Article
Chemistry, Medicinal
Leyla Yurttas, Halide Edip Temel, Mehmet Onur Aksoy, Emre Fatih Bulbul, Gulsen Akalin Ciftci
Summary: The novel synthesized compounds showed high cytotoxicity against lung cancer and fibroblast cells, affecting apoptosis and cell cycle by inducing loss of mitochondrial potential and regulating protein expression.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Eman Y. Ahmed, Nehad A. Abdel Latif, Tamer Nasr, Hanem M. Awad, Omaima M. Abdelhafez
Summary: A series of MDM2 inhibitors targeting breast cancer were designed and synthesized using the coumarin ring as a central scaffold. These compounds exhibited high selectivity and anticancer activity. Compound 7c induced cell apoptosis through multiple mechanisms and its interaction with MDM2 protein was confirmed by molecular docking study.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Arpita Dey, Kumud Pandav, Mala Nath, Ritu Barthwal, Ramasare Prasad
Summary: This study investigated the interaction between laboratory synthesized piperidine-based anthraquinone derivatives (N-1P and N-2P) and G-quadruplex DNA, as well as their impact on oxidative stress, late apoptosis, and induced senescence in cancer cells. The results showed that these anthraquinone derivatives could bind to G-quadruplex DNA, leading to oxidative stress and cellular changes in cancer cells. The binding also increased the stability of G-quadruplex DNA, thereby restricting telomerase binding and potentially inhibiting cancer cell growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Dusan S. Dimic, Goran N. Kaluderovic, Edina H. Avdovic, Dejan A. Milenkovic, Marko N. Zivanovic, Ivan Potocnak, Erika Samolova, Milena S. Dimitrijevic, Luciano Saso, Zoran S. Markovic, Jasmina M. Dimitric Markovic
Summary: In this study, four new compounds synthesized from 4-hydroxycoumarin and tyramine/octopamine/norepinephrine/3-methoxytyramine were characterized and analyzed spectroscopically, chromatographically, and structurally. The stability, antitumor activity, and ecotoxicology of these compounds were investigated using experimental and computational methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hairong Lan, Junying Song, Juan Yuan, Aiping Xing, Dai Zeng, Yating Hao, Zhenqiang Zhang, Shuying Feng
Summary: In this study, a series of 4,6-dihydrazone pyrimidine derivatives containing the pyridine moiety were synthesized and evaluated for their antitumor activity. The tested compounds showed broad-spectrum antitumor activity against selected tumor cell lines and low toxicity towards normal cells. Compounds 10a and 10f exhibited the most promising antitumor activity and further mechanism investigations indicated that they bind with DNA and induce apoptosis of tumor cells.
Article
Chemistry, Multidisciplinary
Zahra Hosseini-Hashemi, Mahboube Eslami Moghadam, Masoud Mirzaei, Behrouz Notash
Summary: Metal complexes have the potential to be used in cancer therapy due to their ability to disrupt nucleic acids. In this study, two new Pt complexes were synthesized and characterized, and their binding properties with DNA were investigated. The results showed that these complexes exhibited good anticancer activity against colon cancer cells.
