Article
Immunology
Fang Huang, Li Zhang, Hong Tu, Yan-Wen Cui, Shui-Sen Zhou, Zhi-Gui Xia, Hong-Ning Zhou
Summary: Malaria cases along the China-Myanmar border have significantly decreased due to the 1-3-7 approach, with no indigenous cases reported since 2017. However, there is a higher risk for malaria importation and reestablishment in counties in the middle and southern part of the border area post-elimination.
EMERGING INFECTIOUS DISEASES
(2021)
Editorial Material
Infectious Diseases
Fang Huang, Li Zhang, Zhi-Gui Xia
Summary: This article highlights China's practices and experience in targeting vivax malaria control and elimination, including radical cure strategies, comprehensive but adaptive strategies, mass drug administration, and case-/focus-centered surveillance and response systems. After nearly 70 years of effort, China was certified as a malaria-free country in June 2021.
INFECTIOUS DISEASES OF POVERTY
(2023)
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Jian-Wei Xu, Dao-Wei Deng, Chun Wei, Xing-Wu Zhou, Jian-Xiong Li
Summary: China has been certified malaria free, but imported malaria remains a continuous challenge in the border area. Understanding risk factors of malaria along the China-Myanmar border is beneficial for preventing reintroduction and achieving malaria elimination goals.
Article
Immunology
Weilin Zeng, Hui Zhao, Wei Zhao, Qi Yang, Xinxin Li, Xiaosong Li, Mengxi Duan, Xun Wang, Cuiying Li, Zheng Xiang, Xi Chen, Liwang Cui, Zhaoqing Yang
Summary: Drug resistance in Plasmodium vivax presents a challenge to malaria elimination, with studies indicating decreased sensitivity in some regions. Research on P. vivax isolates from the China-Myanmar border found potential resistance to certain antimalarial drugs, highlighting the need for continued surveillance. Genetic variations in resistance-related genes were observed, with specific mutations associated with reduced drug sensitivity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Tian-Qi Shi, Hai-Mo Shen, Shen-Bo Chen, Kokouvi Kassegne, Yan-Bing Cui, Bin Xu, Jun-Hu Chen, Bin Zheng, Yue Wang
Summary: Although China was certified malaria-free in 2021, the presence of malaria in border areas and importation of cases remain challenges. Research on genetic diversity and natural selection of PvDBP-II from P. vivax isolates in China-Myanmar border area revealed significant characteristics in this region.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Tongke Tang, Yanchun Xu, Long Cao, Penghai Tian, Jiang Shao, Yan Deng, Hongning Zhou, Bo Xiao
Summary: The study analyzed the polymorphism and prevalence of molecular markers associated with resistance to antimalarial drugs in the China-Myanmar border region of the Greater Mekong Subregion. Results showed that artemisinin-based combination therapies are still suitable as the first choice of antimalarial strategy in the future.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Parasitology
Xin Zhao, Yubing Hu, Yan Zhao, Lin Wang, Zifang Wu, Myat Thu Soe, Myat Phone Kyaw, Liwang Cui, Xiaotong Zhu, Yaming Cao
Summary: Low genetic diversity of Pvs230 was observed in Plasmodium vivax populations from the China-Myanmar border and central Myanmar. Geographically specific haplotypes were identified. Some mutations were located within potential B-cell epitopes.
