Article
Chemistry, Multidisciplinary
Yangjian Quan, Wenjie Shi, Yang Song, Xiaomin Jiang, Cheng Wang, Wenbin Lin
Summary: A bifunctional metal-organic layer, Hf-EY-Fe, designed by bridging EY-capped Hf-6 SBUs with Fe-TPY ligands, efficiently catalyzes various reactions on alkenes and synthesis of CF3-substituted derivatives of large bioactive molecules. The proximity between EY and iron centers in Hf-EY-Fe enhances catalytic activity and inhibits mutual deactivation, resulting in high turnover numbers and good recyclability of the MOL catalyst.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Shan-Shan Fu, Qiang-Qiang Yuan, Lihua Ma, Zhi-Ming Zhang, Tong-Bu Lu, Song Guo
Summary: A series of TEMPO@PCN-222 composite photocatalysts were developed by coordinating different amount of 4-carboxy-TEMPO with the secondary building units of PCN-222. Visible-light irradiation enables the transfer of photogenerated holes in the highest occupied molecular orbital of PCN-222 to TEMPO, significantly increasing the photosynthesis of bioactive (iso)quinolones. With an outstanding catalytic stability and substrate tolerance, TEMPO@PCN-222 exhibits a yield of 86.7% for 1-methyl-2-quinolinone, over four times higher than PCN-222 (21.4%). This study provides a new route for constructing composite photocatalysts from abundant starting materials for efficient photosynthesis of high value-added chemicals.
Article
Nanoscience & Nanotechnology
Robert G. Surbella, Dallas D. Reilly, Michael A. Sinnwell, Bruce K. McNamara, Lucas E. Sweet, Jon M. Schwantes, Praveen K. Thallapally
Summary: Two lanthanide-containing porous coordination polymers with different pore structures were successfully synthesized via hydrothermal methods and show potential applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Sujing Wang, Liyu Chen, Mohammad Wahiduzzaman, Antoine Tissot, Lin Zhou, Ilich A. Ibarra, Aida Gutierrez-Alejandre, Ji Sun Lee, Jong-San Chang, Zheng Liu, Jerome Marrot, William Shepard, Guillaume Maurin, Qiang Xu, Christian Serre
Summary: Researchers have developed a robust mesoporous metal-organic framework, MIP-206, using a novel strategy to overcome limitations of previous mesoporous materials, showing excellent performance and potential for a wide range of applications.
Review
Chemistry, Multidisciplinary
Yuting Lin, Yuehua Li, Yu Cao, Xiaozhi Wang
Summary: Two-dimensional materials, including two-dimensional MOF, have garnered significant attention for their unique properties and potential applications. The applications of two-dimensional MOF spanning catalysis, supercapacitors, gas adsorption/separation, sensors have been increasingly explored by researchers. Challenges and opportunities in this field have been discussed to offer a promising outlook for future developments.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Shengxian Cheng, Jiayue Tang, Yangjian Quan
Summary: This Concept summarizes recent advances in integrating versatile metal-organic frameworks with organic photosensitizers.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Maria de Lourdes Gonzalez-Juarez, Mark A. Isaacs, Darren Bradshaw, Iris Nandhakumar
Summary: In this study, molecular iodine was incorporated into a two-dimensional semiconducting metal-organic framework (MOF) Cu3(2,3,6,7,10,11-hexahy-droxytriphenylene)2 Cu3(HHTP)2 via incipient wetness impregnation to enhance its thermoelectric properties. A power factor of 0.757 mu W m-1 K-2 was obtained for this MOF, demonstrating an effective route for the preparation of moderate-performance thermoelectric MOFs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Xuefu Hu, Zhiye Wang, Yuming Su, Peican Chen, Yibin Jiang, Cankun Zhang, Cheng Wang
Summary: This study demonstrates that incorporating chromophores into metal-organic layers can enhance two-photon absorption effects and reduce light scattering, leading to improved nonlinear optical performance.
