Article
Food Science & Technology
Kirinde Gedara Isuru Sandanuwan Kirindage, Arachchige Maheshika Kumari Jayasinghe, Eui-Jeong Han, Hee-Jin Han, Kil-Nam Kim, Lei Wang, Soo-Jin Heo, Kyung-Sook Jung, Ginnae Ahn
Summary: The study investigated the potential anti-inflammatory effects of PFF-A in TNF-alpha/IFN-gamma-stimulated HaCaT keratinocytes and an acute ear edema mice model. The results showed that PFF-A had a dose-dependent cytoprotective effect and downregulated the expression of inflammatory cytokines and chemokines. Additionally, PFF-A inhibited NFicB/MAPK signaling and activated Nrf2/HO-1 signaling. Furthermore, PFF-A treatment reduced ear thickness and expression of inflammatory mediators in the mice model.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Seong-Lae Jo, Hyun Yang, Kang-Joo Jeong, Hye-Won Lee, Eui-Ju Hong
Summary: Inflammation is a natural defense mechanism, but chronic inflammation can lead to various chronic diseases. Neuroinflammation in the central nervous system is important in the development of neurodegenerative diseases. Polyphenol-rich natural products, such as Ecklonia cava, have anti-inflammatory and antioxidant properties and can be used to control neuroinflammation in the treatment of neurodegenerative diseases. In this study, we found that Ecklonia cava extract can reduce the levels of pro-inflammatory cytokines and markers of inflammation and neurodegeneration in mice with chronic inflammation induced by lipopolysaccharide.
Article
Chemistry, Applied
Jong Jin Park, Won Young Lee
Summary: This study developed efficient adsorption and desorption processes for purifying phenolic compounds from Ecklonia cava, with HP2MG resin showing the highest adsorption and desorption capacities. The thermodynamic parameters indicated that the absorption process was physically driven. The purified extract showed significantly increased levels of dieckol and phlorofucofuroeckol-A, as well as higher anti-glycation and antioxidant activities.
Article
Chemistry, Medicinal
Jun-Geon Je, Yunfei Jiang, Jun-Ho Heo, Xining Li, You-Jin Jeon, Bo-Mi Ryu
Summary: This study evaluated the anti-melanogenic effects of PFF-A derived from Ecklonia cava, showing that low doses of PFF-A can suppress pigmentation in vivo and melanogenesis in vitro. This suggests the potential use of PFF-A as a new anti-melanogenic agent in the cosmeceutical industries.
Article
Biochemistry & Molecular Biology
Wei Zhang, Eun-Koung An, Hae-Bin Park, Juyoung Hwang, Yadav Dhananjay, So-Jung Kim, Hee-Yun Eom, Tatsuya Oda, Minseok Kwak, Peter Chang-Whan Lee, Jun-O Jin
Summary: The study found that Ecklonia cava fucoidan (ECF) had the strongest effect on activating NK cells in mice, increasing the number of NK cells in the spleen and promoting NK cell activation by affecting dendritic cells. ECF treatment also effectively prevented infiltration of cancer cells in the lungs of mice, demonstrating its potential to enhance NK cell-mediated anti-cancer immunity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Hyunjun Woo, Min-Kyung Kim, Sohyeon Park, Seung-Hee Han, Hyeon-Cheol Shin, Byeong-gon Kim, Seung-Ha Oh, Myung-Whan Suh, Jun-Ho Lee, Moo-Kyun Park
Summary: Noise exposure is a well-known cause of hearing loss, and compounds like PFF-A and dieckol have been found to have antioxidant properties that can alleviate the adverse effects of noise exposure in mice.
