Article
Biophysics
Sailahari Ponnaluri, Emma J. Christensen, Bryan C. Good, Cody J. Kubicki, Steven Deutsch, Joshua P. Cysyk, William J. Weiss, Keefe B. Manning
Summary: The Fontan operation is a treatment option for children with a single functional ventricle, but many patients require heart transplantation later in life. There is currently no FDA-approved device for subpulmonary support. Penn State University is developing a hydrodynamically levitated Fontan circulatory assist device (FCAD) as a potential therapy.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Engineering, Multidisciplinary
Imre Janos Barabas, Bela Merkely, Istvan Hartyanszky, Daniel Palkovics
Summary: This study provides an innovative solution for LVAD implantation using 3D technology and 3D printing. The production and validation of a patented exoskeleton was presented by comparing virtual and 3D printed models.
ACTA POLYTECHNICA HUNGARICA
(2023)
Article
Engineering, Biomedical
Harutyun Sarkisyan, Randy Stevens, Vakhtang Tchantchaleishvili, Joseph Rossano, Amy Throckmorton
Summary: The study presents a magnetically suspended, versatile pumping technology for pediatric heart failure patients. Through design, optimization, and testing, the feasibility and effectiveness of this new technology have been demonstrated.
Article
Biology
Christoph Gross, Kamen Dimitrov, Julia Riebandt, Dominik Wiedemann, Guenther Laufer, Heinrich Schima, Francesco Moscato, Michael C. Brown, Abhijit Kadrolkar, Robert W. Stadler, Daniel Zimpfer, Thomas Schloeglhofer
Summary: This study found that an adaptive pump power-tracking algorithm can improve therapy for patients implanted with a centrifugal LVAD, particularly in preventing pump thrombosis.
Article
Biophysics
Shreyas Sarfare, M. D. Shujan Ali, Alan Palazzolo, Mark Rodefeld, Tim Conover, Richard Figliola, Guruprasad Giridharan, Richard Wampler, Edward Bennett, Artem Ivashchenko
Summary: This study simulated and compared the fluid dynamics of Fontan CPAD, finding that traditional VAD RANS models have some issues, and recommending the use of LES for the final design simulations.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Engineering, Biomedical
Anna Joong, Katsuhide Maeda, David M. Peng
Summary: Data on the outcomes of ventricular assist device (VAD) in infants with stage 1 single ventricle (SV) palliation are limited. This study examined the outcomes of SV patients undergoing VAD implantation between March 2018 and October 2020. The results showed that stage 1 SV patients have high preimplant illness severity and experience significant morbidity and mortality postimplant.
Article
Cardiac & Cardiovascular Systems
Joseph Philip, Emma Powers, Desiree Machado, Dalia Lopez Colon, Dipankar Gupta, Renata Shih, Mohammad Ebraheem, Curt Fudge, Mark Bleiweis
Summary: This retrospective study describes successful use of paracorporeal pulsatile VADs in high-risk single ventricle patients before or after the first stage of palliation, showing it as a feasible bridge-to-transplant option. Patients implanted with Berlin Heart EXCOR VAD were early implanted with good survival outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Chemistry, Analytical
Ivona Voracova, Jan Prikryl, Jakub Novotny, Vladimira Datinska, Jaeyoung Yang, Yann Astier, Frantisek Foret
Summary: A new electrophoretic technique has been introduced using 3D printing to create rigid stabilizing manifolds for minimizing liquid flow during separation processes. The device can concentrate analytes from 3 or 4 mL of sample to 150 mu L or less, with an enrichment factor ranging from 20 to 27. Concentration times varied from 15 to 25 minutes, depending on the stabilization media and power used.
ANALYTICA CHIMICA ACTA
(2021)
Article
Cardiac & Cardiovascular Systems
Taylor Merritt, Avihu Z. Gazit, Horacio Carvajal, Brock K. Montgomery, Mark Shepard, Mary Mehegan, Matthew Canter, Jacob Miller, Pirooz Eghtesady, Dilip S. Nath
Summary: The study outlines the experience of supporting 18 children with single ventricle (SV) physiology on ventricular assist devices (VADs), showing successful bridging to desired endpoints with proper patient selection and specific cannulation strategies.
