Review
Engineering, Biomedical
Derek W. Nelson, Ryan J. Gilbert
Summary: ECM-mimetic hydrogels are promising regenerative scaffolds for injured nervous system, providing 3D bioactive interfaces to modulate cellular response and support tissue remodeling. Future advancements in their design and use may lead to viable treatments for patients with neural injury.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Sonja Dragojevic, Lindsay Turner, Pallabi Pal, Amol Janorkar, Drazen Raucher
Summary: Glioblastoma (GBM) is a primary brain tumor with poor prognosis. Tumor recurrence and resistance to chemotherapy are the main challenges. This study evaluated the potential of using elastin-like polypeptide (ELP) hydrogels as a local drug delivery system for GBM treatment. Results showed that ELP hydrogels can be engineered to release anti-cancer drugs over time, significantly reducing GBM cell survival and proliferation in vitro. These findings highlight the potential of ELP hydrogels for improving prognosis in GBM patients after tumor resection.
Review
Biochemistry & Molecular Biology
Rikako Hama, Anudari Ulziibayar, James W. Reinhardt, Tatsuya Watanabe, John Kelly, Toshiharu Shinoka
Summary: Hydrogels are being researched for tissue regeneration with tailored mechanical properties, degradation period, degradation mechanism, and cell affinity through molecular structure modifications, particularly in polymers. Additionally, high-functional hydrogels with drug delivery systems have been reported, which contain drugs or bioactive substances within controlled hydrogels. This review focuses on biopolymer-based hydrogels' molecular design, function, and recent developments for clinical applications.
Article
Biochemistry & Molecular Biology
Fernando Bento Cunha, Karina Torres Pomini, Ana Maria de Guzzi Plepis, Virginia da Conceicao Amaro Martins, Eduardo Gomes Machado, Renato de Moraes, Marcelo de Azevedo e Souza Munhoz, Michela Vanessa Ribeiro Machado, Marco Antonio Hungaro Duarte, Murilo Priori Alcalde, Daniela Vieira Buchaim, Rogerio Leone Buchaim, Victor Augusto Ramos Fernandes, Eliana de Souza Bastos Mazuqueli Pereira, Andre Antonio Pelegrine, Marcelo Rodrigues da Cunha
Summary: The study investigated the effects of elastin and collagen matrix on bone repair in critical size defects in rat calvaria. The results showed that using these matrices as scaffolds was feasible and increased the formation of new bone tissue in critical size defects.
Article
Engineering, Biomedical
Zhuoyue Chen, Qiang Zhang, Hongmin Li, Qi Wei, Xin Zhao, Fulin Chen
Summary: By modifying silk fibroin (SF) scaffolds with engineered elastin-like polypeptides (ELP), cell adhesion and proliferation can be improved, leading to enhanced formation of mature bone and cartilage tissues.
BIOACTIVE MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Yingshu Guo, Shiwei Liu, Dan Jing, Nianzu Liu, Xiliang Luo
Summary: Elastin-like polypeptides (ELPs) are thermally responsive biopolymers with unique properties that can be tailored through genetic engineering. They have been widely used in drug delivery and tissue repair applications due to their biocompatibility, prolonged drug release, and nanostructure formation capabilities.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yusuke Sugioka, Jin Nakamura, Chikara Ohtsuki, Ayae Sugawara-Narutaki
Summary: This study reports the formation of thixotropic hydrogels containing nanofibers of double-hydrophobic elastin-like polypeptides at a concentration an order of magnitude lower than previously reported ELP hydrogels. Chemical crosslinking of nanofibers improves the recovery of the hydrogels, providing deeper insight into the structure-property relationships of self-assembling polypeptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Sihan Zhang, Guanglei Zhao, Wei Ma, Yanghui Song, Cheng Huang, Chong Xie, Kebing Chen, Xiaofeng Li
Summary: A porous chitosan nanofiber scaffold (CSNFS) with an extracellular matrix-like structure was prepared through a cross-linking reaction, showing high porosity and adequate micro-scale pores. CSNFS has good mechanical strength and biocompatibility, and can be used as a repair material for bone tissue engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Xingzhu Liu, Yajie Zhang, Zahid Hussain, Penghui Zheng, Mingsheng Xu, Hongbo Zhao, Yuanshan Liu, Yi Cao, Ismat Ullah, Akiyoshi Osaka, Renjun Pei
Summary: This study developed an injectable polymer-based hydrogel that can fill irregular defects and promote tissue regeneration. The hydrogel, embedded with calcium sulfate nanorods, showed the ability for self-biomineralization and controlled release of calcium ions, facilitating cell adhesion, proliferation, and in situ bone growth.
