Article
Medicine, General & Internal
Noman Ali, Umaira Aftab, Salman Muhammad Soomar, Hafsa Tareen, Uzma Rahim Khan, Badar Afzal Khan, Junaid Abdul Razzak
Summary: This study aimed to determine the clinical utility of routine investigations and risk factors of end-organ damage in patients presented to the emergency department with asymptomatic severe hypertension. The results showed that out of 180 patients, 33.3% had abnormal investigation findings and 8.3% were diagnosed with new-onset end-organ damage, with the kidney being the most common organ affected. Age over 60 years, diabetes, ischemic heart disease, and cerebrovascular accident were significantly associated with a higher risk of end-organ damage.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Cell Biology
Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Tzu-Ling Huang, Zhih-Cherng Chen, Chi-Long Chen, Jan-Show Chu, Ping Yen Liu
Summary: This study reveals the association between miR-21 and pressure overload-induced cardiac remodeling in aged hearts. It suggests the potential therapeutic role of miR-21 in treating cardiac diseases in elderly individuals.
Article
Medicine, General & Internal
Anja Linde, Eva Gerdts, Kare Steinar Tveit, Ester Kringeland, Helga Midtbo
Summary: Psoriasis patients on infliximab treatment had a lower prevalence of cardiac organ damage compared to controls, and hypertension was identified as the major covariable for subclinical cardiac organ damage in psoriasis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Leslie Marisol Lugo-Gavidia, Dylan Burger, Janis M. M. Nolde, Vance B. B. Matthews, Markus P. P. Schlaich
Summary: Elevated circulating platelet-derived extracellular vesicles (pEVs) have been associated with arterial hypertension, but their relationship with hypertension-mediated organ damage, endothelial function, and psychosocial status is unclear. Our study found that pEV levels were associated with macrovascular damage, but not with microvascular damage, endothelial function, or emotional status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Christelle Haddad, Pierre-Yves Courand, Constance Berge, Brahim Harbaoui, Pierre Lantelme
Summary: This study explored the association between cortisol levels and blood pressure, organ damage, and metabolic parameters in hypertensive patients. Results showed that cortisol weakly influenced blood pressure levels independently from plasma aldosterone, particularly in older patients. Additionally, there was a weak association between cortisol levels and hypertensive-mediated organ damage, suggesting a potential interest in testing specific treatments targeting cortisol excess in selected hypertensive patients.
JOURNAL OF HYPERTENSION
(2021)
Review
Pharmacology & Pharmacy
Xiaolin Liao, Yuanshan Han, Ying He, Jianjun Liu, Yuhong Wang
Summary: Hypertension commonly leads to target organ damage in the heart, brain, kidney, and blood vessels, including atherosclerosis, plaque formation, cardiovascular and cerebrovascular events, and renal failure. Mitochondrial dysfunction has been identified as a crucial factor in hypertensive target organ damage, leading to increasing interest in mitochondria-targeted therapies. Natural compounds have shown potential in ameliorating mitochondrial dysfunction in hypertensive target organ damage. This review summarizes the contribution of mitochondrial dysfunction to the development of target organ damage in hypertension and discusses therapeutic strategies based on natural compounds that target mitochondrial dysfunction, which may be beneficial for preventing and treating hypertensive target organ damage.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pierre-Yves Courand, Jerome Lenoir, Adrien Grandjean, Damien Garcia, Brahim Harbaoui, Pierre Lantelme
Summary: The study found that SCORE underestimates the 10-year cardiovascular mortality risk in both historical and contemporary cohorts of hypertensive patients. An update to the algorithm predicting cardiovascular mortality in hypertensive patients is needed.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zhongyuan Ren, Jun Zhang, Shikai Yu, Song Zhao, Jiamin Tang, Yixing Zheng, Weilun Meng, Chong Xu, Yi Zhang, Yawei Xu
Summary: The study found a significant association between HMOD and hyperhomocysteinemia in elderly Chinese, particularly with renal dysfunction and arterial stiffening.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Nestor Vazquez-Agra, Ana-Teresa Marques-Afonso, Anton Cruces-Sande, Ignacio Novo-Veleiro, Jose-Enrique Lopez-Paz, Antonio Pose-Reino, Alvaro Hermida-Ameijeiras
Summary: The study found that the influence of inflammatory markers on organ damage is not directly related to circadian blood pressure changes, with certain inflammatory markers strongly correlated with HMOD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Xiaolin Liao, Yuanshan Han, Chuanpu Shen, Jianjun Liu, Yuhong Wang
Summary: This review provides an overview of the role of NLRP3 inflammasome in hypertensive target organ damage (TOD) and the natural products and formulations that inhibit it. The activation of NLRP3 inflammasome exacerbates tissue damage and dysfunction in hypertensive TOD, and natural products such as curcumin, resveratrol, triptolide, and allicin have been shown to have protective effects.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pediatrics
Zhiyong Yang, Yanyun Huang, Yan Qin, Yusheng Pang
Summary: The majority of pediatric hypertension cases in this study were secondary, with renal disease being the the leading cause. Elevated levels of serum uric acid, blood urea nitrogen, serum creatinine, and albuminuria may indicate secondary hypertension in childhood. Elevated serum uric acid, blood urea nitrogen, and triglyceride levels were associated with left ventricular hypertrophy, hypertensive encephalopathy, and hypertensive retinopathy, respectively.
