Article
Chemistry, Analytical
Dimitrios Livas, Maria Trachioti, Sofia Banou, Michailia Angelopoulou, Anastasios Economou, Mamas Prodromidis, Panagiota Petrou, Sotirios Kakabakos, Christos Kokkinos
Summary: This work presents a novel electrochemical immunoassay device for analyzing adulteration in complex matrices, utilizing competitive immunoassays and stripping voltammetric detection. The device shows high sensitivity and wide applicability, making it suitable for various quantum dot-based bioassays.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Jie Chen, Chonglin Yuan, Weili Liang, Nanlin Zhang, Xiaolin Zhang, Zhiwei Wang, Chengqun Wang, Xiuting Li
Summary: The study found that the shell and core Pb(II) of PbS-PbI2 QDs can be distinguished by an electrochemical method, and the shell/core composition of the QDs can be determined based on the peak charge ratio. XPS analysis and UV-vis spectroscopy further indicated that the shell/core ratio of PbS-PbI2 QDs varies with changes in ligand PbI2 concentration.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Electrochemistry
Kantharao Kancharla, Kiran Kumar Tadi
Summary: In this study, ultrasensitive electrochemical detection of lead ions was achieved using MoS2 quantum dots. The sensor showed a wide linear range, low detection limit, and stable response even in the presence of other metal ions. Practical applicability of the sensor was demonstrated through successful detection of lead ions in agricultural soil and groundwater samples.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Zhiyuan Huang, Ji Hao, Jeffrey L. Blackburn, Matthew C. Beard
Summary: This research demonstrates control of pyroelectricity in nanocrystalline systems by constructing a system built from spherical PbS quantum dots that can self-assemble into close-packed arrays or disperse into a polymer, both exhibiting a pyroelectric response. The polarization of each quantum dot can be easily tuned by constructing different Janus-ligand shells.
Article
Chemistry, Analytical
Michailia Angelopoulou, Dimitra Kourti, Maria Mertiri, Panagiota Petrou, Sotirios Kakabakos, Christos Kokkinos
Summary: In this study, a 3D printed electrochemical immunosensor was developed for the detection of Salmonella typhimurium in fresh chicken. The sensor exhibited high sensitivity, simplicity, and potential for on-site analysis. The quantification of Salmonella was achieved through a sandwich immunoassay and anodic stripping voltametric determination. Additionally, the use of electroplated bismuth film enhanced the sensitivity of the sensor.
Article
Chemistry, Analytical
Aylen Di Tocco, Gabriela Valeria Porcal, Gabriel Lassabe, Andres Gonzalez-Techera, Maria Alicia Zon, Hector Fernandez, Gualberto Gonzalez-Sapienza, Sebastian Noel Robledo, Fernando Javier Arevalo
Summary: Research on immunoassays and immunosensors focuses on developing strategies to amplify signals. This study introduces an electrochemical immunosensor that uses viral particles and nanocrystals to conduct more simplified, sensitive, and reliable immunoassays. The developed immunosensor successfully detects molinate in river water samples with high accuracy and excellent recovery rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Multidisciplinary Sciences
Mohammad Mehdi Habibi, Jahan B. Ghasemi, Alireza Badiei, Parviz Norouzi
Summary: A sensitive electrochemical sensor was successfully developed for simultaneous analysis of morphine and methadone. The sensor was optimized and trained using modern electrochemical techniques and multivariable analysis. The model showed good performance in both test and real matrix samples with high predictive accuracy.
SCIENTIFIC REPORTS
(2022)
Article
Biophysics
Bao-Yu Liao, Chih-Chia Cheng, Chih-Feng Wang, Chien-Hsing Lu, Jem-Kun Chen
Summary: The particle gradient assembly patterning formed with magnetic field gradient enhances the performance of ECL measurement by improving the sensitivity of the immunosensor. It provides a simple method to improve ECL performance with a wide linear range and low detection limit for quantifying human serum albumin.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Artur Huseinov, Abdul Hoque, Kyle A. Ruble, Brandon J. Dee, Noe T. Alvarez
Summary: This study presents a reagentless sample preparation method for the detection of particulate Pb contaminants in tap water using membrane electrolysis. The membrane electrolysis allows for the in-situ generation of nitric acid, which, when combined with anodic stripping voltammetry, provides a powerful and reagent-free detection of Pb2+. The setup configuration enables semi-autonomous operation and requires minimal attention, making it more suitable for continuous measurements of particulate contaminants in tap water.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Pratik Kolhe, Akanksha Roberts, Sonu Gandhi
Summary: The unregulated usage of Cephalexin (CFX) in animal source food products has led to antimicrobial resistance (AMR) in humans. Graphene quantum dots (GQD) were utilized to enhance the electrochemical response of the sensor for the sensitive detection of CFX. The developed biofunctionalized electrode may have potential applications for on-site detection of other antibiotics in food samples.
Article
Chemistry, Analytical
Beibei Wang, Chao Wang, Yuyang Li, Xuejing Liu, Dan Wu, Qin Wei
Summary: In this study, a sensitive sandwiched electrochemiluminescence (ECL) immunosensor was developed for the detection of cardiac troponin I (cTnI). The sensor showed a wide linear range and low detection limit, making it suitable for the sensitive detection of biomarkers for acute myocardial infarction.
Article
Chemistry, Physical
Chunli Zhao, Yuan Gao, Tiantian Song, Jing Wang, Jianbei Qiu
Summary: In this study, Cs2NaScCl6:Er3+ crystals were successfully synthesized and showed efficient luminescence under excitation by ultraviolet and near-infrared light. The strong localization effect of Er3+ ions in the crystal lattice was observed through calculations, and charge transfer sensitization was identified as the reason for the high luminescence efficiency.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Engineering, Chemical
Riya Gupta, Usisipho Feleni, Emmanuel Iwuoha
Summary: Prostate cancer is a major global threat, with PSA serving as a potential biomarker for early diagnosis. An extremely sensitive electrochemical immunosensor was developed with a detection limit of 0.36 ng/mL, making it suitable for clinical applications.
Article
Chemistry, Analytical
Mehmet Lutfi Yola
Summary: A novel voltammetric immunosensor for HER2 detection was developed with high sensitivity and detection limit, as well as high selectivity, stability, reproducibility, and reusability.
Article
Chemistry, Analytical
Beatriz A. Braz, Manuel Hospinal-Santiani, Gustavo Martins, Breno C. B. Beirao, Marcio F. Bergamini, Luiz H. Marcolino-Junior, Carlos R. Soccol, Vanete Thomaz-Soccol
Summary: Neglected tropical diseases, which are endemic in low-income populations, lack research investment and have unacceptable indicators. Electrochemical immunosensors show promise for diagnosis in isolated regions. In this study, different peptides were investigated for detecting Leishmania antibodies with outstanding performance achieved using a graphene affinity peptide as a recognition site.
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)