Article
Clinical Neurology
Nathan J. Creber, Hayden T. Eastwood, Amy J. Hampson, Jonathon Lo, Dongcheng Zhang, Scott A. Chambers, Christo W. Bester, Peter R. Thorne, Stephen J. O'Leary
Summary: The study found that administration of the mineralocorticoid receptor antagonist spironolactone can suppress EH in the week after cochlear implantation. Reduction in EH did not lead to any change in hearing, and there was no indication of synaptopathy signalled by reduced CAP amplitude at high sound intensities. There was no electrophysiological evidence that EH early after implantation impacts negatively upon preservation of residual hearing.
OTOLOGY & NEUROTOLOGY
(2022)
Review
Engineering, Biomedical
Filip Hrncirik, Iwan Roberts, Ilkem Sevgili, Chloe Swords, Manohar Bance
Summary: As the first clinically translated machine-neural interface, cochlear implants (CI) have shown success in restoring hearing for severe to profound hearing loss patients. However, challenges such as hearing damage from insertion forces during implantation and limited focusing ability due to current spread hinder wider CI eligibility. This review provides an overview of cochlear anatomy and physical properties as a resource to improve accurate models for future CI treatments. It also discusses the advancements, challenges, and future directions in the development of physical, animal, tissue engineering, and computational models of the cochlea.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Waldeck, Rania Helal, Ibraheem Al-Dhamari, Sandra Schmidt, Christian von Falck, Rene Chapot, Marc Brockmann, Daniel Overhoff
Summary: This study evaluated the time required for diagnosing correct or incorrect cochlear implant (CI) placement using a novel algorithm for image analysis (ACIR) compared to manual multiplanar reconstruction (MPR) analysis. The results showed that 3D postoperative imaging accurately diagnosed CI misalignment, and the application of the novel ultra-fast algorithm significantly reduced the time for diagnosis compared to MPR analysis.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Polymer Science
Gianluca Ciarleglio, Federica Cinti, Elisa Toto, Maria Gabriella Santonicola
Summary: Alginate-based beads containing a porous zeolite filler were developed as carriers of bioactive compounds with hydrophobic nature, such as curcumin. The beads showed good sphericity and diameter when fabricated under optimized process parameters. The addition of chitosan coating improved stability and controlled degradation behavior, while the zeolite filler reinforced the beads. This study suggests that pH-responsive alginate gel beads have the potential to deliver lipophilic drugs to specific inflammatory sites.
Article
Clinical Neurology
Cuncun Ren, Ying Lin, Zhuo Xu, Xiaoqin Fan, Xinyu Zhang, Dingjun Zha
Summary: This study analyzed children with cochlear nerve deficiency (CND) and found that the internal auditory meatus (IAM) nerve grading system could not predict the outcomes of cochlear implants (CIs) in these children.
FRONTIERS IN NEUROLOGY
(2022)
Article
Otorhinolaryngology
Nathan J. Creber, Hayden T. Eastwood, Amy J. Hampson, Stephen J. O'Leary
Summary: This study investigates the impact of systemic administration of dexamethasone on steroid distribution and uptake following cochlear implantation. The results show that systemic administration of dexamethasone after surgery can enhance its distribution in the inner ear, providing a rationale for the use of perioperative systemic steroids in hearing preservation surgery.
ACTA OTO-LARYNGOLOGICA
(2023)
Review
Chemistry, Analytical
Yavuz Nuri Ertas, Derya Ozpolat, Saime Nur Karasu, Nureddin Ashammakhi
Summary: This paper provides a comprehensive resource on the electrodes currently used in cochlear implant devices. It discusses the impact of electrode materials, shape, and spacing on stimulation and the performance of electrode arrays. The electrical, mechanical, and electrochemical properties of electrode arrays, as well as recent advancements in electrode design parameters, are examined. The limitations and challenges of the current technology are discussed, along with proposals for future directions in the field.