FRONTIERS IN PEDIATRICS
(2021)
Review
Cardiac & Cardiovascular Systems
Surina Surina, Rosaria Anna Fontanella, Lucia Scisciola, Raffaele Marfella, Giuseppe Paolisso, Michelangela Barbieri
Summary: miR-21, a 22-nucleotide long microRNA, plays a crucial role in various cardiomyopathies by regulating gene expression and providing cardiac protection after injury. It is also closely linked to cardiac dysfunctions such as hypertrophy and fibrosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chun-Lei Deng, Cheng-Biao Hu, Sheng-Tao Ling, Na Zhao, Li-Hui Bao, Feng Zhou, Ye-Cheng Xiong, Tao Chen, Bing-Dong Sui, Xiao-Rui Yu, Cheng-Hu Hu
Summary: The study revealed the therapeutic effects and mechanisms of mesenchymal stem cell transplantation and exosomal transplantation on photoreceptor injuries, with a focus on miR-21 mediation for photoreceptor viability. These methods demonstrated long-lasting efficacy in treating retinal degenerative diseases, highlighting their potential as a therapeutic approach.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Peripheral Vascular Disease
Byung Sik Kim, Hyun-Jin Kim, Minhyung Lyu, Wook-Dong Kim, Yonggu Lee, Miso Kim, Suein Lee, Jin-Kyu Park, Jinho Shin, Hyungoo Shin, Changsun Kim, Jeong-Hun Shin
Summary: Data from a cross-sectional study at a tertiary referral center revealed that 5.9% of patients visiting the emergency department had acute severe hypertension, with 24.5% of them experiencing acute hypertension-mediated organ damage (HMOD). The mortality rates for these patients were 4.8% at 3 months, 8.8% at 1 year, and 13.9% at 3 years, with significantly higher mortality rates in patients with HMOD compared to those without. This study highlights the importance of evaluating and managing HMOD in patients with acute severe hypertension to improve outcomes and emphasizes the need for disease-specific guidelines in this area.
JOURNAL OF HYPERTENSION
(2021)
Article
Oncology
Marta Correia de Sousa, Nicolas Calo, Cyril Sobolewski, Monika Gjorgjieva, Sophie Clement, Christine Maeder, Dobrochna Dolicka, Margot Fournier, Laurent Vinet, Xavier Montet, Jean-Francois Dufour, Bostjan Humar, Francesco Negro, Christine Sempoux, Michelangelo Foti
Summary: Despite being considered a potent oncomiR in human cancers, genetic deletion of miR-21 in mouse models surprisingly promotes hepatocellular carcinoma (HCC) development by affecting various signaling pathways and immune responses. These results challenge the current belief in miR-21 as an oncogene and raise caution regarding using miR-21 inhibition as a therapeutic approach for HCC.