Article
Food Science & Technology
Hyo-Geun Lee, Thilina U. Jayawardena, Kyung-Mo Song, Yun-Sang Choi, You-Jin Jeon, Min-Cheol Kang
Summary: Fucoidan from marine algae, specifically Ecklonia cava, has been found to have anti-obesity effects. The purified fucoidan fractions from Ecklonia cava showed significant reductions in lipid accumulation in fat cells, both in vitro and in high-fat diet-induced obese mice. Oral administration of Ecklonia cava extract led to reduced body weight, serum lipid content, and white adipose tissue mass. These findings suggest that Ecklonia cava extract and its fucoidan fractions can be used as anti-obesity ingredients in the food and nutraceutical industries.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biology
Chen Tao, Jia Liu, Ziqi Li, Pinglin Lai, Sheng Zhang, Jiankun Qu, Yujin Tang, Anling Liu, Zhipeng Zou, Xiaochun Bai, Jianwei Li
Summary: The role and mechanism of DNA methylation in osteogenesis/chondrogenesis are still unclear. This study reveals that DNA methyltransferase 1 (DNMT1) is overexpressed in sponge bone of people and mice with senile osteoporosis, and it suppresses the osteoblast differentiation of mesenchymal stem cells (MSCs) and osteoprogenitors. Depletion of DNMT1 leads to demethylation at the promoters of key osteogenic genes and transcriptional upregulation. DNMT1 binds to the promoters of these genes and is responsible for their 5-mc methylation. RORA or Fgfr2 may play crucial roles in modulating osteogenic differentiation downstream of DNMT1.
Article
Chemistry, Medicinal
Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Hyun-Jin Kim, Ho Jin Heo
Summary: The study found that water extract from Ecklonia cava has significant preventive effects on neurotoxicity induced by PM2.5, improving cognitive dysfunction by inhibiting inflammatory responses and oxidative damage.
Article
Chemistry, Multidisciplinary
Hyun Yang, Hye Jin Kim, Hye Won Lee
Summary: The study showed that Ecklonia cava extract can inhibit bone loss and depressive symptoms in a menopausal mouse model by modulating bone metabolism markers and serotonin levels.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Ning Zhao, Jiaci Shi, Ming Li, Pengcheng Xu, Xuefeng Wang, Xinxin Li
Summary: We developed an electrochemical sensor based on three-dimensional graphene networks (3DGNs) for efficient detection of alkaline phosphatase (ALP) activity. The sensor showed a quick response, cost-effectiveness, and non-destructiveness, making it promising for monitoring living adherent osteoblast cell activity and quantifying ALP in other biological systems and clinical samples.
Article
Food Science & Technology
Hyung Jin Lim, Chi-Heung Cho, Sang-Hoon Lee, Yeong Seon Won, Seon Gyeong Bak, Mingyeong Kim, Sera Kim, Minseok Yoon, Hyun Joo Ha, Ji Tae Jang, Seung Jae Lee
Summary: Menopause is the cessation of a woman's menstrual cycle due to reduced secretion of estrogen and progesterone, resulting in various symptoms such as hot flushes, sleep difficulties, depression, and osteoporosis. Hormone replacement therapy and nonhormonal therapy are commonly used to manage these symptoms. This study investigated the estrogenic activity of Ecklonia cava extract (ECE) and its therapeutic effects on depression and osteoporosis symptoms in a mouse model of menopause. The results showed that ECE treatment improved depressive symptoms by increasing neurotransmitter levels and ameliorated osteoporosis by enhancing bone microarchitectures and bone mineral density. These findings highlight the potential use of E. cava in managing menopausal symptoms.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Jong Jin Park, Won Young Lee
Summary: The study examined the anti-glycation effects of polysaccharides extracted from Ecklonia cava using different methods such as hot buffer, ultrasound, enzyme, or a combination of ultrasound and enzyme. Results showed that the polysaccharides with higher fucose and galactose compositions, as well as higher sulfate contents, had better inhibition effects on AGE formation. Specifically, the combination of ultrasound and enzyme extraction method showed the highest extraction yield and lowest protein and uronic acid contents, making it a suitable method for obtaining anti-glycation agents from E. cava.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Multidisciplinary
Meng Li, Bhaskar Gurram, Shan Lei, Nicholas T. Blum, Peng Huang, Jing Lin
Summary: Phosphatase is crucial in many biological functions, with alkaline phosphatase (ALP) serving as a key prognostic indicator for various diseases, though current detection methods are limited to in vitro colorimetric techniques. Fluorescence imaging provides a reliable way to monitor real-time changes in ALP levels, with research focusing mainly on ALP imaging probes grouped by their luminescence mechanisms. Challenges and future prospects for phosphatase probes were also discussed.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biotechnology & Applied Microbiology
Dong Mun Choi, Seokwoo Hong, Kwon Mo Yang, Young Wook Ko, Jeong Ha Kim
Summary: This study examined the genetic connectivity of Ecklonia cava populations in the northwest Pacific region and identified two genetic groups based on geographical patterns. The results suggest that gene flow in E. cava is influenced by multiple seascape factors and their interactions at a regional scale.
