Review
Cell Biology
Hanna Helotera, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. It is classified into dry and neovascular forms, with neovascular AMD being associated with angiogenesis and inflammatory regulators.
Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Nutrition & Dietetics
Yuan-Yuei Chen, Ying-Jen Chen
Summary: This study investigated the association between dietary micronutrients and age-related macular degeneration (ARMD) in older adults. The data collected from 5227 participants showed a negative association between dietary calcium and ARMD. However, further longitudinal studies are needed to explore these findings.
Article
Food Science & Technology
Nguyen Dao, Thilini Thrimawithana, Terrence J. Piva, Danilla Grando, Huynh Tien
Summary: Age-related macular degeneration (AMD) is a chronic disease that causes blindness in older adults and has a significant economic impact on the healthcare system. Carotenoids from plants, such as lutein, zeaxanthin, and mesozeaxanthin, accumulate in the macula and protect against light exposure, oxidation, and inflammation, making them a potential preventative and therapeutic treatment for AMD. The dose and duration of treatment with carotenoids are important factors that influence their protective effects and can potentially improve visual outcomes in AMD patients. This review discusses the application of carotenoid supplementation as a non-invasive alternative for the prevention and treatment of AMD.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Medicine, Research & Experimental
Alexandre Vallee
Summary: This review article describes the different mechanisms of curcumin in exudative AMD, focusing on its effects on oxidative stress, inflammation, and angiogenesis, by interacting with Wnt/beta-catenin signaling.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Kah-Hui Wong, Hui-Yin Nam, Sze-Yuen Lew, Murali Naidu, Pamela David, Tengku Ain Kamalden, Siti Nurma Hanim Hadie, Lee-Wei Lim
Summary: This review evaluates the potential therapeutic roles of natural antioxidants in age-related macular degeneration (AMD). The literature search identifies various natural antioxidants, including active compounds, carotenoids, extracts and polysaccharides, flavonoids, formulations, vitamins, and whole foods, that may have therapeutic effects in AMD. The study suggests that natural antioxidants have the potential to improve or halt the progression of AMD, and tailoring therapeutics to the specific disease stages may be crucial in preventing irreversible vision loss.
Review
Biochemistry & Molecular Biology
Ryo Terao, Tazbir Ahmed, Ayana Suzumura, Hiroko Terasaki
Summary: Aging leads to a decline in organ function, including the eyes, resulting in age-related ocular diseases. Cellular senescence, characterized by cell cycle arrest, plays a significant role in aging and age-related diseases by altering cellular function and secretory phenotypes. Oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers through reactive oxygen species and mitochondrial dysfunction.
Review
Biochemistry & Molecular Biology
Laura Garcia-Quintanilla, Lorena Rodriguez-Martinez, Enrique Bandin-Vilar, Maria Gil-Martinez, Miguel Gonzalez-Barcia, Cristina Mondelo-Garcia, Anxo Fernandez-Ferreiro, Jesus Mateos
Summary: Age-related macular degeneration (AMD) is a common eye disease in the elderly population, and proteomics-based approaches are powerful tools for studying the molecular mechanisms of its progression and identifying new therapeutic targets and biomarkers for monitoring. Key factors related to the onset and progression of AMD have been identified, but further understanding of the underlying disease mechanisms is needed for next-generation therapies for late-stage forms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sonali Nashine, Pinchas Cohen, Junxiang Wan, M. Cristina Kenney
Summary: Inflammation plays a crucial role in the etiology and pathogenesis of AMD. This study found that Humanin protein levels were reduced in the plasma of AMD patients, while inflammation marker protein levels were increased. In AMD cells, treatment with Humanin G reduced the levels of inflammatory proteins, potentially alleviating inflammation.
Review
Biochemistry & Molecular Biology
Mayank Choubey, Munichandra B. Tirumalasetty, Nalini S. Bora, Puran S. Bora
Summary: This review explores the intricate relationship between adiponectin and ocular pathologies, highlighting its influence on retinal health and role in protecting against eye ailments. The review emphasizes the importance of adiponectin and its receptors in maintaining ocular homeostasis and potential therapeutic interventions for aging eye conditions. It also uncovers the interplay between adiponectin signaling pathways and age-related macular degeneration, providing insights for personalized treatments and preventative measures.
Article
Medicine, General & Internal
Alan G. Palestine, Brandie D. Wagner, Jennifer L. Patnaik, Rebecca Baldermann, Marc T. Mathias, Naresh Mandava, Anne M. Lynch
Summary: The study aimed to investigate the relationship between C-C chemokines and intermediate age-related macular degeneration (iAMD) patients. The results showed that plasma concentrations of CCL2 were elevated, while CCL3 and CCL5 concentrations were decreased in iAMD patients compared with controls. This suggests a potential role for C-C chemokines in the systemic inflammatory processes associated with disease development.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Matteo Stravalaci, Mariantonia Ferrara, Varun Pathak, Francesca Davi, Barbara Bottazzi, Alberto Mantovani, Reinhold J. Medina, Mario R. Romano, Antonio Inforzato
Summary: Age related macular degeneration (AMD) and diabetic retinopathy (DR) are neurodegenerative and inflammatory diseases of the eye. Both diseases involve cellular components of the blood-retina barrier (BRB) and share common drivers, such as chronic inflammation. Long pentraxin 3 (PTX3), a soluble pattern recognition molecule, is emerging as a potential therapeutic target in retinal diseases, as it plays a role in trapping complement and modulating inflammation at the BRB.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Michael N. Cohen, Denis O'Shaughnessy, Kate Fisher, Jennifer Cerami, Carl C. Awh, Daniel E. Salazar, Philip Rosenfeld, Jeffrey S. Heier
Summary: The X-82 oral therapy combined with pro re nata anti-VEGF injections showed non-inferiority in visual acuity outcomes compared with placebo, and there was a dose-dependent decrease in the number of anti-VEGF injections over the 52-week period. However, due to limited tolerability and safety issues observed, X-82 does not have a sufficient benefit to risk profile in the treatment of AMD patients.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Immunology
Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen, Heping Xu
Summary: This study investigated the effect of ageing on subretinal fibrosis secondary to choroidal neovascularization and the mechanism of action. The results showed that ageing increased the number of circulating fibrocytes and the profibrotic potential of BM-derived macrophages. Additionally, aged mice had significantly more severe subretinal fibrosis compared to young mice. The transplantation of BM from aged mice significantly increased subretinal fibrosis in young mice.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, General & Internal
Yi-Hsiang Chiu, Jehn-Yu Huang, Ya-Ping Huang, Shin-Liang Pan
Summary: This study found that individuals with osteoarthritis have an increased risk of developing age-related macular degeneration (AMD), regardless of age and sex.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Oncology
Keun-Yeong Jeong
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2019)
Article
Oncology
Sun Young Park, Jae Ki Lee, Min Hee Park, Keun-Yeong Jeong, Hwan Mook Kim
ANTICANCER RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Keun-Yeong Jeong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Keun-Yeong Jeong
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Keun-Yeong Jeong, Min Hee Park
Summary: Genome-wide studies have identified a subpopulation of pancreatic cancer cells with unstable genomic characteristics, leading to a focus on the deleterious effects of PARP-1 in oncology. PARP-1 plays a crucial role in DNA repair, oxidative stress regulation, and mitosis in cancer cells, impacting their survival and growth. Targeting PARP-1 in the treatment of pancreatic cancer through recent approaches may offer promising prospects for clinical and non-clinical research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Keun-Yeong Jeong, Jae-Jun Sim, Min Hee Park, Hwan Mook Kim
Summary: This study demonstrated the changes in cancer-specific metabolism induced by lactate calcium salt in colorectal cancer cells, leading to anti-cancer effects. The results suggest that lactate calcium salt can alter anaerobic glycolysis, reduce HIF-1 alpha and VEGF expression, and inhibit tumor growth and metastasis.
Review
Oncology
Keun-Yeong Jeong, Minhee Park
Summary: PARP-1 and PARylation are crucial factors in the malignant formation of CRC, playing roles in DNA repair, regulation of epigenetic markers and chromatin structure, and are at the forefront of pathological changes required for CRC progression. This understanding could help in targeting PARP-1 and PARylation for potential treatments and various research challenges in both nonclinical and clinical settings.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Keun-Yeong Jeong
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Keun-Yeong Jeong, Seon Young Park, Min Hee Park, Hwan Mook Kim
Summary: Calcium supply can lead to the degradation of Src protein, reducing the survival signals in triple-negative breast cancer cells, thus showing potential as an anti-cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Keun-Yeong Jeong
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Meeting Abstract
Oncology
Soobong Park, Haejun Lee, Keun-Yeong Jeong, Jeong-Heum Baek, Chong-Hwan Chang
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Keun-Yeong Jeong
Article
Biochemistry & Molecular Biology
Keun-Yeong Jeong, Minhee Park, Jae-Jun Sim, Hwan Mook Kim
Article
Biochemical Research Methods
Jae Jun Sim, Keun-Yeong Jeong
METHODS AND PROTOCOLS
(2020)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.