Article
Clinical Neurology
Jason P. Appleton, Saoirse E. O'Sullivan, Amanda Hedstrom, Jane A. May, Richard Donnelly, Nikola Sprigg, Philip M. Bath, Timothy J. England
Summary: Remote ischaemic per-conditioning reduced SAP and TNF-alpha levels from pre- to post-intervention. Increases in plasma levels of SAP were associated with worse clinical outcomes after ischaemic stroke.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
News Item
Multidisciplinary Sciences
Kendall Powell
Summary: Data sharing is crucial for scientific advancement, but the challenge lies in finding the balance between sharing information freely and protecting sensitive data.
Review
Endocrinology & Metabolism
Philippa Weir, Ryan Maguire, Saoirse E. O'Sullivan, Timothy J. England
Summary: Remote ischaemic conditioning (RIC) is neuroprotective in experimental ischaemic stroke, reducing lesion volume and improving neurological deficit. Studies suggest that an optimal dose for RIC in experimental stroke is between 10 and 45 minutes, with further research needed to determine the best administration methods and timings.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
R. M. Bell, M. Basalay, H. E. Botker, S. Beikoghli Kalkhoran, R. D. Carr, J. Cunningham, S. M. Davidson, T. J. England, S. Giesz, A. K. Ghosh, P. Golforoush, A. V. Gourine, D. J. Hausenloy, G. Heusch, B. Ibanez, P. Kleinbongard, S. Lecour, K. Lukhna, M. Ntsekhe, M. Ntsekhe, M. Ovize, A. D. Salama, G. Vilahur, J. M. Walker, D. M. Yellon
Summary: The Hatter Cardiovascular Institute biennial workshop focused on the future of Remote Ischaemic Conditioning (RIC), discussing the mechanisms of conditioning, the disconnect between preclinical and clinical studies, and the potential applications of RIC in other diseases. The workshop proposed specific classifications to identify responders and non-responders.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Lucie Pearce, Sean M. Davidson, Derek M. Yellon
Summary: The anti-inflammatory effects of remote ischaemic conditioning (RIC) may be beneficial for cardiac protection, especially during the COVID-19 pandemic. Studies show that RIC attenuates inflammation in animals through immune conditioning and cytokine inhibition, suggesting that RIC may exert its effects by inhibiting the release of inflammatory cytokines.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos Galan-Arriola, Rocio Villena-Gutierrez, Maria Higuero-Verdejo, Ivan A. Diaz-Rengifo, Gonzalo Pizarro, Gonzalo J. Lopez, Antonio de Molina-Iracheta, Claudia Perez-Martinez, Rodrigo D. Garcia, David Gonzalez-Calle, Manuel Lobo, Pedro L. Sanchez, Eduardo Oliver, Raul Cordoba, Valentin Fuster, Javier Sanchez-Gonzalez, Borja Ibanez
Summary: This study demonstrates that RIPC applied immediately before each doxorubicin injection can preserve cardiac contractility, result in significantly higher long-term left ventricular ejection fraction, and less cardiac fibrosis in a translatable large-animal model of AIC. RIPC is able to prevent mitochondrial fragmentation and dysregulated autophagy from AIC early stages, suggesting it as a promising intervention for testing in clinical trials for AIC.