ANNALS OF THORACIC SURGERY
(2022)
Review
Materials Science, Multidisciplinary
Louis van der Elst, Camila Faccini de Lima, Meve Gokce Kurtoglu, Veda Narayana Koraganji, Mengxin Zheng, Alexander Gumennik
Summary: Recent advancements in additive manufacturing have allowed for the redesigning of material morphology on nano-, micro-, and meso- scales to enhance functionality on the macro-scale. This technology is being used in various scientific and technological areas, from non-planar electronic circuits to personalized shoe soles. Fiber-device technology is currently undergoing a transformation, with 3D printing enabling the redesign and enhancement of material properties for desired functionalities.
ADVANCED FIBER MATERIALS
(2021)
Article
Engineering, Biomedical
Bryan C. Good, Sailahari V. Ponnaluri, William J. Weiss, Keefe B. Manning
Summary: Computational fluid dynamics modeling of the Penn State Fontan Circulatory Assist Device (FCAD) shows promising results in terms of hemolysis and thrombosis resistance, supporting its potential for successful application in long-term mechanical support for failing Fontan patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin D. Holland, Seth Lee, Harrison Kim
Summary: A cost-effective, easy-to-use, and reliable prototype of an MRI-compatible syringe pump was developed, which can deliver liquid agents to multiple subjects inside a clinical MRI bore during a scan.
Article
Surgery
Pierre-Emmanuel Noly, Xiaoting Wu, Hechuan Hou, Kathleen L. Grady, James W. Stewart, Robert B. Hawkins, Guangyu Yang, K. Dennie Kim, Min Zhang, Lourdes Cabrera, Keith D. Aaronson, Francis D. Pagani, Donald S. Likosky
Summary: This study evaluates a new performance metric, days alive and out of hospital (DAOH), for patients undergoing durable left ventricular assist device (LVAD) therapy. The results show significant variability in the percentage of DAOH within a year after LVAD implantation, and this metric is associated with the cumulative burden of adverse events.
Article
Engineering, Biomedical
Sarah E. Fahnhorst, Katie Brandewie, Tanya Perry, Alexander R. Opotowsky, Adam M. Lubert, Angela Lorts, David L. S. Morales, Chet R. Villa
Summary: This study retrospectively reviewed the use of durable, continuous flow single ventricular assist device (SVAD) therapy in Fontan circulatory failure patients. The findings suggest that continuous flow SVAD therapy can be effective for patients with Fontan circulatory failure and systolic dysfunction, serving as a bridge to candidacy or temporary support before transplantation.
Article
Engineering, Biomedical
Barbara Karner, Andreas Escher, Therese Schorn, Krishnaraj Narayanaswamy, Joerg Sachweh, Guenther Laufer, Michael Huebler, Daniel Zimpfer, Marcus Granegger
Summary: This study aimed to assess the anatomical compatibility of proposed device designs in Fontan patients. The results showed that a single-outlet design may provide intracorporeal cavopulmonary MCS to a broad spectrum of failing Fontan patients.
Article
Cardiac & Cardiovascular Systems
Kamen Dimitrov, Alexandra Kaider, Philipp Angleitner, Thomas Schloeglhofer, Christoph Gross, Dietrich Beitzke, Marcus Granegger, Julia Riebandt, Dominik Wiedemann, Sigrid Sandner, Anne-Kristin Schaefer, Heinrich Schima, Gunther Laufer, Daniel Zimpfer
Summary: This study reviewed the institutional experience with outflow graft stenosis in three contemporary left ventricular assist devices. It found that outflow graft stenosis is a rare but potentially lethal complication, which preferably occurs in the covered portions of the graft. Modifications to pump design and implant techniques may be necessary.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Engineering, Biomedical
Thomas Schloeglhofer, Philipp Aigner, Marcel Migas, Dietrich Beitzke, Kamen Dimitrov, Franziska Wittmann, Julia Riebandt, Marcus Granegger, Dominik Wiedemann, Guenther Laufer, Francesco Moscato, Heinrich Schima, Daniel Zimpfer
Summary: This study found that IC malposition derived from standard chest X-rays serves as a risk factor for neurological dysfunction, ischemic stroke, and worse survival in HM3 patients.