Letter
Urology & Nephrology
Emrah Ermis, Sinem Ozyilmaz, Emre Salabas, Cem Senol, Mahir Cengiz, Samir Allahverdiyev, Hakan Ucar
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2021)
Article
Virology
Hande Ikitimur, Betul Borku Uysal, Mahir Cengiz, Baris Ikitimur, Harun Uysal, Erkan Ozcan, Mehmet Sami Islamoglu, Serhat Seyhan, Hakan Yavuzer, Serap Yavuzer
Summary: In this study, a large family cluster of 29 genetically related patients hospitalized with COVID-19 was compared to unrelated patients with SARS-CoV-2 infection. The family cluster showed more severe disease and worse clinical course, with higher hospitalization rates and ICU transfers. Further studies into potential genetic mechanisms of host susceptibility are warranted.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Pathology
Erkan Ozcan, Serap Yavuzer, Betul Borku Uysal, Mehmet Sami Islamoglu, Hande Ikitimur, Omer Faruk Unal, Yunus Emre Akpinar, Serhat Seyhan, Suna Koc, Hakan Yavuzer, Mahir Cengiz
Summary: The study found that among suspected COVID-19 patients with pneumonia symptoms and lung infiltrates consistent with COVID-19 on CT imaging, there were no significant differences in symptoms, physical examination, total CT scores, hospitalization duration, ICU requirement, and mortality rate between RT-PCR-positive and RT-PCR-negative patients. However, PCR-positive patients appeared to require more specific treatments.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2021)
Article
Geriatrics & Gerontology
Rabia Bag Soytas, Veysel Suzan, Pinar Arman, Tugce Emiroglu Gedik, Damla Unal, Mahir Cengiz, Ibrahim Murat Bolayirli, Deniz Suna Erdincler, Alper Doventas, Hakan Yavuzer
Summary: This study aimed to explore the relationship between serum fibroblast growth factor (FGF)-19 and FGF-21 levels and sarcopenia in elderly patients. The results showed that low FGF-19 and high FGF-21 levels may be associated with sarcopenia, potentially due to their impact on muscle strength.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Betul Borku Uysal, Serap Yavuzer, Mehmet Sami Islamoglu, Mahir Cengiz
Summary: This study examined the relationship between antibody titers and age and sex among patients with confirmed COVID-19. The results showed that antibody titers increased six months after infection and were positively correlated with age.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Virology
Rabia Bag Soytas, Mahir Cengiz, Mehmet S. Islamoglu, Betul Borku Uysal, Serap Yavuzer, Hakan Yavuzer
Summary: The study compared the antibody levels of patients aged 60 and older who received different COVID-19 vaccine regimens, showing that the immunity formed after two doses of CoronaVac plus one dose of Pfizer-BioNTech was significantly higher in older adults than after three doses of CoronaVac.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Erkan Yildirim, Nilgun Yildirim, Mahir Cengiz, Gulce Naz Yazici, Resit Coskun, Bahadir Suleyman, Abdulkadir Coban, Halis Suleyman
Summary: This study investigated the protective effects of ATP and benidipine, either separately or in combination, against bevacizumab-induced cardiac damage. The results showed that the combined therapy of ATP and benidipine produced the most favorable outcomes in reducing cardiac damage.
BIOTECHNIC & HISTOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Cengiz Sabanoglu, Umit Yasar Sinan, Mehmet Kadri Akboga, Ali Coner, Gulay Gok, Umut Kocabas, Lutfu Bekar, Emine Gazi, Mahir Cengiz, Salih Kilic, Ibrahim Halil Inanc, Huseyin Altug Cakmak, Mehdi Zoghi
Summary: Despite advancements in therapeutic management, heart failure patients still experience increasing morbidity and mortality worldwide. This retrospective study presents the 3-year follow-up outcomes of patients from the Journey HF-TR study, evaluating the clinical characteristics and management of acute heart failure patients admitted to the hospital and providing national registry data. Among 1311 patients, the ratio of hospitalization and mortality during the follow-up period was 70.5% and 52.1% respectively. Acute decompensation of heart failure and acute coronary syndrome were common causes of mortality. Angiotensin receptor blockers, beta blockers, statins, and sacubitril/valsartan were found to reduce mortality.
ANATOLIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Berna Stavileci, Emrah Ereren, Emrah Ozdemir, Bahar Ozdemir, Mahir Cengiz, Rasim Enar
Summary: The study retrospectively analyzed 205 hospitalized COVID-19 patients and found that levels of troponin I and D-dimer were associated with mortality and intensive care requirement. Higher levels of these markers can be used to assess the severity of COVID-19 in patients.
CARDIOVASCULAR JOURNAL OF AFRICA
(2023)
Article
Endocrinology & Metabolism
Filiz Demirdag, Serap Yavuzer, Mahir Cengiz, Hakan Yavuzer, Zehra Kara, Adnan Ayvaci, Suna Avci, Mehmet Yurueyen, Hafize Uzun, Mehmet Riza Altiparmak, Alper Doventas, Deniz Suna Erdincler
Summary: This study aimed to investigate the role of NF-κB, PPAR-α, and PPAR-β in older adults with MetS. The results showed that CRP, NF-κB levels, and CIMT were significantly higher in the MetS group compared to the control group, while PPAR-α and PPAR-β levels were significantly lower. ROC analysis indicated that NF-κB, PPAR-α, and PPAR-β could serve as indicators of MetS in younger adults, but not in older adults.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Oncology
Burcu Isik, Metin Suleymanzade, Mahir Cengiz, Serap Yavuzer, Mehmet Sami Islamoglu, Betul Borku Uysal, N. Ozlem Harmankaya, Mehmet Giray Ersoz
Summary: Choroidal thickness is decreased in patients with type 2 diabetes and glomerular hyperfiltration, but there is no significant difference in choroidal vascularity index compared to patients without diabetic nephropathy.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Medical Laboratory Technology
Halit Tokman, Sevgi Ergin, Suat Saribas, Harika Dinc, Mahir Cengiz, Serap Yavuzer, Utku Cizmecigil, Nuri Onder, Huseyin Yilmaz, Onder Eryigit, Nesrin Gareayaghi, Bekir Kocazeybek
Summary: The presence of neutralizing antibodies against Ad-36 was found to be significantly different between obese patients with type 2 diabetes and non-obese individuals, suggesting that Ad-36 seropositivity is a risk factor for developing type 2 diabetes independent of obesity. Additionally, BMI and Ad-36 were found to significantly increase the risk of type 2 diabetes in both obese and non-obese individuals.
CLINICAL LABORATORY
(2022)
Article
Medicine, General & Internal
Suna Koc, Serdar Celebi, Ferhat Hanikoglu, Yalcin Polat, Betul Borku Uysal, Mehmet Dokur, Turkan Ozer, Serap Yavuzer, Mehmet Sami Islamoglu, Mahir Cengiz, Gokay Vardar, Ilke Kupeli
Summary: This study analyzed the effects of cytokine hemadsorption as an immunomodulation therapy in ICU patients. The results showed that cytokine hemadsorption significantly reduced cytokine levels and other inflammatory indicators, decreased mortality rate, and improved organ failure. IL-10 levels, APACHE scores, and mortality rates were found to be important predictors of mortality in ICU patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medical Laboratory Technology
Mehmet Sami Islamoglu, Mahir Cengiz, Betul Borku Uysal, Hande Ikitimur, Zeynep Ozdemir, Ahsen Karamehmetoglu, Ayse Ezgi Akbulut, Ayse Nur Bakdur, Azize Ozdemir, Habibe Kayikcioglu, Hatice Ozdemir, Rumeysa Uces, Sema Ersoy, Serap Yavuzer
Summary: This study found that humoral antibodies against SARS-CoV-2 were protective against COVID-19 reinfection, with a reinfection rate of 0.8%, mostly seen in asymptomatic PCR negative patients.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2021)
Article
Medical Laboratory Technology
Mehmet S. Islamoglu, Betul Borku-Uysal, Serap Yavuzer, Hande Ikitimur, Serhat Seyhan, Suna Koc, Mahir Cengiz
Summary: The study showed that the inflammation markers NLR and PLR were correlated with disease severity in COVID-19 patients, with NLR exhibiting the highest specificity and sensitivity among other markers. Levels of NLR, PLR, CRP, and LMR were found to change in accordance with disease severity, indicating their potential to predict disease severity.
CLINICAL LABORATORY
(2021)