PARASITES & VECTORS
(2022)
Article
Immunology
Yan-Bing Cui, Hai-Mo Shen, Shen-Bo Chen, Kokouvi Kassegne, Tian-Qi Shi, Bin Xu, Jun-Hu Chen, Jia-Hong Wu, Yue Wang
Summary: This study analyzed the genetic polymorphism and selection of the PvAMA-1 gene in Plasmodium vivax isolates from imported cases to China. The results showed high genetic diversity and positive selection in the PvAMA-1 gene, which are important for the design and development of malaria vaccines.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Ipsita Pal Bhowmick, Tulika Nirmolia, Apoorva Pandey, Sarala K. Subbarao, Aatreyee Nath, Susmita Senapati, Debabrata Tripathy, Rocky Pebam, Suman Nag, Rajashree Roy, Dipanjan Dasgupta, Jayanta Debnath, Kongkona Gogoi, Karuna Gogoi, Lakhyajit Borah, Rajdeep Chanda, Arup Borgohain, Chelapro Mog, Ujjwal Sarkar, Phiroz Gogoi, Bishal Debnath, Jyotish Debbarma, Dibya Ranjan Bhattacharya, Pyare Lal Joshi, Harpreet Kaur, Kanwar Narain
Summary: A study in Tripura, India found a significant burden of P. vivax malaria cases and mixed infections with P. vivax and P. falciparum during mass surveillance in dry winter months. Molecular diagnostic techniques detected a high proportion of asymptomatic infections, emphasizing the importance of screening for malarial reservoirs in pre-Jhum months.
Article
Infectious Diseases
Zhensheng Wang, Chunyan Wei, Yunchun Pan, Zhihua Wang, Xin Ji, Qianqian Chen, Lianhui Zhang, Zenglei Wang, Heng Wang
Summary: Mutations related to resistance to antifolate drugs are prevalent in the China-Myanmar border area, but their frequencies decrease significantly with time. Resistance to chloroquine is possibly emerging. Therefore, close monitoring of clinical drug efficacy and continuous research is highly important.
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Public, Environmental & Occupational Health
Wei Ding, Shenning Lu, Qiuli Xu, Xuejiao Ma, Bei Wang, Jingbo Xue, Xiaodong Sun, Jianwei Xu, Chris Cotter, Duoquan Wang, Yayi Guan, Ning Xiao
Summary: Healthcare workers at township hospitals in the China-Myanmar border region face challenges in sustaining Community Case Management of malaria, including insufficient training, lack of timely treatment for patients, and risks of workforce instability. To address these challenges, regular training and supervision, as well as incentive mechanisms and career development paths, are needed to strengthen malaria diagnosis and treatment capacity in the region.
Article
Immunology
Weilin Zeng, Siqi Wang, Shi Feng, Daibin Zhong, Yue Hu, Yao Bai, Yonghua Ruan, Yu Si, Hui Zhao, Qi Yang, Xinxin Li, Xi Chen, Yanmei Zhang, Cuiying Li, Zheng Xiang, Yanrui Wu, Fang Chen, Pincan Su, Benjamin M. Rosenthal, Zhaoqing Yang
Summary: Drug-resistant markers in Plasmodium vivax populations along the China-Myanmar border are prevalent and widely spread, with multiple mutant haplotypes found in specific parasite genes. The study also suggests that SP-resistant P. vivax may have alternative mechanisms to maintain sufficient folate levels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Ying Liu, Tao Zhang, Shen-Bo Chen, Yan-Bing Cui, Shu-Qi Wang, Hong-Wei Zhang, Hai-Mo Shen, Jun-Hu Chen
Summary: This study retrospectively reported the whole-genome sequence variation of 10 Plasmodium vivax isolates from inland China, aiming to investigate the molecular epidemiology during the pre-elimination stage. The results showed that China's inland population was highly structured with a single potential ancestor. Furthermore, selective signatures of drug resistance genes were identified, and an increase in the proportion of wild-type dhps and dhfr-ts after the prohibition of specific drugs was observed.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Zu-Rui Lin, Shi-Gang Li, Xiao-Dong Sun, Xiang-Rui Guo, Zhi Zheng, Jie Yang, Hong-Ru Pian, Peng Tian, Qi-Yan Chen, Xiao-Ying Sun, Chun-Li Ding, Kai-Xia Duan, Hong-Wei Chen, Dakhidam Yaw Bee, Hong-Ning Zhou
Summary: The pilot project on the 3 + 1 strategy has been significantly effective in the study areas and a buffer zone of border malaria was successfully established between Laiza City of Myanmar and Yingjiang County of China.
BMC INFECTIOUS DISEASES
(2021)