Article
Engineering, Biomedical
Andreas Escher, Henrike Goebel, Marcel Nicolai, Thomas Schloeglhofer, Emanuel J. Hubmann, Gunther Laufer, Barbara Messner, Ulrich Kertzscher, Daniel Zimpfer, Marcus Granegger
Summary: This study compared the hemolytic profiles of two different models of rotodynamic blood pumps under different operating conditions. The results showed that an increase in pump speed was associated with increased hemolysis, while low flow conditions resulted in higher levels of hemolysis compared to high flow conditions. Computational fluid dynamics analysis revealed a correlation between hydraulic losses and hemolysis. However, predicting the clinical impact of different operating conditions using current hemolysis metrics is difficult.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Ecology
Timm A. Wild, Martin Wikelski, Stephen Tyndel, Gustavo Alarcon-Nieto, Barbara C. Klump, Lucy M. Aplin, Mirko Meboldt, Hannah J. Williams
Summary: Biologging devices are used to collect ultra-fine-scale movement data on animals, but there are limitations on collecting different types of data simultaneously. This study uses Wi-Fi as a solution, combined with smart software, to improve the efficiency of biologging data retrieval.
METHODS IN ECOLOGY AND EVOLUTION
(2023)
Article
Engineering, Biomedical
Kai Petersdorff-Campen, Matthias A. Dupuch, Konstantinos Magkoutas, Mirko Meboldt, Christofer Hierold, Marianne Schmid Daners
Summary: This study demonstrates the integration of pressure sensors into a ventricular assist device, allowing continuous and accurate measurement of left ventricular pressure. The developed sensor model improves measurement accuracy by eliminating the influence of flow inside the device. This has significant implications for the validation of physiological control concepts in vivo.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Leonie Korn, Seraina Dual, Joeran Rixen, Mirko Meboldt, Steffen Leonhardt, Marianne Schmid Daners, Marian Walter
Summary: The study aimed to integrate ultrasound and impedance volume measurement techniques, overcoming the need for recalibration in single sensor modality. Results showed that the dual-modality approach provided high accuracy and robustness in ventricular volume measurement, indicating its potential clinical significance in monitoring heart failure patients with VADs.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Marcus Granegger, Christoph Gross, David Siemer, Andreas Escher, Sigrid Sandner, Martin Schweiger, Guenther Laufer, Daniel Zimpfer
Summary: Successful therapy of heart failure with preserved ejection fraction remains a major clinical need. This study evaluated the hemodynamic effects of four device-based treatment approaches. The findings suggest that all four therapies can reduce left atrial pressure and improve cardiac function, but individualized treatment plans are required for different patient populations.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Thomas Schloeglhofer, Franziska Wittmann, Robert Paus, Julia Riebandt, Anne-Kristin Schaefer, Philipp Angleitner, Marcus Granegger, Philipp Aigner, Dominik Wiedemann, Gunther Laufer, Heinrich Schima, Daniel Zimpfer
Summary: Right heart failure (RHF) is a severe complication after left ventricular assist device (LVAD) implantation. This study analyzed the incidence, risk factors, and biomarkers for late RHF. The use of HVAD, lower heart rate, and higher central venous pressure were identified as independent risk factors for RHF following LVAD implantation.
Article
Multidisciplinary Sciences
Andreas Escher, Emanuel Johannes Hubmann, Barbara Karner, Barbara Messner, Gunther Laufer, Ulrich Kertzscher, Daniel Zimpfer, Marcus Granegger
Summary: This study applies computational fluid dynamics to analyze the hydraulic energy dissipation in rotodynamic blood pumps (RBPs) and compares it with hemolysis performance. The results show a strong correlation between hydraulic energy dissipation and hemolysis, which can be described as a function of shear stresses and exposure time.
