Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 198, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2019.111558
Keywords
Silver nanoparticle; Garlic clove; Antibiofilm, antiparasite; Anti breastcancer
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Funding
- DST, New Delhi, India under INSPIRE programme [1E140145]
- FONDECYT [11170155]
- RUSA phase 2.0 grant TN Multi-Gen. Department of Education, Government of India [24-512014-U policy]
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Facile and low cost garlic clove extract based silver nanoparticles was synthesized and its broad spectrum of therapeutic activity including antibiofilm, antiparasitic and anti-breast cancer activity was evaluated. The synthesized garlic-silver nanoparticles (G-AgNPs) were characterized by various physico-chemical techniques. GAgNPs showed good optical property, highly crystalline nature, spherical shape and uniformly dispersed with size measuring between 10 and 50 nm. G-AgNPs have shown greater anti-bacterial and antibiofilm activity on clinically important pathogens methicillin-resistant S. aureus and P. aerigunosa at 100 mu g ml(-1). The efficacy of GAgNPs against earthworm evidenced its effectiveness as anti-helminthic agent in treating intestinal parasites. The significant inhibition of BSA protein denaturation proves its anti-inflammatory property. In addition, GAgNPs have shown remarkable anticancer effect and significantly inhibited the human breast cancer cell (MCF7) viability at 100 mu g ml(-1) after 24 h. A noticeable change in the morphology of MCF-7 cells was also noticed. GAgNPs were non-toxic to human HEK293 embryonic cells. Also, the non-toxic nature of G-AgNPs to C. cornuta and no morphological, physiological changes proved its safety to the environment. It is concluded that G-AgNPs have a broad range of biological applications and it can be used as an eco-friendly material without having negative effects in the environment.
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