Article
Neurosciences
Ian D. Tomlinson, Oleg Kovtun, Ruben Torres, Laurel G. Bellocchio, Travis Josephs, Sandra J. Rosenthal
Summary: The study focused on developing a novel ligand, IDT785, that effectively studied the cellular trafficking and membrane dynamics of SERT, providing valuable insights into SERT localization and function. The ligand demonstrated biological activity by inhibiting SERT-mediated reuptake of serotonin and enabling membrane labeling of SERT for further research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
B. Jonas, D. Heinze, E. Schoell, P. Kallert, T. Langer, S. Krehs, A. Widhalm, K. D. Joens, D. Reuter, S. Schumacher, A. Zrenner
Summary: The authors introduce an all-optical nonlinear method to tailor and control the single photon emission. They demonstrate energy tuning and polarization control of the emitted photons through a laser-controlled down-conversion process.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Hao-Yang Liu, Zhi-Gang Wang, Yusi Hu, Xue-Hui Shi, Hua-Jie Chen, Xiao Li, Shu-Lin Liu, Dai-Wen Pang
Summary: The fusion of the viral membrane and genome release are hallmark events of enveloped virus infections. Through single-virus tracking and in-situ pH quantification, this study provides insights into the infection pathway of Japanese encephalitis virus (JEV) and its dependence on actin and microtubules. The study also reveals that viral fusion events predominantly occur in maturing endosomes.
Article
Chemistry, Multidisciplinary
Mahdi Asgari, Dominique Coquillat, Guido Menichetti, Valentina Zannier, Nina Diakonova, Wojciech Knap, Lucia Sorba, Leonardo Viti, Miriam Serena Vitiello
Summary: Low-dimensional nanosystems show promise in manipulating and controlling photons with large sensitivities, and by quantum engineering tailored energy levels of localized electrons can result in efficient quantum sensors. Utilizing few-electron physics, millimeter-wave nanodetectors have been developed to efficiently sense radiation at 0.6 THz with low noise levels, opening up prospects for quantum communications and cryptography.
Article
Biotechnology & Applied Microbiology
Jiayi Lin, Linlin Xu, Yuling Zheng, Dalin Wu, Jun Yue
Summary: This study reports a fluorescence probe with a core-shell structure that can selectively label different types of bacteria and biofilms. The results demonstrate the potential application of this probe in bacterial research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Minho Choi, Mireu Lee, Sung-Yul L. Park, Byung Su Kim, Seongmoon Jun, Suk In Park, Jin Dong Song, Young-Ho Ko, Yong-Hoon Cho
Summary: In this study, a method is proposed to deterministically integrate single quantum dots with tailor-made photonic structures. A nondestructive luminescence picking method called nanoscale-focus pinspot (NFP) is used to reduce the luminous quantum dot density. The selected quantum dot is then deterministically integrated with a tailor-made photonic structure, leading to improved extraction efficiency.
ADVANCED MATERIALS
(2023)
Article
Biochemical Research Methods
Micha Hersch, Adriano Biasini, Ana C. Marques, Sven Bergmann
Summary: In this study, a new method is proposed to estimate RNA synthesis, processing and degradation rates from a single sample. The method was validated on mouse embryonic stem cells and compared with other methods. The results show that the method is computationally efficient, reliable and correlates well with previous data sets. Furthermore, the application of this method reveals differences between dynamic and stable biological processes.
BMC BIOINFORMATICS
(2022)
Article
Chemistry, Multidisciplinary
Jun-Yu Li, Wei Li, Jin Liu, Jie Zhong, Renming Liu, Huanjun Chen, Xue-Hua Wang
Summary: By integrating a single quantum dot with a single gold nanorod, the strong coupling between quantum dots and plasmonic nanoparticles has been achieved, opening up a new pathway for solid-state quantum information processing. Utilizing a wedge nanogap cavity, the plasmonic electric fields were effectively confined in the nanoshell of the quantum dot, leading to the largest spectral Rabi splitting reported so far.
Article
Nanoscience & Nanotechnology
Francesco Maddalena, Marcin E. Witkowski, Michal Makowski, Abdellah Bachiri, Benoit Mahler, Ying-Chieh Wong, Cheng Yi Eric Chua, Jia Xing Lee, Winicjusz Drozdowski, Stuart Victor Springham, Christophe Dujardin, Muhammad Danang Birowosuto, Cuong Dang
Summary: In this study, CsPbBr3 quantum dots blended with resin at different concentrations were used to create sheets with high light yield, stable scintillation properties, and negligible trap density. The CsPbBr3 QD-resin sheets showed fast scintillation decay times and good imaging performance, making them a promising candidate for low-cost, flexible X-ray imaging screens and gamma-ray applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Quantum Science & Technology
Woong Bae Jeon, Jong Sung Moon, Kyu-Young Kim, Young-Ho Ko, Christopher J. K. Richardson, Edo Waks, Je-Hyung Kim
Summary: This study demonstrates a highly efficient fiber-interfacing photonic device that launches single photons from quantum dots directly into a standard single-mode fiber. The device utilizes optimized photonic structures and a precise pick-and-place technique, resulting in a plug-and-play single-photon device.