CHEMISTRY OF MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Hongli Zhang, Yiling Zheng, Shuwen Yu, Weixing Chen, Jie Yang
Summary: Membrane-based nanotechnology has been widely used in various separation fields due to its high separation efficiency, low energy consumption, continuous operation modes, and environmental benefits. Two-dimensional nanomaterials (2DNMs) have emerged as ideal building blocks for developing high-performance separation membranes. By precisely controlling the nanochannels and/or nanoporous apertures of 2DNMs, 2DNM-based membranes can exhibit unprecedentedly high permeation and selectivity properties.
Article
Chemistry, Multidisciplinary
Yutian Qin, Yue Wan, Jun Guo, Meiting Zhao
Summary: This review article introduces the unique properties of two-dimensional metal-organic framework (MOF) nanosheet composites and their applications in various fields. It provides guidance for researchers in the design, preparation, and application of MOF nanosheet composites.
CHINESE CHEMICAL LETTERS
(2022)
Review
Chemistry, Physical
Tingting Zhan, Yingbing Zou, Ying Yang, Xiuling Ma, Zhangjing Zhang, Shengchang Xiang
Summary: 2D MOFs show significant advantages in CO2 electrocatalytic reduction, with their large porosity and ultrathin structure contributing to unique properties that enhance electrical conductivity and mass transport. The research on design strategies and synthesis of high-performance CO2 electroreduction provides guidance for surpassing bulk MOFs.
Article
Chemistry, Physical
Shuxian Sun, Jiahe Zang, Jiafeng Ruan, Fang Fang, Dalin Sun, Yun Song, Fei Wang
Summary: A two-dimensional sheet morphology MOF-coated CuGaSe2@ZnSe-NC heterostructure has been synthesized and utilized as an anode material for sodium ion batteries, showing stable capacity of 276 mAh g(-1) over 2000 cycles at a high current density of 2.0 A g(-1).
ACS APPLIED ENERGY MATERIALS
(2021)
Review
Chemistry, Physical
Cheng Chang, Wei Chen, Ye Chen, Yonghua Chen, Yu Chen, Feng Ding, Chunhai Fan, Hong Jin Fan, Zhanxi Fan, Cheng Gong, Yongji Gong, Qiyuan He, Xun Hong, Sheng Hu, Weida Hu, Wei Huang, Yuan Huang, Wei Ji, Dehui Li, Lain-Jong Li, Qiang Li, Li Lin, Chongyi Ling, Minghua Liu, Nan Liu, Zhuang Liu, Kian Ping Loh, Jianmin Ma, Feng Miao, Hailin Peng, Mingfei Shao, Li Song, Shao Su, Shuo Sun, Chaoliang Tan, Zhiyong Tang, Dingsheng Wang, Huan Wang, Jinlan Wang, Xin Wang, Xinran Wang, Andrew T. S. Wee, Zhongming Wei, Yuen Wu, Zhong-Shuai Wu, Jie Xiong, Qihua Xiong, Weigao Xu, Peng Yin, Haibo Zeng, Zhiyuan Zeng, Tianyou Zhai, Han Zhang, Hui Zhang, Qichun Zhang, Tierui Zhang, Xiang Zhang, Li-Dong Zhao, Meiting Zhao, Weijie Zhao, Yunxuan Zhao, Kai-Ge Zhou, Xing Zhou, Yu Zhou, Hongwei Zhu, Hua Zhang, Zhongfan Liu
Summary: Research on two-dimensional materials has been rapidly increasing in the past seventeen years, starting from graphene and expanding into a diverse family with unique structures and properties, making them attractive candidates for various applications. Major breakthroughs have been made in the last five years in developing synthetic methods, exploring new properties, identifying innovative applications, and pushing for commercialization in the field of 2D materials.
ACTA PHYSICO-CHIMICA SINICA
(2021)
Review
Chemistry, Physical
Huakai Xu, Xiaofei Wei, Hui Zeng, Chuanhai Jiang, Zhifei Wang, Yuguo Ouyang, Chunyu Lu, Yuan Jing, Shiwei Yao, Fangna Dai
Summary: Two-dimensional metal-organic framework (MOF) and its derivatives have shown great potential as electrocatalysts for oxygen evolution reaction (OER). They possess advantages such as rich metal nodes, large specific surface area, and adjustable structures. However, there are still challenges that need to be addressed for further development.
