progression of lupus-like nephritis in adult MRL/lpr mice.
LUPUS SCIENCE & MEDICINE
(2023)
Review
Medicine, General & Internal
Kenji Saito, Jumpei Temmoku, Yuya Sumichika, Shuhei Yoshida, Eisuke Takano, Shuhei Watanabe, Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Hiroshi Watanabe, Kiyoshi Migita
Summary: We report a case of adult-onset Still's disease (AOSD) with severe acute kidney injury (AKI). The patient was successfully treated with high-dose steroids, hemodialysis, and plasma exchange. Additionally, we reviewed previously published reports to further discuss this rare complication in AOSD.
Article
Medicine, General & Internal
Jumpei Temmoku, Masayuki Miyata, Eiji Suzuki, Yuya Sumichika, Kenji Saito, Shuhei Yoshida, Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Hiroshi Watanabe, Kiyoshi Migita
Summary: This study found that drug-induced lymphocytopenia is associated with reduced drug retention rates of JAK inhibitors (tofacitinib or baricitinib) in rheumatoid arthritis (RA) patients. A quarter of RA patients treated with JAK inhibitors showed lymphocytopenia, which was associated with lower drug retention rates of tofacitinib but not baricitinib. Pre-treatment absolute lymphocyte counts did not affect the drug retention rates of JAK inhibitors in patients with RA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Shuhei Yoshida, Yuya Sumichika, Kenji Saito, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Kiyoshi Migita
Summary: This study investigated the clinical features and treatment response of Japanese patients with FMF. It found that colchicine was effective in the majority of patients, but some patients showed resistance to colchicine. Canakinumab showed good efficacy in colchicine-resistant patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Haruki Matsumoto, Yuya Sumichika, Kenji Saito, Shuhei Yoshida, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Kiyoshi Migita
Summary: Articular involvement, specifically axial joint involvement, is a rare manifestation in patients with familial Mediterranean fever (FMF). This case report describes a Japanese male patient with FMF-related axial joint involvement. While colchicine treatment improved febrile attacks and hip joint pain, sacroiliitis-related symptoms continued to progress until canakinumab treatment successfully resolved them.
MODERN RHEUMATOLOGY CASE REPORTS
(2023)
Article
Medicine, General & Internal
Haruki Matsumoto, Kenji Saito, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Kiyoshi Migita
Summary: Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease characterized by recurrent episodes of fever, serositis, and synovitis. The synovitis attacks in FMF present as acute monoarthritis with pain and hydrarthrosis, which resolve spontaneously. Colchicine is effective in preventing these painful arthritis attacks in FMF, but distinguishing them from other febrile attacks with various clinical manifestations is crucial.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jumpei Temmoku, Masayuki Miyata, Eiji Suzuki, Yuya Sumichika, Kenji Saito, Shuhei Yoshida, Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Kiyoshi Migita
Summary: This study examined the drug retention rate and safety data of Janus kinase inhibitors (JAKis) in elderly patients with rheumatoid arthritis. The overall drug retention rates of JAKis were comparable between the very elderly group and the elderly group. Similarly, the discontinuation rates of JAKis due to adverse events were also comparable in both groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