Article
Chemistry, Medicinal
Emre Mentese, Adem Guner, Elifsu Polatli, Mustafa Emirik, Hakan Bektas, Bahittin Kahveci
Summary: This study reported the synthesis of coumarin derivatives containing the triazole ring and investigated their anticancer activities, showing strong cytotoxic effects against various cancer cell lines. In silico studies were also conducted to explore the binding interactions of the molecules.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Physical
Mucahit Ozdemir, Duygu Taskin, Deniz Ceyhan, Baybars Koksoy, Turgut Taskin, Mustafa Bulut, Bahattin Yalcin
Summary: This study investigated the inhibitory potential of acetylcholinesterase enzyme (AChE) and antioxidant activity of ten different coumarin derivatives. The results showed that all compounds exhibited inhibitory activity on AChE, with compounds 1, 3, and 2 showing the highest activity. Compound 7 showed strong inhibition of AChE, similar to the standard galantamine. Additionally, compound 7 demonstrated the highest antioxidant activity among all tested compounds. The pharmacokinetic properties of the compounds were also evaluated, suggesting that coumarins, particularly compound 7, may be potential candidates for treating Alzheimer's disease and as future antioxidant agents.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Nilofer Shaikh, Aruna Sivaram, Renu Vyas
Summary: Despite the growing research on breast cancer treatment options, developing an effective drug with minimal side effects remains a challenge. This study screened a library of natural compounds using computational methods to target specific proteins involved in cancer. The compound b tetralone showed promising results against MDM2 E3 ubiquitin ligase and Bcl-w anti-apoptotic protein, indicating its potential as an anti-cancer drug.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Xin Zhang, Ying-Ying Zheng, Chun-Mei Hu, Xiao-Zheng Wu, Jing Lin, Zhuang Xiong, Kun Zhang, Xue-Tao Xu
Summary: In this study, potent coumarin derivatives were developed as alpha-glucosidase inhibitors through structure optimization. Compound 20 exhibited outstanding inhibitory activity and was a reversible and uncompetitive inhibitor. The interaction between compound 20 and alpha-glucosidase caused changes in the enzyme's microenvironment and polypeptide structure. Molecular docking analysis revealed the binding of compound 20 to specific residues, reducing the catalytic activity of alpha-glucosidase.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Li-Mei Jia, Shao-Ling Huang, Wei-Gao Pan, Yun-Hou Huang, Peng Luo
Summary: A series of coumarin-isoxazole derivatives were synthesized and characterized, and their cytotoxicity against HepG2 cell lines and toxicity against Vero cell lines were evaluated. MC-16, a monoclinic crystal with P21/c space group, was confirmed by X-ray and 2D-NMR. Eight compounds exhibited varying levels of cytotoxicity against HepG2 cells, with MC-14 showing the strongest activity and inducing apoptosis. Docking results revealed effective protein interactions for the bioactive compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Priya R. Kadam, Yadav D. Bodke, Itte. Pushpavathi, N. D. Satyanarayan, B. N. Nippu
Summary: In this study, a series of new methylene thio-linked coumarin derivatives were synthesized and the structural conformation was analyzed using various spectroscopic techniques and DFT studies. The in vitro anticancer activity evaluation showed that one compound exhibited better efficacy against the MCF-7 cell line. Molecular docking studies revealed the highest binding affinity for a compound containing a benzoxazole ring.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Samar S. Fatahala, Amira Sayed, Shahenda Mahgoub, Heba Taha, Mohamed-I Kotb El-Sayed, Mohamed F. El-Shehry, Samir M. Awad, Rania H. Abd El-Hameed
Summary: The designed and synthesized 2-thiouracil-5-sulfonamides derivatives showed promising anticancer activity and significant inhibition of CDK2A in various human cancer cell lines. The most active compound 6e induced cell growth arrest and apoptotic death in different phases of the cell cycle in cancer cells, ultimately leading to potent anticancer effects. Molecular docking of compound 6e confirmed its proper binding to CDK2A, explaining its strong anticancer activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Demokrat Nuha, Asaf Evrim Evren, Ozge Kapusiz, Ulkuye Dudu Gul, Nalan Gundogdu-Karaburun, Ahmet Cagri Karaburun, Halil Berber
Summary: A series of novel coumarin derivatives have been synthesized and their chemical structures have been elucidated. These compounds were tested against bacteria and fungi, and some of them exhibited good antimicrobial activity, surpassing the activity of standard drugs. Molecular docking and dynamic simulation were performed on certain compounds, and the chemical reactivity properties of all molecules were examined using density functional theory.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Eva Konkolova, Monika Hudacova, Slavka Hamulakova, Katarzyna E. E. Nowak, Maria Kozurkova
Summary: Identifying the binding mode of tacrine-coumarin derivatives with DNA is essential for understanding their pharmacological activity. This study evaluated the binding affinity of seven derivatives to ctDNA using various spectroscopic techniques and determined that they bind through a non-intercalative groove binding mode. Molecular docking results further confirmed the non-intercalative DNA binding mode for two specific derivatives.
Review
Oncology
Elham Kamal Kazemi, Fereydoon Abedi-Gaballu, Tala Farid Mohammad Hosseini, Ali Mohammadi, Behzad Mansoori, Gholamreza Dehghan, Behzad Baradaran, Nader Sheibani
Summary: Lipid-based nanoparticles are used as drug delivery carriers for anti-cancer therapies. By modifying the nanoparticles with specific ligands, they can be recognized by receptors on cancer cells and internalized, enhancing the uptake of desired drugs. The cellular uptake of these nanoparticles is influenced by their physical and chemical properties, as well as the internalization pathways utilized by cells.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Food Science & Technology
Simin Khataee, Gholamrez Dehghan, Reza Yekta, Samaneh Rashtbari, Somayyeh Maleki, Alireza Khataee
Summary: This research investigated the effects of natural yellow on the performance of carmoisine-inhibited bovine liver catalase using multispectral and theoretical methods. The results showed that natural yellow can restore the activity of carmoisine-inhibited catalase and repair the structural changes caused by carmoisine. Furthermore, natural yellow can reduce the stability of the carmoisine-catalase complex. Surface plasmon resonance analysis indicated that natural yellow has a higher affinity to catalase compared to carmoisine.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mina Adampourezare, Arezoo Saadati, Mohammad Hasanzadeh, Gholamreza Dehghan, Mohammad-Ali Hosseinpoure Feizi
Summary: In this study, a novel and affordable method was developed for sensitive detection of DNA methylation using Ag/GQDs nano ink and p[β-CD]. Through electrochemical techniques, DNA methylation can be detected in human plasma samples.
JOURNAL OF MOLECULAR RECOGNITION
(2022)
Review
Cell Biology
Fereydoon Abedi-Gaballu, Elham Kamal Kazemi, Seyed Ahmad Salehzadeh, Behnaz Mansoori, Farhad Eslami, Ali Emami, Gholamreza Dehghan, Behzad Baradaran, Behzad Mansoori, William C. Cho
Summary: Cancer cells reprogram their metabolism to meet high energy demands and promote uncontrolled cell proliferation. Non-coding RNAs (ncRNAs) play a regulatory role in breast cancer metabolism, including glucose, lipid, and glutamine metabolism. Understanding the involvement of ncRNAs in metabolic reprogramming may provide new approaches for diagnosis, prognosis, and treatment of breast cancer.
Article
Pharmacology & Pharmacy
Tannaz Novinbahador, Mostafa Araj-Khodaei, Majid Mahdavi
Summary: Hesperidin, a polyphenol glycoside, has shown pro-apoptotic effects in combating cancer cells. This study found that hesperidin decreased the viability of leukemia cells, induced apoptotic changes, and altered gene expression. Therefore, hesperidin may be a promising candidate for the treatment of AML.
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Khudhair Rashid Khudhair Alzubaidi, Majid Mahdavi, Sanam Dolati, Mehdi Yousefi
Summary: This study found that autophagy is elevated in women with preeclampsia compared to healthy pregnant women, contradicting some previous studies. Further research is needed to explore the role of autophagy in pre-eclamptic women.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Davoud Malekzadeh, Asadollah Asadi, Arash Abdolmaleki, Gholamreza Dehghan
Summary: This study reports the therapeutic efficacy of fullerene C60 nanoparticles (FC60 NPs) in animals with aluminum-induced oxidative stress. The effects of FC60 NPs on neurobiochemical enzymes and oxidative parameters in brain and liver tissues were evaluated. Results showed a significant improvement in the markers, suggesting FC60 NPs as a potential therapeutic option for neurodegenerative diseases.
Article
Pharmacology & Pharmacy
Leila Parsa, Rouhollah Motafakkerazad, Sarvin Taleb Soheyli, Amin Haratian, Morteza Kosari-Nasab, Majid Mahdavi
Summary: Although ATRA is effective in APL therapy, further studies are needed due to clinical limitations. Silymarin, extracted from milk thistle, can regulate apoptosis in cancer cells. This study investigated the apoptosis-inducing effect of Silymarin alone and in combination with ATRA on NB4 cells. It was found that the combination of these two compounds is more effective in inducing apoptosis in NB4 cells.
