CrossTalk proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin‐4

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

(2019) Lauren M. Hablitz et al.   Science Advances

Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue

(2018) Jan Tønnesen et al.   CELL

Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

(2018) Matthew J. Simon et al.   Scientific Reports

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

(2018) Humberto Mestre et al.   eLife

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface

(2017) Anne- Cécile Boulay et al.   Cell Discovery

Glymphatic clearance controls state-dependent changes in brain lactate concentration

(2016) Iben Lundgaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

(2016) Thiyagaragan M. Achariyar et al.   Molecular Neurodegeneration

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

(2015) Natalya Korogod et al.   eLife

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS