Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice

Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes

(2015) Aixin Yu et al.   DIABETES

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients

(2015) Michelle Rosenzwajg et al.   JOURNAL OF AUTOIMMUNITY

Extension of the CD4+Foxp3+CD25−/low regulatory T-cell subpopulation in type 1 diabetes mellitus

(2014) András Zóka et al.   AUTOIMMUNITY

Surge in regulatory cells does not prevent onset of hyperglycemia in NOD mice

(2013) Ayelet Kaminitz et al.   AUTOIMMUNITY

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

(2013) Madhav D. Sharma et al.   IMMUNITY

OX40L/Jagged1 Cosignaling by GM-CSF-Induced Bone Marrow-Derived Dendritic Cells Is Required for the Expansion of Functional Regulatory T Cells

(2013) A. Gopisetty et al.   JOURNAL OF IMMUNOLOGY

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

MHC Class II Tetramers

(2012) G. T. Nepom   JOURNAL OF IMMUNOLOGY

Central Role for Interleukin-2 in Type 1 Diabetes

(2011) M. A. Hulme et al.   DIABETES

Science gone translational: the OX40 agonist story

(2011) Andrew D. Weinberg et al.   IMMUNOLOGICAL REVIEWS

Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment

(2011) Damien Bresson et al.   JOURNAL OF AUTOIMMUNITY

Detection of   cell death in diabetes using differentially methylated circulating DNA

(2011) E. M. Akirav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An update on the use of NOD mice to study autoimmune (Type 1) diabetes

(2010) Rodolfo José Chaparro et al.   Expert Review of Clinical Immunology

OX40 is required for regulatory T cell–mediated control of colitis

(2010) Thibault Griseri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms

(2010) Palash Bhattacharya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

(2009) D. Q. Tran et al.   BLOOD

Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function

(2009) Donald Cheatem et al.   CLINICAL IMMUNOLOGY

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right

(2009) C. E. Ruby et al.   JOURNAL OF IMMUNOLOGY

Fc-mOX40L Fusion Protein Produces Complete Remission and Enhanced Survival in 2 Murine Tumor Models

(2009) Rebecca E. Sadun et al.   JOURNAL OF IMMUNOTHERAPY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Strategies for Treating Autoimmunity

(2008) Matthew N. Meriggioli et al.   Annals of the New York Academy of Sciences

Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis

(2008) Jian Rong Sheng et al.   CLINICAL IMMUNOLOGY

Insulin as an autoantigen in NOD/human diabetes

(2008) Li Zhang et al.   CURRENT OPINION IN IMMUNOLOGY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Disruption of the homeostatic balance between autoaggressive (CD4+ CD40+ ) and regulatory (CD4+ CD25+ FoxP3+ ) T cells promotes diabetes

(2008) Dan M. Waid et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-2 signaling and CD4+CD25+Foxp3+ regulatory T cells

(2007) Laurence et al.   Frontiers in Bioscience-Landmark