Article
Cell Biology
Guoqiang Sun, Yandong Zheng, Xiaolong Fu, Weiqi Zhang, Jie Ren, Shuai Ma, Shuhui Sun, Xiaojuan He, Qiaoran Wang, Zhejun Ji, Fang Cheng, Kaowen Yan, Ziyi Liu, Juan Carlos Izpisua Belmonte, Jing Qu, Si Wang, Renjie Chai, Guang-Hui Liu
Summary: By establishing a dynamic single-cell transcriptomic landscape of cochlear aging, we found that loss of proteostasis and elevated apoptosis are the key features of cochlear aging. We also discovered unexpected transcriptional fluctuations in intermediate cells located in the stria vascularis. Additionally, upregulation of the ER chaperone protein HSP90AA1 can mitigate ER stress-induced damages associated with aging, suggesting a potential therapeutic target for delaying age-related hearing loss.
Article
Cell Biology
Haiying Sun, Tian Wang, Patrick J. Atkinson, Sara E. Billings, Wuxing Dong, Alan G. Cheng
Summary: The study reveals that Gpr125 is dynamically expressed in various cell types in the developing and mature cochlea, but it is not essential for cochlear development and hearing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Kathrin Malfeld, Nina Armbrecht, Holger A. Volk, Thomas Lenarz, Verena Scheper
Summary: Recent research has found that auditory synaptopathies play a crucial role in sensorineural hearing loss, and cochlear implant procedures may lead to physiological hearing loss in patients with residual hearing. The study developed a new method to examine the inner ear at the synapse level, aiming to better understand the cascade of hearing pathologies with the goal of developing targeted therapeutics.
Review
Biochemistry & Molecular Biology
Quentin-Alexandre Parys, Pauline Van Bulck, Elke Loos, Nicolas Verhaert
Summary: Intracochlear drug delivery is a feasible method to reduce inflammation after cochlear implantation, but evidence of its anti-inflammatory effects in humans is still scarce.
Article
Engineering, Biomedical
Chen Jiang, Shreya Singhal, Thomas Landry, Iwan Roberts, Simone R. de Rijk, Tim Brochier, Tobias Goehring, Yu Tam, Robert Carlyon, George Malliaras, Manohar Bance
Summary: Researchers simulated and compared electrical current spread under different stimulation modes using a 3D-printed physical cochlea model with integrated sensing wires. The results show a trade-off between stimulation amplitude and current focusing among different stimulation modes.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Polymer Science
Chung-Kai Sun, Cherng-Jyh Ke, Yi-Wen Lin, Feng-Huei Lin, Tung-Hu Tsai, Jui-Sheng Sun
Summary: The study aims to establish an effective antibiotic slow-release system and evaluate its efficacy in preventing implant-related infections through an animal model experiment.
Article
Audiology & Speech-Language Pathology
Peter A. Santi, Shane Johnson, Julian Wuester, Matthew Griesbach, Alexander Claussen, Jonathon Kirk
Summary: Postmortem examination of the cochlea with a cochlear implant presents challenges due to the presence of wires and metal components that make sectioning difficult. Plastic embedded implanted cochleas have been successfully sectioned using specialized methods. An alternative non-destructive method is optical sectioning of a chemically cleared cochlea, but the presence of metal components results in artifacts in the 2D optical sections. Removal of the implant prior to imaging yields the best image quality.
Article
Chemistry, Medicinal
Mingpeng Wang, Lei Chen, Zhengyu Lou, Xueting Yuan, Guiping Pan, Xiaoyan Ren, Pengyu Wang
Summary: Alginate oligosaccharides (AOS) are low molecular weight alginate with improved water solubility and comprehensive health benefits. In this study, a novel alginate lyase called Algpt was discovered and characterized from a marine bacterium. Algpt exhibited high stability and adaptability, making it suitable for efficient preparation of AOS with different sizes and AOS-based products.
