Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 39, Pages 15515-15518Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b08892
Keywords
-
Categories
Funding
- New York University
- National Institutes of Health [R01GM126228]
- National Science Foundation through REU Site for Chemical Biology at New York University [CHE-1659619]
Ask authors/readers for more resources
A short, biomimetic synthesis of the fungal metabolite preuisolactone A is described. Its key steps are a purpurogallin-type (5 + 2)-cycloaddition, followed by fragmentation, vinylogous aldol addition, oxidative lactonization, and a final benzilic acid rearrangement. Our work explains why preuisolactone A has been isolated as a racemate and suggests that the natural product is not a sesquiterpenoid but a phenolic polyketide.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