ADVANCED THEORY AND SIMULATIONS
(2022)
Article
Engineering, Manufacturing
Urs Hofmann, Matthias Fankhauser, Simon Willen, Dario Inniger, Christoph Klahn, Kaspar Loeffel, Mirko Meboldt
Summary: This paper presents an industrial case study of an additively manufactured hydraulic spool valve designed in collaboration with Wandfluh AG. The redesign of a conventional valve resulted in a 60% reduction in pressure drop and a 50% weight reduction. The study concludes by highlighting the importance of generating a variety of concepts and conducting computational fluid dynamics simulations.
VIRTUAL AND PHYSICAL PROTOTYPING
(2023)
Article
Computer Science, Cybernetics
Felix S. S. Wang, Thomas Kreiner, Alexander Lutz, Quentin Lohmeyer, Mirko Meboldt
Summary: This study presents a new Peripheral Vision-Based HMM (PVHMM) classification framework for egocentric action recognition, which utilizes context-rich and object-related gaze features. The framework achieves high classification performances in a safety-critical medical device handling task sequence and surpasses an image-based classification model. The gaze-enhanced PVHMM shows potential for implementation in real-world applications involving action sequence-dependent tasks.
USER MODELING AND USER-ADAPTED INTERACTION
(2023)
Article
Engineering, Manufacturing
Aschraf N. Danun, Remo Elmiger, Fabio Leuenberger, Luca Niederhauser, Jan Szlauzys, Lorin Fasel, Mirko Meboldt
Summary: Micro-additive manufacturing techniques can create monolithic, compliant mechanisms with micro-sized free-form structures for minimally invasive surgical instruments. These mechanisms can be tailored to fit patient-specific surgical procedures by converting user-specified curves into shape-programmable structures using an algorithmic-based computational workflow. The mechanisms are manufactured using micro-laser powder bed fusion and 17-4 PH stainless steel.
VIRTUAL AND PHYSICAL PROTOTYPING
(2023)
Proceedings Paper
Computer Science, Cybernetics
Felix Sihan Wang, Quentin Lohmeyer, Andrew Duchowski, Mirko Meboldt
Summary: In mobile eye-tracking, fixation-based measures are commonly used to evaluate visual attention, but there is little research on quantifying peripheral vision. This work enhances traditional mapping methods with near-peripheral information and presents a novel machine learning-based gaze measure, the visual attention index (VAI), for visual attention analysis using dynamic stimuli. Results from two multi-object mobile eye tracking cases are discussed and visualized using radar graphs. The VAI shows effectiveness in comparing visual attention across various tasks, trials, and subjects, providing new possibilities for a more realistic and detailed depiction of visual attention in multi-object tasks.
ACM SYMPOSIUM ON EYE TRACKING RESEARCH & APPLICATIONS, ETRA 2023
(2023)
Article
Acoustics
Emil Heyden, Urs Hofmann, Mirko Meboldt, Dieter Krause
Summary: This publication presents the development of a compact and adjustable hydraulic damper that fulfills the requirements for vibration testing. Existing dampers from literature fail to meet all the requirements, including compact design, vibration resistance, high strength, adjustable and symmetrical damping, and modularity. By utilizing additive manufacturing technology, an additively manufactured damper is created that compensates for the shortcomings of known dampers. The final damper is more compact and requires fewer components. It has been tested under various conditions and demonstrates reliable damping performance even under high loads, making it suitable for other vibration-prone systems.
JOURNAL OF LOW FREQUENCY NOISE VIBRATION AND ACTIVE CONTROL
(2023)
Article
Engineering, Biomedical
Julian Wolf, Dietmar Luchmann, Quentin Lohmeyer, Mazda Farshad, Philipp Furnstahl, Mirko Meboldt
Summary: This study compares five different configurations of augmented reality visualizations for assisting surgeons in placing pedicle screws in spinal fusion surgery. The results show that two of the visualizations resulted in lower trajectory deviations and better user experience.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