ADVANCED QUANTUM TECHNOLOGIES
(2022)
Article
Biochemistry & Molecular Biology
Natalia Zareba, Lukasz Lewandowski, Dominika Kunachowicz, Rene Kizek, Marta Kepinska
Summary: This study reveals that quantum dots (QDs) can influence the activity of superoxide dismutase (SOD) in a size-dependent manner. Additionally, the migration time of QDs-SOD1 complexes varies depending on the type of QD used, with different effects on fluorescence signals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Quanbo Jiang, Prithu Roy, Jean-Benoit Claude, Jerome Wenger
Summary: In this research, plasmonic nanoantennas were used to trap single colloidal quantum dots and enhance their photoluminescence without the need for further processing, achieving precise positioning of the quantum emitter at the nanoantenna hotspot. The dedicated nanoantenna design exhibited high trap stiffness for quantum dot trapping and relatively low trapping power, resulting in significantly improved emission characteristics of the single quantum dot.
Article
Nanoscience & Nanotechnology
Jan Kettler, Nitika Vaish, Laure Mercier de Lepinay, Benjamin Besga, Pierre-Louis de Assis, Olivier Bourgeois, Alexia Auffeves, Maxime Richard, Julien Claudon, Jean-Michel Gerard, Benjamin Pigeau, Olivier Arcizet, Pierre Verlot, Jean-Philippe Poizat
Summary: Hybrid quantum optomechanical systems interface a macroscopic mechanical degree of freedom with a single two-level system, such as a single spin, a superconducting qubit, or a single optical emitter. While progress has been made in the microwave domain, challenges remain in the optical domain in achieving the reciprocal effect of a single quantum system on a macroscopic mechanical resonator.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hyeongwoo Lee, Ju Young Woo, Dae Young Park, Inho Jo, Jusun Park, Yeunhee Lee, Yeonjeong Koo, Jinseong Choi, Hyojung Kim, Yong-Hyun Kim, Mun Seok Jeong, Sohee Jeong, Kyoung-Duck Park
Summary: Strain engineering of perovskite quantum dots (pQDs) at the single-emitter level has been achieved using tip-enhanced photoluminescence (TEPL) spectroscopy. By systematically modulating tip-induced compressive strain, dynamic bandgap engineering in a reversible manner has been successfully demonstrated on a single pQD.
Article
Chemistry, Multidisciplinary
Yuqi Yang, Baolong Wang, Xu Zhang, Hongchuang Li, Sen Yue, Yifan Zhang, Yunhuang Yang, Maili Liu, Chaohui Ye, Peng Huang, Xin Zhou
Summary: In this study, acidity-activated graphene quantum dots-based nanotransformers (GQD NT) were developed as photosensitizer vehicles for long-period tumor imaging and repeated PDT. The GQD NT actively targeted tumor tissues and underwent loosening and enlargement in tumor acidity, enabling longer tumor retention. The GQD NT also generated mild hyperthermia upon laser irradiation, enhancing cell membrane permeability and promoting photosensitizer uptake. This study overcame the overdose obstacle in repeated PDT by using programmed deformation to enhance accumulation, retention, and release of photosensitizers in tumors.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Guobin Mao, Yingxin Ma, Guoqiang Wu, Mingyuan Du, Songbai Tian, Siqi Huang, Xinghu Ji, Zhike He
Summary: The novel method proposes preparing two types of clickable quantum dots through the strong interaction of -SH with metal ions. One type is used to improve QDs' stability and enhance GOx activity, while the other type is utilized for in situ bioorthogonal labeling of HeLa cells through metabolic oligosaccharide engineering.
ANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Yingxin Ma, Guobin Mao, Guoqiang Wu, Zongqiang Cui, Xian-En Zhang, Weiren Huang
Summary: A CRISPR-dCas9-guided nanosystem was constructed for nuclear targeting and smart release of anticancer drugs, using telomerase-responsive technology to enhance efficiency. The nanosystem achieved precise drug delivery to the nucleus and triggered effective drug release in tumor cells. This study provides a promising strategy for nuclear-targeted delivery and tumor-specific release of anticancer drugs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Virology
Wei Li, Ji Liu, Yuanyuan Liu, Qin Li, Wen Yin, Kevin K. Wanderi, Xiaowei Zhang, Zhiping Zhang, Xian-En Zhang, Zongqiang Cui
Summary: This study reveals the dynamic podosome-mediated entry of HIV-1 into macrophages, where the core and ring structures of podosomes play complex roles in viral entry, with the CCR5 coreceptor recruited to form specific clusters. The podosome facilitates HIV-1 entry with a rotation mode triggered by dynamic actin.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Yang Zheng, Qing Zhang, Ashaq Ali, Ke Li, Nan Shao, Xiaoli Zhou, Zhiqin Ye, Xiaomin Chen, Shanshan Cao, Jing Cui, Juan Zhou, Dianbing Wang, Baidong Hou, Min Li, Mengmeng Cui, Lihua Deng, Xinyi Sun, Qian Zhang, Qinfang Yang, Yong li, Hui Wang, Yake Lei, Bo Yu, Yegang Cheng, Xiaolin Tong, Dong Men, Xian-En Zhang
Summary: The majority of convalescent COVID-19 patients displayed sustained high levels of antibodies for over six months, while a small percentage showed declining levels to undetectable, warranting further attention. This indicates a typical dynamic of acquired immunity in the humoral immune response against SARS-CoV-2 infection in COVID-19 patients.