Article
Engineering, Biomedical
Samuel Mueller, Lueder A. Kahrs, Johannes Gaa, Sebastian Tauscher, Marcel Kluge, Samuel John, Thomas S. Rau, Thomas Lenarz, Tobias Ortmaier, Omid Majdani
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2019)
Article
Engineering, Biomedical
Thomas S. Rau, Diana Kreul, Jakob Lexow, Silke Huegl, M. Geraldine Zuniga, Thomas Lenarz, Omid Majdani
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2019)
Review
Engineering, Mechanical
Lena Zentner, Stefan Griebel, Silke Huegl
MECHANISM AND MACHINE THEORY
(2019)
Article
Engineering, Biomedical
Thomas S. Rau, M. Geraldine Zuniga, Rolf Salcher, Thomas Lenarz
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2020)
Article
Clinical Neurology
M. Geraldine Zuniga, Silke Hugl, Benjamin G. Engst, Thomas Lenarz, Thomas S. Rau
Summary: The study demonstrated that using ultra-slow insertion velocities in cochlear implant surgery can significantly reduce insertion forces, leading to less trauma to the artificial scala tympani model. Adjusting the insertion velocity resulted in a 50% decrease in insertion forces, indicating that insertion velocity is a key factor affecting insertion forces.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jana Schwieger, Anna Sophie Frisch, Thomas S. Rau, Thomas Lenarz, Silke Hugl, Verena Scheper
Summary: Cochlear hair cell damage and spiral ganglion neuron degeneration are the main causes of sensory neural hearing loss. Neurotrophic factors can enhance the survival and neurite outgrowth of spiral ganglion neurons, optimizing the interaction with cochlear implants. An inner ear inspired Neurite Outgrowth Chamber (NOC) was designed for investigating chronic drug delivery, which proved to be suitable for explant cultivation and observed drug delivery.
Article
Engineering, Biomedical
Thomas S. Rau, Tim Ehmann, M. Geraldine Zuniga, Katarzyna Plaskonka, Andreas Keck, Omid Majdani, Thomas Lenarz
Summary: This study presents a prototype of an electrode array for cochlear implants that utilizes a shape memory effect to shift the array towards the inner wall of the cochlea. By adjusting the properties of Nitinol and implementing a suitable cooling strategy, the array can be gently inserted into an artificial cochlear model. The results demonstrate the feasibility of using the body temperature responsive shape memory effect for perimodiolar electrode array positioning.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Thomas S. Rau, Samuel John, Marcel Kluge, Felix Repp, M. Geraldine Zuniga, Jan Stieghorst, Max E. Timm, Max Froehlich, Omid Majdani, Thomas Lenarz
Summary: This article describes a new micro-stereotactic targeting system designed for cochlear implant surgery and its evaluation in an ex vivo study. The system demonstrated successful performance of minimally invasive posterior tympanotomy in all specimens.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Otorhinolaryngology
Lena Geiger, M. Geraldine Zuniga, Thomas Lenarz, Omid Majdani, Thomas S. Rau
Summary: This study aims to perform minimally invasive cochlear implant surgery using a micro-stereotactic surgical targeting system with on-site moulding of the template. The accuracy of the system was evaluated through ex-vivo testing on cadaveric temporal bone specimens. The results showed a high success rate of the surgery and suitability for various applications.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Engineering, Biomedical
Georg Boettcher-Rebmann, Viktor Schell, Leon Budde, M. Geraldine Zuniga, Claas Baier, Thomas Lenarz, Thomas S. S. Rau
Summary: A method to intraoperatively measure insertion forces during cochlear implant surgery was developed. The proposed design of a manual insertion tool with an embedded force sensor and inertial measurement unit was evaluated and showed the feasibility of measuring insertion forces. Surgeons successfully used the tool in human cadaver cochleae, providing insights on the relationship between forces and hearing outcomes in cochlear implant surgery.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Georg Boettcher-Rebmann, Viktor Schell, M. Geraldine Zuniga, Rolf Salcher, Thomas Lenarz, Thomas S. Rau
Summary: This study developed a tool for measuring insertion force during cochlear implant surgery and evaluated its usability in ex vivo experiments. The results showed a 100% success rate of electrode array insertion using the tool and the surgical workflow was deemed equivalent to standard procedures. Peak insertion forces significantly correlated with final electrode insertion depth, indicating the measured forces mainly correspond to intracochlear events.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Article
Engineering, Biomedical
Jakob Cramer, Georg Boettcher-Rebmann, Thomas Lenarz, Thomas S. Rau
Summary: Using CBCT images, this study developed a 3D printable pose setting adapter to align specimens along a desired trajectory for reproducible force measurement and reduced intracochlear trauma in cochlear implant electrode insertion tests. The performance of the adapter was evaluated and demonstrated practical applicability in automated electrode insertions.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)