CARDIOVASCULAR RESEARCH
(2021)
Article
Immunology
Marie B. Nielsen, Kristian Ravlo, Marco Eijken, Nicoline Krogstrup, Morten Bue Svendsen, Chadi Abdel-Halim, Mikkel Steen Petersen, Henrik Birn, Mihai Oltean, Bente Jespersen, Bjarne K. Moller
Summary: The study investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors. The results showed no significant differences in immune cell and cytokine levels between the two groups, but both exhibited dynamic changes over time in response to the kidney transplantation and immunosuppression.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
J. Ranjit Arnold, Andrew P. Vanezis, Glenn C. Rodrigo, Florence Y. Lai, Prathap Kanagala, Sheraz Nazir, Jamal N. Khan, Leong Ng, Kamal Chitkara, J. Gerry Coghlan, Simon Hetherington, Nilesh J. Samani, Gerald P. McCann
Summary: Remote ischaemic conditioning (CRIC) following primary percutaneous coronary intervention (P-PCI) can improve longitudinal strain in infarct-related segments and attenuate the increase in circumferential strain in remote segments.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Pediatrics
Ian Howard Jones, Denise Tao, Bhumita Vagdama, Michael Orford, Simon Eaton, Jane Collins, Nigel John Hall
Summary: Remote ischaemic conditioning (RIC) has therapeutic potential for intestinal diseases in the newborn by reducing the extent and severity of bowel injury and decreasing neutrophil infiltration/activation.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Rohin Francis, Jun Chong, Manish Ramlall, Chiara Bucciarelli-Ducci, Tim Clayton, Matthew Dodd, Thomas Engstrom, Richard Evans, Vanessa M. Ferreira, Marianna Fontana, John P. Greenwood, Rajesh K. Kharbanda, Won Yong Kim, Tushar Kotecha, Jacob T. Lonborg, Anthony Mathur, Ulla Kristine Moller, James Moon, Alexander Perkins, Roby D. Rakhit, Derek M. Yellon, Hans Erik Botker, Heerajnarain Bulluck, Derek J. Hausenloy
Summary: The study found that limb remote ischaemic conditioning did not have a significant effect on myocardial infarct size and left ventricular ejection fraction. Cardiovascular magnetic resonance scans conducted both acutely and at 6 months showed no reduction in infarct size or improvement in heart function with limb RIC.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Physiology
Zhibing Yan, Lei Du, Quanhua Liu, Leng Zhou, Zhaoyang Hu
Summary: The study investigated the effects of remote limb ischaemic conditioning on arrhythmogenesis in rats with testicular ischaemia-reperfusion injury, finding that it can protect the heart against arrhythmia through JNK inhibition and Cx43 activation.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Gregory Wood, Pia Hedegaard Johnsen, Anders Lehmann Dahl Pedersen, Christian Alcaraz Frederiksen, Steen Hvitfeldt Poulsen, Hans Erik Botker, Won Yong Kim
Summary: Remote ischaemic conditioning (RIC) applied before primary percutaneous coronary intervention (PPCI) in patients with ST-elevation myocardial infarction does not improve left ventricular function 3 months after infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Bethany Moyle, Nik Kudiersky, Nikki Totton, Matilde Sassani, Simon Nichols, Tom Jenkins, Jessica Redgrave, Sheharyar Baig, Krishnan Padmakumari Sivaraman Nair, Arshad Majid, Ali N. Ali
Summary: This study evaluated the safety and feasibility of remote ischaemic conditioning (RIC) for post stroke fatigue (PSF), as well as assessed measures of cellular bioenergetics. The results showed that RIC is safe and acceptable for treating PSF, and may lead to improvements in fatigue and muscle bioenergetics.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Kishal Lukhna, Helison R. P. do Carmo, Alejandro Rossell Castillo, Sean M. Davidson, Hayli Geffen, Sara Giesz, Pelin Golforoush, Ticiane Goncalez Bovi, Diana Gorag, Alan Salama, Aqeela Imamdin, Siavash Kalkhoran, Sandrine Lecour, Mauricio W. Perroud Jr, Mpiko Ntsekhe, Andrei C. Sposito, Derek M. Yellon
