Article
Multidisciplinary Sciences
Alex J. Vecchio, Sewwandi S. Rathnayake, Robert M. Stroud
Summary: The study reveals the molecular and structural basis of how CpE targets susceptible claudins, as well as differences in the primary CpE receptors in mice and humans due to sequence changes in the target motif.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Rina Fujiwara-Tani, Shiori Mori, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Shingo Kishi, Masuo Kondoh, Hiroki Kuniyasu
Summary: CLDN4 is a crucial component of tight junctions in epithelial cells and is overexpressed in many epithelial malignancies. Changes in CLDN4 expression are associated with epigenetic factors, inflammation, and growth factor signaling. CLDN4 plays a role in maintaining the tumor microenvironment and acts as a barrier to anticancer drug entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Shuangshuang Zhai, Yongwen Zhu, Peishi Feng, Macheng Li, Wence Wang, Lin Yang, Ye Yang
Summary: OTA is a widespread mycotoxin that is nephrotoxic, hepatotoxic, teratogenic, immunotoxic, and enterotoxic to various animal species. Poultry are more sensitive to OTA with a lower absorption rate, making the gut an important target tissue. OTA can lead to gut dysbiosis, increased gut permeability, immunity, and bacterial translocation, ultimately causing gut and other organ injury.
Article
Food Science & Technology
Yunika Mayangsari, Mayu Okudaira, Chinatsu Mano, Yuki Tanaka, Osamu Ueda, Tomohiro Sakuta, Yoshiharu Suzuki, Yoshinari Yamamoto, Takuya Suzuki
Summary: Research showed that DMF can enhance intestinal TJ barrier integrity by increasing the expression of occludin and claudin-1, while reducing the expression of claudin-2. This regulation involves the induction of occludin protein translation via mTOR and silencing Cldn2 mRNA via miR-16-5p.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Multidisciplinary Sciences
Koya Suzuki, Kosuke Yamaga, Reitaro Tokumasu, Tatsuya Katsuno, Hiroo Tanaka, Shuhei Chiba, Takeshi Yagi, Ichiro Katayama, Atsushi Tamura, Hiroyuki Murota, Sachiko Tsukita
Summary: Hair retention in infant mice is regulated by Claudin (CLDN)-1 and CLDN3, which maintain the appropriate layered architecture of hair follicles. Deficiencies in these proteins can lead to hair loss.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Lin Xiao, Weidong Dou, Yajie Wang, Huan Deng, Hao Xu, Yisheng Pan
Summary: This study investigated the protective effects of S-adenosylmethionine (SAM) on irinotecan-induced intestinal barrier dysfunction and microbial ecological dysregulation. SAM pretreatment significantly reduced body weight loss and diarrhea induced by irinotecan in mice. In Caco-2 monolayers, SAM reduced reactive oxygen species (ROS) expression and improved transepithelial electrical resistance (TER). SAM also protected barrier function by inhibiting certain signaling pathways.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuhan Ding, Kun Wang, Chang Xu, Mengdi Hao, Huimin Li, Lei Ding
Summary: This study found that the deletion of the Cldn7 gene increased susceptibility to colitis and may lead to dysbiosis of the intestinal microbiota. The research reveals the important role of Cldn7 in intestinal barrier protection and provides new insights into the treatment of inflammatory bowel disease.
BMC GASTROENTEROLOGY
(2022)
Review
Immunology
Bei Yue, Ruiyang Gao, Zhengtao Wang, Wei Dou
Summary: Irinotecan (CPT11) and its active metabolite SN38 are broad-spectrum cytotoxic anticancer agents that can cause gastrointestinal toxicity. The gut microbiota plays a crucial role in modulating the efficacy and toxicity of CPT11 chemotherapy through mechanisms such as microbial ecocline, enzyme catalysis, and immunoregulation. Targeting the gut microbiota with specific inhibitors, dietary interventions, probiotics, and strain-engineered interventions can potentially improve CPT11 chemotherapy efficiency and alleviate toxicity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhi-Yuan Pan, Yu-Xiao Chang, Ni Han, Feng-Yi Hou, B. J. Yang Lee, Fa-Chao Zhi, Rui-Fu Yang, Yu-Jing Bi
Summary: Hydroxychloroquine has significant effects on the gut microbiota of mice, reducing microbial diversity and altering the relative abundance of certain bacterial phyla. However, short-term high dose HCQ challenge does not affect intestinal integrity and immune responses in mice. Special attention should be paid to the effects of HCQ on intestinal microecology in future clinical use.
Article
Agriculture, Dairy & Animal Science
Chuanlong Wang, Liangzhi Wang, Qingyi Chen, Xiaofeng Guo, Liyang Zhang, Xiudong Liao, Yanling Huang, Lin Lu, Xugang Luo
Summary: The dietary pattern of trace minerals, especially when the trace minerals are inorganic sources, has an impact on the intestinal health of broilers. This study provides scientific evidence for improving the intestinal health of broilers through nutritional strategies.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Kumi Takasawa, Akira Takasawa, Taishi Akimoto, Kazufumi Magara, Tomoyuki Aoyama, Hiroshi Kitajima, Taro Murakami, Yusuke Ono, Daisuke Kyuno, Hiromu Suzuki, Makoto Osanai
Summary: The abnormal expression of claudin-1 in cervical adenocarcinoma cells not only affects conventional tight junction functions, but also influences the expression and activity of a wide range of proteins associated with cell adhesion and actin cytoskeleton remodeling, contributing to malignant potentials and microvilli formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Jingfei Zhang, Yuxiang Yang, Hongli Han, Lili Zhang, Tian Wang
Summary: The study found that dietary supplementation of bisdemethoxycurcumin can attenuate LPS-induced intestinal damage in broiler chickens by improving intestinal morphology, maintaining intestinal tight junction, downregulating pro-inflammatory mediators, and restoring cecal microbiota.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Kenta Shigetomi, Yumiko Ono, Kenji Matsuzawa, Junichi Ikenouchi
Summary: It has been found that cholesterol accumulation is essential for the formation of tight junctions, which are crucial for the epithelial barrier. Despite the absence of tight junctions, cholesterol still accumulates normally in the vicinity of the apical junctions. Moreover, a claudin mutant that cannot bind to Zonula Occludens (ZO) proteins can still form tight junction strands. ZO proteins are not only scaffolds for claudins, but also promote the formation of cholesterol-rich membrane domains at apical junctions through their effect on the junctional actomyosin cytoskeleton.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Hye-Bin Lee, Mi-Jin Oh, Moon Ho Do, Yoonsook Kim, Inwook Choi, Young-Soo Kim, Ho-Young Park
Summary: This study found that molokhia leaf polysaccharide fraction (MPF) can attenuate obesity induced by high-fat diet by modulating the gut microbiota. Mice treated with MPF showed decreased body weight, adipocyte size, serum triglyceride and low-density lipoprotein cholesterol levels, as well as downregulated expression of lipid synthesis-related proteins.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Food Science & Technology
Linda Liang, Clarissa Saunders, Nerses Sanossian
Summary: Dysfunction of gut barrier, also known as leaky gut or increased intestinal permeability, has been found to be associated with various gastrointestinal tract (GI) and non-GI diseases. This review examines recent research on the relationship between dietary factors, intestinal permeability dysfunction, and related diseases, using animal models, cell models, and human research in vitro and in vivo. The review discusses the mechanism of gut barrier and function, food and dietary supplements for promoting gut health, and food or medication that may alter gut function. The synthesized information is organized in a table, categorizing diseases related to leaky gut/intestinal permeability and associated dietary influences. Future research could explore dietary intervention as a new approach to individualized disease prevention and management.
FOOD SCIENCE & NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Shanwen Chen, Dingfang Bu, Yuanyuan Ma, Jing Zhu, Lie Sun, Shuai Zuo, Ju Ma, Tengyu Li, Zeyang Chen, Youwen Zheng, Xin Wang, Yisheng Pan, Pengyuan Wang, Yucun Liu
BIOCHEMICAL PHARMACOLOGY
(2016)
Article
Gastroenterology & Hepatology
Shan-wen Chen, Peng-yuan Wang, Yu-cun Liu, Lie Sun, Jing Zhu, Shuai Zuo, Ju Ma, Teng-yu Li, Jun-ling Zhang, Guo-wei Chen, Xin Wang, Qiu-ru Zhu, You-wen Zheng, Ze-yang Chen, Zi-hao Yao, Yi-sheng Pan
INFLAMMATORY BOWEL DISEASES
(2016)
Article
Gastroenterology & Hepatology
Shanwen Chen, Shuai Zuo, Jing Zhu, Taohua Yue, Dingfang Bu, Xin Wang, Pengyuan Wang, Yisheng Pan, Yucun Liu
JOURNAL OF CROHNS & COLITIS
(2019)
Article
Oncology
Shanwen Chen, Taohua Yue, Zhihao Huang, Jing Zhu, Dingfang Bu, Xin Wang, Yisheng Pan, Yucun Liu, Wang Pengyuan
Editorial Material
Gastroenterology & Hepatology
Yurong Wang, Yisheng Pan, Zhengfei Zhou
Article
Biochemistry & Molecular Biology
Shanwen Chen, Tao Liu, Dingfang Bu, Jing Zhu, Xin Wang, Yisheng Pan, Yucun Liu, Zhi John Lu, Pengyuan Wang
Summary: The study found significantly increased methylation of TCHH in the process of liver metastasis in colorectal cancer, and Methylight analysis of TCHH methylation in CfDNA showed promising discriminative power between CRC with and without liver metastasis.
Article
Medicine, Research & Experimental
Hao Xu, Qisheng Hou, Jing Zhu, Mei Feng, Pengyuan Wang, Yisheng Pan
Summary: EcN protects intestinal barrier function in endotoxemia by inhibiting the activation of RhoA/ROCK2/MLC signaling via TLR-4.
Article
Oncology
Tao Liu, Junling Zhang, Hu Chen, Tashi Bianba, Yisheng Pan, Xin Wang, Yong Jiang, Zhen Yang
Summary: Gastric cancer is a common malignant tumor and understanding its development mechanism and finding effective therapeutic target genes are crucial. This study found that PSMC2 and RPS15A were highly expressed in gastric cancer. PSMC2 enhanced RPS15A levels by targeting hsa-let-7c-3p, which then activated the mTOR pathway, promoting the progression of gastric cancer.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.