JOURNAL OF APPLIED PHYCOLOGY
(2023)
Article
Cell & Tissue Engineering
Jung Hwan Oh, Fatih Karadeniz, Jung Im Lee, Youngwan Seo, Chang-Suk Kong
Summary: Ligustrum japonicum fruits and its active compound salidroside exhibit antiosteoporotic effects by enhancing osteoblast formation and inhibiting adipogenesis, suggesting a potential as a source of antiosteoporotic substances.
STEM CELLS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Jung Hwan Oh, Junse Kim, Fatih Karadeniz, Hye Ran Kim, So Young Park, Youngwan Seo, Chang-Suk Kong
Summary: The study found that santamarine is a promising natural antioxidant with anti-photoaging properties, which can combat UVA-induced skin cell damage by inhibiting MMP-1 release and promoting collagen production through multiple mechanisms.
Article
Biochemistry & Molecular Biology
Fatih Karadeniz, Jung Hwan Oh, Hyun Jin Jo, Jiho Yang, Hyunjung Lee, Youngwan Seo, Chang-Suk Kong
Summary: This study reported the anti-adipogenic effect of dracunculin (DCC) in human bone marrow-derived mesenchymal stromal cells (hBM-MSCs). DCC inhibits lipid accumulation and the expression of adipogenic transcription factors. The mechanism of action involves activating the beta-catenin pathway via AMPK. DCC has potential use as a nutraceutical against bone marrow adiposity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jung Hwan Oh, Gi Baeg Nam, Fatih Karadeniz, Chang-Suk Kong, Jaeyoung Ko
Summary: Exposure to UV radiation is the main cause of extrinsic skin aging, also known as photoaging. This study investigated the anti-photoaging properties of Camellia japonica flowers, particularly focusing on the active compound Camellenodiol (CMD), which was found to effectively ameliorate UV-induced collagen deterioration and inhibit MMP-1 production.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2022)
Article
Cell Biology
Fatih Karadeniz, Jung Hwan Oh, Hyun Jin Jo, Youngwan Seo, Chang-Suk Kong
Summary: M3G treatment stimulates osteoblast differentiation and inhibits adipocyte differentiation in hBM-MSCs, respectively through the Wnt/BMP and PPAR gamma pathways. These findings suggest the therapeutic potential of M3G in regulating bone marrow stromal cell differentiation for osteoporosis treatment.