Summary: RIC did not reduce the hypercytokinaemia induced by COVID-19 or prevent clinical deterioration to critical care.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Kishal Lukhna, Derek J. Hausenloy, Abdelbagi Sidahmed Ali, Abdullah Bajaber, Alistair Calver, Arthur Mutyaba, Awad Abdalla Mohamed, Brian Kiggundu, Chishala Chishala, Ebrahim Variava, Ehab Ali Elmakki, Elijah Ogola, Eltayeb Hamid, Emmy Okello, Isam Gaafar, Keiran Mwazo, Makoali Makotoko, Mergan Naidoo, Mohamed Elhadi Abdelhameed, Motasim Badri, Nasief van der Schyff, Omaima Abozaid, Paul Xafis, Sara Giesz, Trevor Gould, Waldo Welgemoed, Malcolm Walker, Mpiko Ntsekhe, Derek M. Yellon
Summary: Despite evidence of myocardial infarct size reduction in animal studies, remote ischaemic conditioning (RIC) failed to improve clinical outcomes in the large CONDI-2/ERIC-PPCI trial. The RIC-AFRICA trial aims to investigate whether RIC can improve clinical outcomes in higher-risk STEMI patients in environments with limited access to early reperfusion or PPCI.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
A. P. Vanezis, G. C. Rodrigo, I. B. Squire, N. J. Samani
HEART FAILURE REVIEWS
(2016)
Review
Cardiac & Cardiovascular Systems
Jack M. J. Pickard, Hans Erik Botker, Gabriele Crimi, Brian Davidson, Sean M. Davidson, David Dutka, Peter Ferdinandy, Rocky Ganske, David Garcia-Dorado, Zoltan Giricz, Alexander V. Gourine, Gerd Heusch, Rajesh Kharbanda, Petra Kleinbongard, Raymond MacAllister, Christopher McIntyre, Patrick Meybohm, Fabrice Prunier, Andrew Redington, Nicola J. Robertson, M. Saadeh Suleiman, Andrew Vanezis, Stewart Walsh, Derek M. Yellon, Derek J. Hausenloy
BASIC RESEARCH IN CARDIOLOGY
(2015)
Article
Medicine, General & Internal
Nikhil Pawa, Andrew Vanezis, Asiya Maula
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2011)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. P. Vanezis, S. A. Edroos, N. J. Samani, G. C. Rodrigo
Meeting Abstract
Cardiac & Cardiovascular Systems
S. A. Edroos, A. P. Vanezis, M. J. Davies, N. J. Samani, G. C. Rodrigo
Meeting Abstract
Cardiac & Cardiovascular Systems
A. P. Vanezis, M. Butt, N. J. Samani, G. C. Rodrigo
Meeting Abstract
Cardiac & Cardiovascular Systems
Jennifer Kwan, Humera Ansar, Hayley Crumbie, Andrew Vanezis, Farook Al-Azzawi, Glenn Rodrigo
Meeting Abstract
Cardiac & Cardiovascular Systems
Andrew Vanezis, Chokanan Thaitirarot, Madiha Butt, Iain Squire, Nilesh Samani, Glenn Rodrigo
Article
Cardiac & Cardiovascular Systems
M. Denniff, Helen E. Turrell, Andrew Vanezis, Glenn C. Rodrigo
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2014)
Article
Cardiac & Cardiovascular Systems
Andrew Peter Vanezis, William Wilson, William Smith
JOURNAL OF INVASIVE CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Andrew Peter Vanezis, Jayanth Ranjit Arnold, Glenn Rodrigo, Florence Y. Lai, Radek Debiec, Sheraz Nazir, Jamal Nasir Khan, Leong L. Ng, Kamal Chitkara, John G. Coghlan, Simon Lee Hetherington, Gerry P. McCann, Nilesh J. Samani
Article
Cardiac & Cardiovascular Systems
Andrew P. Vanezis, Mirza K. Baig, Ian M. Mitchel, Matloob Shajar, Surendra K. Naik, Robert A. Henderson, Thomas Mathew
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2011)
Article
Medicine, General & Internal
A. P. Vanezis, S. K. Suvarna, P. Vanezis
JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
(2011)
Article
Neurosciences
Andrew Peter Vanezis, Dudley Manns
PROGRESS IN NEUROLOGY AND PSYCHIATRY
(2010)
