Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 17, Pages 11261-11267Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01545
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Funding
- National Natural Science Foundation of China [21772027, 21702032]
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An efficient approach to access functionalized 1,4- and 1,5-amino alcohols has been developed through the nucleophilic addition of semicyclic N,O-acetal with organozinc reagents. A number of substituted benzyl zinc reagents (including nitrile and ester substituted) could react with semicyclic N,O-acetals 1 and 2, affording the desired products 3a-3p and 4a-4o in good to excellent yields.
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