Review
Chemistry, Physical
Samira Shirvani, Mohammad Ghashghaee, Kevin J. Smith
Summary: 2D nanomaterials have the potential to be used as thermocatalysts, but there are challenges in terms of activity and stability, such as low thermal stability, susceptibility to poisoning, and rapid loss of activity. In addition, the complex synthesis procedures make reproducibility and scale-up difficult.
CATALYSIS REVIEWS-SCIENCE AND ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Wenyao Zhen, Ralph R. Weichselbaum, Wenbin Lin
Summary: Radiotherapy uses ionizing radiation to eliminate localized tumors and occasionally control tumors outside the treated area via the abscopal effect. However, it is often limited by physiological barriers in the tumor microenvironment, such as hypoxia, abnormal blood vessels, dense extracellular matrix, and immunosuppression. Therefore, it is crucial to develop new radiotherapy strategies that can remodel the tumor microenvironment to overcome radiation resistance and immune suppression.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Gan Lin, Geoffrey T. Nash, Taokun Luo, Indranil Ghosh, Siddhartha Sohoni, Andrew J. Christofferson, Gang Liu, Gregory S. Engel, Wenbin Lin
Summary: Efficient nano-sonosensitizers have been designed by anchoring sensitizers onto 2D nanoscale metal-organic layers, leading to higher singlet oxygen generation and improved sonodynamic therapy efficacy. In mouse models of colorectal and breast cancer, these nano-sonosensitizers demonstrated superior therapeutic effects compared to traditional sonodynamic therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Taokun Luo, Yingjie Fan, Jianming Mao, Xiaomin Jiang, Luciana Albano, Eric Yuan, Tomas Germanas, Wenbin Lin
Summary: A dual-organelle-targeted nanoparticle platform was developed for enhanced photodynamic therapy (PDT) of cancer. The platform grafted 5-aminolevulinic acid (ALA) to a Hf-12-based nanoscale metal-organic layer (Hf-MOL), which improved ALA delivery and protoporphyrin IX (PpIX) synthesis in mitochondria, and trapped 5,15-di-p-benzoatoporphyrin (DBP) photosensitizers in lysosomes. By simultaneously exciting PpIX and DBP with light irradiation at 630 nm, synergistic enhancement of PDT efficacy was achieved through the damage to both mitochondria and lysosomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Xiaomin Jiang, Jianqiao Liu, Jianming Mao, Wenbo Han, Yingjie Fan, Taokun Luo, Junjie Xia, Morten J. Lee, Wenbin Lin
Summary: Conventional chemotherapy alone may fail due to the plasticity of tumor cells acquiring chemo-resistance. This study demonstrates that high-dose pharmacologic ascorbate, in combination with nanoscale coordination polymers (NCPs) delivering chemotherapeutics, can effectively reduce cancer stem cells (CSCs) in solid tumors and inhibit tumor recurrence and metastasis in mouse models of cancer.