APPLIED MATERIALS TODAY
(2023)
Article
Engineering, Biomedical
Nashaita Y. Patrawalla, Nilabh S. Kajave, Vipuil Kishore
Summary: Biomimetic scaffolds composed of bioactive ceramic-based materials incorporated within a polymeric framework have shown great potential for use in bone tissue engineering applications. This study compared the efficacy of three different bioceramics (Bioglass 45S5, Laponite XLG, and beta-Tricalcium Phosphate) on bone bioactivity and osteogenic differentiation and found that beta-Tricalcium Phosphate exhibited superior osteogenic potential, making it a preferred choice for the design of cell-laden hydrogels in biomimetic bone tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Materials Science, Paper & Wood
Zahra Sadat Sajadi-Javan, Jaleh Varshosaz, Mina Mirian, Maziar Manshaei, Atousa Aminzadeh
Summary: In this study, a novel thermosensitive hydrogel based on blended methylcellulose with Persian gum was developed and enriched with taxifolin loaded halloysite nanotubes to enhance its mechanical and biological properties in bone tissue engineering. The hydrogel showed better cell adhesion, proliferation, and gene expression as well as promoting osteogenic differentiation in vitro. Animal studies also demonstrated improved remedy when using the hydrogel carrying MG-63 cells.
Article
Engineering, Biomedical
Omar Alheib, Lucilia P. da Silva, Alain da Silva Morais, Katia A. Mesquita, Rogerio P. Pirraco, Rui L. Reis, Vitor M. Conrelo
Summary: We developed an injectable gellan gum-based hydrogel that delivers C2C12 into a localized myopathic model. The gellan gum was biofunctionalized with a laminin-derived peptide to mimic the natural muscular extracellular matrix. Furthermore, the hydrogel was physically adjusted to replicate the mechanical properties of native tissue. This formula was utilized for the first time in the field of skeletal muscle tissue regeneration. The injectability of the hydrogel allowed for non-invasive administration, creating a reliable microenvironment that supported C2C12 with minimal inflammation. The treatment of skeletal muscle defects with the cell-laden hydrogel significantly enhanced regeneration of localized muscular trauma.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Roberta Teixeira Polez, Maria Morits, Christopher Jonkergouw, Josphat Phiri, Juan Jose Valle-Delgado, Markus B. Linder, Thaddeus Maloney, Orlando J. Rojas, Monika Osterberg
Summary: This study explores the potential of plant-based hydrogels in tissue engineering, combining polysaccharide tragacanth gum, antioxidant lignin nanoparticles, and TEMPO-oxidized cellulose nanofibrils. The hydrogels exhibited adjustable rheological properties and swelling capacity, with Young's moduli comparable to soft tissues. In vitro experiments also demonstrated their ability to promote cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Pharmacology & Pharmacy
Promita Bhattacharjee, Mark Ahearne
Summary: This paper provides an overview of different crosslinking techniques and chemical additives used in hydrogels for corneal tissue engineering, drug delivery, or corneal repair. Factors influencing the success of a crosslinker, such as material composition, dosage, fabrication method, immunogenicity, and toxicity, are considered. The choice of crosslinking technique significantly affects the biocompatibility, mechanical properties, and chemical structure of hydrogels suitable for corneal tissue engineering and regenerative applications.
Article
Biotechnology & Applied Microbiology
Abigail L. Wright, Lucrezia Righelli, T. J. Broomhall, Hannah C. Lamont, Alicia J. El Haj
Summary: Despite the high incidence of tendon injuries worldwide, an optimal treatment strategy has yet to be defined. This article presents a study on the remote magnetic alignment of collagen hydrogels, which can facilitate long-term collagen orientation. The presence of magnetic nanoparticles within the hydrogels allows for alignment in response to a magnetic field, providing a potential solution for tendon repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