Review
Neurosciences
Mohammad Sobhan Karvandi, Farzam Sheikhzadeh Hesari, Amir Reza Aref, Majid Mahdavi
Summary: Neuronal loss is a major cause of central nervous system disorders, including neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, and ALS. Protein misfolding, mitochondrial dysfunction, oxidative stress, and neuroinflammation are the critical factors contributing to neuronal cell death. Understanding and targeting these pathways could lead to promising therapeutic approaches.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Elham Kamalkazemi, Gholamreza Dehghan, Fereydoon Abedi-Gaballu, Esmaeil Babaei, Behzad Baradaran
Summary: This study aimed to enhance apoptosis in colorectal cancer cells by encapsulating Umbelliprenin (Umb) in nanostructured lipid carriers (NLCs). The results demonstrated that Umb-loaded NLCs had favorable particle size, encapsulation efficiency, and release pattern, and showed significantly increased cytotoxicity and apoptosis in tumor cells by upregulating P53 and Bax and downregulating survivin and Bcl-2.
Article
Dentistry, Oral Surgery & Medicine
Masumeh Babayi, Mohammed N. Ashtiani, Amirhossein Emamian, Hosseinali Ramezanpour, Hashem Yousefi, Majid Mahdavi
Summary: This study investigated the effect of immediate versus delayed dental implant placement strategies on cell differentiation. The results showed that delayed loading led to greater bone formation than immediate loading. In the delayed strategy, bone cells were appropriately supplied during the first few weeks following surgery, resulting in higher and faster secondary stability of the dental implant.
ARCHIVES OF ORAL BIOLOGY
(2023)
Review
Behavioral Sciences
Seyed Saman Nemati, Leila Sadeghi, Gholamreza Dehghan, Nader Sheibani
Summary: The hippocampus, located in the brain's medial temporal lobe, plays a crucial role in collecting and transferring information for memory consolidation and spatial orientation. It is implicated in cognitive disorders such as epilepsy and Alzheimer's disease. Research on the hippocampus has been motivated by its asymmetry in healthy individuals and its disruption in neurological diseases. This article reviews the structure and importance of the hippocampus in related diseases, and discusses the asymmetry observed in the brain, particularly in the hippocampus, during the growth and maturation of healthy individuals, as well as the changes observed in patients at molecular, functional, and physiological levels.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Shahrebanoo Gholizadeh, Farhad Eslami, Sanam Arami, Gholamreza Dehghan, Seyed Abolfazl Hosseini-Yazdi, Saeed Hesami Tackallou, Majid Mahdavi
Summary: This study evaluated the anti-proliferative effect and oxidative stress-induced apoptosis in human leukemia stem-like KG1a cells by Nickel (II) phenylthiosemicarbazone complex (4-NPTC). The results showed that 4-NPTC can block the development of leukemia cells by inducing oxidative stress and apoptosis.
IRANIAN JOURNAL OF SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Maryam Ghaffari, Dariush Shanehbandi, Solmaz Sarhadi, Mina Hanifeh Ahagh, Mahsa Maleki Moghaddam, Gholamreza Dehghan, Razieh Ghodsi, Jafar Ezzati Nazhad Dolatabadi
Summary: This study evaluated the anti-proliferative and apoptotic effect of tetrahydrobenzo[h]quinoline on MCF-7 human breast cancer cells. The results showed that tetrahydrobenzo[h]quinoline reduced cell growth and induced apoptosis in MCF-7 cells. It also affected the expression of genes and proteins involved in the apoptosis signaling pathway.
PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Masoud Gazizadeh, Gholamreza Dehghan, Jafar Soleymani
Summary: A dual-emission ratiometric fluorescent sensor was developed for the determination of metformin concentration in biological samples. The sensor showed a good linear correlation and a low detection limit for metformin. Therefore, this sensor can be used as a sensitive and simple fluorimetric method for detecting metformin in real samples.