Review
Biochemistry & Molecular Biology
Youyou Li, Wenbin Lin
Summary: The low success rate of cancer nanomedicines has prompted discussions on the effectiveness of the enhanced permeability and retention (EPR) effect in delivering drugs to tumors. In this review, we discuss alternative strategies for improving nanoparticle delivery to tumors, including transcellular extravasation, receptor-mediated pathways, and protein corona interactions. We summarize recent advancements in platinum-based combination nanomedicines that combine multiple chemotherapeutics and anticancer therapies to enhance drug delivery and antitumor activities. Additionally, we highlight future opportunities and challenges for the translation of these combination nanomedicines into clinical practice.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Andrew C. Dunbar, John E. Gozum, Wenbin Lin, Vincent J. Flores, Gregory S. Girolami
Summary: Treating ThCl4 with LiBH4 in different ethereal solvents results in the formation of complexes Th(BH4)4(Et2O)2, Th(BH4)4(thf)2, and Th(BH4)4(dme). The crystal structures of these compounds have been determined by single-crystal X-ray diffraction. The Th(BH4)4(Et2O)2 and Th(BH4)4(thf)2 complexes adopt trans octahedral coordination geometries, while the Th(BH4)4(dme) complex exhibits a cis-octahedral structure. These compounds have potential applications as precursors for the chemical vapor deposition of thorium boride films.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zitong Wang, Pierce Yeary, Xuanyu Feng, Wenbin Lin
Summary: Despite efforts, it is challenging to design artificial enzymes that mimic the structures and functions of natural enzymes. This study successfully constructed binuclear iron catalysts in MOF-253 to mimic natural di-iron monooxygenases. The MOF-based artificial monooxygenase showed higher catalytic activity and effectively catalyzed oxidative transformations of organic compounds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yingjie Fan, Haifeng Zheng, Steven Labalme, Wenbin Lin
Summary: Metal-organic layers (MOLs) have emerged as a novel platform for designing multifunctional catalysts based on the monolayered version of metal-organic frameworks (MOFs). In this study, six MOLs were synthesized through solvothermal synthesis and subsequent modification, and characterized as flat nanoplates with a hexagonal lattice structure. The MOLs demonstrated efficient catalytic activity in tandem dehydrogenative coupling reactions and synergistic Heck-type coupling reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Haifeng Zheng, Yingjie Fan, Abigail L. Blenko, Wenbin Lin
Summary: Here, we report the synthesis of a bifunctional photocatalyst, Zr-OTf-EY, by modifying metal cluster nodes in a metal-organic layer (MOL). Zr-OTf-EY with eosin Y and strong Lewis acids on the nodes, catalyzes cross coupling reactions between C-H compounds and electron-deficient alkenes or azodicarboxylate to produce C-C and C-N coupling products, with high turnover numbers. The proximity between photostable EY sites and Lewis acids on the nodes enhances the catalytic efficiency by about 400 times compared to the homogeneous counterpart in the cross-coupling reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Ziwan Xu, Wenyao Zhen, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R. Weichselbaum, Wenbin Lin
Summary: In this study, a novel nanoscale metal-organic framework (nMOF) Hf-TP-SN, containing an X-ray-triggerable 7-ethyl-10-hydroxycamptothecin (SN38) prodrug, was designed for synergistic radiotherapy and chemotherapy. Upon X-ray irradiation, Hf-12 secondary building units served as radiosensitizers to enhance the generation of hydroxyl radicals, leading to the on-demand release of SN38. The Hf-TP-SN showed 5-fold higher release of SN38 compared to its molecular counterpart, resulting in significant cytotoxicity to cancer cells and efficient tumor growth inhibition in colon and breast cancer mouse models.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Wenyao Zhen, Taokun Luo, Zitong Wang, Xiaomin Jiang, Eric Yuan, Ralph R. Weichselbaum, Wenbin Lin
Summary: This study introduces a cholesterol oxidase-functionalized metal-organic framework that can simultaneously increase mechanical tension of plasma membranes and reduce the tolerance of cancer cells to reactive oxygen species and pyroptosis, leading to immunogenic cell death of cancer cells and reinvigorated T cells through inhibition of multiple immune checkpoints.
Article
Chemistry, Multidisciplinary
Feng-Xing Li, Xinmou Wang, Jiaxin Lin, Xiangyu Lou, Jing Ouyang, Guanwen Hu, Yangjian Quan
Summary: Selective difunctionalization of N-heterocyclic carbene (NHC) boranes with alkenes has been achieved via decatungstate and thiol synergistic catalysis. The catalytic system also allows stepwise trifunctionalization, leading to complex NHC boranes with three different functional groups which are challenging to prepare by other methods. The strong hydrogen-abstracting ability of the excited decatungstate enables the generation of boryl radicals from mono- and di-substituted boranes for realizing borane multifunctionalization. This proof-of-principle research provides a new chance for fabricating unsymmetrical boranes and developing boron-atom-economic synthesis.