Article
Nanoscience & Nanotechnology
Yingxin Ma, Guobin Mao, Guoqiang Wu, Minghai Chen, Fujun Qin, Luping Zheng, Xian-En Zhang
Summary: The study created a dual color pseudo-SARS-CoV-2 virus using a pseudovirus strategy, allowing tracking of virus movement and fate of labeled components. Pseudo-SARS-CoV-2 mainly entered host cells through endocytosis, with infection efficiency correlated to the expression of ACE2 receptor on host cell surface. The dual-color fluorescently labeled pseudovirus system is believed to be a useful tool for various purposes in SARS-CoV-2/COVID-19 research.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biology
Rui Gong, Dianbing Wang, Ghulam Abbas, Shimin Li, Qian Liu, Mengmeng Cui, Xian-En Zhang
Summary: This study introduces a genetically encoded switch-on mNeonGreen2-based biosensor for detecting caspase-3 activity. The biosensor demonstrated shortened response time, higher sensitivity, and prolonged functional shelf life in detecting caspase-3 compared to existing counterparts. Additionally, the biosensor was used to evaluate the effect of various drugs on inducing apoptosis in HeLa and MCF-7 tumor cells and inhibiting Zika virus invasion.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Letter
Virology
Xiaohua Chen, Juan Zhou, Chen Chen, Baidong Hou, Ashaq Ali, Feng Li, Zhaolin Hua, Yingtao Wu, Qin Yang, Min Chen, Rong Zhang, Qianchuan Huang, Jinya Ding, Xian-En Zhang, Dong Men
Review
Chemistry, Multidisciplinary
Dian-Bing Wang, Meng-Meng Cui, Min Li, Xian-En Zhang
Summary: Detecting Bacillus anthracis quickly and sensitively poses challenges due to the need for accurate differentiation from other Bacillus species, preserving spores for direct detection, and rapid testing in complex samples without prior processing. Various biosensors offer potential solutions with different detection targets, molecular recognition elements, and sensing systems, utilizing nanotechnology to enhance performance. Further advancements are needed to address remaining challenges and improve practicality in B. anthracis detection methods.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Electrochemistry
Jin Song, Yiwei Li, Dingkun Ke, Dianbing Wang, Xian-En Zhang
Summary: By integrating graphene with carbon microelectrode arrays, a sensitive biosensor platform has been developed for studying biofilm formation and screening antibiofilm drugs. The graphene-modified microelectrode arrays demonstrated better performance and higher specificity in detecting biofilm growth.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Minghai Chen, Chuang Yan, Luping Zheng, Xian-En Zhang
Summary: The study developed near-infrared BiFC and TriFC systems using miRFP670nano, enabling efficient visualization of protein interactions. The sensor system showed faster maturation rate, higher photostability, and cellular stability compared to existing systems, demonstrating its potential for various applications in cell imaging studies.
Article
Chemistry, Physical
Cuihua Wei, Juan Zhou, Tiangang Liu, Wanqi Zhao, Xian-En Zhang, Dong Men
Summary: The study developed a self-assembled enzymatic nanowire with a unique interface, improving enzyme stability and catalytic activity in organic solvents. By fusing JTA with Sup35 to construct JTAnw, the reaction time in organic solvents was significantly reduced, and the thermal and pH stability of the enzyme was enhanced.
Article
Chemistry, Multidisciplinary
Weiwei Zhu, Ti Fang, Wenjing Zhang, Ao Liang, Hui Zhang, Zhi-Ping Zhang, Xian-En Zhang, Feng Li
Summary: Dps, a natural protein nanocage, has been developed for antioxidant treatment by inhibiting the generation of ROS. With its ferroxidase activity, Dps not only protects cells from oxidative stress but also alleviates inflammation induced by ROS. This unique material shows great potential in various applications such as antiaging, anti-inflammation, and cosmetics.
Article
Biology
Song Lu, Dianbing Wang, Yu Hou, Dongge Guo, Yulin Deng, Xian-En Zhang
Summary: This study successfully reduced the number of fluorescent modules entering the nucleus by redesigning the CRISPR/dCas9-SunTag labeling system, resulting in decreased background fluorescence and increased signal-to-background ratio.
SCIENCE CHINA-LIFE SCIENCES
(2021)