Article
Medicine, Research & Experimental
Dong Xiang, Jinyu Yang, Yanjiao Xu, Lulu Lan, Guodong Li, Chengliang Zhang, Dong Liu
Summary: Estrogen cholestasis induces liver inflammation and oxidative stress, while also increasing cell apoptosis in both the liver and intestine. It activates the NF-κB signaling pathway in the liver, and PI3K/Akt and MAPK signaling pathways in both gut and liver. Understanding EC-induced gut and liver injury may help in developing new therapeutic strategies.
Article
Food Science & Technology
Tian Jin, Yong Zhang, Benson O. A. Botchway, Jian Zhang, Ruihua Fan, Yufeng Zhang, Xuehong Liu
Summary: Curcumin has neuroprotective effects in Parkinson's disease by activating the BDNF and PI3K/Akt signaling pathways, thereby delaying the progression of the disease.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Heng Yin, Zhicai Zuo, Zhuangzhi Yang, Hongrui Guo, Jing Fang, Hengmin Cui, Ping Ouyang, Xia Chen, Jian Chen, Yi Geng, Zhengli Chen, Chao Huang, Yanqiu Zhu
Summary: Nickel, a widely distributed metal and important environmental pollutant, induces autophagy in kidneys and causes renal injury via the PI3K/AKT/mTOR and AMPK pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Yan Sun, Huan Zhang, Junpeng Meng, Feng Guo, Dianyun Ren, Heshui Wu, Xin Jin
Summary: This study demonstrates that aberrant PCSK9 upregulation promotes cell proliferation and sorafenib resistance in HCC by inducing AKT activation. Additionally, competitive inhibition of PCSK9 palmitoylation enhances the antitumor effects of sorafenib in HCC.
Article
Pharmacology & Pharmacy
Lingyu Li, Jing Li, Hui Chen, Yajun Shen, Yunping Lu, Min Zhang, Xiaofei Tang
Summary: This study investigated the roles and mechanisms of AZOX in oral leukoplakia (OLK) using network pharmacology and experimental validation. The results showed that AZOX may induce apoptosis in OLK through the PI3K/AKT and MAPK pathways. This study reveals the potential therapeutic targets of AZOX in OLK.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yonggang Xu, Rong Fang, Jie Shao, Zihao Cai
Summary: Erianin inhibits the proliferation of TNBC cells and induces cell cycle arrest and apoptosis by suppressing the activation of the PI3K/Akt pathway.
BIOSCIENCE REPORTS
(2021)
Article
Environmental Sciences
Lei Li, Yunhui Xia, Junhan Chen, Xiaodong Han, Lanxiang Hao, Dongmei Li, Yanmei Liu
Summary: This study aimed to assess the impact of DBP exposure on the thyroid of male rats and the associated mechanisms. The results demonstrated that DBP exposure caused impaired thyroid structure and thyroid inflammation in male rats. Furthermore, RB1 was found to play an essential role in promoting the activation of NLRP3 inflammasome.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Yun Hee Jeong, Tae In Kim, You-Chang Oh, Jin Yeul Ma
Summary: The ethanol extract of Selaginella tamariscina (STE) has been found to exhibit neuroprotective effects by reducing oxidative stress and inhibiting autophagic cell death induced by glutamate in HT22 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Shiqing Jiang, E. Zhang, Hang Ruan, Jiahui Ma, Xingming Zhao, Yaoyao Zhu, Xiaoyu Xie, Ningning Han, Jianjiang Li, Hao Zhang, Weidong Xie, Xia Li
Summary: Actinomycin (Act) V induces apoptosis in colorectal cancer cells via mitochondrial dysfunction and inhibition of the PI3K/AKT pathway, presenting a potential targeted therapy option for CRC.
Article
Medicine, General & Internal
Mingyan Yao, Jing Zhang, Zhihong Li, Xiaoliang Bai, Jinhui Ma, Yukun Li
Summary: The study demonstrates that liraglutide can protect nucleus pulposus cells from high glucose-induced apoptosis by activating the PI3K/AKT/mTOR/caspase-3 and PI3K/AKT/GSK3 beta/caspase-3 signaling pathways.
FRONTIERS IN MEDICINE
(2021)
Article
Plant Sciences
Bo Fang, Soeun Kim, Yebon Kim, Yinda Qiu, Chang-Min Lee, Yinshuang Lai, Zhiguo Liu, Kun Wang, Namki Cho
Summary: The pharmacological effect of 1-methoxyerythrabyssin II, a compound found in the roots of Lespedeza bicolor, on leukemic cells was evaluated using a network pharmacology strategy. It was found that 1-methoxyerythrabyssin II inhibits cell proliferation in a concentration-dependent manner, with a higher potency against human acute leukemia T cells. The compound induces cell cycle arrest and autophagy, and its mechanism of action involves the inhibition of the PI3K/Akt/mTOR pathway. This discovery provides potential targets for the development of novel therapeutics against leukemia.