Article
Integrative & Complementary Medicine
Jung Hwan Oh, Fatih Karadeniz, Youngwan Seo, Chang-Suk Kong
Summary: This study found that treatment with hyunganol II (HNG) can inhibit adipogenesis of human bone marrow mesenchymal stromal cells (hBM-MSCs) and is associated with alterations in the MAPK signaling pathway. The findings suggest that HNG may prevent bone marrow adiposity by suppressing hBM-MSC adipogenesis and has potential as a drug or nutraceutical.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fatih Karadeniz, Jung Hwan Oh, Mi Soon Jang, Youngwan Seo, Chang-Suk Kong
Summary: Bone marrow adiposity is a complication in osteoporotic patients, and phytochemicals can alleviate it. This study evaluated the effect of libanoridin on the adipogenic differentiation of bone marrow-derived mesenchymal stromal cells. The results showed that libanoridin inhibited adipogenic differentiation through suppressing MAPK-mediated PPAR gamma signaling. Future studies will further explore the anti-adipogenic effects of libanoridin in vivo and elucidate its action mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Jung Hwan Oh, Fatih Karadeniz, Jung Im Lee, Youngwan Seo, Chang-Suk Kong
Summary: In this study, the protective effects of oleracone C against UVB-induced photoaging in human keratinocytes were investigated. The results showed that oleracone C can reduce the production of reactive oxygen species, reverse the increase in MMPs release, and the decrease in type I procollagen release caused by UVB exposure. Furthermore, oleracone C stimulated collagen production through the TGF-beta signaling pathway.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Xianrong Zhou, Jung Hwan Oh, Fatih Karadeniz, Jiho Yang, Hyunjung Lee, Youngwan Seo, Chang-Suk Kong
Summary: R. rugosa extract and its solvent fractions have a melanogenesis-suppressing effect by downregulating the PKA/CREB signaling pathway, possibly due to their high polyphenol content.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Hyun Jin Jo, Jung Hwan Oh, Fatih Karadeniz, Youngwan Seo, Chang-Suk Kong
Summary: This study investigated the antimelanogenic effects of Cnidium japonicum extract in a mouse melanoma cell model. The results showed that the extract inhibited tyrosinase activity and DOPA oxidation, and suppressed melanin production. The mechanism of action was suggested to be related to the downregulation of specific proteins and the inhibition of certain signaling pathways. The methanol fraction of the extract was found to be the most effective in suppressing the signaling pathway associated with tyrosinase production.
PREVENTIVE NUTRITION AND FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fatih Karadeniz, Jung Hwan Oh, Youngwan Seo, Jiho Yang, Hyunjung Lee, Chang-Suk Kong
Summary: The current study investigated the anti-melanogenic effect of Quercetin 3-O-galactoside (Q3G) and revealed its underlying mechanism of action in B16F10 melanoma cells. Q3G treatment downregulated melanogenesis-related enzymes and transcription factor MITF, inhibited cAMP/PKA and MAPK signaling pathways, and reduced melanin production. These findings suggest that Q3G has potential as a cosmetic ingredient for treating hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Fatih Karadeniz
Summary: Amino acid-conjugated chitosan oligomers (COS-N and COS-Q) have greater potential in inhibiting HIV-1 compared to chitosan itself. These conjugates protect human T cells from HIV-1 infection and inhibit viral protein production. Further research on different peptide and amino acid conjugates may lead to more effective compounds against HIV-1.
Article
Chemistry, Multidisciplinary
Jung Hwan Oh, Fatih Karadeniz, Mi-Soon Jang, Hojun Kim, Youngwan Seo, Chang-Suk Kong
Summary: Loliolide shows potential as a functional food ingredient with anti-obesity properties. It can decrease lipid accumulation, suppress the expression of adipogenic transcription factors, and activate specific signaling pathways to inhibit adipogenesis.
APPLIED SCIENCES-BASEL
(2021)
Article
Tropical Medicine
Jung Im Lee, Jung Hwan Oh, Fatih Karadeniz, So Young Park, Hye Ran Kim, Hyun Jin Jo, Kyung Im Jung, Byung-Jin Jeon, Chang-Suk Kong
Summary: Lentinula edodes extract effectively inhibits the expression of MMP-1 and MMP-9 and increases type I procollagen production through the p38 MAPK/c-Fos signaling pathway in UVA and UVB-irradiated HaCaT keratinocytes, suggesting its potential as a cosmetic material to suppress UV exposure-mediated skin aging.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2021)
Article
Medicine, Research & Experimental
Fatih Karadeniz, Jung Hwan Oh, Hye Ran Kim, Jaeyoung Ko, Chang-Suk Kong
Summary: CMDA may have potential anti-photoaging properties by suppressing UVA-induced MMP-1 production, which helps prevent excessive degradation of collagen.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