Article
Chemistry, Medicinal
Xin Yang, Long Wang, Jing Zeng, Anguo Wu, Mi Qin, Min Wen, Ting Zhang, Wang Chen, Qibing Mei, Dalian Qin, Jing Yang, Yu Jiang, Jianming Wu
Summary: This study demonstrates that CPM may be a promising thrombopoietic agent for treating chemotherapy and radiation-induced thrombocytopenia.
Article
Cell Biology
Fan Cui, Xin He
Summary: In this study, it was demonstrated that IGF-1 could protect pancreatic beta cells treated with STZ by enhancing cell viability, suppressing apoptosis, increasing insulin secretion, reducing oxidative damage, and inhibiting glycolysis. These effects may be achieved through the activation of the IRS1/PI3K/Akt/FOXO1 pathway.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Yan-Lin Chen, De-Yi Yan, Chen-Yu Wu, Jiang-Wei Xuan, Chen-Qiang Jin, Xin-Li Hu, Guo-Dong Bao, Yu-Jie Bian, Zhi-Chao Hu, Zhong-Hai Shen, Wen-Fei Ni
Summary: OA is characterized by destruction of articular cartilage and inflammation plays a key role in its progression. Maslinic acid (MA) from olive fruit has been shown to have anti-inflammatory effects. In in vitro and in vivo experiments, MA was found to attenuate inflammatory mediators and inhibit the progression of OA disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Plant Sciences
Xiao-chen Li, Shuai Wang, Xin-xin Yang, Tian-jiao Li, Jia-xing Gu, Lin Zhao, Yong-rui Bao, Xian-sheng Meng
Summary: This study aimed to investigate the treatment of colorectal cancer (CRC) using Patrinia villosa Juss. (P.V) and clarify its underlying mechanism. The results from animal models showed that P.V can reduce tumor number and diameter, improve colon cell injury, and decrease levels of CRC biomarkers. Metabolomics analysis revealed changes in endogenous metabolites, indicating that P.V modulates the glycerol phospholipid metabolites closely related to the PI3K target and PI3K/Akt signaling pathway for CRC treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Jingli Li, Hao Yuan, Mingming Xu, Fenglan Tian, Zijian Wang, Junyue Ren
Summary: This paper focuses on the establishment and application of arc models, and analyzes the influence of arc length on arc characteristics. By introducing dynamic arc length consideration into the improved Schwarz model, the accuracy of the model is improved, and its effectiveness is verified through comparison with other models.
JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY
(2023)
Review
Clinical Neurology
Duan Sun, Weishi Liang, Yong Hai, Peng Yin, Bo Han, Jincai Yang
Summary: The study compared the clinical and radiological outcomes of OLIF and ALIF for treating lumbar degenerative diseases. The results showed no significant difference in disc height, segmental lordosis angle, lumbar lordosis, VAS score, and ODI between the two groups. Operation time, blood loss, and hospital stay were comparable. Both groups achieved over 90% fusion rate, but OLIF had a higher complication rate, particularly cage subsidence. In conclusion, OLIF and ALIF are both effective treatments with similar therapeutic effects, but ALIF may be more costly for patients due to the involvement of vascular surgeons.
EUROPEAN SPINE JOURNAL
(2023)
Article
Surgery
Xi-Nuo Zhang, Li-Jin Zhou, Qing-Jun Su, Li Guan, Dong-Yue Li, Bao-Qing Pei, Ai-Xing Pan, Hong-Hao Yang, Hong-Tao Ding, Yu-Zeng Liu, Yong Hai
Summary: This study evaluated the accuracy of cortical bone trajectory screw placement guided by spinous process clamp. Using 8 lumbar specimens, a total of 96 screws were implanted. The results showed that the SPC guide group had higher clinically acceptable placement and reduced severe deviations in important directions. Therefore, implanting CBT screws guided by SPC can improve surgical accuracy.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Article
Mechanics
Lu Jin, Yong Chen, Xu Tang, Jiguo Zhang, Zijian Wang
Summary: The design of tapered composite fan blades with increased thickness near the root helps carry the load, but also introduces material and geometric discontinuities that can lead to interlayer stresses and damage initiation. A study using high-fidelity finite element modeling and a constitutive equation found that the maximum damage index occurs at the ply interface and resin pocket of the laminates. Static damage and weak-link index assessment were proposed to predict the location of fatigue damage. The study also found that fatigue crack growth rates are sensitive to cyclic loading at the first natural frequency and the weak-link zone appears in the crack growth area.
COMPOSITE STRUCTURES
(2023)
Article
Orthopedics
Yunsheng Wang, Yong Hai, Nan Kang, Jincai Yang, Qingjun Su, Yuzeng Liu, Li Guan, Xianglong Meng
Summary: This study evaluates the long-term outcomes of using dual growing rods to treat severe early-onset scoliosis. The results show that the treatment is effective in improving spinal curvature and pulmonary function in patients with severe early-onset scoliosis.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Engineering, Civil
Bin Zhang, Yuanfu Zhou, Xuefu Zhang, Zijian Wang, Wei Yang, Yixuan Ban
Summary: This study investigated the diffusion shape and the relation between diffusion radius and time of grouting in tunnel lining cracks. The diffusion equation of grouting in lining cracks was established, and the correlation between experimental and calculated values was analyzed. The results showed that the diffusion shape in tunnel lining cracks can be categorized into circular, excessive, and elliptical zones, and the diffusion equation accurately describes the relationship between diffusion radius and time. These findings provide a theoretical basis for predicting diffusion radius in grouting repair for tunnel lining cracks.
KSCE JOURNAL OF CIVIL ENGINEERING
(2023)
Review
Cell Biology
Zhangfu Li, Honghao Yang, Yong Hai, Yunzhong Cheng
Summary: Intervertebral disc degeneration (IDD) is a major cause of back, neck, and radicular pain, and is associated with changes in tissue structure and function. Inflammatory mediators have been identified as playing a crucial role in IDD and are being investigated as potential treatment targets.
MEDIATORS OF INFLAMMATION
(2023)
Article
Veterinary Sciences
Jie Wang, Xiaojie Zhu, Zijian Wang, Yingyu Chen, Ian D. Robertson, Aizhen Guo, Joshua W. Aleri
Summary: The prevalence and antimicrobial resistance of Salmonella and ESBL-producing E. coli in healthy lactating dairy cows in Hubei Province, China was investigated in this study. Salmonella was found in 5.2% of sampled cows, with a herd prevalence of 20.0%. ESBL E. coli was detected in all farms, with an animal level prevalence of 59.1% and more than 104 CFU/g of feces. These findings provide valuable information for controlling Salmonella in Hubei Province.
PREVENTIVE VETERINARY MEDICINE
(2023)
Review
Medicine, General & Internal
Honghao Yang, Jixuan Huang, Yong Hai, Zhexuan Fan, Yiqi Zhang, Peng Yin, Jincai Yang
Summary: This study compared the outcomes of posterior cervical decompression and fusion (PCF) terminating at the lower cervical spine and crossing the cervicothoracic junction (CTJ). The results showed that terminating at the lower cervical spine was associated with fewer wound-related complications, lower reoperation rate for wound-related complications, and less neck pain at the final follow-up. However, it also had a higher incidence of overall adjacent segment disease and hardware failure. The operating time and estimated blood loss were shorter when the PCF construct did not cross the CTJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Honghao Yang, Aixing Pan, Yong Hai, Fengqi Cheng, Hongtao Ding, Yuzeng Liu
Summary: This study compared the biomechanical performance of combining multiple pelvic screws and multirod construct to other advanced sacropelvic fixation constructs for the augmentation of lumbosacral junction in long spinal fusion surgery through finite element analysis. The results showed that both multiple pelvic screws and multirod construct could increase the mechanical stability of lumbosacral junction and reduce stress on instrumentation, cages, S1 superior endplate, and sacrum. The MS-MR construct was the most adequate to reduce the risk of lumbosacral pseudarthrosis, implant failure, and sacrum fracture. This study provides important evidence for the application of MS-MR construct in clinical settings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Clinical Neurology
Yihan Yang, Weishi Liang, Duan Sun, Bo Han, Peng Yin, Yuehong Sun, Yong Hai
Summary: This study found that stretching-based exercises can partially correct scoliosis and thoracic hyperkyphosis, reduce pain, and improve quality of life. However, the optimal duration of stretching exercises remains to be determined.
WORLD NEUROSURGERY
(2023)
Article
Mathematics, Applied
Zijian Wang, Xinhui Shao
Summary: This article presents a new type of automated statement proof algorithm that is generalized, self-evolving, and efficient, using new data structures (brackets and map graphs) and algorithms. The brackets structure provides a concise representation of mathematical concepts, while the map graphs enable the computer to learn while proving using an efficient machine-learning method. Additionally, the algorithm is based entirely on category theory. Finally, a prototype of the program is introduced and its performance examined.
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Plant Sciences
Han Zhang, Yige Cao, Zijian Wang, Meixia Ye, Rongling Wu
Summary: Shade avoidance syndrome (SAS) is important for plants to increase light capture in dense stands, but the genetic basis of developmental variation in leaves related to leaf area, petiole length, and leaf length remains unresolved.
Article
Veterinary Sciences
Huitian Gou, Qihang Cao, Zijian Wang, Yuanyuan Liu, Yanan Sun, Huiling Wei, Chen Song, Changqing Tian, Yanquan Wei, Huiwen Xue
Summary: This study used transcriptomics to analyze differential gene expression between biofilm and planktonic bacteria at different stages of biofilm formation and growth in Listeria monocytogenes. They identified a significant number of differentially expressed genes and demonstrated changes associated with various biological processes and pathways. The expression of the top upregulated and downregulated genes was validated through real-time quantitative polymerase chain reaction. These findings lay the foundation for further research on biofilm formation mechanisms and the development of biofilm inhibitors to reduce LM infection risk.
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2023)
